KR102493894B1 - 인간화 tmprss 유전자를 갖는 설치류 - Google Patents

인간화 tmprss 유전자를 갖는 설치류 Download PDF

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KR102493894B1
KR102493894B1 KR1020187026552A KR20187026552A KR102493894B1 KR 102493894 B1 KR102493894 B1 KR 102493894B1 KR 1020187026552 A KR1020187026552 A KR 1020187026552A KR 20187026552 A KR20187026552 A KR 20187026552A KR 102493894 B1 KR102493894 B1 KR 102493894B1
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gene
tmprss
human
rodent
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KR20180117122A (ko
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은감보 리사 퍼셀
알렉산더 오 무지카
야준 탕
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리제너론 파마슈티칼스 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/07—Animals genetically altered by homologous recombination
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    • A—HUMAN NECESSITIES
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    • A01K2227/10—Mammal
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    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

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KR1020187026552A 2016-02-29 2017-02-27 인간화 tmprss 유전자를 갖는 설치류 Active KR102493894B1 (ko)

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US201662301023P 2016-02-29 2016-02-29
US62/301,023 2016-02-29
PCT/US2017/019574 WO2017151453A1 (en) 2016-02-29 2017-02-27 Rodents having a humanized tmprss gene

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US (5) US10070632B2 (cg-RX-API-DMAC10.html)
EP (2) EP3895529B1 (cg-RX-API-DMAC10.html)
JP (1) JP6980674B2 (cg-RX-API-DMAC10.html)
KR (2) KR102493894B1 (cg-RX-API-DMAC10.html)
CN (1) CN109068621B (cg-RX-API-DMAC10.html)
AU (1) AU2017228293B2 (cg-RX-API-DMAC10.html)
CA (1) CA3014645C (cg-RX-API-DMAC10.html)
DK (2) DK3422845T3 (cg-RX-API-DMAC10.html)
ES (2) ES2886958T3 (cg-RX-API-DMAC10.html)
IL (1) IL261139B (cg-RX-API-DMAC10.html)
PT (2) PT3422845T (cg-RX-API-DMAC10.html)
RU (1) RU2749715C2 (cg-RX-API-DMAC10.html)
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