KR102546748B1 - 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-3,7-다이온 스테로이드 - Google Patents

스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-3,7-다이온 스테로이드 Download PDF

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KR102546748B1
KR102546748B1 KR1020177016857A KR20177016857A KR102546748B1 KR 102546748 B1 KR102546748 B1 KR 102546748B1 KR 1020177016857 A KR1020177016857 A KR 1020177016857A KR 20177016857 A KR20177016857 A KR 20177016857A KR 102546748 B1 KR102546748 B1 KR 102546748B1
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KR20170104453A (ko
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알렉산더 웨이머스-윌슨
조피아 콤스타
제임스 보델
로라 월리스
리스 배철러
칼 오터
이안 데이비스
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엔제트피 유케이 리미티드
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Priority claimed from GBGB1505676.5A external-priority patent/GB201505676D0/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020177016857A 2014-11-19 2015-11-19 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-3,7-다이온 스테로이드 Active KR102546748B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GB1420593.4 2014-11-19
GB1420594.2 2014-11-19
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GB1505676.5 2015-04-01
GBGB1505676.5A GB201505676D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053518 WO2016079519A1 (en) 2014-11-19 2015-11-19 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators

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KR20170104453A KR20170104453A (ko) 2017-09-15
KR102546748B1 true KR102546748B1 (ko) 2023-06-22

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US (1) US10538550B2 (https=)
EP (1) EP3221333B1 (https=)
JP (1) JP6735748B2 (https=)
KR (1) KR102546748B1 (https=)
CN (1) CN107108688B (https=)
CA (1) CA2968305A1 (https=)
DK (1) DK3221333T3 (https=)
EA (1) EA034739B1 (https=)
ES (1) ES2748692T3 (https=)
MX (1) MX375865B (https=)
PL (1) PL3221333T3 (https=)
TW (1) TWI686401B (https=)
WO (1) WO2016079519A1 (https=)

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GB201608779D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
EP3431486A1 (en) 2017-07-18 2019-01-23 Bionice, S.L.U. Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
US12186329B2 (en) 2018-08-23 2025-01-07 President And Fellows Of Harvard College Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes
CN111138509B (zh) * 2018-11-02 2022-12-06 东莞东阳光药物研发有限公司 奥贝胆酸的制备方法
WO2020117945A1 (en) * 2018-12-04 2020-06-11 President And Fellows Of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof
AU2020274319B2 (en) 2019-05-10 2026-02-12 President And Fellows Of Harvard College Small molecule modulators of gut bacterial bile acid metabolism

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MX2017006565A (es) 2018-01-26
WO2016079519A1 (en) 2016-05-26
PL3221333T3 (pl) 2020-01-31
JP6735748B2 (ja) 2020-08-05
EP3221333B1 (en) 2019-07-24
TWI686401B (zh) 2020-03-01
WO2016079519A9 (en) 2018-08-09
TW201632538A (zh) 2016-09-16
KR20170104453A (ko) 2017-09-15
CA2968305A1 (en) 2016-05-26
EP3221333A1 (en) 2017-09-27
US10538550B2 (en) 2020-01-21
US20180340006A1 (en) 2018-11-29
EA201790879A1 (ru) 2017-11-30
CN107108688A (zh) 2017-08-29
ES2748692T3 (es) 2020-03-17
HK1244287A1 (en) 2018-08-03
DK3221333T3 (da) 2019-09-30
JP2017538690A (ja) 2017-12-28
MX375865B (es) 2025-03-07
CN107108688B (zh) 2019-10-29
EA034739B1 (ru) 2020-03-16

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