|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
DE3546807C2
(enExample)
|
1985-03-30 |
1991-03-28 |
Marc Genf/Geneve Ch Ballivet |
|
|
US6492107B1
(en)
|
1986-11-20 |
2002-12-10 |
Stuart Kauffman |
Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
|
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
DE3600905A1
(de)
|
1986-01-15 |
1987-07-16 |
Ant Nachrichtentech |
Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen
|
|
US5681718A
(en)
|
1986-03-14 |
1997-10-28 |
Celltech Limited |
Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
EP0478627A4
(en)
|
1989-05-16 |
1992-08-19 |
William D. Huse |
Co-expression of heteromeric receptors
|
|
CA2016841C
(en)
|
1989-05-16 |
1999-09-21 |
William D. Huse |
A method for producing polymers having a preselected activity
|
|
CA2016842A1
(en)
|
1989-05-16 |
1990-11-16 |
Richard A. Lerner |
Method for tapping the immunological repertoire
|
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
AU8507191A
(en)
|
1990-08-29 |
1992-03-30 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ES2113940T3
(es)
|
1990-12-03 |
1998-05-16 |
Genentech Inc |
Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
|
|
PT1696031E
(pt)
|
1991-12-02 |
2010-06-25 |
Medical Res Council |
Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
|
|
JP4157160B2
(ja)
|
1991-12-13 |
2008-09-24 |
ゾーマ テクノロジー リミテッド |
改変抗体可変領域の調製のための方法
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US6696248B1
(en)
|
1995-08-18 |
2004-02-24 |
Morphosys Ag |
Protein/(poly)peptide libraries
|
|
ATE219517T1
(de)
|
1995-08-18 |
2002-07-15 |
Morphosys Ag |
Protein-/(poly)peptidbibliotheken
|
|
WO1997011971A1
(en)
|
1995-09-28 |
1997-04-03 |
Alexion Pharmaceuticals, Inc. |
Porcine cell interaction proteins
|
|
EP0866805A1
(en)
*
|
1995-12-12 |
1998-09-30 |
Karolinska Innovations AB |
PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b)
|
|
US5714352A
(en)
|
1996-03-20 |
1998-02-03 |
Xenotech Incorporated |
Directed switch-mediated DNA recombination
|
|
DE69736247T2
(de)
|
1996-05-20 |
2007-05-24 |
Novozymes A/S |
Verfahren zur herstellung von proteinhydrolysate
|
|
US6696251B1
(en)
|
1996-05-31 |
2004-02-24 |
Board Of Trustees Of The University Of Illinois |
Yeast cell surface display of proteins and uses thereof
|
|
US6699658B1
(en)
|
1996-05-31 |
2004-03-02 |
Board Of Trustees Of The University Of Illinois |
Yeast cell surface display of proteins and uses thereof
|
|
JP3614866B2
(ja)
|
1997-06-12 |
2005-01-26 |
リサーチ コーポレイション テクノロジーズ，インコーポレイティド |
人工抗体ポリペプチド
|
|
US6696260B1
(en)
|
1997-08-01 |
2004-02-24 |
The Johns Hopkins University School Of Medicine |
Methods to identify growth differentiation factor (GDF) binding proteins
|
|
US6656475B1
(en)
|
1997-08-01 |
2003-12-02 |
The Johns Hopkins University School Of Medicine |
Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
|
|
AU8666398A
(en)
|
1997-08-01 |
1999-02-22 |
Johns Hopkins University School Of Medicine, The |
Methods to identify growth differentiation factor (gdf) receptors
|
|
US6891082B2
(en)
|
1997-08-01 |
2005-05-10 |
The Johns Hopkins University School Of Medicine |
Transgenic non-human animals expressing a truncated activintype II receptor
|
|
CA2305712A1
(en)
|
1997-10-03 |
1999-04-15 |
Chugai Seiyaku Kabushiki Kaisha |
Natural humanized antibody
|
|
EE05627B1
(et)
|
1998-12-23 |
2013-02-15 |
Pfizer Inc. |
CTLA-4 vastased inimese monoklonaalsed antikehad
|
|
US6914128B1
(en)
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
|
ATE482275T1
(de)
|
1999-07-02 |
2010-10-15 |
Morphosys Ag |
Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden
|
|
PA8535501A1
(es)
|
2001-01-05 |
2003-07-28 |
Pfizer |
Anticuerpos contra el receptor del factor de crecimiento similar a insulina
|
|
US7117096B2
(en)
|
2001-04-17 |
2006-10-03 |
Abmaxis, Inc. |
Structure-based selection and affinity maturation of antibody library
|
|
AU2003217912A1
(en)
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
|
US7538195B2
(en)
|
2002-06-14 |
2009-05-26 |
Immunogen Inc. |
Anti-IGF-I receptor antibody
|
|
GB0216648D0
(en)
|
2002-07-18 |
2002-08-28 |
Lonza Biologics Plc |
Method of expressing recombinant protein in CHO cells
|
|
HUE026914T2
(en)
|
2002-11-07 |
2016-08-29 |
Immunogen Inc |
Anti-CD33 antibodies and a method of treating acute myeloid leukemia
|
|
US9259459B2
(en)
|
2003-01-31 |
2016-02-16 |
Celldex Therapeutics Inc. |
Antibody vaccine conjugates and uses therefor
|
|
JP5110877B2
(ja)
|
2003-06-02 |
2012-12-26 |
ワイス・エルエルシー |
神経筋障害を処置するための、コルチコステロイドと組み合わせたミオスタチン（ｇｄｆ８）インヒビターの使用
|
|
WO2005116052A2
(en)
|
2004-04-27 |
2005-12-08 |
Research Development Foundation |
ANTAGONISM OF TGF-β SUPERFAMILY RECEPTOR SIGNALING
|
|
EP3489257A1
(en)
|
2004-07-23 |
2019-05-29 |
Acceleron Pharma Inc. |
Actrii receptor polypeptides, methods and compositions
|
|
GB0417487D0
(en)
|
2004-08-05 |
2004-09-08 |
Novartis Ag |
Organic compound
|
|
MX2007000976A
(es)
|
2004-08-12 |
2007-04-10 |
Wyeth Corp |
Tratamiento combinado para diabetes, obesidad y enfermedades cardiovasculares utilizando inhibidores del factor 8 de crecimiento y diferenciacion.
|
|
AU2005279347A1
(en)
|
2004-08-30 |
2006-03-09 |
Lonza Biologics Plc. |
Affinity- plus ion exchange- chromatography for purifying antibodies
|
|
US7700099B2
(en)
|
2005-02-14 |
2010-04-20 |
Merck & Co., Inc. |
Non-immunostimulatory antibody and compositions containing the same
|
|
CA2538208A1
(en)
|
2005-05-04 |
2006-11-04 |
Universite Laval |
Modulation of myostatin and use thereof in cell transplantation-based treatment of muscle disease
|
|
EP1929305A2
(en)
|
2005-08-31 |
2008-06-11 |
Cell Signaling Technology, Inc. |
Reagents for the detection of protein phosphorylation in leukemia signaling pathways
|
|
EP1968621A2
(en)
|
2005-12-06 |
2008-09-17 |
Amgen Inc. |
Uses of myostatin antagonists
|
|
ES2965283T3
(es)
|
2006-03-15 |
2024-05-28 |
Alexion Pharma Inc |
Tratamiento de pacientes con hemoglobinuria paroxística nocturna mediante un inhibidor del complemento
|
|
WO2007109668A2
(en)
|
2006-03-20 |
2007-09-27 |
The Uab Research Foundation |
Compositions and methods for improving bone mass through modulation of novel receptors of pth and fragments thereof
|
|
US20100120627A1
(en)
|
2006-08-02 |
2010-05-13 |
Abdelmajid Belouchi |
Genemap of the human genes associated with psoriasis
|
|
US7691980B2
(en)
|
2007-01-09 |
2010-04-06 |
Bio-Rad Laboratories, Inc. |
Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
|
|
CA2677007A1
(en)
|
2007-02-01 |
2008-08-07 |
Acceleron Pharma Inc. |
Activin-actriia antagonists and uses for treating or preventing breast cancer
|
|
TW201803890A
(zh)
|
2007-02-02 |
2018-02-01 |
艾瑟勒朗法瑪公司 |
衍生自ＡｃｔＲＩＩＢ的變體與其用途
|
|
EP2481415B1
(en)
*
|
2007-02-09 |
2019-09-11 |
Acceleron Pharma Inc. |
Pharmaceutical compositions comprising Activin-ActRIIA antagonists
|
|
US7947646B2
(en)
|
2007-03-06 |
2011-05-24 |
Amgen Inc. |
Variant activin receptor polypeptides
|
|
US20090155275A1
(en)
|
2007-07-31 |
2009-06-18 |
Medimmune, Llc |
Multispecific epitope binding proteins and uses thereof
|
|
EP3124497B1
(en)
|
2007-09-14 |
2020-04-15 |
Adimab, LLC |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
US8093364B2
(en)
|
2008-01-18 |
2012-01-10 |
Bio-Rad Laboratories, Inc. |
Enhanced purification of antibodies and antibody fragments by apatite chromatography
|
|
JP5470817B2
(ja)
|
2008-03-10 |
2014-04-16 |
日産自動車株式会社 |
電池用電極およびこれを用いた電池、並びにその製造方法
|
|
NZ627111A
(en)
|
2008-11-26 |
2015-10-30 |
Amgen Inc |
Variants of activin iib receptor polypeptides and uses thereof
|
|
US8110355B2
(en)
|
2009-02-20 |
2012-02-07 |
GenRemedy, LLC |
Methods for identifying agents that inhibit cell migration, promote cell adhesion and prevent metastasis
|
|
ITAN20090010U1
(it)
|
2009-04-27 |
2010-10-28 |
Arnaldo Sorci |
Staffa di bloccaggio protettiva
|
|
CA2993053A1
(en)
*
|
2009-04-27 |
2010-11-04 |
Novartis Ag |
Antagonistic activin receptor iib (actriib) antibodies for increasing muscle growth
|
|
JP6211767B2
(ja)
|
2009-09-09 |
2017-10-11 |
アクセルロン ファーマ， インコーポレイテッド |
ＡｃｔＲＩＩｂアンタゴニストならびにその投薬および使用
|
|
EP2496600A1
(en)
*
|
2009-11-04 |
2012-09-12 |
Fabrus LLC |
Methods for affinity maturation-based antibody optimization
|
|
KR102085919B1
(ko)
|
2009-11-05 |
2020-03-06 |
더 리전츠 오브 더 유니버시티 오브 캘리포니아 |
에칭된 미러들을 구비하는 반극성 ｛20-21｝ ⅲ-족 질화물 레이저 다이오드들
|
|
US8524217B2
(en)
|
2010-05-11 |
2013-09-03 |
Merck Sharp & Dohme Corp. |
MCP1-Ig fusion variants
|
|
KR102024922B1
(ko)
|
2010-07-16 |
2019-09-25 |
아디맵 엘엘씨 |
항체 라이브러리
|
|
WO2012012759A2
(en)
|
2010-07-22 |
2012-01-26 |
The Regents Of The University Of California |
Anti-tumor antigen antibodies and methods of use
|
|
KR20130132824A
(ko)
*
|
2010-11-08 |
2013-12-05 |
악셀레론 파마 인코포레이티드 |
Actriia 결합제 및 이의 용도
|
|
TW201249867A
(en)
|
2011-04-01 |
2012-12-16 |
Astellas Pharma Inc |
Novel anti-human il-23 receptor antibody
|
|
DK2726099T3
(en)
|
2011-07-01 |
2018-11-05 |
Novartis Ag |
Method of treating metabolic disorders
|
|
BR112014000392A2
(pt)
*
|
2011-07-14 |
2017-02-21 |
Pfizer |
tratamento com anticorpos anti-pcsk9
|
|
US8765385B2
(en)
*
|
2011-10-27 |
2014-07-01 |
Ravindra Kumar |
Method of detection of neutralizing anti-actriib antibodies
|
|
WO2013063536A1
(en)
*
|
2011-10-27 |
2013-05-02 |
Acceleron Pharma, Inc. |
Actriib binding agents and uses thereof
|
|
BR112014015003A2
(pt)
|
2011-12-19 |
2019-09-24 |
Amgen Inc |
composição farmacêutica, método para tratar um cancer e método para reduzir o tamanho de uma massa tumoral
|
|
US9029510B2
(en)
|
2012-03-30 |
2015-05-12 |
Sorrento Therapeutics, Inc. |
Fully human antibodies that bind to VEGFR2 and methods of use thereof
|
|
EA201492282A1
(ru)
|
2012-06-11 |
2015-07-30 |
Амген Инк. |
Антагонистические антигенсвязывающие белки к двум рецепторам и их применение
|
|
JP6136279B2
(ja)
|
2013-01-15 |
2017-05-31 |
株式会社ジェイテクト |
転がり軸受装置
|
|
JP6049767B2
(ja)
|
2013-02-01 |
2016-12-21 |
株式会社ブリリアントサービス |
栽培システム、栽培プログラム、および栽培方法
|
|
TWI503850B
(zh)
|
2013-03-22 |
2015-10-11 |
Polytronics Technology Corp |
過電流保護元件
|
|
WO2014172448A2
(en)
*
|
2013-04-17 |
2014-10-23 |
Anaptysbio, Inc. |
Antibodies directed against activin receptor type ii (actrii)
|
|
WO2014179363A1
(en)
|
2013-04-29 |
2014-11-06 |
Adimab, Llc |
Polyspecificity reagents, methods for their preparation and use
|
|
CA2918300A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Methods of treating sporadic inclusion body myositis
|
|
TWI510996B
(zh)
|
2013-10-03 |
2015-12-01 |
Acer Inc |
控制觸控面板的方法以及使用該方法的可攜式電腦
|
|
TW201622746A
(zh)
|
2014-04-24 |
2016-07-01 |
諾華公司 |
改善或加速髖部骨折術後身體復原之方法
|
|
CA2969800A1
(en)
|
2014-12-08 |
2016-06-16 |
Novartis Ag |
Myostatin or activin antagonists for the treatment of sarcopenia
|
|
CA3015277A1
(en)
|
2016-03-10 |
2017-09-14 |
Acceleron Pharma Inc. |
Activin type 2 receptor binding proteins and uses thereof
|
|
US9816280B1
(en)
|
2016-11-02 |
2017-11-14 |
Matthew Reitnauer |
Portable floor
|