SG11202001826YA - Triterpene saponin analogues - Google Patents
Triterpene saponin analoguesInfo
- Publication number
- SG11202001826YA SG11202001826YA SG11202001826YA SG11202001826YA SG11202001826YA SG 11202001826Y A SG11202001826Y A SG 11202001826YA SG 11202001826Y A SG11202001826Y A SG 11202001826YA SG 11202001826Y A SG11202001826Y A SG 11202001826YA SG 11202001826Y A SG11202001826Y A SG 11202001826YA
- Authority
- SG
- Singapore
- Prior art keywords
- triterpene saponin
- saponin analogues
- analogues
- triterpene
- saponin
- Prior art date
Links
- 229930182493 triterpene saponin Natural products 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762572857P | 2017-10-16 | 2017-10-16 | |
| US201762573501P | 2017-10-17 | 2017-10-17 | |
| PCT/US2018/055828 WO2019079160A1 (en) | 2017-10-16 | 2018-10-15 | Triterpene saponin analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202001826YA true SG11202001826YA (en) | 2020-03-30 |
Family
ID=66173854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202001826YA SG11202001826YA (en) | 2017-10-16 | 2018-10-15 | Triterpene saponin analogues |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11324821B2 (en) |
| EP (1) | EP3697802A4 (en) |
| JP (2) | JP2020536946A (en) |
| KR (1) | KR20200098476A (en) |
| CN (1) | CN111212846B (en) |
| AU (1) | AU2018350887A1 (en) |
| CA (1) | CA3075822A1 (en) |
| CL (1) | CL2020000879A1 (en) |
| IL (1) | IL273691A (en) |
| SG (1) | SG11202001826YA (en) |
| WO (1) | WO2019079160A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL290897B2 (en) * | 2014-05-30 | 2023-10-01 | Memorial Sloan Kettering Cancer Center | Minimal saponin analogues, synthesis and use thereof |
| JP2020536946A (en) * | 2017-10-16 | 2020-12-17 | アジュバンス・テクノロジーズ・インコーポレーテッド | Triterpene saponin analog |
| EP4153210A2 (en) | 2020-05-19 | 2023-03-29 | Othair Prothena Limited | Multi-epitope vaccine for the treatment of alzheimer's disease |
| US20230263886A1 (en) * | 2020-06-18 | 2023-08-24 | Adjuvance Technologies, Inc. | Vaccines, vaccine priming, and antigen dose sparing |
| JP2023542141A (en) | 2020-09-15 | 2023-10-05 | ザ ユニバーシティー オブ モンタナ | Compositions and methods for targeting filamentous bacteriophages |
| WO2023081505A1 (en) * | 2021-11-08 | 2023-05-11 | Adjuvance Technologies, Inc. | Adjuvant compounds and formulations |
| EP4190359A1 (en) | 2021-12-03 | 2023-06-07 | Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE | Saponin-based adjuvants and vaccines |
| WO2023139145A1 (en) | 2022-01-19 | 2023-07-27 | Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune | Saponin-based adjuvants and vaccines |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916588A (en) | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
| US5231112A (en) | 1984-04-12 | 1993-07-27 | The Liposome Company, Inc. | Compositions containing tris salt of cholesterol hemisuccinate and antifungal |
| US4684479A (en) | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
| US6759057B1 (en) | 1986-06-12 | 2004-07-06 | The Liposome Company, Inc. | Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
| IE60901B1 (en) | 1986-08-21 | 1994-08-24 | Vestar Inc | Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics |
| US6406713B1 (en) | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
| AU598958B2 (en) | 1987-11-12 | 1990-07-05 | Vestar, Inc. | Improved amphotericin b liposome preparation |
| US5215680A (en) | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
| DK0929293T3 (en) | 1996-08-23 | 2004-02-02 | Sequus Pharm Inc | Liposomes containing a cisplatin compound |
| WO1998016201A1 (en) | 1996-10-11 | 1998-04-23 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| ATE423547T1 (en) | 1996-10-15 | 2009-03-15 | Transave Inc | N-ACYL-PHOSPHATIDYLETHANOLAMINE-MEDIATED ACTIVE INGREDIENT DOSAGE IN LIPOSOME FORM |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| AU5565599A (en) | 1998-08-14 | 2000-03-06 | Dante J. Marciani | Chemically modified saponins and the use thereof as adjuvants |
| AU7085400A (en) | 1999-09-02 | 2001-03-26 | Antigenics, Inc. | Compositions of immunostimulatory polymers and saponin adjuvants and uses thereof |
| GB0401239D0 (en) | 2004-01-21 | 2004-02-25 | Molecularnature Ltd | Adjuvant compositions |
| GB0504436D0 (en) | 2005-03-03 | 2005-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
| TWI457133B (en) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | Novel composition |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| US20090035360A1 (en) * | 2007-05-24 | 2009-02-05 | Dominique Ingrid Lemoine | Lyophilised antigen composition |
| AU2008339980A1 (en) | 2007-12-21 | 2009-07-02 | Glaxosmithkline Biologicals S.A. | Vaccines for malaria |
| EP3868771A1 (en) | 2008-04-08 | 2021-08-25 | Sloan-Kettering Institute for Cancer Research | Triterpene saponins, methods of synthesis, and uses thereof |
| HUE026586T2 (en) * | 2008-04-16 | 2016-06-28 | Glaxosmithkline Biologicals Sa | Vaccine |
| GB0910046D0 (en) | 2009-06-10 | 2009-07-22 | Glaxosmithkline Biolog Sa | Novel compositions |
| CN102844047B (en) | 2009-09-02 | 2017-04-05 | 诺华股份有限公司 | Immunogenic composition containing TLR active regulators |
| US20130309273A1 (en) | 2012-05-17 | 2013-11-21 | Kimberly Hassett | Thermostable Vaccine Compositions and Methods of Preparing Same |
| EA201391456A1 (en) * | 2011-05-17 | 2014-05-30 | Глаксосмитклайн Байолоджикалс С.А. | VACCINE AGAINST Streptococcus pneumoniae |
| WO2014124860A1 (en) | 2013-02-14 | 2014-08-21 | Boehringer Ingelheim International Gmbh | Specific pde4b-inhibitors for the treatment of diabetes mellitus |
| US20150037374A1 (en) * | 2013-07-31 | 2015-02-05 | Csl Limited | Anti-tumor compositions and uses thereof |
| IL290897B2 (en) | 2014-05-30 | 2023-10-01 | Memorial Sloan Kettering Cancer Center | Minimal saponin analogues, synthesis and use thereof |
| SG11201803594TA (en) | 2015-11-06 | 2018-05-30 | Adjuvance Technologies Inc | Triterpene saponin analogues |
| DK3389669T3 (en) | 2015-12-17 | 2023-05-01 | Memorial Sloan Kettering Cancer Center | TRITERPENSAPONINE VARIANTS, METHODS OF SYNTHESIS AND USE THEREOF |
| AU2018253267B2 (en) | 2017-04-13 | 2024-02-29 | Adjuvance Technologies, Inc. | Triterpene saponin synthesis, intermediates and adjuvant combinations |
| WO2018200645A1 (en) * | 2017-04-25 | 2018-11-01 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| WO2018200656A1 (en) | 2017-04-25 | 2018-11-01 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| JP2020536946A (en) * | 2017-10-16 | 2020-12-17 | アジュバンス・テクノロジーズ・インコーポレーテッド | Triterpene saponin analog |
-
2018
- 2018-10-15 JP JP2020521329A patent/JP2020536946A/en active Pending
- 2018-10-15 KR KR1020207007284A patent/KR20200098476A/en not_active Application Discontinuation
- 2018-10-15 WO PCT/US2018/055828 patent/WO2019079160A1/en active Application Filing
- 2018-10-15 SG SG11202001826YA patent/SG11202001826YA/en unknown
- 2018-10-15 AU AU2018350887A patent/AU2018350887A1/en not_active Abandoned
- 2018-10-15 CN CN201880067264.5A patent/CN111212846B/en active Active
- 2018-10-15 EP EP18869029.1A patent/EP3697802A4/en active Pending
- 2018-10-15 US US16/649,892 patent/US11324821B2/en active Active
- 2018-10-15 CA CA3075822A patent/CA3075822A1/en active Pending
-
2020
- 2020-03-29 IL IL273691A patent/IL273691A/en unknown
- 2020-04-01 CL CL2020000879A patent/CL2020000879A1/en unknown
-
2022
- 2022-03-04 US US17/687,094 patent/US20220184207A1/en not_active Abandoned
- 2022-10-04 JP JP2022160138A patent/JP2022191329A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022191329A (en) | 2022-12-27 |
| US11324821B2 (en) | 2022-05-10 |
| CA3075822A1 (en) | 2019-04-25 |
| EP3697802A4 (en) | 2021-11-24 |
| AU2018350887A1 (en) | 2020-03-05 |
| US20220184207A1 (en) | 2022-06-16 |
| WO2019079160A1 (en) | 2019-04-25 |
| EP3697802A1 (en) | 2020-08-26 |
| US20200261571A1 (en) | 2020-08-20 |
| IL273691A (en) | 2020-05-31 |
| CN111212846A (en) | 2020-05-29 |
| JP2020536946A (en) | 2020-12-17 |
| CN111212846B (en) | 2023-05-26 |
| CL2020000879A1 (en) | 2020-10-02 |
| KR20200098476A (en) | 2020-08-20 |
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