KR102486607B1 - 이소성 골화를 치료하는 방법 - Google Patents

이소성 골화를 치료하는 방법 Download PDF

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KR102486607B1
KR102486607B1 KR1020197000339A KR20197000339A KR102486607B1 KR 102486607 B1 KR102486607 B1 KR 102486607B1 KR 1020197000339 A KR1020197000339 A KR 1020197000339A KR 20197000339 A KR20197000339 A KR 20197000339A KR 102486607 B1 KR102486607 B1 KR 102486607B1
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palovarotene
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KR20190017883A (ko
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클라리사 데스자딘스
도나 로이 그로간
제프리 닐 팩맨
마크 하네트
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클레멘티아 파마슈티컬즈, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020197000339A 2016-06-08 2017-06-08 이소성 골화를 치료하는 방법 Active KR102486607B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662347381P 2016-06-08 2016-06-08
US62/347,381 2016-06-08
PCT/CA2017/050701 WO2017210792A1 (en) 2016-06-08 2017-06-08 Methods for treating heterotopic ossification

Publications (2)

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KR20190017883A KR20190017883A (ko) 2019-02-20
KR102486607B1 true KR102486607B1 (ko) 2023-01-11

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EP (2) EP3468554B1 (enExample)
JP (2) JP7023868B2 (enExample)
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CN (2) CN109562099A (enExample)
AU (2) AU2017276835B2 (enExample)
BR (1) BR112018075422A2 (enExample)
CA (1) CA3025854A1 (enExample)
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CN111773213B (zh) 2010-09-01 2023-02-24 托马斯杰弗逊大学 用于肌肉修复和再生的组合物和方法
ES2963348T3 (es) * 2016-06-08 2024-03-26 Clementia Pharmaceuticals Inc Métodos para tratar la osificación heterotópica
JP7018957B2 (ja) 2016-11-16 2022-02-14 クレメンティア ファーマシューティカルズ インコーポレイテッド 多発性骨軟骨腫（ｍｏ）を処置するための方法
WO2020118405A1 (en) * 2018-12-13 2020-06-18 Clementia Pharmaceuticals Inc. Methods for treating heterotopic ossification
EP4186505A4 (en) * 2020-06-11 2024-06-19 Yang Sheng Tang Company, Ltd. USE OF PALOVAROTEN TO TREAT HBV VIRUS
EP4470537A1 (en) * 2023-05-30 2024-12-04 Queen's University At Kingston Compound for use in treating fibrodysplasia ossificans progressiva (fop)
EP4470536A1 (en) * 2023-05-30 2024-12-04 Queen's University At Kingston Compound for use in treating fibrodysplasia ossificans progressiva (fop)
CN119185298B (zh) * 2024-10-30 2025-09-26 武汉大学人民医院（湖北省人民医院） 帕罗伐汀在制备用于治疗脑出血后急性脑损伤的药物中的应用

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JP2019517528A (ja) 2019-06-24
NZ748939A (en) 2025-03-28
CN120204216A (zh) 2025-06-27
US11622959B2 (en) 2023-04-11
CA3025854A1 (en) 2017-12-14
AU2017276835A1 (en) 2018-12-13
JP2022019995A (ja) 2022-01-27
EP3468554A1 (en) 2019-04-17
US20210069152A1 (en) 2021-03-11
IL317726A (en) 2025-02-01
EP4249490A2 (en) 2023-09-27
BR112018075422A2 (pt) 2019-03-12
MX390115B (es) 2025-03-20
CL2018003502A1 (es) 2019-04-26
EP3468554B1 (en) 2023-08-09
MY200642A (en) 2024-01-08
CN109562099A (zh) 2019-04-02
US20260021073A1 (en) 2026-01-22
SG11201810658PA (en) 2018-12-28
WO2017210792A1 (en) 2017-12-14
IL295440A (en) 2022-10-01
EA201892497A1 (ru) 2019-05-31
EP3468554C0 (en) 2023-08-09
US20190216781A1 (en) 2019-07-18
US20240350457A1 (en) 2024-10-24
IL295440B2 (en) 2025-05-01
US12458626B2 (en) 2025-11-04
ES2963348T3 (es) 2024-03-26
IL263440A (en) 2019-01-31
PH12018502563A1 (en) 2019-10-14
US10864194B2 (en) 2020-12-15
US20230285360A1 (en) 2023-09-14
MX2018015108A (es) 2019-08-29
IL295440B1 (en) 2025-01-01
MX2022001991A (es) 2022-03-11
AU2017276835B2 (en) 2022-03-31
US20240277667A1 (en) 2024-08-22
AU2022202148A1 (en) 2022-04-21
EP3468554A4 (en) 2020-01-22
IL263440B (en) 2022-09-01
KR20190017883A (ko) 2019-02-20
US12138245B2 (en) 2024-11-12
JP7023868B2 (ja) 2022-02-22
EP4249490A3 (en) 2023-12-13
AU2022202148B2 (en) 2023-08-24
ZA201808102B (en) 2024-04-24
US12201614B2 (en) 2025-01-21

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