KR102489143B1 - 재조합 ｈｃｇ를 포함하는 약학 조제물 - Google Patents

재조합 ｈｃｇ를 포함하는 약학 조제물 Download PDF

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KR102489143B1
KR102489143B1 KR1020217037028A KR20217037028A KR102489143B1 KR 102489143 B1 KR102489143 B1 KR 102489143B1 KR 1020217037028 A KR1020217037028 A KR 1020217037028A KR 20217037028 A KR20217037028 A KR 20217037028A KR 102489143 B1 KR102489143 B1 KR 102489143B1
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hcg
mol
rhcg
leu
sialylation
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KR20210141771A (ko
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이안 코팅햄
다니엘 플락신
리차드 보이드 화이트
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훼링 비.브이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020217037028A 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물 Active KR102489143B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237001308A KR20230012104A (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09252360 2009-10-05
EP09252360.4 2009-10-05
PCT/GB2010/001854 WO2011042688A1 (en) 2009-10-05 2010-10-04 Pharmaceutical preparation comprising recombinant hcg
KR1020217003233A KR20210014767A (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물

Related Parent Applications (1)

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KR1020217003233A Division KR20210014767A (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물

Related Child Applications (1)

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KR1020237001308A Division KR20230012104A (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물

Publications (2)

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KR20210141771A KR20210141771A (ko) 2021-11-23
KR102489143B1 true KR102489143B1 (ko) 2023-01-13

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Family Applications (7)

Application Number Title Priority Date Filing Date
KR1020217037028A Active KR102489143B1 (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물
KR1020127008827A Active KR101804479B1 (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물
KR1020217003233A Ceased KR20210014767A (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물
KR1020177034392A Withdrawn KR20170133531A (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물
KR1020197016021A Active KR102213154B1 (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물
KR1020197007226A Active KR101987982B1 (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물
KR1020237001308A Pending KR20230012104A (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물

Family Applications After (6)

Application Number Title Priority Date Filing Date
KR1020127008827A Active KR101804479B1 (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물
KR1020217003233A Ceased KR20210014767A (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물
KR1020177034392A Withdrawn KR20170133531A (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물
KR1020197016021A Active KR102213154B1 (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물
KR1020197007226A Active KR101987982B1 (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물
KR1020237001308A Pending KR20230012104A (ko) 2009-10-05 2010-10-04 재조합 ｈｃｇ를 포함하는 약학 조제물

Country Status (25)

Country Link
US (5) US8975226B2 (OSRAM)
EP (2) EP2486051B1 (OSRAM)
JP (6) JP6176924B2 (OSRAM)
KR (7) KR102489143B1 (OSRAM)
CN (1) CN107050434B (OSRAM)
AR (2) AR079876A1 (OSRAM)
AU (1) AU2010304922B2 (OSRAM)
BR (1) BR112012007990A2 (OSRAM)
CA (1) CA2776790A1 (OSRAM)
DK (1) DK2486051T3 (OSRAM)
ES (2) ES3036152T3 (OSRAM)
HR (1) HRP20200941T1 (OSRAM)
HU (1) HUE050793T2 (OSRAM)
IL (3) IL218548A (OSRAM)
IN (1) IN2012DN02073A (OSRAM)
JO (1) JOP20200039A1 (OSRAM)
LT (1) LT2486051T (OSRAM)
MX (1) MX2012003951A (OSRAM)
PL (1) PL2486051T3 (OSRAM)
PT (1) PT2486051T (OSRAM)
RS (1) RS60413B1 (OSRAM)
RU (2) RU2724528C2 (OSRAM)
SI (1) SI2486051T1 (OSRAM)
TW (2) TWI604850B (OSRAM)
WO (1) WO2011042688A1 (OSRAM)

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AR090095A1 (es) * 2011-06-06 2014-10-22 Ferring Bv Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante
JO3092B1 (ar) * 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
WO2013093760A2 (en) * 2011-12-19 2013-06-27 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
ES2784510T3 (es) 2012-12-10 2020-09-28 Seikagaku Kogyo Co Ltd Método para producir un nuevo Factor C recombinante, método para mitigar la inhibición de la reacción en ensayos de endotoxina, y método para medir endotoxina
CN107429237B (zh) * 2014-12-22 2021-09-28 豪夫迈·罗氏有限公司 Cmp依赖性的唾液酸酶活性
EA034022B1 (ru) * 2015-04-24 2019-12-19 Ферринг Б.В. Способ получения гонадотропина
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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US20080226681A1 (en) 2004-02-13 2008-09-18 Glycotope Gmbh Highly Active Glycoproteins-Process Conditions and an Efficient Method for their Production

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BR112012007990A2 (pt) 2017-07-25
JP2016074680A (ja) 2016-05-12
US20130023476A1 (en) 2013-01-24
HRP20200941T1 (hr) 2020-09-18
KR20230012104A (ko) 2023-01-25
SI2486051T1 (sl) 2020-08-31
KR20120094909A (ko) 2012-08-27
TWI604850B (zh) 2017-11-11
US12234272B2 (en) 2025-02-25
JP2023075144A (ja) 2023-05-30
RS60413B1 (sr) 2020-07-31
HUE050793T2 (hu) 2021-01-28
JP6310440B2 (ja) 2018-04-11
JP2020000246A (ja) 2020-01-09
EP2486051B1 (en) 2020-03-25
EP3611185A1 (en) 2020-02-19
TWI532495B (zh) 2016-05-11
RU2724528C2 (ru) 2020-06-23
US10526390B2 (en) 2020-01-07
DK2486051T3 (da) 2020-06-22
WO2011042688A1 (en) 2011-04-14
AU2010304922A1 (en) 2012-03-29
JP2018076296A (ja) 2018-05-17
US8975226B2 (en) 2015-03-10
KR20210014767A (ko) 2021-02-09
US11292824B2 (en) 2022-04-05
JP2021176867A (ja) 2021-11-11
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