JP6987072B2 - アクチビン２型受容体結合タンパク質及びその使用 - Google Patents

アクチビン２型受容体結合タンパク質及びその使用 Download PDF

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JP6987072B2
JP6987072B2 JP2018547941A JP2018547941A JP6987072B2 JP 6987072 B2 JP6987072 B2 JP 6987072B2 JP 2018547941 A JP2018547941 A JP 2018547941A JP 2018547941 A JP2018547941 A JP 2018547941A JP 6987072 B2 JP6987072 B2 JP 6987072B2
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seq
amino acid
actrii
actriib
acid sequence
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JP2019513015A (ja
JP2019513015A5 (enExample
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クマール，ラビンドラ
ベルク，ジョナサン
グリンバーグ，アシャ
サコ，ダイアン
カストングアイ，ロゼリン
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アクセレロン ファーマ インコーポレーテッド
アディマブ， エルエルシー
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Priority to JP2023198762A priority patent/JP7755634B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof

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  • Proteomics, Peptides & Aminoacids (AREA)
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JP2018547941A 2016-03-10 2017-03-10 アクチビン２型受容体結合タンパク質及びその使用 Active JP6987072B2 (ja)

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JP2021194152A JP7469284B2 (ja) 2016-03-10 2021-11-30 アクチビン２型受容体結合タンパク質及びその使用
JP2023198762A JP7755634B2 (ja) 2016-03-10 2023-11-24 アクチビン２型受容体結合タンパク質及びその使用
JP2025167026A JP2026004489A (ja) 2016-03-10 2025-10-03 アクチビン２型受容体結合タンパク質及びその使用

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US201662306354P 2016-03-10 2016-03-10
US62/306,354 2016-03-10
PCT/US2017/021958 WO2017156488A2 (en) 2016-03-10 2017-03-10 Activin type 2 receptor binding proteins and uses thereof

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JP2019513015A5 JP2019513015A5 (enExample) 2020-04-23
JP6987072B2 true JP6987072B2 (ja) 2021-12-22

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JP2018547941A Active JP6987072B2 (ja) 2016-03-10 2017-03-10 アクチビン２型受容体結合タンパク質及びその使用
JP2021194152A Active JP7469284B2 (ja) 2016-03-10 2021-11-30 アクチビン２型受容体結合タンパク質及びその使用
JP2023198762A Active JP7755634B2 (ja) 2016-03-10 2023-11-24 アクチビン２型受容体結合タンパク質及びその使用
JP2025167026A Pending JP2026004489A (ja) 2016-03-10 2025-10-03 アクチビン２型受容体結合タンパク質及びその使用

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JP2023198762A Active JP7755634B2 (ja) 2016-03-10 2023-11-24 アクチビン２型受容体結合タンパク質及びその使用
JP2025167026A Pending JP2026004489A (ja) 2016-03-10 2025-10-03 アクチビン２型受容体結合タンパク質及びその使用

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US (4) US10307455B2 (enExample)
EP (2) EP3426680B1 (enExample)
JP (4) JP6987072B2 (enExample)
KR (4) KR102457751B1 (enExample)
CN (2) CN116284392A (enExample)
AU (1) AU2017230091B2 (enExample)
BR (1) BR112018067813A2 (enExample)
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ES (1) ES2987504T3 (enExample)
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PL (1) PL3426680T3 (enExample)
PT (1) PT3426680T (enExample)
RS (1) RS66251B1 (enExample)
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US20230174620A1 (en) * 2020-04-28 2023-06-08 Acceleron Pharma Inc. Actrii proteins and use in treating post-capillary pulmonary hypertension
AU2021273014A1 (en) 2020-05-13 2022-11-17 AbbVie Deutschland GmbH & Co. KG Anti-hemojuvelin (HJV) antibodies for treating anemia of chronic disease
ES3075793T3 (en) 2020-05-13 2026-08-07 Disc Medicine Inc Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
US20230391880A1 (en) * 2020-11-11 2023-12-07 Hq Han Bifunctional antagonists of activin/tgf-beta and rankl and uses thereof
CA3200465A1 (en) * 2020-11-30 2022-06-02 Xiwu HUI Anti-cldn18.2 antibody, drug conjugate, and preparation method therefor and use thereof
JP2024511315A (ja) * 2021-03-10 2024-03-13 アクセルロン ファーマ インコーポレイテッド Ａｃｔｒｉｉ－ａｌｋ４アンタゴニスト及び心不全の治療方法
WO2022261436A2 (en) * 2021-06-11 2022-12-15 Acceleron Pharma Inc. Actrii proteins and uses thereof
EP4577301A1 (en) 2022-08-26 2025-07-02 Versanis Bio, Inc. Actrii antibody fixed unit dose treatments
IL326224A (en) 2023-07-31 2026-03-01 Sixpeaks Bio Ag Antibody conjugates and fusion proteins
WO2026080757A2 (en) * 2024-10-09 2026-04-16 Diagonal Therapeutics Inc. Activin receptor type ii a/b (actriia/b) antibodies
CN122404555A (zh) * 2025-01-17 2026-07-17 沈阳三生制药有限责任公司 结合acvr2a和/或acvr2b的抗体及其制备与应用
WO2026158505A1 (zh) * 2025-01-24 2026-07-30 信立泰(成都)生物技术有限公司 一种抗acvr2a抗体或其抗原结合片段及用途
EP4785960A1 (en) 2025-01-31 2026-08-05 SixPeaks Bio AG Glp-1 antibody conjugates

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