CN107108688B - 作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇 - Google Patents

作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇 Download PDF

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Publication number
CN107108688B
CN107108688B CN201580062897.3A CN201580062897A CN107108688B CN 107108688 B CN107108688 B CN 107108688B CN 201580062897 A CN201580062897 A CN 201580062897A CN 107108688 B CN107108688 B CN 107108688B
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alkyl
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group
compounds
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CN107108688A (zh
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A·韦茅斯-威尔逊
Z·科姆斯塔
J·博伊德尔
L·沃利斯
R·巴彻勒
C·奥特
I·戴维斯
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Nzp Uk Ltd
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Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505676.5A external-priority patent/GB201505676D0/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580062897.3A 2014-11-19 2015-11-19 作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇 Active CN107108688B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GB1420593.4 2014-11-19
GB1420594.2 2014-11-19
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GB1505676.5 2015-04-01
GBGB1505676.5A GB201505676D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053518 WO2016079519A1 (en) 2014-11-19 2015-11-19 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators

Publications (2)

Publication Number Publication Date
CN107108688A CN107108688A (zh) 2017-08-29
CN107108688B true CN107108688B (zh) 2019-10-29

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CN201580062897.3A Active CN107108688B (zh) 2014-11-19 2015-11-19 作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇

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US (1) US10538550B2 (https=)
EP (1) EP3221333B1 (https=)
JP (1) JP6735748B2 (https=)
KR (1) KR102546748B1 (https=)
CN (1) CN107108688B (https=)
CA (1) CA2968305A1 (https=)
DK (1) DK3221333T3 (https=)
EA (1) EA034739B1 (https=)
ES (1) ES2748692T3 (https=)
MX (1) MX375865B (https=)
PL (1) PL3221333T3 (https=)
TW (1) TWI686401B (https=)
WO (1) WO2016079519A1 (https=)

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KR102527821B1 (ko) 2014-11-19 2023-05-02 엔제트피 유케이 리미티드 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-6,7-다이온 스테로이드
CN107207559B (zh) 2014-11-19 2019-10-25 Nzp英国有限公司 作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇
JP2018538331A (ja) * 2015-12-22 2018-12-27 インターセプト ファーマシューティカルズ， インコーポレイテッド オベチコール酸の多型結晶形態
GB201608779D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
EP3431486A1 (en) 2017-07-18 2019-01-23 Bionice, S.L.U. Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
US12186329B2 (en) 2018-08-23 2025-01-07 President And Fellows Of Harvard College Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes
CN111138509B (zh) * 2018-11-02 2022-12-06 东莞东阳光药物研发有限公司 奥贝胆酸的制备方法
WO2020117945A1 (en) * 2018-12-04 2020-06-11 President And Fellows Of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof
AU2020274319B2 (en) 2019-05-10 2026-02-12 President And Fellows Of Harvard College Small molecule modulators of gut bacterial bile acid metabolism

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Publication number Publication date
MX2017006565A (es) 2018-01-26
WO2016079519A1 (en) 2016-05-26
PL3221333T3 (pl) 2020-01-31
JP6735748B2 (ja) 2020-08-05
EP3221333B1 (en) 2019-07-24
TWI686401B (zh) 2020-03-01
WO2016079519A9 (en) 2018-08-09
TW201632538A (zh) 2016-09-16
KR20170104453A (ko) 2017-09-15
CA2968305A1 (en) 2016-05-26
EP3221333A1 (en) 2017-09-27
US10538550B2 (en) 2020-01-21
US20180340006A1 (en) 2018-11-29
EA201790879A1 (ru) 2017-11-30
KR102546748B1 (ko) 2023-06-22
CN107108688A (zh) 2017-08-29
ES2748692T3 (es) 2020-03-17
HK1244287A1 (en) 2018-08-03
DK3221333T3 (da) 2019-09-30
JP2017538690A (ja) 2017-12-28
MX375865B (es) 2025-03-07
EA034739B1 (ru) 2020-03-16

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