KR102457751B1 - 액티빈 타입 2 수용체 결합 단백질 및 이의 용도 - Google Patents

액티빈 타입 2 수용체 결합 단백질 및 이의 용도 Download PDF

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KR102457751B1
KR102457751B1 KR1020187029049A KR20187029049A KR102457751B1 KR 102457751 B1 KR102457751 B1 KR 102457751B1 KR 1020187029049 A KR1020187029049 A KR 1020187029049A KR 20187029049 A KR20187029049 A KR 20187029049A KR 102457751 B1 KR102457751 B1 KR 102457751B1
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seq
amino acid
actrii
actriib
acid sequence
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KR20180128421A (ko
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라빈드라 쿠마
조나단 벨크
아샤 그린버그
다이엔 사코
로즐린 캐스톤과이
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악셀레론 파마 인코포레이티드
아디맵 엘엘씨
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Priority to KR1020227036266A priority Critical patent/KR102592109B1/ko
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
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KR1020187029049A 2016-03-10 2017-03-10 액티빈 타입 2 수용체 결합 단백질 및 이의 용도 Active KR102457751B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227036266A KR102592109B1 (ko) 2016-03-10 2017-03-10 액티빈 타입 2 수용체 결합 단백질 및 이의 용도

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662306354P 2016-03-10 2016-03-10
US62/306,354 2016-03-10
PCT/US2017/021958 WO2017156488A2 (en) 2016-03-10 2017-03-10 Activin type 2 receptor binding proteins and uses thereof

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KR1020227036266A Division KR102592109B1 (ko) 2016-03-10 2017-03-10 액티빈 타입 2 수용체 결합 단백질 및 이의 용도

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KR20180128421A KR20180128421A (ko) 2018-12-03
KR102457751B1 true KR102457751B1 (ko) 2022-10-21

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KR1020187029049A Active KR102457751B1 (ko) 2016-03-10 2017-03-10 액티빈 타입 2 수용체 결합 단백질 및 이의 용도
KR1020257032143A Pending KR20250142947A (ko) 2016-03-10 2017-03-10 액티빈 타입 2 수용체 결합 단백질 및 이의 용도
KR1020227036266A Active KR102592109B1 (ko) 2016-03-10 2017-03-10 액티빈 타입 2 수용체 결합 단백질 및 이의 용도
KR1020237035480A Active KR102866147B1 (ko) 2016-03-10 2017-03-10 액티빈 타입 2 수용체 결합 단백질 및 이의 용도

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KR1020227036266A Active KR102592109B1 (ko) 2016-03-10 2017-03-10 액티빈 타입 2 수용체 결합 단백질 및 이의 용도
KR1020237035480A Active KR102866147B1 (ko) 2016-03-10 2017-03-10 액티빈 타입 2 수용체 결합 단백질 및 이의 용도

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US (4) US10307455B2 (enExample)
EP (2) EP3426680B1 (enExample)
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CN (2) CN116284392A (enExample)
AU (1) AU2017230091B2 (enExample)
BR (1) BR112018067813A2 (enExample)
CA (1) CA3015277A1 (enExample)
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CA3015277A1 (en) 2016-03-10 2017-09-14 Acceleron Pharma Inc. Activin type 2 receptor binding proteins and uses thereof
CA3142149A1 (en) 2019-05-30 2020-12-03 Acceleron Pharma, Inc. Actrii-binding proteins and uses thereof
CA3156007A1 (en) 2019-09-27 2021-04-01 Disc Medicine, Inc. METHODS OF TREATING MYELOFIBROSE AND ASSOCIATED CONDITIONS
US20230174620A1 (en) * 2020-04-28 2023-06-08 Acceleron Pharma Inc. Actrii proteins and use in treating post-capillary pulmonary hypertension
AU2021273014A1 (en) 2020-05-13 2022-11-17 AbbVie Deutschland GmbH & Co. KG Anti-hemojuvelin (HJV) antibodies for treating anemia of chronic disease
ES3075793T3 (en) 2020-05-13 2026-08-07 Disc Medicine Inc Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
US20230391880A1 (en) * 2020-11-11 2023-12-07 Hq Han Bifunctional antagonists of activin/tgf-beta and rankl and uses thereof
CA3200465A1 (en) * 2020-11-30 2022-06-02 Xiwu HUI Anti-cldn18.2 antibody, drug conjugate, and preparation method therefor and use thereof
JP2024511315A (ja) * 2021-03-10 2024-03-13 アクセルロン ファーマ インコーポレイテッド Ａｃｔｒｉｉ－ａｌｋ４アンタゴニスト及び心不全の治療方法
WO2022261436A2 (en) * 2021-06-11 2022-12-15 Acceleron Pharma Inc. Actrii proteins and uses thereof
EP4577301A1 (en) 2022-08-26 2025-07-02 Versanis Bio, Inc. Actrii antibody fixed unit dose treatments
IL326224A (en) 2023-07-31 2026-03-01 Sixpeaks Bio Ag Antibody conjugates and fusion proteins
WO2026080757A2 (en) * 2024-10-09 2026-04-16 Diagonal Therapeutics Inc. Activin receptor type ii a/b (actriia/b) antibodies
CN122404555A (zh) * 2025-01-17 2026-07-17 沈阳三生制药有限责任公司 结合acvr2a和/或acvr2b的抗体及其制备与应用
WO2026158505A1 (zh) * 2025-01-24 2026-07-30 信立泰(成都)生物技术有限公司 一种抗acvr2a抗体或其抗原结合片段及用途
EP4785960A1 (en) 2025-01-31 2026-08-05 SixPeaks Bio AG Glp-1 antibody conjugates

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