KR102510238B1 - 대사적으로 최적화된 세포 배양 - Google Patents

대사적으로 최적화된 세포 배양 Download PDF

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KR102510238B1
KR102510238B1 KR1020227003381A KR20227003381A KR102510238B1 KR 102510238 B1 KR102510238 B1 KR 102510238B1 KR 1020227003381 A KR1020227003381 A KR 1020227003381A KR 20227003381 A KR20227003381 A KR 20227003381A KR 102510238 B1 KR102510238 B1 KR 102510238B1
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cell culture
cells
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lactate
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KR20220020415A (ko
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숀 로렌스
앤 킴
에이미 죤슨
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리제너론 파마슈티칼스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
KR1020227003381A 2013-10-11 2014-10-10 대사적으로 최적화된 세포 배양 Active KR102510238B1 (ko)

Priority Applications (1)

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KR1020237008467A KR102610425B1 (ko) 2013-10-11 2014-10-10 대사적으로 최적화된 세포 배양

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361889815P 2013-10-11 2013-10-11
US61/889,815 2013-10-11
PCT/US2014/059993 WO2015054554A1 (en) 2013-10-11 2014-10-10 Metabolically optimized cell culture
KR1020217011547A KR102358807B1 (ko) 2013-10-11 2014-10-10 대사적으로 최적화된 세포 배양

Related Parent Applications (1)

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KR1020217011547A Division KR102358807B1 (ko) 2013-10-11 2014-10-10 대사적으로 최적화된 세포 배양

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KR20220020415A KR20220020415A (ko) 2022-02-18
KR102510238B1 true KR102510238B1 (ko) 2023-03-16

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KR1020227003381A Active KR102510238B1 (ko) 2013-10-11 2014-10-10 대사적으로 최적화된 세포 배양
KR1020167009163A Active KR102243980B1 (ko) 2013-10-11 2014-10-10 대사적으로 최적화된 세포 배양
KR1020237008467A Active KR102610425B1 (ko) 2013-10-11 2014-10-10 대사적으로 최적화된 세포 배양
KR1020217011547A Active KR102358807B1 (ko) 2013-10-11 2014-10-10 대사적으로 최적화된 세포 배양

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KR1020167009163A Active KR102243980B1 (ko) 2013-10-11 2014-10-10 대사적으로 최적화된 세포 배양
KR1020237008467A Active KR102610425B1 (ko) 2013-10-11 2014-10-10 대사적으로 최적화된 세포 배양
KR1020217011547A Active KR102358807B1 (ko) 2013-10-11 2014-10-10 대사적으로 최적화된 세포 배양

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US (2) US20160244725A1 (enExample)
EP (3) EP3351620B1 (enExample)
JP (3) JP6663854B2 (enExample)
KR (4) KR102510238B1 (enExample)
CN (2) CN114717196A (enExample)
AU (2) AU2014331776B2 (enExample)
CA (1) CA2926049C (enExample)
DK (2) DK3055409T3 (enExample)
EA (2) EA033783B1 (enExample)
ES (2) ES2833471T3 (enExample)
HU (2) HUE051049T2 (enExample)
IL (2) IL244511A0 (enExample)
MX (2) MX376623B (enExample)
PL (2) PL3351620T3 (enExample)
SG (2) SG10201800772TA (enExample)
WO (1) WO2015054554A1 (enExample)
ZA (1) ZA201601550B (enExample)

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JP7231355B2 (ja) * 2018-08-22 2023-03-01 日機装株式会社 細胞培養方法および細胞培養装置
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Publication number Publication date
US20210087535A1 (en) 2021-03-25
KR20210046835A (ko) 2021-04-28
DK3351620T3 (da) 2020-10-26
PL3055409T3 (pl) 2018-10-31
MX2020011334A (es) 2021-07-30
IL244511A0 (en) 2016-04-21
EA201991976A1 (ru) 2020-04-02
MX2016004564A (es) 2016-07-12
AU2021200193B2 (en) 2023-08-24
EP3351620B1 (en) 2020-09-02
CN114717196A (zh) 2022-07-08
HK1223122A1 (en) 2017-07-21
HUE051049T2 (hu) 2021-01-28
JP6663854B2 (ja) 2020-03-13
SG10201800772TA (en) 2018-03-28
KR20230038324A (ko) 2023-03-17
KR102358807B1 (ko) 2022-02-08
EA201690600A1 (ru) 2016-09-30
SG11201601681QA (en) 2016-04-28
EP3055409A4 (en) 2016-09-28
KR102610425B1 (ko) 2023-12-06
MX384960B (es) 2025-03-14
AU2014331776A1 (en) 2016-03-24
JP2020072760A (ja) 2020-05-14
EP3351620A1 (en) 2018-07-25
AU2014331776B2 (en) 2020-10-22
CA2926049C (en) 2023-09-05
EA033783B1 (ru) 2019-11-25
US20160244725A1 (en) 2016-08-25
JP2016532457A (ja) 2016-10-20
HK1253275A1 (en) 2019-06-14
JP2022009453A (ja) 2022-01-14
EP3055409A1 (en) 2016-08-17
DK3055409T3 (en) 2018-07-30
JP7377243B2 (ja) 2023-11-09
MX376623B (es) 2025-03-07
KR20160062032A (ko) 2016-06-01
WO2015054554A1 (en) 2015-04-16
ZA201601550B (en) 2023-05-31
CN105637085A (zh) 2016-06-01
ES2833471T3 (es) 2021-06-15
PL3351620T3 (pl) 2021-03-08
JP6967620B2 (ja) 2021-11-17
EP3812453A1 (en) 2021-04-28
HUE039551T2 (hu) 2019-01-28
CA2926049A1 (en) 2015-04-16
ES2678945T3 (es) 2018-08-21
EP3055409B1 (en) 2018-04-25
IL262833A (en) 2018-12-31
AU2021200193A1 (en) 2021-03-18
KR102243980B1 (ko) 2021-04-26
KR20220020415A (ko) 2022-02-18

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