KR102420322B1 - 포스포이노시타이드 3-키나아제 억제제로서 인돌리진 유도체 - Google Patents

포스포이노시타이드 3-키나아제 억제제로서 인돌리진 유도체 Download PDF

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KR102420322B1
KR102420322B1 KR1020177000424A KR20177000424A KR102420322B1 KR 102420322 B1 KR102420322 B1 KR 102420322B1 KR 1020177000424 A KR1020177000424 A KR 1020177000424A KR 20177000424 A KR20177000424 A KR 20177000424A KR 102420322 B1 KR102420322 B1 KR 102420322B1
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amino
ethyl
pyrazolo
pyrimidin
indolizin
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KR20170015487A (ko
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마테오 비아제티
알레산드로 아체타
안나 마리아 카펠리
마틸데 구알라
미켈레 레티니
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키에시 파르마슈티시 엣스. 피. 에이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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KR1020177000424A 2014-06-17 2015-06-16 포스포이노시타이드 3-키나아제 억제제로서 인돌리진 유도체 Expired - Fee Related KR102420322B1 (ko)

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Application Number Priority Date Filing Date Title
EP14172764 2014-06-17
EP14172764.4 2014-06-17
PCT/EP2015/063390 WO2015193263A1 (en) 2014-06-17 2015-06-16 Indolizine derivatives as phoshoinositide 3-kinases inhibitors

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KR20170015487A KR20170015487A (ko) 2017-02-08
KR102420322B1 true KR102420322B1 (ko) 2022-07-13

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US (1) US9527869B2 (enExample)
EP (1) EP3157920B1 (enExample)
JP (1) JP6730200B2 (enExample)
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CN (1) CN106661019B (enExample)
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AU (1) AU2015276264B2 (enExample)
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Cited By (1)

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Publication number Priority date Publication date Assignee Title
KR20240110273A (ko) 2023-01-06 2024-07-15 연세대학교 산학협력단 새로운 인돌리진-피롤로피리미딘 하이브리드 유도체 제조방법 및 이를 포함하는 항암제 조성물

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JP6426694B2 (ja) 2013-03-15 2018-11-21 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
KR101815193B1 (ko) * 2015-12-29 2018-01-30 (주)스파크바이오파마 PPARγ 인산화 저해제 및 이를 포함하는 약학적 조성물
CN109071524A (zh) * 2016-01-15 2018-12-21 布里格姆及妇女医院股份有限公司 作为eaat2活化剂的哒嗪衍生物
WO2017134053A1 (en) 2016-02-04 2017-08-10 Chiesi Farmaceutici S.P.A. Pyrazole derivatives as phosphoinositide 3-kinases inhibitors
KR20190129851A (ko) 2017-03-16 2019-11-20 지앙수 헨그루이 메디슨 컴퍼니 리미티드 헤테로아릴[4,3-c]피리미딘-5-아민 유도체, 이의 제조 방법 및 이의 의학적 용도
CN108129480A (zh) * 2018-03-11 2018-06-08 赵艳阳 一种含芳杂环亚甲基吲嗪衍生物的制备方法
ES3041367T3 (en) * 2018-06-04 2025-11-11 Ohio State Innovation Foundation Eaat2 activators and methods of using thereof
EP3947384B1 (en) * 2019-04-04 2023-11-01 Chiesi Farmaceutici S.p.A. Isochromene derivatives as phosphoinositide 3-kinases inhibitors
CN110156785B (zh) * 2019-04-15 2020-08-28 浙江大学 吲唑类化合物及其制备方法和应用
WO2021003398A1 (en) * 2019-07-03 2021-01-07 Sanford Burnham Prebys Medical Discovery Institute Inhibitors of low molecular weight protein tyrosine phosphatase (lmptp) and uses thereof
CA3154079A1 (en) 2019-09-19 2021-03-25 Totus Medicines Inc. Therapeutic conjugates
US20250002491A1 (en) 2021-10-04 2025-01-02 Forx Therapeutics Ag N,n-dimethyl-4-(7-(n-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives as parg inhibitors for the treatment of cancer
WO2024186827A2 (en) * 2023-03-06 2024-09-12 The Regents Of The University Of California Novel host-directed therapeutic agent for the treatment of infectious diseases
WO2026110074A1 (en) * 2024-11-20 2026-05-28 Recursion Pharmaceuticals, Inc. Heterocyclic risk inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005121147A1 (en) 2004-06-03 2005-12-22 Bayer Pharmaceuticals Corporation Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
JP5552121B2 (ja) * 2008-09-04 2014-07-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のインドリジン阻害剤
AR077428A1 (es) * 2009-07-29 2011-08-24 Sanofi Aventis (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos
JP5951600B2 (ja) 2010-05-21 2016-07-13 インフィニティー ファーマシューティカルズ， インコーポレイテッド キナーゼ調節のための、化合物、組成物および方法
MX342326B (es) * 2011-09-27 2016-09-26 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005121147A1 (en) 2004-06-03 2005-12-22 Bayer Pharmaceuticals Corporation Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240110273A (ko) 2023-01-06 2024-07-15 연세대학교 산학협력단 새로운 인돌리진-피롤로피리미딘 하이브리드 유도체 제조방법 및 이를 포함하는 항암제 조성물

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