KR102537088B1 - 고체 형태의 ttk 억제제 - Google Patents

고체 형태의 ttk 억제제 Download PDF

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KR102537088B1
KR102537088B1 KR1020197001829A KR20197001829A KR102537088B1 KR 102537088 B1 KR102537088 B1 KR 102537088B1 KR 1020197001829 A KR1020197001829 A KR 1020197001829A KR 20197001829 A KR20197001829 A KR 20197001829A KR 102537088 B1 KR102537088 B1 KR 102537088B1
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crystal
compound
cancer
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phosphoric acid
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KR20190029601A (ko
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시즈-완 리
하인즈 더블유. 폴스
피터 브렌트 샘슨
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유니버시티 헬스 네트워크
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C30CRYSTAL GROWTH
    • C30BSINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54Organic compounds
    • C30B29/58Macromolecular compounds
    • CCHEMISTRY; METALLURGY
    • C30CRYSTAL GROWTH
    • C30BSINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C30B7/02Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent
    • CCHEMISTRY; METALLURGY
    • C30CRYSTAL GROWTH
    • C30BSINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C30B7/14Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions the crystallising materials being formed by chemical reactions in the solution
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Metallurgy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020197001829A 2016-07-18 2017-07-13 고체 형태의 ttk 억제제 Active KR102537088B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237017039A KR102700233B1 (ko) 2016-07-18 2017-07-13 고체 형태의 ttk 억제제

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662363424P 2016-07-18 2016-07-18
US62/363,424 2016-07-18
PCT/CA2017/050848 WO2018014116A1 (en) 2016-07-18 2017-07-13 Solid forms of ttk inhibitor

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KR1020237017039A Division KR102700233B1 (ko) 2016-07-18 2017-07-13 고체 형태의 ttk 억제제

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KR20190029601A KR20190029601A (ko) 2019-03-20
KR102537088B1 true KR102537088B1 (ko) 2023-05-25

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KR1020197001829A Active KR102537088B1 (ko) 2016-07-18 2017-07-13 고체 형태의 ttk 억제제
KR1020237017039A Active KR102700233B1 (ko) 2016-07-18 2017-07-13 고체 형태의 ttk 억제제

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US (3) US10584130B2 (https=)
EP (1) EP3484888B1 (https=)
JP (2) JP6961675B2 (https=)
KR (2) KR102537088B1 (https=)
CN (2) CN115093416B (https=)
AU (2) AU2017299850B2 (https=)
BR (1) BR112019000813A2 (https=)
DK (1) DK3484888T3 (https=)
ES (1) ES2945108T3 (https=)
FI (1) FI3484888T5 (https=)
HR (1) HRP20230481T1 (https=)
HU (1) HUE061872T2 (https=)
IL (1) IL264173B2 (https=)
LT (1) LT3484888T (https=)
MA (1) MA45691A (https=)
MX (2) MX385289B (https=)
PL (1) PL3484888T3 (https=)
PT (1) PT3484888T (https=)
RS (1) RS64210B1 (https=)
RU (2) RU2753905C2 (https=)
SG (2) SG10202103332UA (https=)
SI (1) SI3484888T1 (https=)
SM (1) SMT202300156T1 (https=)
TW (2) TWI824313B (https=)
WO (1) WO2018014116A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3484888T3 (pl) 2016-07-18 2023-06-26 University Health Network Stałe postacie inhibitora TTK
KR20240175121A (ko) 2023-06-12 2024-12-19 한국재료연구원 희토류 산화물을 이용한 입계확산물질의 제조방법 및 이를 이용한 R-Fe-B계 영구자석의 제조방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014075168A1 (en) * 2012-11-16 2014-05-22 University Health Network Pyrazolopyrimidine compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100876327B1 (ko) 2001-02-21 2008-12-31 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 진단에서의, 그리고 암에서 치료 표적으로서의 ttk
PT1812440E (pt) * 2004-11-04 2011-01-25 Vertex Pharma Pirazolo[1,5-a]pirimidinas úteis enquanto inibidores de proteínas cinases
TW201107329A (en) * 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
TWI541243B (zh) * 2010-09-10 2016-07-11 拜耳知識產權公司 經取代咪唑并嗒
JP2014503521A (ja) * 2010-12-17 2014-02-13 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 過増殖性障害の処置におけるmps−1およびtkk阻害剤としての使用のための、イミダゾピラジン類
EA029372B1 (ru) * 2013-11-15 2018-03-30 Юниверсити Хелс Нетуорк Пиразолопиримидиновые соединения
PL3484888T3 (pl) 2016-07-18 2023-06-26 University Health Network Stałe postacie inhibitora TTK

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014075168A1 (en) * 2012-11-16 2014-05-22 University Health Network Pyrazolopyrimidine compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ACS Chemical Biology, 2016, Vol.11, pp.2105-2111.

Also Published As

Publication number Publication date
US11878980B2 (en) 2024-01-23
KR102700233B1 (ko) 2024-08-28
SI3484888T1 (sl) 2023-07-31
HUE061872T2 (hu) 2023-08-28
US20190292193A1 (en) 2019-09-26
SG11201900113UA (en) 2019-02-27
JP6961675B2 (ja) 2021-11-05
WO2018014116A1 (en) 2018-01-25
CN109476667A (zh) 2019-03-15
SMT202300156T1 (it) 2023-07-20
US20200270259A1 (en) 2020-08-27
MX2021008658A (es) 2021-08-19
CA3030230A1 (en) 2018-01-25
MX2019000744A (es) 2019-05-02
TWI745400B (zh) 2021-11-11
CN109476667B (zh) 2022-06-28
RU2021124795A (ru) 2021-09-14
MA45691A (fr) 2019-05-22
NZ749844A (en) 2024-03-22
RU2019101109A3 (https=) 2021-02-05
RU2753905C2 (ru) 2021-08-24
LT3484888T (lt) 2023-06-12
AU2017299850A8 (en) 2019-03-21
FI3484888T3 (fi) 2023-05-03
AU2021221447A1 (en) 2021-10-07
CN115093416A (zh) 2022-09-23
KR20190029601A (ko) 2019-03-20
SG10202103332UA (en) 2021-05-28
TW201803876A (zh) 2018-02-01
KR20230074839A (ko) 2023-05-31
TWI824313B (zh) 2023-12-01
MX385289B (es) 2025-03-18
CN115093416B (zh) 2024-04-12
AU2017299850A1 (en) 2019-01-24
EP3484888A4 (en) 2020-01-08
DK3484888T3 (da) 2023-05-30
HRP20230481T1 (hr) 2023-07-21
IL264173A (en) 2019-02-28
RS64210B1 (sr) 2023-06-30
US20220089601A1 (en) 2022-03-24
BR112019000813A2 (pt) 2019-04-30
ES2945108T3 (es) 2023-06-28
EP3484888B1 (en) 2023-02-22
FI3484888T5 (fi) 2024-02-26
IL264173B1 (en) 2025-01-01
RU2019101109A (ru) 2020-08-18
US10584130B2 (en) 2020-03-10
AU2017299850B2 (en) 2021-05-27
JP7263473B2 (ja) 2023-04-24
EP3484888A1 (en) 2019-05-22
IL264173B2 (en) 2025-05-01
AU2021221447B2 (en) 2023-09-21
PT3484888T (pt) 2023-05-26
TW202202507A (zh) 2022-01-16
JP2019521155A (ja) 2019-07-25
US11104681B2 (en) 2021-08-31
PL3484888T3 (pl) 2023-06-26
JP2022001598A (ja) 2022-01-06

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