ZA200600224B - Novel modified corin molecules having substitute activation sequences and uses thereof - Google Patents
Novel modified corin molecules having substitute activation sequences and uses thereof Download PDFInfo
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- ZA200600224B ZA200600224B ZA200600224A ZA200600224A ZA200600224B ZA 200600224 B ZA200600224 B ZA 200600224B ZA 200600224 A ZA200600224 A ZA 200600224A ZA 200600224 A ZA200600224 A ZA 200600224A ZA 200600224 B ZA200600224 B ZA 200600224B
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- molecule
- corin
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- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000003151 transfection method Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
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- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
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- 230000002792 vascular Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
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- 238000002424 x-ray crystallography Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47768303P | 2003-06-11 | 2003-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200600224B true ZA200600224B (en) | 2007-04-25 |
Family
ID=33551745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200600224A ZA200600224B (en) | 2003-06-11 | 2006-01-10 | Novel modified corin molecules having substitute activation sequences and uses thereof |
Country Status (15)
Country | Link |
---|---|
US (1) | US7176013B2 (pt) |
EP (1) | EP1636356A1 (pt) |
JP (1) | JP2007502132A (pt) |
KR (1) | KR20060022683A (pt) |
CN (2) | CN101109011A (pt) |
AU (1) | AU2004248192A1 (pt) |
BR (1) | BRPI0411353A (pt) |
CA (1) | CA2527361A1 (pt) |
IL (1) | IL172095A0 (pt) |
MX (1) | MXPA05013321A (pt) |
NO (1) | NO20060144L (pt) |
PL (1) | PL379196A1 (pt) |
RU (1) | RU2006100035A (pt) |
WO (1) | WO2004111225A1 (pt) |
ZA (1) | ZA200600224B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050026255A1 (en) * | 2002-06-25 | 2005-02-03 | Morser John Michael | Corin, a serine protease |
TW200723151A (en) * | 2005-12-07 | 2007-06-16 | Era Digital Media Co | Business website method |
US20110160128A1 (en) * | 2008-03-28 | 2011-06-30 | Qingyu Wu | Corin for Treating Obesity and Diabetes |
US20110306069A1 (en) | 2009-02-19 | 2011-12-15 | Qingyu Wu | Corin As A Marker For Heart Failure |
US10314894B2 (en) * | 2014-02-12 | 2019-06-11 | The Cleveland Clinic Foundation | Treatment of cardio-renal disease using PCSK6 |
KR102493894B1 (ko) | 2016-02-29 | 2023-01-31 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 tmprss 유전자를 갖는 설치류 |
CN105734070A (zh) * | 2016-04-11 | 2016-07-06 | 苏州大学 | Corin基因变异体及其用途 |
CN108066286B (zh) * | 2016-11-10 | 2021-06-29 | 复旦大学 | 炔丙基半胱氨酸纳米粒长循环脂质体及其制备方法和用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI882407A (fi) * | 1987-05-22 | 1988-11-23 | Zymogenetics Inc | Fibrinolytiska proteiner. |
US5869637A (en) * | 1996-07-22 | 1999-02-09 | Incyte Pharmaceuticals, Inc. | Human Kallikrein |
WO1998024886A1 (en) * | 1996-12-04 | 1998-06-11 | Brigham And Women's Hospital, Inc. | Mast cell protease that cleaves fibrinogen |
WO1998036054A1 (en) * | 1997-02-13 | 1998-08-20 | Amrad Operations Pty. Ltd. | Novel molecules |
DK1012307T3 (da) * | 1997-08-22 | 2005-09-05 | Roche Diagnostics Gmbh | Autokatalytisk aktiverbare zymogene proteaseforstadier og deres anvendelse |
EP0927764B1 (de) | 1997-12-03 | 2004-05-26 | Boehringer Mannheim Gmbh | Chimäre Serinproteasen |
HUP0102811A3 (en) | 1998-06-05 | 2005-11-28 | Schering Ag | Corin, a serine protease |
US6420157B1 (en) * | 1999-04-30 | 2002-07-16 | Ortho-Mcneil Pharmaceutical, Inc. | Zymogen activation system |
ATE496123T1 (de) * | 2000-02-03 | 2011-02-15 | Dendreon Corp | Nukleinsäuren, welche für tramsmembran serin proteasen kodieren, die kodierten proteine und darauf basierende methoden |
JP2004503219A (ja) * | 2000-06-19 | 2004-02-05 | ダイアックス コーポレーション | 新規エンテロキナーゼ開裂配列 |
SK6312002A3 (en) * | 2000-09-04 | 2002-09-10 | Hyo-Joon Kim | Mimetic peptides for epitope of apolipoprotein b-110, concatemer and modified peptides thereof, and the vaccine composition comprising the same |
FR2831170B1 (fr) * | 2001-10-19 | 2004-03-19 | Inst Nat Sante Rech Med | Proteines c modifiees activables directement par la thrombine |
EP1558731A4 (en) * | 2002-10-04 | 2007-01-10 | Schering Ag | MODIFIED HEPSINE MOLECULES COMPRISING A SUBSTITUTION ACTIVATION SEQUENCE AND USES THEREOF |
-
2004
- 2004-06-09 EP EP04755046A patent/EP1636356A1/en not_active Withdrawn
- 2004-06-09 CN CNA2007101280546A patent/CN101109011A/zh active Pending
- 2004-06-09 KR KR1020057023612A patent/KR20060022683A/ko not_active Application Discontinuation
- 2004-06-09 CN CNA2004800230099A patent/CN1836037A/zh active Pending
- 2004-06-09 BR BRPI0411353-5A patent/BRPI0411353A/pt not_active IP Right Cessation
- 2004-06-09 US US10/865,978 patent/US7176013B2/en not_active Expired - Fee Related
- 2004-06-09 MX MXPA05013321A patent/MXPA05013321A/es not_active Application Discontinuation
- 2004-06-09 JP JP2006533746A patent/JP2007502132A/ja active Pending
- 2004-06-09 RU RU2006100035/13A patent/RU2006100035A/ru not_active Application Discontinuation
- 2004-06-09 WO PCT/US2004/018669 patent/WO2004111225A1/en active Application Filing
- 2004-06-09 PL PL379196A patent/PL379196A1/pl not_active Application Discontinuation
- 2004-06-09 AU AU2004248192A patent/AU2004248192A1/en not_active Abandoned
- 2004-06-09 CA CA002527361A patent/CA2527361A1/en not_active Abandoned
-
2005
- 2005-11-22 IL IL172095A patent/IL172095A0/en unknown
-
2006
- 2006-01-10 NO NO20060144A patent/NO20060144L/no not_active Application Discontinuation
- 2006-01-10 ZA ZA200600224A patent/ZA200600224B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP1636356A1 (en) | 2006-03-22 |
CA2527361A1 (en) | 2004-12-23 |
WO2004111225A8 (en) | 2006-04-06 |
WO2004111225A1 (en) | 2004-12-23 |
KR20060022683A (ko) | 2006-03-10 |
IL172095A0 (en) | 2009-02-11 |
AU2004248192A1 (en) | 2004-12-23 |
CN101109011A (zh) | 2008-01-23 |
US20050003416A1 (en) | 2005-01-06 |
US7176013B2 (en) | 2007-02-13 |
NO20060144L (no) | 2006-01-10 |
CN1836037A (zh) | 2006-09-20 |
MXPA05013321A (es) | 2006-03-09 |
RU2006100035A (ru) | 2006-08-27 |
PL379196A1 (pl) | 2006-07-24 |
JP2007502132A (ja) | 2007-02-08 |
BRPI0411353A (pt) | 2006-07-11 |
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