KR102417601B1 - Tgf-r 신호의 억제제로서의 안티센스-올리고뉴클레오티드 - Google Patents

Tgf-r 신호의 억제제로서의 안티센스-올리고뉴클레오티드 Download PDF

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KR102417601B1
KR102417601B1 KR1020217028947A KR20217028947A KR102417601B1 KR 102417601 B1 KR102417601 B1 KR 102417601B1 KR 1020217028947 A KR1020217028947 A KR 1020217028947A KR 20217028947 A KR20217028947 A KR 20217028947A KR 102417601 B1 KR102417601 B1 KR 102417601B1
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lna
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마커스 호스바흐
모니카 크람퍼트
한스-로타 아르트
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뉴로비전 파마 게엠베하
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KR1020217028947A 2014-11-16 2015-11-16 Tgf-r 신호의 억제제로서의 안티센스-올리고뉴클레오티드 Active KR102417601B1 (ko)

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Application Number Priority Date Filing Date Title
EP14193368.9 2014-11-16
EP14193368.9A EP3020813A1 (en) 2014-11-16 2014-11-16 Antisense-oligonucleotides as inhibitors of TGF-R signaling
KR1020177016366A KR102310899B1 (ko) 2014-11-16 2015-11-16 Tgf-r 신호의 억제제로서의 안티센스-올리고뉴클레오티드
PCT/EP2015/076730 WO2016075339A1 (en) 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling

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KR20210113697A KR20210113697A (ko) 2021-09-16
KR102417601B1 true KR102417601B1 (ko) 2022-07-05

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KR1020217028947A Active KR102417601B1 (ko) 2014-11-16 2015-11-16 Tgf-r 신호의 억제제로서의 안티센스-올리고뉴클레오티드

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US (4) US11213541B2 (enExample)
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EP3020813A1 (en) * 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling
WO2019010226A1 (en) * 2017-07-03 2019-01-10 The Regents Of The University Of California CHEMICALLY MODIFIED MICROARN-214 ANTISENS AND USE THEREOF FOR THE TREATMENT OF HEMORRHAGIC RECTOCOLITE AND PROCTITE
SG11202003862PA (en) * 2017-11-01 2020-05-28 Editas Medicine Inc Methods, compositions and components for crispr-cas9 editing of tgfbr2 in t cells for immunotherapy
CA3085406A1 (en) * 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorodithioate internucleoside linkage
MX2020005754A (es) * 2017-12-22 2020-08-20 Roche Innovation Ct Copenhagen As Oligonucleotidos gapmeros que comprenden un enlace internucleosido fosforoditioato.
EP4092118A1 (en) * 2017-12-22 2022-11-23 Roche Innovation Center Copenhagen A/S Novel thiophosphoramidites
IL316397A (en) 2018-05-22 2024-12-01 Ionis Pharmaceuticals Inc Modulators of APOL1 expression
WO2020025527A1 (en) * 2018-07-31 2020-02-06 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
EP4122943B1 (en) * 2018-07-31 2024-05-29 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
BR112021016460A2 (pt) * 2019-02-20 2021-10-13 Roche Innovation Center Copenhagen A/S Oligonucleotídeo gapmer antissenso de fita simples, sal farmaceuticamente aceitável de um oligonucleotídeo, conjugado, composição farmacêutica e invenção
US20250368999A1 (en) * 2020-10-29 2025-12-04 Board Of Regents, The University Of Texas System Soluble interleukin-7 receptor (sil7r) modulating therapy to treat cancer
CN114588160A (zh) * 2020-12-07 2022-06-07 四川大学华西医院 具有抗肺纤维化作用的次黄碱衍生物
CN113992687B (zh) * 2021-12-28 2022-04-08 浙江宇视科技有限公司 智能业务集群调度方法、装置、电子设备及存储介质
WO2024186656A1 (en) 2023-03-03 2024-09-12 Arsenal Biosciences, Inc. Systems targeting psma and ca9
WO2025254160A1 (ja) * 2024-06-05 2025-12-11 湧永製薬株式会社 ＴＧＦ－βシグナル阻害剤又は抗線維化剤のスクリーニング方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100501863B1 (ko) 1996-02-19 2005-09-27 아머샴 헬스 에이에스 열안정화된조영제
US20030064944A1 (en) 2001-06-21 2003-04-03 Isis Pharmaceuticals Inc. Antisense modulation of transforming growth factor beta receptor II expression
CA2506576C (en) 2002-11-18 2018-03-06 Santaris Pharma A/S Antisense gapmer oligonucleotides
SG145713A1 (en) * 2003-08-13 2008-09-29 Univ Illinois SILENCING OF TGFss TYPE II RECEPTOR EXPRESSION BY SIRNA
CA2555463C (en) 2004-02-09 2013-05-14 Regenion Gmbh Inhibitors of tgf-r signaling for treatment of cns disorders
WO2007031091A2 (en) 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
JP5342881B2 (ja) 2006-01-27 2013-11-13 アイシス ファーマシューティカルズ， インコーポレーテッド ６−修飾された二環式核酸類似体
CA3024953A1 (en) 2006-04-03 2007-10-11 Roche Innovation Center Copenhagen A/S Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
US7547684B2 (en) 2006-05-11 2009-06-16 Isis Pharmaceuticals, Inc. 5′-modified bicyclic nucleic acid analogs
EP2090127A2 (en) 2006-10-30 2009-08-19 Nokia Corporation Method, apparatus and system providing operator controlled mobility for user equipment
WO2008109546A2 (en) 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting tgfbr gene expression and uses thereof
EP2170917B1 (en) 2007-05-30 2012-06-27 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
EP2173760B2 (en) 2007-06-08 2015-11-04 Isis Pharmaceuticals, Inc. Carbocyclic bicyclic nucleic acid analogs
CA2692579C (en) 2007-07-05 2016-05-03 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs
WO2009067647A1 (en) 2007-11-21 2009-05-28 Isis Pharmaceuticals, Inc. Carbocyclic alpha-l-bicyclic nucleic acid analogs
EP2313505A2 (en) * 2008-07-15 2011-04-27 F. Hoffmann-La Roche AG Compositions and methods for inhibiting expression of tgf-beta receptor genes
US8598334B2 (en) * 2009-10-16 2013-12-03 Glaxo Group Limited HBV antisense inhibitors
CN103068983A (zh) * 2010-06-11 2013-04-24 安提森斯制药有限公司 用于选择性寡核苷酸修饰的方法
US9115371B2 (en) * 2011-08-18 2015-08-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Reduction of TGF beta signaling in myeloid cells in the treatment of cancer
CN104004762B (zh) * 2014-05-20 2016-03-30 南京医科大学附属南京儿童医院 Tgf-r反义序列及其在制备抗气道炎症反应药物中的应用
EP3020813A1 (en) * 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling

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