KR102450873B1 - 마이크로유체 장치에서의 버블 제거 - Google Patents

마이크로유체 장치에서의 버블 제거 Download PDF

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KR102450873B1
KR102450873B1 KR1020217031073A KR20217031073A KR102450873B1 KR 102450873 B1 KR102450873 B1 KR 102450873B1 KR 1020217031073 A KR1020217031073 A KR 1020217031073A KR 20217031073 A KR20217031073 A KR 20217031073A KR 102450873 B1 KR102450873 B1 KR 102450873B1
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pressure
bubbles
fluid
bubble
microchannel
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KR20210124498A (ko
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다니엘 레브너
조시아 다니엘 슬리츠
크리스토퍼 데이비드 히노조사
조슈아 고메즈
경 진 장
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에뮬레이트, 인크.
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/20—Degassing; Venting; Bubble traps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
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  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
KR1020217031073A 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거 Active KR102450873B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227033971A KR102634221B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662361266P 2016-07-12 2016-07-12
US62/361,266 2016-07-12
PCT/US2017/041656 WO2018013646A1 (en) 2016-07-12 2017-07-12 Removing bubbles in a microfluidic device
KR1020197003605A KR102308594B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거

Related Parent Applications (1)

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KR1020197003605A Division KR102308594B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거

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Publication Number Publication Date
KR20210124498A KR20210124498A (ko) 2021-10-14
KR102450873B1 true KR102450873B1 (ko) 2022-10-06

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Application Number Title Priority Date Filing Date
KR1020197003605A Active KR102308594B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거
KR1020227033971A Active KR102634221B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거
KR1020247003890A Ceased KR20240023193A (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서 유체의 기체 보유 능력을 증가시키고 유체 내에 존재하는 임의의 버블을 제거하는 방법
KR1020217031073A Active KR102450873B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거

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KR1020197003605A Active KR102308594B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거
KR1020227033971A Active KR102634221B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거
KR1020247003890A Ceased KR20240023193A (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서 유체의 기체 보유 능력을 증가시키고 유체 내에 존재하는 임의의 버블을 제거하는 방법

Country Status (9)

Country Link
US (7) US11141727B2 (enExample)
EP (2) EP3484620B1 (enExample)
JP (4) JP7398955B2 (enExample)
KR (4) KR102308594B1 (enExample)
AU (1) AU2017296322A1 (enExample)
CA (2) CA3130928A1 (enExample)
GB (2) GB2569000B (enExample)
SG (1) SG11201900081QA (enExample)
WO (1) WO2018013646A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2544152A (en) * 2015-08-26 2017-05-10 Emulate Inc Perfusion manifold assembly
US11285478B2 (en) 2016-04-04 2022-03-29 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
US11141727B2 (en) * 2016-07-12 2021-10-12 EMULATE, Inc. Removing bubbles in a microfluidic device
USD860471S1 (en) * 2016-07-12 2019-09-17 EMULATE, Inc. Perfusion module lid
EP3541519B1 (en) 2016-11-17 2021-12-01 Combinati Incorporated Methods and systems for nucleic acid analysis and quantification
EP3749453A4 (en) * 2018-02-07 2021-12-15 The Trustees of the University of Pennsylvania HIGH RATE MICROFLUIDIC DEVICE
JP7341148B2 (ja) * 2018-02-16 2023-09-08 アストレゴ ダイアグノスティクス エービー 微小流体装置
US11878300B2 (en) 2018-09-04 2024-01-23 The Charles Stark Draper Laboratory, Inc. Method and device for high field strength electrotransfection of microvescicles and cells
CN113423503A (zh) 2018-12-10 2021-09-21 康比纳提公司 用于样品数字化的微流体阵列
FR3094012B1 (fr) * 2019-03-20 2022-08-12 Cherry Biotech Sas Procédé d'enrichissement en gaz et simultanément de déplacement d’un fluide et dispositif pour le contrôle de l'environnement cellulaire sur une plaque de culture cellulaire multipuits correspondant.
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