KR102523786B1 - 트리아졸로피리딘 화합물의 제조 방법 - Google Patents

트리아졸로피리딘 화합물의 제조 방법 Download PDF

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KR102523786B1
KR102523786B1 KR1020197015696A KR20197015696A KR102523786B1 KR 102523786 B1 KR102523786 B1 KR 102523786B1 KR 1020197015696 A KR1020197015696 A KR 1020197015696A KR 20197015696 A KR20197015696 A KR 20197015696A KR 102523786 B1 KR102523786 B1 KR 102523786B1
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compound
salt
acid
formula
reaction
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KR20190085004A (ko
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후미토 시모마
다카시 야마구치
쇼이치 사가와
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니뽄 다바코 산교 가부시키가이샤
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Assigned to 시오노기세야쿠 가부시키가이샤 reassignment 시오노기세야쿠 가부시키가이샤 권리의 전부이전등록 Assignors: 니뽄 다바코 산교 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020197015696A 2016-11-25 2017-11-24 트리아졸로피리딘 화합물의 제조 방법 Active KR102523786B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2016-228897 2016-11-25
JP2016228897 2016-11-25
PCT/JP2017/042239 WO2018097254A1 (ja) 2016-11-25 2017-11-24 トリアゾロピリジン化合物の製造方法

Publications (2)

Publication Number Publication Date
KR20190085004A KR20190085004A (ko) 2019-07-17
KR102523786B1 true KR102523786B1 (ko) 2023-04-20

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KR1020197015696A Active KR102523786B1 (ko) 2016-11-25 2017-11-24 트리아졸로피리딘 화합물의 제조 방법

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Country Link
US (1) US11434238B2 (https=)
EP (1) EP3546459A4 (https=)
JP (2) JP6600103B2 (https=)
KR (1) KR102523786B1 (https=)
CN (1) CN110214139B (https=)
AU (1) AU2017364725B2 (https=)
CA (1) CA3044654A1 (https=)
IL (1) IL266858B (https=)
MX (1) MX2019006083A (https=)
RU (1) RU2752384C2 (https=)
WO (1) WO2018097254A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019006083A (es) * 2016-11-25 2019-07-10 Japan Tobacco Inc Metodo para la produccion de compuesto de triazolopiridina.
CN113387948B (zh) * 2021-02-06 2022-06-10 成都诺和晟泰生物科技有限公司 一种稠环杂芳基衍生物及其药物组合物和治疗方法及用途
CN115246830A (zh) * 2021-04-28 2022-10-28 广东东阳光药业有限公司 一种酸的固体形式及其制备方法
CN114773333A (zh) * 2021-12-25 2022-07-22 上海泰坦科技股份有限公司 一种卤代三唑并吡啶的合成方法
CN117327066A (zh) * 2022-06-30 2024-01-02 上海济煜医药科技有限公司 一种新多晶型、其制备方法及其用于制备药物的用途
CN117486878A (zh) * 2023-10-27 2024-02-02 扬州市普林斯医药科技有限公司 一种恩那司他的制备方法
CN119039291A (zh) * 2024-09-09 2024-11-29 南京药坦生物科技有限公司 一种恩那度司他中间体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2455381T1 (sl) * 2009-07-17 2014-08-29 Japan Tobacco Inc. Triazolopiridinova spojina in njeno delovanje kot zaviralec prolil-hidroksilaze in induktor produkcije eritropoietina
US20180243271A1 (en) * 2015-05-28 2018-08-30 Japan Tobacco Inc. Method for Treating or Preventing Diabetic Nephropathy
WO2017083431A2 (en) * 2015-11-09 2017-05-18 Forge Therapeutics, Inc. Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections
MX2019006083A (es) * 2016-11-25 2019-07-10 Japan Tobacco Inc Metodo para la produccion de compuesto de triazolopiridina.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Heterocyclic chemistry, 2008, Vol. 45, No, 5, pp.1451-1456(2009.03.13.) 1부.*

Also Published As

Publication number Publication date
JPWO2018097254A1 (ja) 2019-10-17
RU2019119584A (ru) 2020-12-25
JP2020073474A (ja) 2020-05-14
KR20190085004A (ko) 2019-07-17
IL266858A (en) 2019-08-29
MX2019006083A (es) 2019-07-10
AU2017364725B2 (en) 2021-04-01
IL266858B (en) 2021-10-31
CN110214139B (zh) 2022-08-23
AU2017364725A1 (en) 2019-06-13
EP3546459A1 (en) 2019-10-02
US20200339563A1 (en) 2020-10-29
JP6600103B2 (ja) 2019-10-30
RU2019119584A3 (https=) 2021-03-25
WO2018097254A1 (ja) 2018-05-31
BR112019010017A2 (pt) 2019-08-20
CN110214139A (zh) 2019-09-06
EP3546459A4 (en) 2020-05-20
CA3044654A1 (en) 2018-05-31
US11434238B2 (en) 2022-09-06
RU2752384C2 (ru) 2021-07-26

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