CN114717196A - 代谢优化的细胞培养物 - Google Patents

代谢优化的细胞培养物 Download PDF

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Publication number
CN114717196A
CN114717196A CN202210497778.2A CN202210497778A CN114717196A CN 114717196 A CN114717196 A CN 114717196A CN 202210497778 A CN202210497778 A CN 202210497778A CN 114717196 A CN114717196 A CN 114717196A
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cell
cells
cell culture
culture
metabolic
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Pending
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CN202210497778.2A
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English (en)
Chinese (zh)
Inventor
S·劳伦斯
A·金
A·约翰逊
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52813657&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN114717196(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of CN114717196A publication Critical patent/CN114717196A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
CN202210497778.2A 2013-10-11 2014-10-10 代谢优化的细胞培养物 Pending CN114717196A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361889815P 2013-10-11 2013-10-11
US61/889,815 2013-10-11
PCT/US2014/059993 WO2015054554A1 (en) 2013-10-11 2014-10-10 Metabolically optimized cell culture
CN201480055499.4A CN105637085A (zh) 2013-10-11 2014-10-10 代谢优化的细胞培养物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480055499.4A Division CN105637085A (zh) 2013-10-11 2014-10-10 代谢优化的细胞培养物

Publications (1)

Publication Number Publication Date
CN114717196A true CN114717196A (zh) 2022-07-08

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ID=52813657

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202210497778.2A Pending CN114717196A (zh) 2013-10-11 2014-10-10 代谢优化的细胞培养物
CN201480055499.4A Pending CN105637085A (zh) 2013-10-11 2014-10-10 代谢优化的细胞培养物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201480055499.4A Pending CN105637085A (zh) 2013-10-11 2014-10-10 代谢优化的细胞培养物

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US (2) US20160244725A1 (enExample)
EP (3) EP3351620B1 (enExample)
JP (3) JP6663854B2 (enExample)
KR (4) KR102358807B1 (enExample)
CN (2) CN114717196A (enExample)
AU (2) AU2014331776B2 (enExample)
CA (1) CA2926049C (enExample)
DK (2) DK3055409T3 (enExample)
EA (2) EA033783B1 (enExample)
ES (2) ES2833471T3 (enExample)
HU (2) HUE039551T2 (enExample)
IL (2) IL244511A0 (enExample)
MX (2) MX376623B (enExample)
PL (2) PL3055409T3 (enExample)
SG (2) SG10201800772TA (enExample)
WO (1) WO2015054554A1 (enExample)
ZA (1) ZA201601550B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3055409T3 (pl) 2013-10-11 2018-10-31 Regeneron Pharmaceuticals, Inc. Metabolicznie zoptymalizowana hodowla komórkowa
US11390663B2 (en) 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
US20160244726A1 (en) * 2013-10-11 2016-08-25 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
JP7260011B2 (ja) * 2017-03-31 2023-04-18 株式会社三洋物産 遊技機
JP7260020B2 (ja) * 2017-03-31 2023-04-18 株式会社三洋物産 遊技機
JP7260018B2 (ja) * 2017-03-31 2023-04-18 株式会社三洋物産 遊技機
JP7260013B2 (ja) * 2017-04-27 2023-04-18 株式会社三洋物産 遊技機
JP7310952B2 (ja) * 2017-04-27 2023-07-19 株式会社三洋物産 遊技機
JP7310945B2 (ja) * 2017-04-27 2023-07-19 株式会社三洋物産 遊技機
JP7260009B2 (ja) * 2017-04-27 2023-04-18 株式会社三洋物産 遊技機
JP7260012B2 (ja) * 2017-04-27 2023-04-18 株式会社三洋物産 遊技機
JP7260021B2 (ja) * 2017-04-27 2023-04-18 株式会社三洋物産 遊技機
JP7272480B2 (ja) * 2017-04-27 2023-05-12 株式会社三洋物産 遊技機
JP7310947B2 (ja) * 2017-04-27 2023-07-19 株式会社三洋物産 遊技機
WO2019071076A1 (en) 2017-10-06 2019-04-11 Lonza Ltd. AUTOMATED CONTROL OF CELL CULTURE BY SPECTROSCOPY RAMAN
EP3697887B1 (en) 2017-10-16 2022-04-06 Regeneron Pharmaceuticals, Inc. Perfusion methods
EP3717656B1 (en) * 2017-11-30 2024-03-13 F. Hoffmann-La Roche AG Process for culturing mammalian cells
BR112020019726A2 (pt) * 2018-03-29 2021-01-26 Genentech, Inc. células de mamífero, composição, métodos para reduzir ou eliminar a atividade lactogênica em uma célula, para produzir um produto de interesse e para cultivar uma população
GB201810772D0 (en) 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
JP7231355B2 (ja) * 2018-08-22 2023-03-01 日機装株式会社 細胞培養方法および細胞培養装置
CA3100035A1 (en) 2018-08-27 2020-03-05 Regeneron Pharmaceuticals, Inc. Use of raman spectroscopy in downstream purification
JP2020151559A (ja) * 2020-06-24 2020-09-24 株式会社三洋物産 遊技機
JP2020151560A (ja) * 2020-06-24 2020-09-24 株式会社三洋物産 遊技機
EP3985097A1 (en) * 2020-10-14 2022-04-20 Sartorius Stedim Biotech GmbH A method and system for configuring and/or setup of a downstream process for processing a biomass

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101273121A (zh) * 2005-07-25 2008-09-24 免疫医疗公司 用于增加细胞培养物的寿命和蛋白收率的改良方法和组合物
US20110104734A1 (en) * 2009-10-12 2011-05-05 Keck Graduate Institute Novel strategy to reduce lactic acid production and control ph in animal cell culture
US20130084605A1 (en) * 2010-05-28 2013-04-04 Genentech, Inc. Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
KR970029803A (ko) 1995-11-03 1997-06-26 김광호 반도체 메모리장치의 프리차지 회로
US6165741A (en) 1997-05-30 2000-12-26 The Trustees Of The University Of Pennsylvania Method for rapid detection of bacterial growth in cultures
US5972650A (en) 1997-06-26 1999-10-26 Brigham And Women's Hospital Tetracycline repressor regulated mammalian cell transcription and viral replication switch
AU2002245272B2 (en) 2001-01-16 2006-06-29 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
US6953692B2 (en) * 2001-12-18 2005-10-11 Bayer Pharmaceuticals Corporation Device and method for seed-train expansion of mammalian cells
US7039770B1 (en) 2002-03-05 2006-05-02 Juniper Networks, Inc. Low latency request dispatcher
CA2417689C (en) 2002-03-05 2006-05-09 F. Hoffmann-La Roche Ag Improved methods for growing mammalian cells in vitro
US8673589B2 (en) 2002-05-29 2014-03-18 Regeneron Pharmaceuticals, Inc. Inducible eukaryotic expression system
EP1623019B2 (en) 2003-05-15 2017-01-25 Wyeth LLC Restricted glucose feed for animal cell culture
US7335491B2 (en) 2004-08-27 2008-02-26 Wyeth Research Ireland Limited Production of anti-abeta
TWI364458B (en) * 2004-08-27 2012-05-21 Wyeth Res Ireland Ltd Production of tnfr-lg
WO2007056062A2 (en) * 2005-11-02 2007-05-18 Wyeth Methods for adapting mammalian cells
KR101866623B1 (ko) 2005-11-28 2018-07-04 젠맵 에이/에스 재조합 １가 항체 및 그의 제조 방법
US7575890B2 (en) 2006-01-18 2009-08-18 Oxygen Enterprises, Ltd. Method for rapid detection and evaluation of cultured cell growth
US8192951B2 (en) 2006-11-03 2012-06-05 Wyeth Llc Glycolysis-inhibiting substances in cell culture
WO2008151219A1 (en) 2007-06-04 2008-12-11 Regeneron Pharmaceuticals, Inc. Enhanced expression and stability regions
WO2009023562A2 (en) 2007-08-09 2009-02-19 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
WO2009152413A1 (en) * 2008-06-13 2009-12-17 Centocor Ortho Biotech Inc. Methods for obtaining high viable cell density in mammalian cell culture
PL2563904T3 (pl) * 2010-04-26 2015-06-30 Novartis Ag Udoskonalona pożywka do hodowli komórkowej
TWI637057B (zh) 2012-11-09 2018-10-01 拜爾沙納有限公司 具交替生物反應器用途之不連續進料批次製程
US20150353542A1 (en) * 2013-01-14 2015-12-10 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
PL3055409T3 (pl) 2013-10-11 2018-10-31 Regeneron Pharmaceuticals, Inc. Metabolicznie zoptymalizowana hodowla komórkowa

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101273121A (zh) * 2005-07-25 2008-09-24 免疫医疗公司 用于增加细胞培养物的寿命和蛋白收率的改良方法和组合物
US20110104734A1 (en) * 2009-10-12 2011-05-05 Keck Graduate Institute Novel strategy to reduce lactic acid production and control ph in animal cell culture
US20130084605A1 (en) * 2010-05-28 2013-04-04 Genentech, Inc. Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase

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Publication number Publication date
AU2021200193B2 (en) 2023-08-24
KR20230038324A (ko) 2023-03-17
KR20160062032A (ko) 2016-06-01
JP7377243B2 (ja) 2023-11-09
AU2014331776A1 (en) 2016-03-24
EA033783B1 (ru) 2019-11-25
HK1223122A1 (en) 2017-07-21
WO2015054554A1 (en) 2015-04-16
EA201690600A1 (ru) 2016-09-30
MX2020011334A (es) 2021-07-30
KR102358807B1 (ko) 2022-02-08
ES2833471T3 (es) 2021-06-15
JP6967620B2 (ja) 2021-11-17
EP3055409A1 (en) 2016-08-17
US20160244725A1 (en) 2016-08-25
HK1253275A1 (en) 2019-06-14
ES2678945T3 (es) 2018-08-21
EP3351620A1 (en) 2018-07-25
CA2926049A1 (en) 2015-04-16
HUE051049T2 (hu) 2021-01-28
HUE039551T2 (hu) 2019-01-28
JP2020072760A (ja) 2020-05-14
KR102510238B1 (ko) 2023-03-16
DK3351620T3 (da) 2020-10-26
AU2021200193A1 (en) 2021-03-18
PL3055409T3 (pl) 2018-10-31
EA201991976A1 (ru) 2020-04-02
CA2926049C (en) 2023-09-05
US20210087535A1 (en) 2021-03-25
DK3055409T3 (en) 2018-07-30
AU2014331776B2 (en) 2020-10-22
IL244511A0 (en) 2016-04-21
KR20210046835A (ko) 2021-04-28
MX384960B (es) 2025-03-14
JP2016532457A (ja) 2016-10-20
SG10201800772TA (en) 2018-03-28
KR102243980B1 (ko) 2021-04-26
JP2022009453A (ja) 2022-01-14
KR102610425B1 (ko) 2023-12-06
MX376623B (es) 2025-03-07
ZA201601550B (en) 2023-05-31
JP6663854B2 (ja) 2020-03-13
KR20220020415A (ko) 2022-02-18
MX2016004564A (es) 2016-07-12
EP3055409A4 (en) 2016-09-28
EP3351620B1 (en) 2020-09-02
EP3055409B1 (en) 2018-04-25
PL3351620T3 (pl) 2021-03-08
IL262833A (en) 2018-12-31
SG11201601681QA (en) 2016-04-28
EP3812453A1 (en) 2021-04-28
CN105637085A (zh) 2016-06-01

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