KR102314293B1 - Grpr-양성 암의 검출, 진단과 치료를 위한 grpr-길항제 - Google Patents

Grpr-양성 암의 검출, 진단과 치료를 위한 grpr-길항제 Download PDF

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KR102314293B1
KR102314293B1 KR1020207034970A KR20207034970A KR102314293B1 KR 102314293 B1 KR102314293 B1 KR 102314293B1 KR 1020207034970 A KR1020207034970 A KR 1020207034970A KR 20207034970 A KR20207034970 A KR 20207034970A KR 102314293 B1 KR102314293 B1 KR 102314293B1
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grpr
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cancer
antagonist
peptide
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KR20200139846A (ko
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테오도시아 마이나-노크
베르톨드 아써 노크
마리온 데 종 헨드릭스
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어드밴스드 액셀러레이터 애플리케이션즈 유에스에이, 인코퍼레이티드.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
KR1020207034970A 2012-09-25 2013-09-25 Grpr-양성 암의 검출, 진단과 치료를 위한 grpr-길항제 Active KR102314293B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261705513P 2012-09-25 2012-09-25
US61/705,513 2012-09-25
KR1020157007572A KR102190005B1 (ko) 2012-09-25 2013-09-25 Grpr-양성 암의 검출, 진단과 치료를 위한 grpr-길항제
PCT/US2013/061712 WO2014052471A1 (en) 2012-09-25 2013-09-25 Grpr-antagonists for detection, diagnosis and treatment of grpr-positive cancer

Related Parent Applications (1)

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KR1020157007572A Division KR102190005B1 (ko) 2012-09-25 2013-09-25 Grpr-양성 암의 검출, 진단과 치료를 위한 grpr-길항제

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KR20200139846A KR20200139846A (ko) 2020-12-14
KR102314293B1 true KR102314293B1 (ko) 2021-10-19

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KR1020157007572A Active KR102190005B1 (ko) 2012-09-25 2013-09-25 Grpr-양성 암의 검출, 진단과 치료를 위한 grpr-길항제

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US (7) US9839703B2 (enExample)
EP (2) EP2900279B1 (enExample)
JP (4) JP6562838B2 (enExample)
KR (2) KR102314293B1 (enExample)
AU (4) AU2013323596C1 (enExample)
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CA (2) CA3114832A1 (enExample)
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RU (1) RU2693465C9 (enExample)
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Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
US10449260B2 (en) * 2011-07-08 2019-10-22 Theodosia Maina-Nock Enhanced in vivo targeting of radiolabelled peptides with the means of enzyme inhibitors
KR102314293B1 (ko) * 2012-09-25 2021-10-19 어드밴스드 액셀러레이터 애플리케이션즈 유에스에이, 인코퍼레이티드. Grpr-양성 암의 검출, 진단과 치료를 위한 grpr-길항제
EP3015462A1 (en) * 2014-10-29 2016-05-04 OctreoPharm Schiences GmbH Enantiopure chelating agents for chelator coupled pharmaceuticals, corresponding preparation method thereof and chelator coupled pharmaceuticals
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
US11857352B2 (en) 2016-09-06 2024-01-02 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
WO2018096082A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
WO2018132751A1 (en) 2017-01-12 2018-07-19 Radiomedix Inc. Treatment of cancer cells overexpressing somatostatin receptors using ocreotide derivatives chelated to radioisotopes
WO2020074691A1 (en) * 2018-10-12 2020-04-16 Advanced Accelerator Applications International Sa Pharmaceutical composition comprising a radiolabeled gprp antagonist and a surfactant
CN120081907A (zh) * 2018-11-13 2025-06-03 省卫生服务机构 用于胃泌素释放肽受体（grpr）的体内成像和治疗grpr相关病症的放射性标记蛙皮素衍生化合物
PE20211471A1 (es) 2018-11-23 2021-08-05 Bayer Ag Formulacion de medios de contraste y proceso para prepararlos
EP4031193A1 (en) * 2019-09-16 2022-07-27 Novartis AG Stable, concentrated radiopharmaceutical composition
TWI878344B (zh) * 2019-09-17 2025-04-01 瑞士商諾華公司 放射性標記grpr拮抗劑之方法及其套組
US20230321287A1 (en) * 2019-09-24 2023-10-12 Novartis Ag Radiolabelled grpr-antagonist for use as theragnostic
BR112022010906A2 (pt) * 2019-12-19 2022-09-06 Univ Muenchen Tech Composto que se liga a um receptor endógeno, composição farmacêutica e de diagnóstico
JP2025510161A (ja) 2022-03-25 2025-04-14 プロビンシャル・ヘルス・サービシーズ・オーソリティ ガストリン放出ペプチド受容体（ｇｒｐｒ）のインビボイメージング及びｇｒｐｒ関連障害の治療のための放射性標識化合物

Citations (2)

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US5019647A (en) 1988-05-24 1991-05-28 Merck & Co., Inc. Gastrin releasing peptide antagonist
JP2006528644A (ja) 2003-07-24 2006-12-21 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 安定な放射性医薬品組成物およびその製法

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US4943561A (en) 1988-11-28 1990-07-24 Merck & Co., Inc. Gastrin releasing peptide antagonist
US5028692A (en) 1989-04-25 1991-07-02 Merck & Co., Inc. Gastrin releasing peptide antagonist
WO1991006563A1 (en) 1989-11-06 1991-05-16 Farmitalia Carlo Erba S.R.L. Reduced irreversible bombesin antagonists
JPH07505865A (ja) 1992-02-07 1995-06-29 メレルダウファーマスーティカルズ　インコーポレイテッド ボンベシンのフェニルアラニン類似体類
US5620955A (en) 1993-06-18 1997-04-15 Peptide Technologies Corporation Bombesin receptor antagonists and uses thereof
EP1033372A4 (en) 1997-11-18 2000-10-04 Chugai Pharmaceutical Co Ltd COMPOSITIONS WITH ANTI-TUMOR ACTIVITY
EP2100900A1 (en) 2008-03-07 2009-09-16 Universitätsspital Basel Bombesin analog peptide antagonist conjugates
EA026443B1 (ru) 2010-11-22 2017-04-28 Пирамаль Имэджинг Са Меченныелютецием аналоги бомбезина для лучевой терапии
US10449260B2 (en) * 2011-07-08 2019-10-22 Theodosia Maina-Nock Enhanced in vivo targeting of radiolabelled peptides with the means of enzyme inhibitors
KR102314293B1 (ko) * 2012-09-25 2021-10-19 어드밴스드 액셀러레이터 애플리케이션즈 유에스에이, 인코퍼레이티드. Grpr-양성 암의 검출, 진단과 치료를 위한 grpr-길항제

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US5019647A (en) 1988-05-24 1991-05-28 Merck & Co., Inc. Gastrin releasing peptide antagonist
JP2006528644A (ja) 2003-07-24 2006-12-21 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 安定な放射性医薬品組成物およびその製法

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David C. Heimbrook 외. Gastrin Releasing Peptide Antagonists with Improved Potency and Stability. J. Med. Chem. 1991, Vol. 34, pp. 2102-2107*
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AU2019216714A1 (en) 2019-09-05
JP2015533119A (ja) 2015-11-19
IL276300B1 (en) 2024-06-01
SI2900279T1 (sl) 2019-12-31
RU2019119378A (ru) 2020-10-23
AU2013323596C1 (en) 2020-10-15
JP2021191800A (ja) 2021-12-16
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US20220008568A1 (en) 2022-01-13
KR20200139846A (ko) 2020-12-14
IL312551A (en) 2024-07-01
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US20180133349A1 (en) 2018-05-17
US20240366812A1 (en) 2024-11-07
PL2900279T3 (pl) 2020-05-18
KR20150090886A (ko) 2015-08-06
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US12064491B2 (en) 2024-08-20
IL312551B1 (en) 2025-08-01
RU2015115529A (ru) 2016-11-20
BR112015006453B1 (pt) 2023-10-17
US11083805B2 (en) 2021-08-10
JP7534498B2 (ja) 2024-08-14
MX2015003772A (es) 2015-11-09
PT2900279T (pt) 2019-10-14
IL256649A (en) 2018-02-28
US20200009276A1 (en) 2020-01-09
US12064490B2 (en) 2024-08-20
US20150265732A1 (en) 2015-09-24
DK2900279T3 (da) 2019-09-30
AU2018204513A1 (en) 2018-07-12
WO2014052471A1 (en) 2014-04-03
ES2745635T3 (es) 2020-03-03
EP2900279B1 (en) 2019-08-14
AU2021201914A1 (en) 2021-04-29
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IL312551B2 (en) 2025-12-01
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JP7358430B2 (ja) 2023-10-10
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US20210346529A1 (en) 2021-11-11
US20210346528A1 (en) 2021-11-11
US9839703B2 (en) 2017-12-12
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EP3536347A1 (en) 2019-09-11
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