KR102475124B1 - sGC 자극제를 사용한 CNS 질환의 치료 - Google Patents

sGC 자극제를 사용한 CNS 질환의 치료 Download PDF

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KR102475124B1
KR102475124B1 KR1020197016351A KR20197016351A KR102475124B1 KR 102475124 B1 KR102475124 B1 KR 102475124B1 KR 1020197016351 A KR1020197016351 A KR 1020197016351A KR 20197016351 A KR20197016351 A KR 20197016351A KR 102475124 B1 KR102475124 B1 KR 102475124B1
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cns
disease
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pharmaceutical composition
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KR20190094167A (ko
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준 정
토마스 와이-호 리
라제쉬 알. 아이옌가
니콜라스 로버트 펄
피터 게르마노
마리아 디. 리바데네이라
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사이클리온 테라퓨틱스, 인크.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020197016351A 2016-11-08 2017-11-07 sGC 자극제를 사용한 CNS 질환의 치료 Active KR102475124B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662419059P 2016-11-08 2016-11-08
US62/419,059 2016-11-08
PCT/US2017/060299 WO2018089328A1 (en) 2016-11-08 2017-11-07 Treatment of cns diseases with sgc stimulators

Publications (2)

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KR20190094167A KR20190094167A (ko) 2019-08-12
KR102475124B1 true KR102475124B1 (ko) 2022-12-08

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US (3) US11690828B2 (OSRAM)
EP (1) EP3538096B1 (OSRAM)
JP (2) JP7150740B2 (OSRAM)
KR (1) KR102475124B1 (OSRAM)
CN (1) CN110267658B (OSRAM)
AU (2) AU2017359018C1 (OSRAM)
BR (1) BR112019009449A2 (OSRAM)
CA (1) CA3042548A1 (OSRAM)
CL (1) CL2019001256A1 (OSRAM)
EA (1) EA201991147A1 (OSRAM)
ES (1) ES2972711T3 (OSRAM)
IL (1) IL266275B2 (OSRAM)
MA (1) MA46752A (OSRAM)
MX (2) MX2019005342A (OSRAM)
NZ (1) NZ753434A (OSRAM)
PH (1) PH12019501016A1 (OSRAM)
SG (1) SG10202104865UA (OSRAM)
TW (1) TWI812601B (OSRAM)
WO (1) WO2018089328A1 (OSRAM)

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EP3538520B1 (en) * 2016-11-08 2025-12-31 Tisento Therapeutics Inc. CGS STIMULATORS
US11389449B2 (en) 2017-09-14 2022-07-19 Cyclerion Therapeutics, Inc. Treatment of metabolic syndrome with an sGC stimulator
CA3103676A1 (en) 2018-07-11 2020-01-16 Cyclerion Therapeutics, Inc. Use of sgc stimulators for the treatment of mitochonrial disorders
US20220087970A1 (en) * 2019-01-18 2022-03-24 The Johns Hopkins University Prevention of anesthetic-induced neurocognitive dysfunction
WO2021111419A1 (en) * 2019-12-05 2021-06-10 Cadila Healthcare Limited Modified release pharmaceutical compositions of riociguat
JP7412583B2 (ja) 2020-02-07 2024-01-12 ニューロヴェンティ カンパニー リミテッド リルメニジン化合物を有効成分として含む脆弱x症候群または関連発達障害を治療するための組成物
CN112924573B (zh) * 2021-01-21 2022-01-04 山东英盛生物技术有限公司 一种阿比多尔、利巴韦林、氯喹的hplc-ms/ms检测方法
US20250064799A1 (en) * 2021-12-31 2025-02-27 Tenax Therapeutics, Inc. Oral formulations of levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction
EP4658253A1 (en) * 2023-02-03 2025-12-10 R.P. Scherer Technologies, LLC Osmotic pharmaceutical capsules

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MX2022010852A (es) 2022-09-27
WO2018089328A8 (en) 2019-03-28
TWI812601B (zh) 2023-08-21
AU2023270267A1 (en) 2023-12-07
NZ753434A (en) 2025-10-31
JP7150740B2 (ja) 2022-10-11
TW201822765A (zh) 2018-07-01
CN110267658B (zh) 2024-02-02
WO2018089328A1 (en) 2018-05-17
AU2017359018A1 (en) 2019-05-30
MA46752A (fr) 2019-09-18
EP3538096B1 (en) 2024-02-28
JP2022160605A (ja) 2022-10-19
US20250108040A1 (en) 2025-04-03
EP3538096C0 (en) 2024-02-28
CL2019001256A1 (es) 2019-10-04
CA3042548A1 (en) 2018-05-17
US20230381153A1 (en) 2023-11-30
IL266275A (en) 2019-06-30
ES2972711T3 (es) 2024-06-14
JP2019534327A (ja) 2019-11-28
AU2017359018B2 (en) 2023-08-31
AU2017359018C1 (en) 2023-12-21
MX2019005342A (es) 2019-10-02
KR20190094167A (ko) 2019-08-12
SG10202104865UA (en) 2021-06-29
EA201991147A1 (ru) 2019-11-29
EP3538096A1 (en) 2019-09-18
US20190343813A1 (en) 2019-11-14
CN110267658A (zh) 2019-09-20
IL266275B2 (en) 2023-12-01
BR112019009449A2 (pt) 2019-07-30
US11690828B2 (en) 2023-07-04
PH12019501016A1 (en) 2019-09-09
IL266275B1 (en) 2023-08-01

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