KR102307278B1 - 신규 척추동물 세포 및 관심 폴리펩티드의 재조합적 발현 방법 - Google Patents

신규 척추동물 세포 및 관심 폴리펩티드의 재조합적 발현 방법 Download PDF

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KR102307278B1
KR102307278B1 KR1020167032875A KR20167032875A KR102307278B1 KR 102307278 B1 KR102307278 B1 KR 102307278B1 KR 1020167032875 A KR1020167032875 A KR 1020167032875A KR 20167032875 A KR20167032875 A KR 20167032875A KR 102307278 B1 KR102307278 B1 KR 102307278B1
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matriptase
cell
polypeptide
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홀거 라욱스
산드린 로만드
우르술라 보덴도르프
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노파르티스 아게
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
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    • C12P21/00—Preparation of peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21109—Matriptase (3.4.21.109)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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  • Urology & Nephrology (AREA)
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KR1020167032875A 2014-04-29 2015-04-29 신규 척추동물 세포 및 관심 폴리펩티드의 재조합적 발현 방법 Active KR102307278B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461985589P 2014-04-29 2014-04-29
US61/985,589 2014-04-29
US201461994310P 2014-05-16 2014-05-16
US61/994,310 2014-05-16
PCT/IB2015/053110 WO2015166427A2 (en) 2014-04-29 2015-04-29 Novel vertebrate cells and methods for recombinantly expressing a polypeptide of interest

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KR20160147919A KR20160147919A (ko) 2016-12-23
KR102307278B1 true KR102307278B1 (ko) 2021-09-30

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US (2) US11512335B2 (cg-RX-API-DMAC7.html)
EP (3) EP3536776B1 (cg-RX-API-DMAC7.html)
JP (1) JP6636453B2 (cg-RX-API-DMAC7.html)
KR (1) KR102307278B1 (cg-RX-API-DMAC7.html)
CN (1) CN106255749A (cg-RX-API-DMAC7.html)
AU (1) AU2015254913B2 (cg-RX-API-DMAC7.html)
CA (1) CA2947198C (cg-RX-API-DMAC7.html)
DK (2) DK3137595T3 (cg-RX-API-DMAC7.html)
ES (2) ES2968879T3 (cg-RX-API-DMAC7.html)
IL (1) IL248184B (cg-RX-API-DMAC7.html)
LT (2) LT3536776T (cg-RX-API-DMAC7.html)
MX (1) MX368664B (cg-RX-API-DMAC7.html)
PL (2) PL3536776T3 (cg-RX-API-DMAC7.html)
PT (2) PT3536776T (cg-RX-API-DMAC7.html)
RU (1) RU2710726C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201608358VA (cg-RX-API-DMAC7.html)
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201608358VA (en) 2014-04-29 2016-11-29 Novartis Ag Novel vertebrate cells and methods for recombinantly expressing a polypeptide of interest
EP3015475A1 (en) 2014-10-31 2016-05-04 Novartis AG Mammalian cells expressing cytomegalovirus antigens
PE20200697A1 (es) 2017-06-22 2020-06-16 Catalyst Biosciences Inc Polipeptidos de serina proteasa 1 de tipo membrana modificada (mtsp-1) y metodos de uso
WO2019180607A1 (en) * 2018-03-19 2019-09-26 Centre For Cellular And Molecular Platforms A vector, a host cell and a method thereof
US12559526B2 (en) * 2018-10-15 2026-02-24 The Regents Of The University Of California Complement component 1s (C1s) deficient cells for production of vaccines and biopharmaceutical proteins
US20220348632A1 (en) 2019-09-18 2022-11-03 Novartis Ag Nkg2d fusion proteins and uses thereof
AU2021215893A1 (en) * 2020-02-05 2022-08-25 Novartis Ag CHO cell expressing IL-15 heterodimers
CN115605592A (zh) * 2020-05-11 2023-01-13 基因泰克公司（Us） 用于治疗神经系统疾病的补体组分c1r抑制剂以及相关的组合物、系统和使用它们的方法
CN115551519A (zh) * 2020-05-11 2022-12-30 基因泰克公司 用于治疗神经系统疾病的补体组分c1s抑制剂以及相关的组合物、系统和使用它们的方法
US20250313878A1 (en) * 2022-05-19 2025-10-09 Novartis Ag IMPROVED PROTEIN PRODUCTION USING miRNA TECHNOLOGY

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766075A (en) 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
IE56716B1 (en) 1983-01-19 1991-11-20 Genentech Inc Method for producing human tpa and expression vectors therefor
US4775624A (en) 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
ATE159548T1 (de) 1990-11-13 1997-11-15 Immunex Corp Bifunktionelle wählbare fusionsgene
US5371198A (en) * 1991-12-16 1994-12-06 Novo Nordisk A/S Method for protection of proteolysis-susceptible protein during protein production in a fluid medium
AU6953394A (en) 1993-05-21 1994-12-20 Targeted Genetics Corporation Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene
AU2001278488A1 (en) 2000-07-25 2002-02-05 Bayer Aktiengesellschaft Regulation of human matriptase-like serine protease
EP1427744B1 (en) * 2001-08-27 2007-12-26 Genentech, Inc. A system for antibody expression and assembly
WO2004031733A2 (en) * 2002-10-02 2004-04-15 Catalyst Biosciences Methods of generating and screenign for porteases with altered specificity
ATE399872T1 (de) 2003-03-11 2008-07-15 Serono Lab Expressionvektoren, die den promotor des ie2-gens des maus cytomegalovirus enthalten
US20100035240A1 (en) * 2004-08-10 2010-02-11 Cardiff Biologicals Limited Methods and kit for the prognosis of breast cancer
US7572444B2 (en) 2004-12-20 2009-08-11 Amgen Fremont Inc. Binding proteins specific for human matriptase
US7632509B2 (en) * 2005-07-19 2009-12-15 Biosante Pharmaceuticals, Inc. Methods to express recombinant proteins from lentiviral vectors
CA2696263C (en) 2007-08-15 2017-06-13 Bing Liu Monospecific and multispecific antibodies and method of use
ES2546086T3 (es) 2007-12-21 2015-09-18 Novartis Ag Sistema de selección en un cultivo de células eucariotas basado en un gen receptor de folato unido a la membrana
US8399219B2 (en) 2009-02-23 2013-03-19 Cytomx Therapeutics, Inc. Protease activatable interferon alpha proprotein
RU2535986C2 (ru) 2009-02-27 2014-12-20 Новартис Аг Система векторов экспрессии, включающая два селективных маркера
US8722964B2 (en) * 2009-04-23 2014-05-13 Transposagen Biopharmaceuticals, Inc. Genetically engineered or transgenic rats exhibiting a cancer phenotype due to a disruption of germline tumor suppressor genes
AU2011246503B2 (en) 2010-04-26 2013-09-26 Novartis Ag Improved cell culture medium
EP2714716B1 (en) 2011-06-02 2018-04-11 Socpra Sciences Santé Et Humaines S.E.C. Matriptase inhibitors and uses thereof against orthomyxoviridae infections
PE20150605A1 (es) 2012-04-27 2015-05-28 Cytomx Therapeutics Inc Anticuerpos activables que se unen al receptor del factor de crecimiento epidermico
SG11201408554QA (en) 2012-06-22 2015-02-27 Cytomx Therapeutics Inc Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof
SG11201608358VA (en) 2014-04-29 2016-11-29 Novartis Ag Novel vertebrate cells and methods for recombinantly expressing a polypeptide of interest
EP3015475A1 (en) * 2014-10-31 2016-05-04 Novartis AG Mammalian cells expressing cytomegalovirus antigens

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KR20160147919A (ko) 2016-12-23
PT3137595T (pt) 2019-06-19
EP3137595B1 (en) 2019-03-13
CA2947198A1 (en) 2015-11-05
LT3137595T (lt) 2019-06-25
DK3536776T3 (da) 2024-01-15
IL248184B (en) 2021-03-25
EP4332231A2 (en) 2024-03-06
WO2015166427A2 (en) 2015-11-05
ES2731246T3 (es) 2019-11-14
JP2017514484A (ja) 2017-06-08
RU2016145928A3 (cg-RX-API-DMAC7.html) 2018-12-26
BR112016024534A2 (pt) 2017-10-10
EP4332231A3 (en) 2024-05-29
LT3536776T (lt) 2024-01-25
EP3536776B1 (en) 2023-10-25
AU2015254913B2 (en) 2018-05-17
AU2015254913A1 (en) 2016-10-27
PL3137595T3 (pl) 2019-09-30
US20230323419A1 (en) 2023-10-12
RU2016145928A (ru) 2018-05-29
MX2016014222A (es) 2017-05-04
RU2710726C2 (ru) 2020-01-10
MX368664B (es) 2019-10-10
PT3536776T (pt) 2024-01-12
ES2968879T3 (es) 2024-05-14
EP3137595A2 (en) 2017-03-08
JP6636453B2 (ja) 2020-01-29
PL3536776T3 (pl) 2024-03-25
IL248184A0 (en) 2016-11-30
SG11201608358VA (en) 2016-11-29
DK3536776T5 (da) 2024-09-02
EP3536776A1 (en) 2019-09-11
US11512335B2 (en) 2022-11-29
CN106255749A (zh) 2016-12-21
WO2015166427A3 (en) 2016-01-14
DK3137595T3 (da) 2019-06-17
CA2947198C (en) 2023-01-17
US20170044587A1 (en) 2017-02-16

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