KR102366202B1 - 히알루론산 또는 이의 염의 광경화성 에스테르 유도체를 포함하는 나노섬유, 광경화된 나노섬유, 이의 제조 방법, 광경화된 나노섬유를 포함하는 조제물 및 이의 용도 - Google Patents

히알루론산 또는 이의 염의 광경화성 에스테르 유도체를 포함하는 나노섬유, 광경화된 나노섬유, 이의 제조 방법, 광경화된 나노섬유를 포함하는 조제물 및 이의 용도 Download PDF

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KR102366202B1
KR102366202B1 KR1020167016462A KR20167016462A KR102366202B1 KR 102366202 B1 KR102366202 B1 KR 102366202B1 KR 1020167016462 A KR1020167016462 A KR 1020167016462A KR 20167016462 A KR20167016462 A KR 20167016462A KR 102366202 B1 KR102366202 B1 KR 102366202B1
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salt
hyaluronic acid
nanofibers
reaction
ppm
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KR20160089431A (ko
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글로리아 후에르타-앤젤레스
마틴 보벡
에바 프리코포바
야나 루지츠코바
마르티나 모라브코바
마르티나 브란데이소바
블라디미르 벨레브니
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콘티프로 에이.에스.
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Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
JP2017071873A (ja) * 2015-10-07 2017-04-13 キヤノン株式会社 ポリマーナノファイバ集積体及びその製造方法
CZ307158B6 (cs) * 2016-12-23 2018-02-07 Contipro A.S. Oftalmologický prostředek
KR101884873B1 (ko) 2017-10-12 2018-08-02 충남대학교산학협력단 반응기를 가지는 섬유 및 이의 제조방법
KR102203403B1 (ko) * 2019-04-10 2021-01-15 주식회사 아이코어바이오 신규한 구조를 가지는 고분자, 이의 제조 방법, 고분자로부터 합성된 나노섬유 및 이의 제조 방법
WO2022063312A1 (zh) * 2020-09-28 2022-03-31 吾奇生物医疗科技(江苏)有限公司 透明质酸水凝胶和透明质酸膜及其制备方法和应用
CZ202132A3 (cs) * 2021-01-26 2022-04-20 Contipro A.S. Prostředek pro hojení ran, způsob jeho výroby a použití
KR102850229B1 (ko) * 2022-08-31 2025-08-22 강원대학교산학협력단 히알루론산이 결합된 나노피브릴의 제조 방법 및 이에 따라 제조된 나노피브릴
CN115558040B (zh) * 2022-09-30 2024-01-23 华熙生物科技股份有限公司 一种无防腐剂添加的透明质酸或其盐的生产方法
CN116874640B (zh) * 2023-07-24 2025-08-08 江南大学 一种长驻留的用于头发修护的透明质酸钠衍生物及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100293043B1 (ko) * 1992-02-05 2001-10-22 야마야 와따루 광경화성글리코사미노글리칸유도체,가교결합된글리코사미노글리칸및이의제조방법
EP1369441A1 (en) 2001-01-31 2003-12-10 Seikagaku Corporation Crosslinked polysaccharide sponge
JP2012241192A (ja) 2011-05-13 2012-12-10 Rottapharm Spa ヒアルロン酸エステル、それらの製造および皮膚科学における使用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US216453A (en) * 1879-06-10 Improvement in thill-supports for vehicles
GB1527592A (en) 1974-08-05 1978-10-04 Ici Ltd Wound dressing
US5522879A (en) 1991-11-12 1996-06-04 Ethicon, Inc. Piezoelectric biomedical device
EP1249247B1 (en) 2001-03-30 2007-02-28 Chisso Corporation Pharmaceutical preparation for the treatment of gynecological diseases
ITPD20020064A1 (it) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
US7235295B2 (en) * 2003-09-10 2007-06-26 Laurencin Cato T Polymeric nanofibers for tissue engineering and drug delivery
WO2005026214A1 (ja) * 2003-09-12 2005-03-24 Seikagaku Corporation 多糖擬スポンジ
ITMI20040605A1 (it) 2004-03-29 2004-06-29 Coimex S C R L United Companie Esteri butirrici dell'acido ialuronico a basso grado di sostituzione procedimento per la loro preparazione ed uso
US7830833B2 (en) * 2004-05-04 2010-11-09 Qualcomm Incorporated Method and apparatus for ranking of media services and program packages
EP1942117A1 (en) 2006-12-29 2008-07-09 Sigea S.R.L. Derivatives of acid polysaccharides
CA2691541A1 (en) 2007-06-22 2008-12-31 Innovative Surface Technologies, Inc. Nanofibers containing latent reactive groups
JP2010014784A (ja) 2008-07-01 2010-01-21 Fuji Xerox Co Ltd 光書込型表示装置、書込装置、及び光書き込み方法
CZ301899B6 (cs) * 2009-03-17 2010-07-21 Contipro C, A.S. Zpusob prípravy derivátu kyseliny hyaluronové pomocí O-acyl-O´-alkylkarbonátu v prítomnosti substituovaného pyridinu
US20110111012A1 (en) 2009-11-12 2011-05-12 Hemcon Medical Technologies, Inc. Nanomaterial wound dressing assembly
CZ302994B6 (cs) * 2010-12-31 2012-02-08 Cpn S.R.O. Hyaluronová vlákna, zpusob jejich prípravy a použití
JP2013049927A (ja) * 2011-08-30 2013-03-14 Shinshu Univ 生体適合性を有するナノ繊維及びその製造方法並びに創傷被覆材
CZ2012282A3 (cs) * 2012-04-25 2013-11-06 Contipro Biotech S.R.O. Zesítovaný derivát hyaluronanu, zpusob jeho prípravy, hydrogel a mikrovlákna na jeho bázi
CZ2012844A3 (cs) * 2012-11-27 2014-02-05 Contipro Biotech S.R.O. Fotoreaktivní derivát kyseliny hyaluronové, způsob jeho přípravy, 3D síťovaný derivát kyseliny hyaluronové, způsob jeho přípravy a použití

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100293043B1 (ko) * 1992-02-05 2001-10-22 야마야 와따루 광경화성글리코사미노글리칸유도체,가교결합된글리코사미노글리칸및이의제조방법
EP1369441A1 (en) 2001-01-31 2003-12-10 Seikagaku Corporation Crosslinked polysaccharide sponge
JP2012241192A (ja) 2011-05-13 2012-12-10 Rottapharm Spa ヒアルロン酸エステル、それらの製造および皮膚科学における使用

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