BRPI0411353A - moléculas de corina modificadas tendo seqüências de ativação substitutas e aplicações das mesmas - Google Patents

moléculas de corina modificadas tendo seqüências de ativação substitutas e aplicações das mesmas

Info

Publication number
BRPI0411353A
BRPI0411353A BRPI0411353-5A BRPI0411353A BRPI0411353A BR PI0411353 A BRPI0411353 A BR PI0411353A BR PI0411353 A BRPI0411353 A BR PI0411353A BR PI0411353 A BRPI0411353 A BR PI0411353A
Authority
BR
Brazil
Prior art keywords
molecules
modified
corina
applications
activation sequences
Prior art date
Application number
BRPI0411353-5A
Other languages
English (en)
Inventor
Qingyu Wu
Original Assignee
Schering Aktiengellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengellschaft filed Critical Schering Aktiengellschaft
Publication of BRPI0411353A publication Critical patent/BRPI0411353A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"MOLéCULAS DE CORINA MODIFICADAS TENDO SEQüêNCIAS DE ATIVAçãO SUBSTITUTAS E APLICAçõES DAS MESMAS". Esta invenção se refere a novas moléculas corina modificadas, ou fragmentos ou derivados das mesmas, compreendendo uma seqüência de ativação substituta. As moléculas corina modificadas são clivadas em uma seqüência de ativação substituta, deste modo produzindo moléculas corina ativadas, ou fragmentos ou derivados das mesmas, que apresentam a atividade funcional de moléculas corina selvagens, que ocorrem naturalmente. As moléculas corina modificadas podem ser usadas para tratar uma varidade de doenças ou distúrbios, inclusive falência cardíaca congestiva e enfarte agudo do miocárdio.
BRPI0411353-5A 2003-06-11 2004-06-09 moléculas de corina modificadas tendo seqüências de ativação substitutas e aplicações das mesmas BRPI0411353A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47768303P 2003-06-11 2003-06-11
PCT/US2004/018669 WO2004111225A1 (en) 2003-06-11 2004-06-09 Novel modified corin molecules having substitute activation sequences and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0411353A true BRPI0411353A (pt) 2006-07-11

Family

ID=33551745

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411353-5A BRPI0411353A (pt) 2003-06-11 2004-06-09 moléculas de corina modificadas tendo seqüências de ativação substitutas e aplicações das mesmas

Country Status (15)

Country Link
US (1) US7176013B2 (pt)
EP (1) EP1636356A1 (pt)
JP (1) JP2007502132A (pt)
KR (1) KR20060022683A (pt)
CN (2) CN101109011A (pt)
AU (1) AU2004248192A1 (pt)
BR (1) BRPI0411353A (pt)
CA (1) CA2527361A1 (pt)
IL (1) IL172095A0 (pt)
MX (1) MXPA05013321A (pt)
NO (1) NO20060144L (pt)
PL (1) PL379196A1 (pt)
RU (1) RU2006100035A (pt)
WO (1) WO2004111225A1 (pt)
ZA (1) ZA200600224B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026255A1 (en) * 2002-06-25 2005-02-03 Morser John Michael Corin, a serine protease
TW200723151A (en) * 2005-12-07 2007-06-16 Era Digital Media Co Business website method
US20110160128A1 (en) * 2008-03-28 2011-06-30 Qingyu Wu Corin for Treating Obesity and Diabetes
US20110306069A1 (en) 2009-02-19 2011-12-15 Qingyu Wu Corin As A Marker For Heart Failure
US10314894B2 (en) * 2014-02-12 2019-06-11 The Cleveland Clinic Foundation Treatment of cardio-renal disease using PCSK6
KR102493894B1 (ko) 2016-02-29 2023-01-31 리제너론 파마슈티칼스 인코포레이티드 인간화 tmprss 유전자를 갖는 설치류
CN105734070A (zh) * 2016-04-11 2016-07-06 苏州大学 Corin基因变异体及其用途
CN108066286B (zh) * 2016-11-10 2021-06-29 复旦大学 炔丙基半胱氨酸纳米粒长循环脂质体及其制备方法和用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI882407A (fi) * 1987-05-22 1988-11-23 Zymogenetics Inc Fibrinolytiska proteiner.
US5869637A (en) * 1996-07-22 1999-02-09 Incyte Pharmaceuticals, Inc. Human Kallikrein
WO1998024886A1 (en) * 1996-12-04 1998-06-11 Brigham And Women's Hospital, Inc. Mast cell protease that cleaves fibrinogen
WO1998036054A1 (en) * 1997-02-13 1998-08-20 Amrad Operations Pty. Ltd. Novel molecules
DK1012307T3 (da) * 1997-08-22 2005-09-05 Roche Diagnostics Gmbh Autokatalytisk aktiverbare zymogene proteaseforstadier og deres anvendelse
EP0927764B1 (de) 1997-12-03 2004-05-26 Boehringer Mannheim Gmbh Chimäre Serinproteasen
HUP0102811A3 (en) 1998-06-05 2005-11-28 Schering Ag Corin, a serine protease
US6420157B1 (en) * 1999-04-30 2002-07-16 Ortho-Mcneil Pharmaceutical, Inc. Zymogen activation system
ATE496123T1 (de) * 2000-02-03 2011-02-15 Dendreon Corp Nukleinsäuren, welche für tramsmembran serin proteasen kodieren, die kodierten proteine und darauf basierende methoden
JP2004503219A (ja) * 2000-06-19 2004-02-05 ダイアックス　コーポレーション 新規エンテロキナーゼ開裂配列
SK6312002A3 (en) * 2000-09-04 2002-09-10 Hyo-Joon Kim Mimetic peptides for epitope of apolipoprotein b-110, concatemer and modified peptides thereof, and the vaccine composition comprising the same
FR2831170B1 (fr) * 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
EP1558731A4 (en) * 2002-10-04 2007-01-10 Schering Ag MODIFIED HEPSINE MOLECULES COMPRISING A SUBSTITUTION ACTIVATION SEQUENCE AND USES THEREOF

Also Published As

Publication number Publication date
EP1636356A1 (en) 2006-03-22
CA2527361A1 (en) 2004-12-23
WO2004111225A8 (en) 2006-04-06
WO2004111225A1 (en) 2004-12-23
KR20060022683A (ko) 2006-03-10
IL172095A0 (en) 2009-02-11
AU2004248192A1 (en) 2004-12-23
CN101109011A (zh) 2008-01-23
US20050003416A1 (en) 2005-01-06
US7176013B2 (en) 2007-02-13
NO20060144L (no) 2006-01-10
CN1836037A (zh) 2006-09-20
MXPA05013321A (es) 2006-03-09
RU2006100035A (ru) 2006-08-27
PL379196A1 (pl) 2006-07-24
ZA200600224B (en) 2007-04-25
JP2007502132A (ja) 2007-02-08

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.