KR102256410B1 - 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도 - Google Patents

트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도 Download PDF

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KR102256410B1
KR102256410B1 KR1020207006108A KR20207006108A KR102256410B1 KR 102256410 B1 KR102256410 B1 KR 102256410B1 KR 1020207006108 A KR1020207006108 A KR 1020207006108A KR 20207006108 A KR20207006108 A KR 20207006108A KR 102256410 B1 KR102256410 B1 KR 102256410B1
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compound
formula
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KR20200024964A (ko
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데이비드 진
미셀 아담스
카이 뎅
니콜라스 펄
애니 원
필립 리빙스톤
고빈드 라구파시
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슬로안-케테링인스티튜트퍼캔서리서치
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
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    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P33/00—Antiparasitic agents
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C—CHEMISTRY; METALLURGY
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
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    • C07—ORGANIC CHEMISTRY
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    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
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    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
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  • Biochemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
KR1020207006108A 2008-04-08 2009-04-08 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도 Active KR102256410B1 (ko)

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KR1020217015136A KR102453184B1 (ko) 2008-04-08 2009-04-08 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도

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US4319708P 2008-04-08 2008-04-08
US61/043,197 2008-04-08
PCT/US2009/039954 WO2009126737A2 (en) 2008-04-08 2009-04-08 Triterpene saponins, methods of synthesis, and uses thereof
KR1020197003429A KR102085687B1 (ko) 2008-04-08 2009-04-08 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도

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KR102256410B1 true KR102256410B1 (ko) 2021-05-26

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KR1020207006108A Active KR102256410B1 (ko) 2008-04-08 2009-04-08 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
KR1020107024935A Active KR101651695B1 (ko) 2008-04-08 2009-04-08 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
KR1020197003429A Active KR102085687B1 (ko) 2008-04-08 2009-04-08 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
KR1020187002556A Active KR101947332B1 (ko) 2008-04-08 2009-04-08 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
KR1020167022654A Active KR101825315B1 (ko) 2008-04-08 2009-04-08 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
KR1020217015136A Active KR102453184B1 (ko) 2008-04-08 2009-04-08 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도

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KR1020197003429A Active KR102085687B1 (ko) 2008-04-08 2009-04-08 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
KR1020187002556A Active KR101947332B1 (ko) 2008-04-08 2009-04-08 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
KR1020167022654A Active KR101825315B1 (ko) 2008-04-08 2009-04-08 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
KR1020217015136A Active KR102453184B1 (ko) 2008-04-08 2009-04-08 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도

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US (6) US8283456B2 (enExample)
EP (3) EP3868771A1 (enExample)
JP (5) JP5706815B2 (enExample)
KR (6) KR102256410B1 (enExample)
CN (2) CN104710487A (enExample)
AU (1) AU2009233757B2 (enExample)
CA (3) CA2993582C (enExample)
ES (1) ES2827804T3 (enExample)
HK (1) HK1211591A1 (enExample)
IL (4) IL208535A (enExample)
WO (1) WO2009126737A2 (enExample)

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