JP7150740B2 - ｓＧＣ刺激薬による中枢神経系疾患の治療 - Google Patents

ｓＧＣ刺激薬による中枢神経系疾患の治療 Download PDF

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JP7150740B2
JP7150740B2 JP2019545723A JP2019545723A JP7150740B2 JP 7150740 B2 JP7150740 B2 JP 7150740B2 JP 2019545723 A JP2019545723 A JP 2019545723A JP 2019545723 A JP2019545723 A JP 2019545723A JP 7150740 B2 JP7150740 B2 JP 7150740B2
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JP2019534327A5 (OSRAM
JP2019534327A (ja
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チュン，ジュン
リー，トーマス・ワイ－ホー
アイアンガー，ラジェシュ・アール
パール，ニコラス・ロバート
ジェルマーノ，ピーター
リバデネイラ，マリア・ディー
タン，キム
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サイクレリオン・セラピューティクス，インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019545723A 2016-11-08 2017-11-07 ｓＧＣ刺激薬による中枢神経系疾患の治療 Active JP7150740B2 (ja)

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JP2022126467A JP2022160605A (ja) 2016-11-08 2022-08-08 ｓＧＣ刺激薬による中枢神経系疾患の治療

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US201662419059P 2016-11-08 2016-11-08
US62/419,059 2016-11-08
PCT/US2017/060299 WO2018089328A1 (en) 2016-11-08 2017-11-07 Treatment of cns diseases with sgc stimulators

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JP2019534327A JP2019534327A (ja) 2019-11-28
JP2019534327A5 JP2019534327A5 (OSRAM) 2020-12-17
JP7150740B2 true JP7150740B2 (ja) 2022-10-11

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JP2022126467A Pending JP2022160605A (ja) 2016-11-08 2022-08-08 ｓＧＣ刺激薬による中枢神経系疾患の治療

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US (3) US11690828B2 (OSRAM)
EP (1) EP3538096B1 (OSRAM)
JP (2) JP7150740B2 (OSRAM)
KR (1) KR102475124B1 (OSRAM)
CN (1) CN110267658B (OSRAM)
AU (2) AU2017359018C1 (OSRAM)
BR (1) BR112019009449A2 (OSRAM)
CA (1) CA3042548A1 (OSRAM)
CL (1) CL2019001256A1 (OSRAM)
EA (1) EA201991147A1 (OSRAM)
ES (1) ES2972711T3 (OSRAM)
IL (1) IL266275B2 (OSRAM)
MA (1) MA46752A (OSRAM)
MX (2) MX2019005342A (OSRAM)
NZ (1) NZ753434A (OSRAM)
PH (1) PH12019501016A1 (OSRAM)
SG (1) SG10202104865UA (OSRAM)
TW (1) TWI812601B (OSRAM)
WO (1) WO2018089328A1 (OSRAM)

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WO2019055859A1 (en) * 2017-09-14 2019-03-21 Ironwood Pharmaceuticals, Inc. TREATMENT OF METABOLIC SYNDROME BY SGC STIMULATOR
BR112021000358A2 (pt) 2018-07-11 2021-04-06 Cyclerion Therapeutics, Inc. Uso de estimulantes de sgc para o tratamento de distúrbios mitocondriais
US20220087970A1 (en) * 2019-01-18 2022-03-24 The Johns Hopkins University Prevention of anesthetic-induced neurocognitive dysfunction
WO2021111419A1 (en) * 2019-12-05 2021-06-10 Cadila Healthcare Limited Modified release pharmaceutical compositions of riociguat
CN115397414A (zh) 2020-02-07 2022-11-25 株式会社纽若梵提 包含利美尼定的用于治疗脆性x染色体综合征的组合物
CN112924573B (zh) * 2021-01-21 2022-01-04 山东英盛生物技术有限公司 一种阿比多尔、利巴韦林、氯喹的hplc-ms/ms检测方法
US20250064799A1 (en) * 2021-12-31 2025-02-27 Tenax Therapeutics, Inc. Oral formulations of levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction
WO2024163888A1 (en) * 2023-02-03 2024-08-08 R.P. Scherer Technologies, Llc Osmotic pharmaceutical capsules

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US20250108040A1 (en) 2025-04-03
NZ753434A (en) 2025-10-31
MX2019005342A (es) 2019-10-02
EP3538096A1 (en) 2019-09-18
PH12019501016A1 (en) 2019-09-09
MA46752A (fr) 2019-09-18
IL266275B2 (en) 2023-12-01
JP2022160605A (ja) 2022-10-19
WO2018089328A8 (en) 2019-03-28
BR112019009449A2 (pt) 2019-07-30
US11690828B2 (en) 2023-07-04
ES2972711T3 (es) 2024-06-14
AU2017359018A1 (en) 2019-05-30
CN110267658B (zh) 2024-02-02
JP2019534327A (ja) 2019-11-28
EP3538096C0 (en) 2024-02-28
SG10202104865UA (en) 2021-06-29
IL266275B1 (en) 2023-08-01
MX2022010852A (es) 2022-09-27
TWI812601B (zh) 2023-08-21
KR102475124B1 (ko) 2022-12-08
TW201822765A (zh) 2018-07-01
CL2019001256A1 (es) 2019-10-04
US20230381153A1 (en) 2023-11-30
CA3042548A1 (en) 2018-05-17
EP3538096B1 (en) 2024-02-28
IL266275A (en) 2019-06-30
EA201991147A1 (ru) 2019-11-29
KR20190094167A (ko) 2019-08-12
WO2018089328A1 (en) 2018-05-17
AU2017359018B2 (en) 2023-08-31
CN110267658A (zh) 2019-09-20
AU2017359018C1 (en) 2023-12-21
US20190343813A1 (en) 2019-11-14
AU2023270267A1 (en) 2023-12-07

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