KR102251127B1 - 이온 교환 크로마토그래피 입력 최적화의 설명 - Google Patents

이온 교환 크로마토그래피 입력 최적화의 설명 Download PDF

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KR102251127B1
KR102251127B1 KR1020167003178A KR20167003178A KR102251127B1 KR 102251127 B1 KR102251127 B1 KR 102251127B1 KR 1020167003178 A KR1020167003178 A KR 1020167003178A KR 20167003178 A KR20167003178 A KR 20167003178A KR 102251127 B1 KR102251127 B1 KR 102251127B1
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polypeptide
antibody
buffer
gradient
delete delete
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KR20160030251A (ko
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다니엘 맥도날드
토마스 페타포프
야준 왕
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제넨테크, 인크.
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8658—Optimising operation parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Confectionery (AREA)
KR1020167003178A 2013-07-12 2014-07-11 이온 교환 크로마토그래피 입력 최적화의 설명 Active KR102251127B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361845890P 2013-07-12 2013-07-12
US61/845,890 2013-07-12
PCT/US2014/046338 WO2015006686A1 (en) 2013-07-12 2014-07-11 Elucidation of ion exchange chromatography input optimization

Publications (2)

Publication Number Publication Date
KR20160030251A KR20160030251A (ko) 2016-03-16
KR102251127B1 true KR102251127B1 (ko) 2021-05-11

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US (2) US10274466B2 (cg-RX-API-DMAC7.html)
EP (2) EP3019516B1 (cg-RX-API-DMAC7.html)
JP (2) JP6462681B2 (cg-RX-API-DMAC7.html)
KR (1) KR102251127B1 (cg-RX-API-DMAC7.html)
CN (1) CN105377873B (cg-RX-API-DMAC7.html)
AU (1) AU2014287044B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016000231A8 (cg-RX-API-DMAC7.html)
CA (1) CA2918052A1 (cg-RX-API-DMAC7.html)
ES (1) ES2705700T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20190071T1 (cg-RX-API-DMAC7.html)
IL (1) IL243305B (cg-RX-API-DMAC7.html)
MX (1) MX368107B (cg-RX-API-DMAC7.html)
PL (1) PL3019516T3 (cg-RX-API-DMAC7.html)
RU (1) RU2016104542A (cg-RX-API-DMAC7.html)
SG (1) SG11201600221YA (cg-RX-API-DMAC7.html)
SI (1) SI3019516T1 (cg-RX-API-DMAC7.html)
TR (1) TR201818966T4 (cg-RX-API-DMAC7.html)
WO (1) WO2015006686A1 (cg-RX-API-DMAC7.html)

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RU2016104542A (ru) 2013-07-12 2017-08-17 Дженентек, Инк. Осуществление оптимизации входных условий ионообменной хроматографии
WO2016075207A1 (en) * 2014-11-12 2016-05-19 Ge Healthcare Bio-Sciences Ab Method and system for determining the influence of experimental parameters on a liquid chromatography protocol
GB2539420B (en) * 2015-06-16 2021-01-13 Cytiva Sweden Ab Determination of chromatography conditions
US11407838B2 (en) * 2018-04-02 2022-08-09 Amgen Inc. Erenumab compositions and uses thereof
WO2020010304A2 (en) * 2018-07-05 2020-01-09 Ovation Diagnostics Llc BCl-2 Antibodies and Immunoassay for Diagnosis of Cancer
KR20200080748A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법
WO2024261724A1 (en) * 2023-06-23 2024-12-26 Lupin Limited Ion-exchange chromatography for separation and analysis of charge variants

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MX368107B (es) 2019-09-18
US10274466B2 (en) 2019-04-30
HRP20190071T1 (hr) 2019-02-22
IL243305B (en) 2019-09-26
EP3019516B1 (en) 2018-11-14
CA2918052A1 (en) 2015-01-15
ES2705700T3 (es) 2019-03-26
HK1222183A1 (zh) 2017-06-23
TR201818966T4 (tr) 2019-01-21
JP6462681B2 (ja) 2019-01-30
CN105377873A (zh) 2016-03-02
MX2016000181A (es) 2016-03-09
SI3019516T1 (sl) 2019-02-28
IL243305A0 (en) 2016-03-31
SG11201600221YA (en) 2016-02-26
AU2014287044B2 (en) 2020-02-06
BR112016000231A8 (pt) 2019-12-31
PL3019516T3 (pl) 2019-04-30
RU2016104542A (ru) 2017-08-17
CN105377873B (zh) 2021-03-30
WO2015006686A8 (en) 2018-10-04
US10921297B2 (en) 2021-02-16
AU2014287044A1 (en) 2016-02-11
JP2019090818A (ja) 2019-06-13
US20160161455A1 (en) 2016-06-09
US20190310234A1 (en) 2019-10-10
WO2015006686A1 (en) 2015-01-15
EP3536699A1 (en) 2019-09-11
JP2016529489A (ja) 2016-09-23
EP3019516A1 (en) 2016-05-18
KR20160030251A (ko) 2016-03-16

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