KR102259588B1 - 과민성 장 증후군 및 염증성 장 질환의 진단 및 치료 - Google Patents

과민성 장 증후군 및 염증성 장 질환의 진단 및 치료 Download PDF

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KR102259588B1
KR102259588B1 KR1020167011774A KR20167011774A KR102259588B1 KR 102259588 B1 KR102259588 B1 KR 102259588B1 KR 1020167011774 A KR1020167011774 A KR 1020167011774A KR 20167011774 A KR20167011774 A KR 20167011774A KR 102259588 B1 KR102259588 B1 KR 102259588B1
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antibody
cdt
vinculin
ibs
ala
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KR20160062161A (ko
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마크 피멘텔
크리스토퍼 장
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세다르스-신나이 메디칼 센터
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
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  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ecology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1020167011774A 2013-10-09 2014-10-09 과민성 장 증후군 및 염증성 장 질환의 진단 및 치료 Active KR102259588B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361888658P 2013-10-09 2013-10-09
US61/888,658 2013-10-09
PCT/US2014/059957 WO2015054529A1 (en) 2013-10-09 2014-10-09 Diagnosis and treatment of irritable bowel syndrome and inflammatory bowel disease

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KR20160062161A KR20160062161A (ko) 2016-06-01
KR102259588B1 true KR102259588B1 (ko) 2021-06-02

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US (2) US9851361B2 (enExample)
EP (1) EP3054977B1 (enExample)
JP (1) JP6567509B2 (enExample)
KR (1) KR102259588B1 (enExample)
CN (1) CN105744956B (enExample)
AU (2) AU2014331841B2 (enExample)
BR (1) BR112016007474A2 (enExample)
CA (1) CA2923651C (enExample)
CL (1) CL2016000820A1 (enExample)
ES (1) ES2892905T3 (enExample)
IL (1) IL244971B2 (enExample)
MX (1) MX383423B (enExample)
NZ (1) NZ717633A (enExample)
PE (1) PE20160882A1 (enExample)
PL (1) PL3054977T3 (enExample)
PT (1) PT3054977T (enExample)
RU (1) RU2683781C2 (enExample)
SG (1) SG11201601733VA (enExample)
WO (1) WO2015054529A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11693009B2 (en) 2009-02-11 2023-07-04 Cedars-Sinai Medical Center Methods for detecting post-infectious irritable bowel syndrome
US12222352B2 (en) 2017-01-30 2025-02-11 Cedars-Sinai Medical Center Diagnosis of scleroderma

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010213708B2 (en) 2009-02-11 2015-12-10 Cedars-Sinai Medical Center Antibody to cytolethal distending toxin of Campylobacter jejuni
MX383428B (es) 2012-09-17 2025-03-13 Cedars Sinai Medical Center Determinaciòn de trastornos de la motilidad de los intestinos y la vejiga, y de la fibromialgia.
KR102259588B1 (ko) 2013-10-09 2021-06-02 세다르스-신나이 메디칼 센터 과민성 장 증후군 및 염증성 장 질환의 진단 및 치료
MX384921B (es) 2014-10-09 2025-03-14 Cedars Sinai Medical Center Métodos y sistemas para distinguir el síndrome del intestino irritable de la enfermedad inflamatoria intestinal y la enfermedad celíaca.
CN105784989A (zh) * 2016-05-17 2016-07-20 上海凯璟生物科技有限公司 一种肠易激综合症标志物CdtB抗体检测试剂盒及其制备方法
CN106053827A (zh) * 2016-05-17 2016-10-26 上海凯璟生物科技有限公司 一种肠易激综合症标志物Vinculin抗体检测试剂盒及其制备方法
US11549146B2 (en) 2016-05-20 2023-01-10 Cedars-Sinai Medical Center Diagnosis of inflammatory bowel disease based on genes
RU2763258C1 (ru) * 2020-07-13 2021-12-28 Евгения Николаевна Воронина Способ дифференциальной диагностики воспалительных заболеваний кишечника у детей по комплексу клинико-анамнестических, лабораторных и инструментальных критериев

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040018528A1 (en) 2002-05-17 2004-01-29 Sugen, Inc. Novel biomarkers of tyrosine kinase inhibitor exposure and activity in mammals
JP2006522817A (ja) 2003-04-08 2006-10-05 プロジェニックス ファーマシューティカルズ，インコーポレーテッド 過敏性腸症候群を処置するための末梢オピオイドアンタゴニスト、特にメチルナルトレキソンの使用
US20110305704A1 (en) 2009-02-11 2011-12-15 Cedars-Sinai Medical Center Antibody to cytolethal distending toxin of campylobacter jejuni

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691151A (en) * 1994-10-07 1997-11-25 Regents Of University Of California Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca
US6562629B1 (en) 1999-08-11 2003-05-13 Cedars-Sinai Medical Center Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
FR2806805A1 (fr) 2000-03-22 2001-09-28 Centre Nat Rech Scient SEQUENCE PEPTIDIQUES COMPRENANT UN OU PLUSIEURS MOTIFS DE LIAISON AUX PROTEINES DE LA FAMILLE Ena/VASP, ET LEURS UTILISATIONS
AU2003291625B2 (en) 2002-09-16 2009-10-08 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US7595386B2 (en) 2003-01-24 2009-09-29 William Beaumont Hospital Methods and compositions for heat activated gene therapy using cytolethal distending toxin
EP2280285A1 (en) * 2003-09-15 2011-02-02 Oklahoma Medical Research Foundation Method of using cytokine assays to diagnose, treat, and evaluate inflammatory and autoimmune diseases
ES2456710T3 (es) 2003-12-05 2014-04-23 Fuso Pharmaceutical Industries Ltd. Genes de toxinas de distensión citoletales como dianas para la detección de bacterias Campylobacter
EP2102367A2 (en) 2006-11-09 2009-09-23 XDX, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
JP2011507509A (ja) 2007-12-20 2011-03-10 インデックス・ダイアグノスティックス・エイビイ Ｉｂｄとｉｂｓとの区別、ｉｂｄの疾患タイプ間の更なる識別における使用する方法およびキット
WO2010060098A1 (en) 2008-11-24 2010-05-27 Cedars-Sinai Medical Center Antioxidant camptothecin derivatives and antioxidant antineoplastic nanospheres thereof
BRPI1008058A8 (pt) 2009-02-11 2018-03-27 Cedars Sinai Medical Center uso de antibióticos para reduzir a probabilidade de desenvolver síndrome do intestino irritável pós-infecciosa
FR2942541A1 (fr) 2009-02-25 2010-08-27 Assist Publ Hopitaux De Paris Procede de diagnostic d'une vascularite
RU2397178C1 (ru) * 2009-02-27 2010-08-20 Федеральное государственное учреждение науки "Центральный научно-исследовательский институт эпидемиологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека Диагностическая тест-система в формате иммуночипа и способ серологической дифференциальной диагностики сифилиса
IT1400989B1 (it) 2010-07-13 2013-07-05 Segix Italia S R L Ora Istituto Biochimico Naz Savio S R L Forme di somministrazione orale a rilascio controllato di rifampicina per il trattamento di infezioni batteriche dell' apparato intestinale.
GB201017520D0 (en) 2010-10-15 2010-12-01 Sense Proteomic Ltd Biomarkers
MX383428B (es) * 2012-09-17 2025-03-13 Cedars Sinai Medical Center Determinaciòn de trastornos de la motilidad de los intestinos y la vejiga, y de la fibromialgia.
KR102259588B1 (ko) 2013-10-09 2021-06-02 세다르스-신나이 메디칼 센터 과민성 장 증후군 및 염증성 장 질환의 진단 및 치료
MX384921B (es) 2014-10-09 2025-03-14 Cedars Sinai Medical Center Métodos y sistemas para distinguir el síndrome del intestino irritable de la enfermedad inflamatoria intestinal y la enfermedad celíaca.
CN106091069A (zh) 2016-06-15 2016-11-09 安徽省绿巨人环境技术有限公司 一种废水再利用装置
EP3573650A4 (en) 2017-01-30 2020-12-09 Cedars-Sinai Medical Center DIAGNOSIS OF SCLERODERMIA

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040018528A1 (en) 2002-05-17 2004-01-29 Sugen, Inc. Novel biomarkers of tyrosine kinase inhibitor exposure and activity in mammals
JP2006522817A (ja) 2003-04-08 2006-10-05 プロジェニックス ファーマシューティカルズ，インコーポレーテッド 過敏性腸症候群を処置するための末梢オピオイドアンタゴニスト、特にメチルナルトレキソンの使用
US20110305704A1 (en) 2009-02-11 2011-12-15 Cedars-Sinai Medical Center Antibody to cytolethal distending toxin of campylobacter jejuni

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Walter Morales et al., 'Antibodies to Cytolethal Distending Toxin B and Auto-Antibodies to Human Vinculin Are Elevated in IBS Subjects', Gastroenterology, 2013, Vol. 144, page S-914. 1부.*

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11693009B2 (en) 2009-02-11 2023-07-04 Cedars-Sinai Medical Center Methods for detecting post-infectious irritable bowel syndrome
US12222352B2 (en) 2017-01-30 2025-02-11 Cedars-Sinai Medical Center Diagnosis of scleroderma

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Publication number Publication date
US9851361B2 (en) 2017-12-26
EP3054977B1 (en) 2021-07-21
RU2016116766A (ru) 2017-11-15
MX2016004167A (es) 2016-06-24
AU2020203468A1 (en) 2020-06-18
EP3054977A4 (en) 2017-04-12
EP3054977A1 (en) 2016-08-17
AU2014331841B2 (en) 2020-03-12
CA2923651C (en) 2023-03-14
MX383423B (es) 2025-03-14
WO2015054529A1 (en) 2015-04-16
NZ717633A (en) 2021-07-30
PT3054977T (pt) 2021-10-14
US10352944B2 (en) 2019-07-16
US20170038393A1 (en) 2017-02-09
US20180196063A1 (en) 2018-07-12
IL244971B2 (en) 2023-12-01
CN105744956A (zh) 2016-07-06
JP2017502253A (ja) 2017-01-19
SG11201601733VA (en) 2016-04-28
IL244971B1 (en) 2023-08-01
PE20160882A1 (es) 2016-09-14
KR20160062161A (ko) 2016-06-01
AU2014331841A1 (en) 2016-03-24
CN105744956B (zh) 2021-07-20
CA2923651A1 (en) 2015-04-16
RU2683781C2 (ru) 2019-04-02
PL3054977T3 (pl) 2021-12-20
BR112016007474A2 (pt) 2017-09-12
ES2892905T3 (es) 2022-02-07
IL244971A0 (en) 2016-05-31
CL2016000820A1 (es) 2016-09-23
HK1221898A1 (zh) 2017-06-16
JP6567509B2 (ja) 2019-08-28

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