GEAP201814349A - Indolizine derivatives as phoshoinositide 3-kinases inhibitors - Google Patents

Indolizine derivatives as phoshoinositide 3-kinases inhibitors

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Publication number
GEAP201814349A
GEAP201814349A GEAP201814349A GEAP2018014349A GEAP201814349A GE AP201814349 A GEAP201814349 A GE AP201814349A GE AP201814349 A GEAP201814349 A GE AP201814349A GE AP2018014349 A GEAP2018014349 A GE AP2018014349A GE AP201814349 A GEAP201814349 A GE AP201814349A
Authority
GE
Georgia
Prior art keywords
phoshoinositide
indolizine derivatives
kinases inhibitors
kinases
inhibitors
Prior art date
Application number
GEAP201814349A
Other languages
English (en)
Inventor
Michele Retini
Matilde Guala
Anna Maria Capelli
Alessandro Accetta
Matteo Biagetti
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of GEAP201814349A publication Critical patent/GEAP201814349A/en

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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GEAP201814349A 2014-06-17 2015-06-16 Indolizine derivatives as phoshoinositide 3-kinases inhibitors GEAP201814349A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14172764 2014-06-17

Publications (1)

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GEAP201814349A true GEAP201814349A (en) 2018-08-27

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GEAP201814349A GEAP201814349A (en) 2014-06-17 2015-06-16 Indolizine derivatives as phoshoinositide 3-kinases inhibitors
GEAP201514349A GEP20186938B (en) 2014-06-17 2015-06-16 Indolizine derivatives as phoshoinositide 3-kinases inhibitors

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GEAP201514349A GEP20186938B (en) 2014-06-17 2015-06-16 Indolizine derivatives as phoshoinositide 3-kinases inhibitors

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US (1) US9527869B2 (enExample)
EP (1) EP3157920B1 (enExample)
JP (1) JP6730200B2 (enExample)
KR (1) KR102420322B1 (enExample)
CN (1) CN106661019B (enExample)
AR (1) AR100879A1 (enExample)
AU (1) AU2015276264B2 (enExample)
BR (1) BR112016028845B1 (enExample)
CA (1) CA2952287C (enExample)
CL (1) CL2016003214A1 (enExample)
EA (1) EA031409B1 (enExample)
ES (1) ES2750791T3 (enExample)
GE (2) GEAP201814349A (enExample)
IL (1) IL249554A0 (enExample)
MX (1) MX373129B (enExample)
PE (1) PE20170303A1 (enExample)
PH (1) PH12016502291A1 (enExample)
PL (1) PL3157920T3 (enExample)
SG (1) SG11201610473QA (enExample)
TN (1) TN2016000555A1 (enExample)
TW (1) TW201625611A (enExample)
WO (1) WO2015193263A1 (enExample)
ZA (1) ZA201608637B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6426694B2 (ja) 2013-03-15 2018-11-21 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
KR101815193B1 (ko) * 2015-12-29 2018-01-30 (주)스파크바이오파마 PPARγ 인산화 저해제 및 이를 포함하는 약학적 조성물
CN109071524A (zh) * 2016-01-15 2018-12-21 布里格姆及妇女医院股份有限公司 作为eaat2活化剂的哒嗪衍生物
WO2017134053A1 (en) 2016-02-04 2017-08-10 Chiesi Farmaceutici S.P.A. Pyrazole derivatives as phosphoinositide 3-kinases inhibitors
KR20190129851A (ko) 2017-03-16 2019-11-20 지앙수 헨그루이 메디슨 컴퍼니 리미티드 헤테로아릴[4,3-c]피리미딘-5-아민 유도체, 이의 제조 방법 및 이의 의학적 용도
CN108129480A (zh) * 2018-03-11 2018-06-08 赵艳阳 一种含芳杂环亚甲基吲嗪衍生物的制备方法
ES3041367T3 (en) * 2018-06-04 2025-11-11 Ohio State Innovation Foundation Eaat2 activators and methods of using thereof
EP3947384B1 (en) * 2019-04-04 2023-11-01 Chiesi Farmaceutici S.p.A. Isochromene derivatives as phosphoinositide 3-kinases inhibitors
CN110156785B (zh) * 2019-04-15 2020-08-28 浙江大学 吲唑类化合物及其制备方法和应用
WO2021003398A1 (en) * 2019-07-03 2021-01-07 Sanford Burnham Prebys Medical Discovery Institute Inhibitors of low molecular weight protein tyrosine phosphatase (lmptp) and uses thereof
CA3154079A1 (en) 2019-09-19 2021-03-25 Totus Medicines Inc. Therapeutic conjugates
US20250002491A1 (en) 2021-10-04 2025-01-02 Forx Therapeutics Ag N,n-dimethyl-4-(7-(n-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives as parg inhibitors for the treatment of cancer
KR102866487B1 (ko) 2023-01-06 2025-10-01 연세대학교 산학협력단 새로운 인돌리진-피롤로피리미딘 하이브리드 유도체 제조방법 및 이를 포함하는 항암제 조성물
WO2024186827A2 (en) * 2023-03-06 2024-09-12 The Regents Of The University Of California Novel host-directed therapeutic agent for the treatment of infectious diseases
WO2026110074A1 (en) * 2024-11-20 2026-05-28 Recursion Pharmaceuticals, Inc. Heterocyclic risk inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY28931A1 (es) * 2004-06-03 2005-12-30 Bayer Pharmaceuticals Corp Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
JP5552121B2 (ja) * 2008-09-04 2014-07-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のインドリジン阻害剤
AR077428A1 (es) * 2009-07-29 2011-08-24 Sanofi Aventis (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos
WO2011075643A1 (en) * 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
JP5951600B2 (ja) 2010-05-21 2016-07-13 インフィニティー ファーマシューティカルズ， インコーポレイテッド キナーゼ調節のための、化合物、組成物および方法
MX342326B (es) * 2011-09-27 2016-09-26 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante.

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