MXPA05013321A - Nuevas moleculas modificadas de corina que tienen secuencias de activacion sustitutiva y sus usos. - Google Patents

Nuevas moleculas modificadas de corina que tienen secuencias de activacion sustitutiva y sus usos.

Info

Publication number
MXPA05013321A
MXPA05013321A MXPA05013321A MXPA05013321A MXPA05013321A MX PA05013321 A MXPA05013321 A MX PA05013321A MX PA05013321 A MXPA05013321 A MX PA05013321A MX PA05013321 A MXPA05013321 A MX PA05013321A MX PA05013321 A MXPA05013321 A MX PA05013321A
Authority
MX
Mexico
Prior art keywords
corin molecules
molecules
modified corin
substitute activation
novel modified
Prior art date
Application number
MXPA05013321A
Other languages
English (en)
Inventor
Qingyu Wu
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of MXPA05013321A publication Critical patent/MXPA05013321A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Esta invencion se refiere a las nuevas moleculas de corina modificada, o fragmentos o derivados de las mismas, que comprenden una secuencia de activacion sustituta. Las moleculas de corina modificada son escindidas en la secuencia de activacion sustituta, con lo cual se generan moleculas de corina modificada, o fragmentos o derivados de las mismas, que muestran la actividad funcional de las moleculas de corina tipo silvestre, de origen natural. Las moleculas de corina modificada pueden ser utilizadas para tratar una variedad de enfermedades o trastornos, incluyendo insuficiencia cardiaca congestiva e infarto agudo al miocardio.
MXPA05013321A 2003-06-11 2004-06-09 Nuevas moleculas modificadas de corina que tienen secuencias de activacion sustitutiva y sus usos. MXPA05013321A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47768303P 2003-06-11 2003-06-11
PCT/US2004/018669 WO2004111225A1 (en) 2003-06-11 2004-06-09 Novel modified corin molecules having substitute activation sequences and uses thereof

Publications (1)

Publication Number Publication Date
MXPA05013321A true MXPA05013321A (es) 2006-03-09

Family

ID=33551745

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05013321A MXPA05013321A (es) 2003-06-11 2004-06-09 Nuevas moleculas modificadas de corina que tienen secuencias de activacion sustitutiva y sus usos.

Country Status (15)

Country Link
US (1) US7176013B2 (es)
EP (1) EP1636356A1 (es)
JP (1) JP2007502132A (es)
KR (1) KR20060022683A (es)
CN (2) CN101109011A (es)
AU (1) AU2004248192A1 (es)
BR (1) BRPI0411353A (es)
CA (1) CA2527361A1 (es)
IL (1) IL172095A0 (es)
MX (1) MXPA05013321A (es)
NO (1) NO20060144L (es)
PL (1) PL379196A1 (es)
RU (1) RU2006100035A (es)
WO (1) WO2004111225A1 (es)
ZA (1) ZA200600224B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026255A1 (en) * 2002-06-25 2005-02-03 Morser John Michael Corin, a serine protease
TW200723151A (en) * 2005-12-07 2007-06-16 Era Digital Media Co Business website method
WO2009120760A1 (en) * 2008-03-28 2009-10-01 The Cleveland Clinic Foundation Corin for treating obesity and diabetes
WO2010096658A1 (en) 2009-02-19 2010-08-26 The Cleveland Clinic Foundation Corin as a marker for heart failure
US10314894B2 (en) * 2014-02-12 2019-06-11 The Cleveland Clinic Foundation Treatment of cardio-renal disease using PCSK6
CN109068621B (zh) 2016-02-29 2021-07-20 再生元制药公司 具有人源化的tmprss基因的啮齿类动物
CN105734070A (zh) * 2016-04-11 2016-07-06 苏州大学 Corin基因变异体及其用途
CN108066286B (zh) * 2016-11-10 2021-06-29 复旦大学 炔丙基半胱氨酸纳米粒长循环脂质体及其制备方法和用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO882226L (no) * 1987-05-22 1988-11-23 Zymogenetics Inc Fibrinolytiske proteiner.
US5869637A (en) 1996-07-22 1999-02-09 Incyte Pharmaceuticals, Inc. Human Kallikrein
US5968782A (en) * 1996-12-04 1999-10-19 Brigham And Womens's Hospital, Inc. Mast cell protease that cleaves fibrinogen
US6479274B1 (en) 1997-02-13 2002-11-12 Amrad Operations Pty., Ltd. DNA molecules encoding human HELA2 or testisin serine proteinases
DE59812768D1 (de) 1997-08-22 2005-06-09 Roche Diagnostics Gmbh Autokatalytisch aktivierbare zymogene vorstufen von proteasen und deren verwendung
EP0927764B1 (de) * 1997-12-03 2004-05-26 Boehringer Mannheim Gmbh Chimäre Serinproteasen
DE69938830D1 (de) 1998-06-05 2008-07-10 Bayer Schering Pharma Ag Corin, eine serinprotease
US6420157B1 (en) * 1999-04-30 2002-07-16 Ortho-Mcneil Pharmaceutical, Inc. Zymogen activation system
ATE496123T1 (de) 2000-02-03 2011-02-15 Dendreon Corp Nukleinsäuren, welche für tramsmembran serin proteasen kodieren, die kodierten proteine und darauf basierende methoden
US6906176B2 (en) * 2000-06-19 2005-06-14 Dyax Corp. Enterokinase cleavage sequences
CA2389739A1 (en) * 2000-09-04 2002-03-14 Hyo-Joon Kim Mimetic peptides for epitope of apolipoprotein b-100, concatemer and modified peptides thereof, and the vaccine composition comprising the same
FR2831170B1 (fr) * 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
US20040132156A1 (en) * 2002-10-04 2004-07-08 Schering Aktiengesellschaft Modified hepsin molecules having a substitute activation sequence and uses thereof

Also Published As

Publication number Publication date
RU2006100035A (ru) 2006-08-27
CN101109011A (zh) 2008-01-23
NO20060144L (no) 2006-01-10
IL172095A0 (en) 2009-02-11
CN1836037A (zh) 2006-09-20
EP1636356A1 (en) 2006-03-22
WO2004111225A8 (en) 2006-04-06
AU2004248192A1 (en) 2004-12-23
US7176013B2 (en) 2007-02-13
KR20060022683A (ko) 2006-03-10
PL379196A1 (pl) 2006-07-24
ZA200600224B (en) 2007-04-25
US20050003416A1 (en) 2005-01-06
WO2004111225A1 (en) 2004-12-23
BRPI0411353A (pt) 2006-07-11
JP2007502132A (ja) 2007-02-08
CA2527361A1 (en) 2004-12-23

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