PE20170303A1 - Derivados de la indolizina como inhibidores de las fosfoinositido-3 quinasas - Google Patents

Derivados de la indolizina como inhibidores de las fosfoinositido-3 quinasas

Info

Publication number
PE20170303A1
PE20170303A1 PE2016002720A PE2016002720A PE20170303A1 PE 20170303 A1 PE20170303 A1 PE 20170303A1 PE 2016002720 A PE2016002720 A PE 2016002720A PE 2016002720 A PE2016002720 A PE 2016002720A PE 20170303 A1 PE20170303 A1 PE 20170303A1
Authority
PE
Peru
Prior art keywords
indolizine
kinases
phosphoinositide
inhibitors
derivatives
Prior art date
Application number
PE2016002720A
Other languages
English (en)
Spanish (es)
Inventor
Alessandro Accetta
Matteo Biagetti
Michele Retini
Matilde Guala
Anna Maria Capelli
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of PE20170303A1 publication Critical patent/PE20170303A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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  • Virology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
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  • Endocrinology (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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PE2016002720A 2014-06-17 2015-06-16 Derivados de la indolizina como inhibidores de las fosfoinositido-3 quinasas PE20170303A1 (es)

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Application Number Priority Date Filing Date Title
EP14172764 2014-06-17

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PE20170303A1 true PE20170303A1 (es) 2017-04-19

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US (1) US9527869B2 (enExample)
EP (1) EP3157920B1 (enExample)
JP (1) JP6730200B2 (enExample)
KR (1) KR102420322B1 (enExample)
CN (1) CN106661019B (enExample)
AR (1) AR100879A1 (enExample)
AU (1) AU2015276264B2 (enExample)
BR (1) BR112016028845B1 (enExample)
CA (1) CA2952287C (enExample)
CL (1) CL2016003214A1 (enExample)
EA (1) EA031409B1 (enExample)
ES (1) ES2750791T3 (enExample)
GE (1) GEP20186938B (enExample)
IL (1) IL249554A0 (enExample)
MX (1) MX373129B (enExample)
PE (1) PE20170303A1 (enExample)
PH (1) PH12016502291A1 (enExample)
PL (1) PL3157920T3 (enExample)
SG (1) SG11201610473QA (enExample)
TN (1) TN2016000555A1 (enExample)
TW (1) TW201625611A (enExample)
WO (1) WO2015193263A1 (enExample)
ZA (1) ZA201608637B (enExample)

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EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
KR101815193B1 (ko) * 2015-12-29 2018-01-30 (주)스파크바이오파마 PPARγ 인산화 저해제 및 이를 포함하는 약학적 조성물
US10787433B2 (en) 2016-01-15 2020-09-29 The Brigham And Women's Hospital, Inc. Pyridazine derivatives as EAAT2 activators
EP3411375B1 (en) 2016-02-04 2020-08-05 Chiesi Farmaceutici S.p.A. Pyrazole derivatives as phosphoinositide 3-kinases inhibitors
CN109963854B (zh) 2017-03-16 2022-04-12 江苏恒瑞医药股份有限公司 杂芳基并[4,3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用
CN108129480A (zh) * 2018-03-11 2018-06-08 赵艳阳 一种含芳杂环亚甲基吲嗪衍生物的制备方法
CA3102762A1 (en) 2018-06-04 2019-12-12 Ohio State Innovation Foundation Eaat2 activators and methods of using thereof
WO2020200918A1 (en) * 2019-04-04 2020-10-08 Chiesi Farmaceutici S.P.A. Isochromene derivatives as phosphoinositide 3-kinases inhibitors
CN110156785B (zh) * 2019-04-15 2020-08-28 浙江大学 吲唑类化合物及其制备方法和应用
AU2020299632A1 (en) * 2019-07-03 2022-02-17 Sanford Burnham Prebys Medical Discovery Institute Inhibitors of low molecular weight protein tyrosine phosphatase (LMPTP) and uses thereof
CA3154079A1 (en) 2019-09-19 2021-03-25 Totus Medicines Inc. Therapeutic conjugates
US20250002491A1 (en) 2021-10-04 2025-01-02 Forx Therapeutics Ag N,n-dimethyl-4-(7-(n-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives as parg inhibitors for the treatment of cancer
KR102866487B1 (ko) 2023-01-06 2025-10-01 연세대학교 산학협력단 새로운 인돌리진-피롤로피리미딘 하이브리드 유도체 제조방법 및 이를 포함하는 항암제 조성물
WO2024186827A2 (en) * 2023-03-06 2024-09-12 The Regents Of The University Of California Novel host-directed therapeutic agent for the treatment of infectious diseases

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