KR102295746B1 - 유전자 변형된 주요 조직적합성 복합체 마우스 - Google Patents

유전자 변형된 주요 조직적합성 복합체 마우스 Download PDF

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KR102295746B1
KR102295746B1 KR1020207002887A KR20207002887A KR102295746B1 KR 102295746 B1 KR102295746 B1 KR 102295746B1 KR 1020207002887 A KR1020207002887 A KR 1020207002887A KR 20207002887 A KR20207002887 A KR 20207002887A KR 102295746 B1 KR102295746 B1 KR 102295746B1
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human
microglobulin
mouse
mhc
polypeptide
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KR20200013810A (ko
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린 맥도날드
앤드류 제이. 머피
카간 규레르
존 맥훠터
베라 보로니나
페이스 해리스
션 스티븐스
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리제너론 파아마슈티컬스, 인크.
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020207002887A 2011-10-28 2012-10-26 유전자 변형된 주요 조직적합성 복합체 마우스 Active KR102295746B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201161552582P 2011-10-28 2011-10-28
US201161552587P 2011-10-28 2011-10-28
US61/552,582 2011-10-28
US61/552,587 2011-10-28
US201261700908P 2012-09-14 2012-09-14
US61/700,908 2012-09-14
KR1020187033187A KR102074145B1 (ko) 2011-10-28 2012-10-26 유전자 변형된 주요 조직적합성 복합체 마우스
PCT/US2012/062042 WO2013063346A1 (en) 2011-10-28 2012-10-26 Genetically modified major histocompatibility complex mice

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KR1020187033187A Division KR102074145B1 (ko) 2011-10-28 2012-10-26 유전자 변형된 주요 조직적합성 복합체 마우스

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KR20200013810A KR20200013810A (ko) 2020-02-07
KR102295746B1 true KR102295746B1 (ko) 2021-09-01

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KR1020207002887A Active KR102295746B1 (ko) 2011-10-28 2012-10-26 유전자 변형된 주요 조직적합성 복합체 마우스
KR1020147014476A Active KR101921126B1 (ko) 2011-10-28 2012-10-26 유전자 변형된 주요 조직적합성 복합체 마우스
KR1020187033187A Active KR102074145B1 (ko) 2011-10-28 2012-10-26 유전자 변형된 주요 조직적합성 복합체 마우스

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KR1020187033187A Active KR102074145B1 (ko) 2011-10-28 2012-10-26 유전자 변형된 주요 조직적합성 복합체 마우스

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US (3) US9615550B2 (enExample)
EP (4) EP3262932B1 (enExample)
JP (4) JP6154391B2 (enExample)
KR (3) KR102295746B1 (enExample)
CN (3) CN104039132B9 (enExample)
AU (3) AU2012324016C1 (enExample)
BR (1) BR112014009259A2 (enExample)
CA (2) CA2850387A1 (enExample)
CY (2) CY1119657T1 (enExample)
DK (2) DK2770821T3 (enExample)
ES (3) ES2962287T3 (enExample)
HK (1) HK1249712B (enExample)
HR (2) HRP20171761T1 (enExample)
HU (2) HUE035652T2 (enExample)
IL (3) IL232097A (enExample)
LT (2) LT3262932T (enExample)
MX (3) MX376167B (enExample)
MY (2) MY178723A (enExample)
NZ (1) NZ734532A (enExample)
PL (2) PL3262932T3 (enExample)
PT (2) PT2770821T (enExample)
RS (2) RS56656B1 (enExample)
SG (2) SG10201603188SA (enExample)
SI (2) SI3262932T1 (enExample)
SM (2) SMT201900478T1 (enExample)
WO (1) WO2013063346A1 (enExample)
ZA (1) ZA201403085B (enExample)

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