KR102250588B1 - 캡슐화 세포의 동결-건조 방법, 동결 건조된 캡슐화 세포, 동결 건조된 캡슐화 세포를 함유하는 조성물, 및 상기 세포 및 조성물의 용도 - Google Patents

캡슐화 세포의 동결-건조 방법, 동결 건조된 캡슐화 세포, 동결 건조된 캡슐화 세포를 함유하는 조성물, 및 상기 세포 및 조성물의 용도 Download PDF

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KR102250588B1
KR102250588B1 KR1020167002913A KR20167002913A KR102250588B1 KR 102250588 B1 KR102250588 B1 KR 102250588B1 KR 1020167002913 A KR1020167002913 A KR 1020167002913A KR 20167002913 A KR20167002913 A KR 20167002913A KR 102250588 B1 KR102250588 B1 KR 102250588B1
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lactobacillus
delete delete
freeze
cells
encapsulated
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KR20160033129A (ko
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브라이언 살몬스
존 에이. 댄저필드
왈터 에이치. 귄츠버그
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오스트리아노바 싱가포르 피티이 리미티드
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    • A01N1/0221—
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    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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KR1020167002913A 2013-07-02 2014-07-02 캡슐화 세포의 동결-건조 방법, 동결 건조된 캡슐화 세포, 동결 건조된 캡슐화 세포를 함유하는 조성물, 및 상기 세포 및 조성물의 용도 Active KR102250588B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13174681.0 2013-07-02
EP13174681 2013-07-02
PCT/EP2014/064087 WO2015000972A1 (en) 2013-07-02 2014-07-02 A method of freeze-drying encapsulated cells, freeze-dried encapsulated cells, compositions containing freeze-dried encapsulated cells and uses of such cells and compositions

Publications (2)

Publication Number Publication Date
KR20160033129A KR20160033129A (ko) 2016-03-25
KR102250588B1 true KR102250588B1 (ko) 2021-05-12

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KR1020167002913A Active KR102250588B1 (ko) 2013-07-02 2014-07-02 캡슐화 세포의 동결-건조 방법, 동결 건조된 캡슐화 세포, 동결 건조된 캡슐화 세포를 함유하는 조성물, 및 상기 세포 및 조성물의 용도

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Country Link
US (1) US10329526B2 (https=)
EP (1) EP3016511B1 (https=)
JP (1) JP6643984B2 (https=)
KR (1) KR102250588B1 (https=)
CN (1) CN105517434B (https=)
AU (1) AU2014286177B2 (https=)
BR (1) BR112015032918B1 (https=)
CA (1) CA2917109C (https=)
DK (1) DK3016511T3 (https=)
ES (1) ES2763968T3 (https=)
PH (1) PH12015502860B1 (https=)
SG (2) SG10201710601YA (https=)
WO (1) WO2015000972A1 (https=)

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ITMI20131467A1 (it) * 2013-09-06 2015-03-07 Sofar Spa Uso di una composizione comprendente microrganismi per aumentare la produzione intestinale di acido butirrico, di acido folico o di niacina e/o per diminuire la produzione intestinale di acido succinico
MA39710A (fr) 2014-04-23 2015-10-29 Sofar Spa Composition topique destinée à être utilisée dans le traitement d'une maladie inflammatoire de l'intestin
GB201408233D0 (en) 2014-05-09 2014-06-25 Austrianova Singapore Pte Ltd Use of polyanionic composition
CN104830689A (zh) * 2015-05-26 2015-08-12 固元本草汉方生物科技股份有限公司 一种乳酸菌冻干保护剂及其应用
KR101845715B1 (ko) * 2015-06-03 2018-04-05 (주)제노텍 동결방지제 조성물
MA41060B1 (fr) 2015-06-15 2019-11-29 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
LT6463B (lt) 2015-12-10 2017-10-10 Uab "Probiosanus" Probiotinių bakterijų (pb) gyvybingumo ir stabilumo padidinimas detergentų turinčiuose asmens higienos ir buities priežiūros produktuose
US9999640B2 (en) 2016-02-02 2018-06-19 University Of Dammam Microencapsulated probiotic bacteria
AU2017240069B2 (en) 2016-03-31 2024-03-07 Gojo Industries, Inc. Sanitizer composition with probiotic/prebiotic active ingredient
EP3435765A1 (en) 2016-03-31 2019-02-06 Gojo Industries, Inc. Antimicrobial peptide stimulating sanitizing composition
WO2017173240A1 (en) 2016-03-31 2017-10-05 Gojo Industries, Inc. Antimicrobial peptide stimulating cleansing composition
BE1024197B1 (fr) * 2016-05-02 2017-12-13 Lacto Research Sprl Procédé d'enrobage de microorganismes, poudre desdits microorganismes enrobés obtenue et composition pharmaceutique, nutraceutique, cosmétique, alimentaire ou sanitaire la comprenant.
IT201600083376A1 (it) 2016-08-08 2018-02-08 Sofar Spa Uso di probiotici per aumentare l’assorbimento proteico
ITUA20164188A1 (it) 2016-06-08 2017-12-08 Sofar Spa Nuovo uso medico di probiotici
BE1023757B1 (nl) * 2016-06-30 2017-07-12 Yun NV Bewaring van micro-organismen
BR112019004935A2 (pt) 2016-09-13 2019-06-04 Allergan, Inc. composições de toxina clostridial não proteíca estabilizada
US10815456B2 (en) * 2016-10-04 2020-10-27 Transwell Biotech Co., Ltd. Composition, kit and method for cryopreserving cells
CN106538512B (zh) * 2016-10-08 2019-07-30 北京汉氏联合干细胞研究院有限公司 一种保持冻存细胞活性的干细胞凝胶制剂及其应用
EP3544575A1 (en) 2016-11-23 2019-10-02 GOJO Industries, Inc. Sanitizer composition with probiotic/prebiotic active ingredient
IT201600122724A1 (it) 2016-12-02 2018-06-02 Sofar Spa Exopolysaccharides and uses thereof
EP3335695B1 (en) 2016-12-15 2020-02-05 UPM-Kymmene Corporation A method for freeze-drying hydrogel comprising nanofibrillar cellulose, a freeze-dried medical hydrogel comprising nanofibrillar cellulose, and a hydrogel comprising nanofibrillar cellulose
IT201600127498A1 (it) 2016-12-16 2018-06-16 Sofar Spa Probiotici per uso nella diverticolosi e malattia diverticolare
MA47439A (fr) * 2017-01-31 2019-12-11 Univ Kansas State Cellules microbiennes, leurs procédés de production, et leurs utilisations
US11191791B2 (en) * 2017-02-22 2021-12-07 Praj Industries Limited Preparation of dry formulations of dairy probiotics
US20220125042A1 (en) * 2017-05-17 2022-04-28 Universidade Nova De Lisboa Cryoprotectant and/or cryopreservant composition, methods and uses thereof
JP6916312B2 (ja) * 2017-06-13 2021-08-11 スン・チュン・チンＣｈｕｎｇ Ｃｈｉｎ ＳＵＮ 新規な血清タンパク質の活性の保存方法
WO2019079764A1 (en) 2017-10-20 2019-04-25 Ms Biotech, Inc. METHODS FOR PRODUCING PLANT MATERIALS EMITTED WITH MEGASPHAERA ELSDENII
CN111432804A (zh) * 2017-11-27 2020-07-17 帝斯曼知识产权资产管理有限公司 冻干的多微粒固体剂型
CN109295182A (zh) * 2018-09-30 2019-02-01 苏州百源基因技术有限公司 一种pcr预分装试剂和预装pcr试剂的反应管
US20210348153A1 (en) * 2018-10-04 2021-11-11 Technion Research & Development Foundation Limited Cellulose-encapsulated oil emulsions and methods for cellulase regeneration
EP3914692A4 (en) * 2019-01-25 2022-11-02 The Australian National University Encapsulated cells
US11968975B2 (en) * 2019-04-30 2024-04-30 Regents Of The University Of Minnesota Compositions and methods for storing liquid biospecimens
EP4027785A1 (en) * 2019-09-13 2022-07-20 Lonza Ltd. Method of producing lyophilized cells
WO2021055352A1 (en) * 2019-09-16 2021-03-25 Vedanta Biosciences, Inc. Methods and compositions for preserving bacteria
US11751597B2 (en) 2019-11-05 2023-09-12 Alfasigma S.P.A. Compositions comprising bacterial strains for use in increasing the bioavailability of amino acids derived from proteins, and related food product methods and systems
NZ791845A (en) * 2020-01-31 2026-02-27 ProAgni Pty Ltd Probiotic formulation and delivery
US20240141282A1 (en) * 2020-02-26 2024-05-02 Chr. Hansen A/S Spray freeze drying of strict anaerobic bacteria
CO2020006220A1 (es) 2020-05-21 2020-11-30 Bialtec Sas Formulaciones de aditivos funcionales y su proceso de encapsulación
CN111534434B (zh) * 2020-06-28 2022-07-05 江南大学 一种冻干保护剂及其在冻干青春双歧杆菌中的应用
US12453805B2 (en) 2020-09-24 2025-10-28 Everest Medical Innovation GmbH Cryoprotective compositions, surgical kits, and methods for protection of a surgical site during cryosurgery
US12426594B2 (en) 2020-09-24 2025-09-30 Everest Medical Innovation GmbH Cryoprotective compositions and methods for protection of a surgical site during cryosurgery
AU2021360828A1 (en) * 2020-10-14 2023-06-15 Dermbiont, Inc. Compositions and methods for improving skin health and for the treatment and prevention of diseases, disorders and conditions associated with fungi and other pathogenic microbes
KR102490870B1 (ko) * 2021-01-18 2023-01-20 씨제이제일제당 주식회사 트라우스토키트리드과 미세조류의 동결 보존용 조성물 및 이를 이용한 트라우스토키트리드과 미세조류의 동결 보존 방법
CN112999198A (zh) * 2021-03-10 2021-06-22 中农宠物营养研究院(江苏)有限公司 基于壳聚糖-Fe包衣的能耐胃酸并肠道靶向释放的合生素微胶囊及其制备方法
EP4304388A1 (en) 2021-03-12 2024-01-17 Société des Produits Nestlé S.A. Gos pre-conditioning lactobacillus strains and gos in final formulation
EP4056053A1 (en) 2021-03-12 2022-09-14 Biogaia AB Pre-conditioning of l. reuteri
EP4056052A1 (en) 2021-03-12 2022-09-14 Biogaia AB Gos pre-conditioning l. reuteri and gos in final formulation
CN113621519B (zh) * 2021-08-11 2023-07-18 河南农业大学 一种复合酵母冻干保护剂
WO2023080281A1 (ko) * 2021-11-05 2023-05-11 주식회사 프롬바이오 펙틴과 알라닌을 이용한 세포 동결 보존용 조성물 및 이를 이용한 세포 동결 보존 방법
CN119630798A (zh) 2021-11-25 2025-03-14 西米德医学研究所 益生菌质粒和其用途
CN114292788A (zh) * 2021-12-30 2022-04-08 江苏德禧生物科技有限公司 一种活性益生菌冷冻干燥的制备方法
CN114451485B (zh) * 2022-01-26 2022-12-30 江苏省淡水水产研究所 中药多糖提取物冻干保护剂、直投发酵剂及其制备方法
WO2023201258A2 (en) * 2022-04-12 2023-10-19 Avenge Bio, Inc. Encapsulated cells and methods of preserving thereof
CN115024310B (zh) * 2022-07-19 2024-06-18 首都医科大学宣武医院 一种细胞冻干保存剂及其制备方法
CN116784452A (zh) * 2023-05-04 2023-09-22 河北同福健康产业有限公司 一种老面馒头复合发酵菌及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002000248A (ja) 2000-06-23 2002-01-08 Daiichi Kagaku Kk 凍結法及び凍結乾燥法
KR100361357B1 (ko) 1993-09-15 2004-12-30 오가노제네시스, 인코오포레이티드 배양된 조직등가물의 동결보존법
WO2010124387A1 (en) * 2009-05-01 2010-11-04 Micropharma Limited Bacterial compositions for prophylaxis and treatment of degenerative disease

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071741A (en) * 1988-04-18 1991-12-10 Cryolife, Inc. Cryoprotective agent and its use in cryopreservation of cellular matter
US5217860A (en) * 1991-07-08 1993-06-08 The American National Red Cross Method for preserving organs for transplantation by vitrification
US5595866A (en) * 1994-05-27 1997-01-21 Methodist Hospital Of Indiana, Inc. Step-wise method to remove cryoprotectant from sperm
US20060246414A1 (en) * 2005-04-28 2006-11-02 Livestock Research Institute, Council Of Agriculture Method for microdrop vitrification of cells
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
AU2009313870B2 (en) 2008-11-14 2013-07-11 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
US20100311036A1 (en) * 2009-06-09 2010-12-09 University Of South Carolina Methods for Augmentation of Cell Cryopreservation
NZ613473A (en) * 2011-01-25 2015-05-29 Austrianova Singapore Pte Ltd Protection of microbial cells from acidic degradation
SG10201609078TA (en) * 2011-12-07 2016-12-29 Asahi Group Holdings Ltd Lipid Metabolism And/Or Sugar Metabolism Improver Containing Lactic Acid Bacterium Or Treatment Product Thereof
CN102586148B (zh) * 2012-02-28 2013-05-08 江南大学 一种能够缓解铅毒性的植物乳杆菌及其用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100361357B1 (ko) 1993-09-15 2004-12-30 오가노제네시스, 인코오포레이티드 배양된 조직등가물의 동결보존법
JP2002000248A (ja) 2000-06-23 2002-01-08 Daiichi Kagaku Kk 凍結法及び凍結乾燥法
WO2010124387A1 (en) * 2009-05-01 2010-11-04 Micropharma Limited Bacterial compositions for prophylaxis and treatment of degenerative disease

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