KR102540515B1 - 인터류킨-2-유도성 t-세포 키나제를 조절하기 위한 화합물 및 방법 - Google Patents
인터류킨-2-유도성 t-세포 키나제를 조절하기 위한 화합물 및 방법 Download PDFInfo
- Publication number
- KR102540515B1 KR102540515B1 KR1020197015471A KR20197015471A KR102540515B1 KR 102540515 B1 KR102540515 B1 KR 102540515B1 KR 1020197015471 A KR1020197015471 A KR 1020197015471A KR 20197015471 A KR20197015471 A KR 20197015471A KR 102540515 B1 KR102540515 B1 KR 102540515B1
- Authority
- KR
- South Korea
- Prior art keywords
- unsubstituted
- substituted
- membered
- independently
- delete delete
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/5545—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having eight-membered rings not containing additional condensed or non-condensed nitrogen-containing 3-7 membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Enzymes And Modification Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662417083P | 2016-11-03 | 2016-11-03 | |
| US62/417,083 | 2016-11-03 | ||
| PCT/US2017/059871 WO2018089261A2 (en) | 2016-11-03 | 2017-11-03 | Compounds and methods for modulating interleukin-2-inducible t-cell kinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20190089891A KR20190089891A (ko) | 2019-07-31 |
| KR102540515B1 true KR102540515B1 (ko) | 2023-06-05 |
Family
ID=62109599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197015471A Active KR102540515B1 (ko) | 2016-11-03 | 2017-11-03 | 인터류킨-2-유도성 t-세포 키나제를 조절하기 위한 화합물 및 방법 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US11008314B2 (enExample) |
| EP (1) | EP3534899B1 (enExample) |
| JP (2) | JP7236996B2 (enExample) |
| KR (1) | KR102540515B1 (enExample) |
| CN (1) | CN110099684B (enExample) |
| AU (1) | AU2017358901B2 (enExample) |
| CA (2) | CA3278142A1 (enExample) |
| DK (1) | DK3534899T3 (enExample) |
| ES (1) | ES2926153T3 (enExample) |
| IL (1) | IL266181B2 (enExample) |
| MX (1) | MX392031B (enExample) |
| PT (1) | PT3534899T (enExample) |
| WO (1) | WO2018089261A2 (enExample) |
| ZA (1) | ZA201903071B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
| TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Ｋｒａｓ ｇ１２ｃ之抑制劑 |
| AU2016245864C1 (en) | 2015-04-10 | 2021-09-09 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
| EP3356347A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| EP3356359B1 (en) | 2015-09-28 | 2021-10-20 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| WO2017058728A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| US10975071B2 (en) | 2015-09-28 | 2021-04-13 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| KR102932353B1 (ko) | 2015-11-16 | 2026-02-27 | 아락세스 파마 엘엘씨 | 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법 |
| PT3534899T (pt) * | 2016-11-03 | 2022-07-07 | Corvus Pharmaceuticals Inc | Compostos e métodos de modulação da cinase de células t induzível por interleucina-2 |
| EP3573971A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| US11136308B2 (en) | 2017-01-26 | 2021-10-05 | Araxes Pharma Llc | Substituted quinazoline and quinazolinone compounds and methods of use thereof |
| EP3573954A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| JP7327802B2 (ja) | 2017-01-26 | 2023-08-16 | アラクセス ファーマ エルエルシー | 縮合ヘテロ－ヘテロ二環式化合物およびその使用方法 |
| WO2018218069A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant kras, hras or nras |
| CN110869358A (zh) | 2017-05-25 | 2020-03-06 | 亚瑞克西斯制药公司 | Kras的共价抑制剂 |
| BR112021001709A2 (pt) | 2018-08-01 | 2021-05-04 | Araxes Pharma Llc | compostos espiro heterocíclicos e métodos de uso dos mesmos para o tratamento de câncer |
| AU2019364417A1 (en) * | 2018-10-24 | 2021-05-20 | Araxes Pharma Llc | 2-(2-acryloyl-2,6-diazaspiro[3.4]octan-6-yl)-6-(1H-indazol-4-yl)-benzonitrile derivatives and related compounds as inhibitors of G12C mutant KRAS protein for inhibiting tumor metastasis |
| US20230029266A1 (en) * | 2019-11-05 | 2023-01-26 | Dermira, Inc. | MrgprX2 Antagonists for the Treatment of Inflammatory Disorders |
| WO2021138391A1 (en) | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
| AU2021297778A1 (en) | 2020-06-23 | 2022-11-24 | Dana-Farber Cancer Institute, Inc. | Compounds for targeted degradation of interleukin-2-inducible T-cell kinase and methods of use |
| CN114605404B (zh) * | 2022-03-23 | 2024-01-05 | 合肥美诺医药有限公司 | 一种新型含噻唑类化合物、中间体及其应用 |
| CN114621213B (zh) * | 2022-03-23 | 2023-12-08 | 合肥美诺医药有限公司 | 含噻唑类化合物及其中间体与应用 |
| KR20240169633A (ko) * | 2022-04-05 | 2024-12-03 | 코버스 파마슈티칼스, 인크. | Th1 세포 활성을 증가시키기 위한 itk 저해제 |
| WO2025085889A1 (en) * | 2023-10-20 | 2025-04-24 | Corvus Pharmaceuticals, Inc. | Interleukin-2-inducible t-cell kinase inhibitors to produce enhanced immune responses |
| WO2025171035A1 (en) * | 2024-02-06 | 2025-08-14 | Corvus Pharmaceuticals, Inc. | Itk inhibitors and uses thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002050071A1 (en) * | 2000-12-21 | 2002-06-27 | Bristol-Myers Squibb Company | Thiazolyl inhibitors of tec family tyrosine kinases |
| US20140011810A1 (en) | 2009-12-23 | 2014-01-09 | Gatekeeper Pharmaceuticals, Inc. | Compounds that Modulate EGFR Activity and Methods for Treating or Preventing Conditions Therewith |
| WO2016079231A1 (en) | 2014-11-19 | 2016-05-26 | Hach Lange Gmbh | Control of wastewater treatment based on regulatory period |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0212101A (pt) * | 2001-08-24 | 2004-08-24 | Pharmacia & Up John Company | 7-aza [2.2.1] biciclo-heptanos substituìdos com heteroarila para o tratamento de doenças |
| US7973169B2 (en) * | 2003-09-06 | 2011-07-05 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| US8222285B2 (en) | 2007-06-11 | 2012-07-17 | Bristol-Myers Squibb Company | 1,3-dihydroxy substituted phenylamide glucokinase activators |
| US20100113520A1 (en) | 2008-11-05 | 2010-05-06 | Principia Biopharma, Inc. | Kinase knockdown via electrophilically enhanced inhibitors |
| US9649313B2 (en) | 2012-11-26 | 2017-05-16 | The University Of North Carolina At Chapel Hill | Use of ITK inhibitors for the treatment of cancer |
| CN105164112B (zh) | 2013-01-31 | 2017-10-13 | 中国科学院上海药物研究所 | 酰胺类化合物及其制备方法、药物组合物和用途 |
| CA2965178C (en) | 2014-10-22 | 2023-09-26 | Dana-Farber Cancer Institute, Inc. | Thiazolyl-containing compounds for treating proliferative diseases |
| CN105884711A (zh) | 2014-12-16 | 2016-08-24 | 中国药科大学 | 噻唑类化合物、其制备方法及其在制药中的用途 |
| WO2017044858A2 (en) * | 2015-09-09 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
| PT3534899T (pt) * | 2016-11-03 | 2022-07-07 | Corvus Pharmaceuticals Inc | Compostos e métodos de modulação da cinase de células t induzível por interleucina-2 |
-
2017
- 2017-11-03 PT PT178687299T patent/PT3534899T/pt unknown
- 2017-11-03 KR KR1020197015471A patent/KR102540515B1/ko active Active
- 2017-11-03 WO PCT/US2017/059871 patent/WO2018089261A2/en not_active Ceased
- 2017-11-03 US US16/346,360 patent/US11008314B2/en active Active
- 2017-11-03 DK DK17868729.9T patent/DK3534899T3/da active
- 2017-11-03 CA CA3278142A patent/CA3278142A1/en active Pending
- 2017-11-03 EP EP17868729.9A patent/EP3534899B1/en active Active
- 2017-11-03 CN CN201780079068.5A patent/CN110099684B/zh active Active
- 2017-11-03 ES ES17868729T patent/ES2926153T3/es active Active
- 2017-11-03 CA CA3042252A patent/CA3042252C/en active Active
- 2017-11-03 IL IL266181A patent/IL266181B2/en unknown
- 2017-11-03 MX MX2019005076A patent/MX392031B/es unknown
- 2017-11-03 JP JP2019522993A patent/JP7236996B2/ja active Active
- 2017-11-03 AU AU2017358901A patent/AU2017358901B2/en active Active
-
2019
- 2019-05-16 ZA ZA2019/03071A patent/ZA201903071B/en unknown
-
2021
- 2021-04-07 US US17/224,410 patent/US11897874B2/en active Active
-
2022
- 2022-11-18 JP JP2022184820A patent/JP2023029752A/ja active Pending
-
2024
- 2024-02-12 US US18/439,695 patent/US12686677B2/en active Active
-
2026
- 2026-03-17 US US19/569,194 patent/US20260209216A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002050071A1 (en) * | 2000-12-21 | 2002-06-27 | Bristol-Myers Squibb Company | Thiazolyl inhibitors of tec family tyrosine kinases |
| US20140011810A1 (en) | 2009-12-23 | 2014-01-09 | Gatekeeper Pharmaceuticals, Inc. | Compounds that Modulate EGFR Activity and Methods for Treating or Preventing Conditions Therewith |
| WO2016079231A1 (en) | 2014-11-19 | 2016-05-26 | Hach Lange Gmbh | Control of wastewater treatment based on regulatory period |
Also Published As
| Publication number | Publication date |
|---|---|
| US20240383884A1 (en) | 2024-11-21 |
| CN110099684A (zh) | 2019-08-06 |
| US11008314B2 (en) | 2021-05-18 |
| CA3042252C (en) | 2025-10-21 |
| DK3534899T3 (da) | 2022-06-20 |
| AU2017358901B2 (en) | 2023-01-05 |
| CA3278142A1 (en) | 2025-10-31 |
| US20220363676A1 (en) | 2022-11-17 |
| JP2023029752A (ja) | 2023-03-06 |
| EP3534899B1 (en) | 2022-06-01 |
| WO2018089261A2 (en) | 2018-05-17 |
| WO2018089261A3 (en) | 2018-08-02 |
| JP2019536763A (ja) | 2019-12-19 |
| IL266181B2 (en) | 2024-04-01 |
| JP7236996B2 (ja) | 2023-03-10 |
| EP3534899A2 (en) | 2019-09-11 |
| MX392031B (es) | 2025-03-21 |
| US20260209216A1 (en) | 2026-07-23 |
| PT3534899T (pt) | 2022-07-07 |
| CA3042252A1 (en) | 2018-05-17 |
| IL266181B1 (en) | 2023-12-01 |
| MX2019005076A (es) | 2019-11-12 |
| AU2017358901A1 (en) | 2019-05-30 |
| EP3534899A4 (en) | 2020-04-29 |
| US11897874B2 (en) | 2024-02-13 |
| ES2926153T3 (es) | 2022-10-24 |
| CN110099684B (zh) | 2022-11-11 |
| IL266181A (en) | 2019-06-30 |
| US12686677B2 (en) | 2026-07-21 |
| KR20190089891A (ko) | 2019-07-31 |
| US20190375743A1 (en) | 2019-12-12 |
| ZA201903071B (en) | 2021-09-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7236996B2 (ja) | インターロイキン－２誘導性ｔ細胞キナーゼを調節する化合物及び方法 | |
| KR102416971B1 (ko) | 브루톤형 티로신 키나제를 조절하기 위한 화합물 및 방법 | |
| JP6346862B2 (ja) | オレキシンレセプターアンタゴニストとしての置換プロリン／ピペリジン | |
| EP4212522A1 (en) | Compounds for suppressing egfr mutant cancer and pharmaceutical use thereof | |
| BR112012011287A2 (pt) | compostos inibidores de cinase, sua formulação farmacêutica e seus usos | |
| CA3115900C (en) | TRIAZOLOTRIAZINE DERIVATIVES AS A2A RECEPTOR ANTAGONISTS | |
| KR102800635B1 (ko) | 단백질 키나아제 저해 활성을 갖는 피리미딘 유도체 및 이를 포함하는 치료용 약학 조성물 | |
| EP3703678A1 (en) | Novel agents targeting inhibitor of apoptosis proteins | |
| HK40014009B (en) | Compounds and methods for modulating interleukin-2-inducible t-cell kinase | |
| HK40014009A (en) | Compounds and methods for modulating interleukin-2-inducible t-cell kinase | |
| WO2025194116A1 (en) | Pcsk9 inhibitors and uses thereof | |
| WO2025175019A1 (en) | Phd ligands and uses thereof | |
| WO2024249488A2 (en) | Inhibitors of dyrk1a | |
| WO2025193711A1 (en) | Peripherally restricted lpar1 antagonists and uses thereof | |
| HK1262897A1 (en) | Compounds and methods for modulating bruton's tyrosine kinase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| A201 | Request for examination | ||
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-5-5-R10-R18-oth-X000 |