AU2017299850B2 - Solid forms of TTK inhibitor - Google Patents

Solid forms of TTK inhibitor Download PDF

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Publication number
AU2017299850B2
AU2017299850B2 AU2017299850A AU2017299850A AU2017299850B2 AU 2017299850 B2 AU2017299850 B2 AU 2017299850B2 AU 2017299850 A AU2017299850 A AU 2017299850A AU 2017299850 A AU2017299850 A AU 2017299850A AU 2017299850 B2 AU2017299850 B2 AU 2017299850B2
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AU
Australia
Prior art keywords
crystal
compound
cancer
phosphoric acid
solvent
Prior art date
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Active
Application number
AU2017299850A
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English (en)
Other versions
AU2017299850A1 (en
AU2017299850A8 (en
Inventor
Sze-Wan Li
Heinz W. Pauls
Peter Brent Sampson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University Health Network
Original Assignee
University Health Network
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Filing date
Publication date
Application filed by University Health Network filed Critical University Health Network
Publication of AU2017299850A1 publication Critical patent/AU2017299850A1/en
Publication of AU2017299850A8 publication Critical patent/AU2017299850A8/en
Application granted granted Critical
Publication of AU2017299850B2 publication Critical patent/AU2017299850B2/en
Priority to AU2021221447A priority Critical patent/AU2021221447B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C30B7/02—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C30B7/14—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions the crystallising materials being formed by chemical reactions in the solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2017299850A 2016-07-18 2017-07-13 Solid forms of TTK inhibitor Active AU2017299850B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021221447A AU2021221447B2 (en) 2016-07-18 2021-08-24 Solid forms of TTK inhibitor

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662363424P 2016-07-18 2016-07-18
US62/363,424 2016-07-18
PCT/CA2017/050848 WO2018014116A1 (en) 2016-07-18 2017-07-13 Solid forms of ttk inhibitor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021221447A Division AU2021221447B2 (en) 2016-07-18 2021-08-24 Solid forms of TTK inhibitor

Publications (3)

Publication Number Publication Date
AU2017299850A1 AU2017299850A1 (en) 2019-01-24
AU2017299850A8 AU2017299850A8 (en) 2019-03-21
AU2017299850B2 true AU2017299850B2 (en) 2021-05-27

Family

ID=60991755

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2017299850A Active AU2017299850B2 (en) 2016-07-18 2017-07-13 Solid forms of TTK inhibitor
AU2021221447A Active AU2021221447B2 (en) 2016-07-18 2021-08-24 Solid forms of TTK inhibitor

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2021221447A Active AU2021221447B2 (en) 2016-07-18 2021-08-24 Solid forms of TTK inhibitor

Country Status (25)

Country Link
US (3) US10584130B2 (https=)
EP (1) EP3484888B1 (https=)
JP (2) JP6961675B2 (https=)
KR (2) KR102700233B1 (https=)
CN (2) CN115093416B (https=)
AU (2) AU2017299850B2 (https=)
BR (1) BR112019000813A2 (https=)
DK (1) DK3484888T3 (https=)
ES (1) ES2945108T3 (https=)
FI (1) FI3484888T5 (https=)
HR (1) HRP20230481T1 (https=)
HU (1) HUE061872T2 (https=)
IL (1) IL264173B2 (https=)
LT (1) LT3484888T (https=)
MA (1) MA45691A (https=)
MX (2) MX385289B (https=)
PL (1) PL3484888T3 (https=)
PT (1) PT3484888T (https=)
RS (1) RS64210B1 (https=)
RU (2) RU2753905C2 (https=)
SG (2) SG10202103332UA (https=)
SI (1) SI3484888T1 (https=)
SM (1) SMT202300156T1 (https=)
TW (2) TWI745400B (https=)
WO (1) WO2018014116A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017299850B2 (en) 2016-07-18 2021-05-27 University Health Network Solid forms of TTK inhibitor
KR20240175121A (ko) 2023-06-12 2024-12-19 한국재료연구원 희토류 산화물을 이용한 입계확산물질의 제조방법 및 이를 이용한 R-Fe-B계 영구자석의 제조방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014075168A1 (en) * 2012-11-16 2014-05-22 University Health Network Pyrazolopyrimidine compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2438092C (en) 2001-02-21 2011-08-09 Chiron Corporation Ttk in diagnosis and as a therapeutic target in cancer
ATE482213T1 (de) * 2004-11-04 2010-10-15 Vertex Pharma Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine
TW201107329A (en) * 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
TWI541243B (zh) * 2010-09-10 2016-07-11 拜耳知識產權公司 經取代咪唑并嗒
CN103415518A (zh) * 2010-12-17 2013-11-27 拜耳知识产权有限责任公司 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的咪唑并吡嗪
JP6095857B2 (ja) * 2013-11-15 2017-03-15 ユニバーシティ・ヘルス・ネットワーク ピラゾロピリミジン化合物
AU2017299850B2 (en) 2016-07-18 2021-05-27 University Health Network Solid forms of TTK inhibitor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014075168A1 (en) * 2012-11-16 2014-05-22 University Health Network Pyrazolopyrimidine compounds
WO2015070349A1 (en) * 2012-11-16 2015-05-21 University Health Network Pyrazolopyrimidine compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
YONG LIU ET AL, "Discovery of Pyrazolo[1,5- a ]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent", ACS MEDICINAL CHEMISTRY LETTERS, (2016-07-14), vol. 7, no. 7, pages 671 - 675 *
YONG LIU ET AL, "Supplementary informations: Discovery of Pyrazolo[1,5- a ]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent", ACS MEDICINAL CHEMISTRY LETTERS, (2016), vol. 7, no. 7, pp 671 - 675 *

Also Published As

Publication number Publication date
JP7263473B2 (ja) 2023-04-24
PL3484888T3 (pl) 2023-06-26
MA45691A (fr) 2019-05-22
HRP20230481T1 (hr) 2023-07-21
CN115093416B (zh) 2024-04-12
AU2017299850A1 (en) 2019-01-24
TW201803876A (zh) 2018-02-01
JP2019521155A (ja) 2019-07-25
IL264173B1 (en) 2025-01-01
US10584130B2 (en) 2020-03-10
ES2945108T3 (es) 2023-06-28
RU2019101109A3 (https=) 2021-02-05
BR112019000813A2 (pt) 2019-04-30
CN109476667B (zh) 2022-06-28
FI3484888T5 (fi) 2024-02-26
HUE061872T2 (hu) 2023-08-28
AU2021221447A1 (en) 2021-10-07
MX2021008658A (es) 2021-08-19
EP3484888B1 (en) 2023-02-22
PT3484888T (pt) 2023-05-26
AU2021221447B2 (en) 2023-09-21
WO2018014116A1 (en) 2018-01-25
NZ749844A (en) 2024-03-22
US11878980B2 (en) 2024-01-23
CN109476667A (zh) 2019-03-15
KR102537088B1 (ko) 2023-05-25
FI3484888T3 (fi) 2023-05-03
SG10202103332UA (en) 2021-05-28
CN115093416A (zh) 2022-09-23
TW202202507A (zh) 2022-01-16
EP3484888A4 (en) 2020-01-08
TWI745400B (zh) 2021-11-11
AU2017299850A8 (en) 2019-03-21
EP3484888A1 (en) 2019-05-22
IL264173A (en) 2019-02-28
DK3484888T3 (da) 2023-05-30
US20220089601A1 (en) 2022-03-24
IL264173B2 (en) 2025-05-01
KR20230074839A (ko) 2023-05-31
RU2753905C2 (ru) 2021-08-24
JP2022001598A (ja) 2022-01-06
RU2021124795A (ru) 2021-09-14
RS64210B1 (sr) 2023-06-30
MX2019000744A (es) 2019-05-02
RU2019101109A (ru) 2020-08-18
JP6961675B2 (ja) 2021-11-05
CA3030230A1 (en) 2018-01-25
US20190292193A1 (en) 2019-09-26
MX385289B (es) 2025-03-18
SMT202300156T1 (it) 2023-07-20
US11104681B2 (en) 2021-08-31
KR102700233B1 (ko) 2024-08-28
KR20190029601A (ko) 2019-03-20
SG11201900113UA (en) 2019-02-27
US20200270259A1 (en) 2020-08-27
LT3484888T (lt) 2023-06-12
SI3484888T1 (sl) 2023-07-31
TWI824313B (zh) 2023-12-01

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Free format text: IN VOL 33 , NO 3 , PAGE(S) 506 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME UNIVERSITY HEALTH NETWORK, APPLICATION NO. 2017299850, UNDER INID (54) CORRECT THE TITLE TO READ SOLID FORMS OF TTK INHIBITOR

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