KR102214419B1 - 벌집형 반응튜브 - Google Patents

벌집형 반응튜브 Download PDF

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KR102214419B1
KR102214419B1 KR1020157010847A KR20157010847A KR102214419B1 KR 102214419 B1 KR102214419 B1 KR 102214419B1 KR 1020157010847 A KR1020157010847 A KR 1020157010847A KR 20157010847 A KR20157010847 A KR 20157010847A KR 102214419 B1 KR102214419 B1 KR 102214419B1
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fluid
well
reaction tube
chamber
substrate
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KR20150067222A (ko
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유-민 챵
도그 도리티
더스틴 디켄스
제니퍼 글라스
루엘 반 아타
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세페이드
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • C12M1/36Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
    • C12M1/38Temperature-responsive control
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0642Filling fluids into wells by specific techniques
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0673Handling of plugs of fluid surrounded by immiscible fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0636Integrated biosensor, microarrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0819Microarrays; Biochips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Food Science & Technology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • External Artificial Organs (AREA)
KR1020157010847A 2012-09-26 2013-09-26 벌집형 반응튜브 Active KR102214419B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261706115P 2012-09-26 2012-09-26
US61/706,115 2012-09-26
US13/843,739 2013-03-15
US13/843,739 US9914968B2 (en) 2012-09-26 2013-03-15 Honeycomb tube
PCT/US2013/062042 WO2014052671A1 (en) 2012-09-26 2013-09-26 Honeycomb tube

Publications (2)

Publication Number Publication Date
KR20150067222A KR20150067222A (ko) 2015-06-17
KR102214419B1 true KR102214419B1 (ko) 2021-02-08

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Country Status (12)

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US (10) US9914968B2 (enExample)
JP (2) JP6525877B2 (enExample)
KR (1) KR102214419B1 (enExample)
CN (2) CN105051546A (enExample)
AP (1) AP2015008394A0 (enExample)
AU (1) AU2013323428B2 (enExample)
BR (1) BR112015006566B1 (enExample)
CA (1) CA2886484C (enExample)
EA (1) EA031989B1 (enExample)
MX (1) MX363399B (enExample)
WO (1) WO2014052671A1 (enExample)
ZA (1) ZA201502463B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108587867B (zh) 2012-05-25 2021-12-17 北卡罗来纳-查佩尔山大学 微流体装置、用于试剂的固体支持体和相关方法
US9914968B2 (en) 2012-09-26 2018-03-13 Cepheid Honeycomb tube
SG2012075792A (en) * 2012-10-09 2014-05-29 Jn Medsys Pte Ltd An improved device and method
BR112015023079B1 (pt) * 2013-03-15 2020-12-29 Cepheid aparelho
US11028432B2 (en) * 2013-11-05 2021-06-08 Biofire Diagnostics, Llc Induction PCR
EP3207472B1 (en) 2014-10-16 2024-11-27 Cepheid Biosecurity screening system and method
RU2712610C2 (ru) * 2015-04-03 2020-01-29 Эбботт Лэборетриз Устройства и способы для анализа образца
CN108025304B (zh) * 2015-07-22 2022-01-21 北卡罗来纳-查佩尔山大学 含有具有空间分离的珠保留和信号检测段的珠孔几何结构的流体装置和相关方法
US10797567B2 (en) * 2015-07-23 2020-10-06 Life Technologies Corporation Rotor assembly including a housing for a sensor array component and methods for using same
HK1252768A1 (zh) 2015-07-24 2019-05-31 塞弗德公司 分子诊断化验系统
JP6808940B2 (ja) * 2016-01-29 2021-01-06 凸版印刷株式会社 アレイデバイス、生体分子解析用キット及び溶媒の封止方法
GB2554377A (en) * 2016-09-23 2018-04-04 Dnanudge Ltd Method and apparatus for analysing a biological sample
KR101997116B1 (ko) * 2016-10-14 2019-07-05 연세대학교 산학협력단 Kras 유전자에 상보적인 가이드 rna 및 이의 용도
WO2018136861A1 (en) * 2017-01-23 2018-07-26 America Diagnosis, Inc. Direct quantitative pcr device and method of use thereof
CN110769925A (zh) * 2017-03-29 2020-02-07 康奈尔大学 使用组合的核酸酶、连结酶、聚合酶以及测序反应测定核酸序列、表达、拷贝数或甲基化变化的装置、方法以及系统
WO2018185871A1 (ja) * 2017-04-05 2018-10-11 株式会社日立ハイテクノロジーズ 核酸増幅方法および核酸解析用装置
WO2019131592A1 (ja) * 2017-12-26 2019-07-04 凸版印刷株式会社 標的分子の検出における偽陰性判定の発生を抑制する方法および検出デバイス
PL425106A1 (pl) 2018-03-30 2019-10-07 Bacteromic Spółka Z Ograniczoną Odpowiedzialnością Chip mikroprzepływowy
CN111218383B (zh) * 2018-11-26 2025-09-09 杭州比格飞序生物科技有限公司 一种核酸提取装置及其方法
EP3897981B1 (en) * 2018-12-20 2023-06-07 Imec VZW Addressable micro-reaction chamber array
EP3941630B1 (en) * 2019-03-18 2025-04-16 Cellular Research, Inc. Precise delivery of components into fluids
US20220170071A1 (en) 2019-03-21 2022-06-02 Sherlock Biosciences, Inc. System
JP7280101B2 (ja) 2019-04-23 2023-05-23 株式会社日立製作所 測定セル製造方法、測定セル
CN119955908A (zh) * 2019-05-08 2025-05-09 Dnae诊断有限公司 组合的液相和固相dna扩增
CN113892035B (zh) * 2019-05-30 2025-05-09 凸版印刷株式会社 向孔中导入液体的方法
US10820847B1 (en) 2019-08-15 2020-11-03 Talis Biomedical Corporation Diagnostic system
US12054320B2 (en) 2019-09-23 2024-08-06 Cepheid Multi-chambered lid apparatus with reagent port
BR112022005373A2 (pt) * 2019-09-23 2022-06-14 Cepheid Aparelho de tampa de múltiplas câmaras com porta de reagente
US11254979B2 (en) 2020-06-01 2022-02-22 Shaheen Innovations Holding Limited Systems and devices for infectious disease screening
US11730193B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Hookah device
CN111190021B (zh) * 2020-02-22 2023-08-11 武汉泰沃科技有限责任公司 一种生物样品处理盒
WO2021245390A1 (en) 2020-06-01 2021-12-09 Shaheen Innovations Holding Limited An infectious disease screening system
GB2635034B (en) 2020-06-01 2025-09-03 Shaheen Innovations Holding Ltd An infectious disease screening device
KR20230058722A (ko) * 2020-09-29 2023-05-03 주식회사 씨젠 핵산 반응 챔버, 이를 이용한 핵산 반응 방법 및 이를 포함하는 샘플 처리용 카트리지
AU2022207990A1 (en) 2021-01-13 2023-08-17 Cepheid Lossy mechatronic systems and methods of estimation
CN115836222A (zh) * 2021-05-27 2023-03-21 京东方科技集团股份有限公司 检测芯片及其制备方法和进样方法
CN118234564A (zh) * 2021-07-09 2024-06-21 塞弗德公司 高级多路复用反应容器、试剂点样装置和相关方法
JP2024531451A (ja) * 2021-08-25 2024-08-29 インテグリス・インコーポレーテッド 剛性フレームバッグ
WO2024263523A1 (en) 2023-06-21 2024-12-26 Cepheid Real-time monitoring of liquid temperature

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060263242A1 (en) 2005-04-28 2006-11-23 Fuji Photo Film Co., Ltd. Microchip and analysis method using the same
JP2011506998A (ja) 2007-12-17 2011-03-03 ハイ−チング ゴング マイクロ流体デバイス

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5168038A (en) 1988-06-17 1992-12-01 The Board Of Trustees Of The Leland Stanford Junior University In situ transcription in cells and tissues
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
JPH03126208A (ja) 1989-10-11 1991-05-29 Nippon Chemicon Corp 電解コンデンサ用電解液
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
SE9002579D0 (sv) * 1990-08-07 1990-08-07 Pharmacia Ab Method and apparatus for carrying out biochemical reactions
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
JP3080178B2 (ja) 1991-02-18 2000-08-21 東洋紡績株式会社 核酸配列の増幅方法およびそのための試薬キット
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
DK1179600T3 (da) 1996-06-04 2005-09-05 Univ Utah Res Found Overvågning af hybridisering under PCR
GB9620934D0 (en) * 1996-10-08 1996-11-27 Molecular Drives Limited Multi-well containers
US6818185B1 (en) * 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US6403037B1 (en) * 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
CA2311622A1 (en) * 2000-06-15 2001-12-15 Moussa Hoummady Sub-nanoliter liquid drop dispensing system and method therefor
US8048386B2 (en) 2002-02-25 2011-11-01 Cepheid Fluid processing and control
CA2425476C (en) 2000-10-10 2011-02-01 Biotrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
US20080202927A1 (en) * 2000-11-03 2008-08-28 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
GB0321158D0 (en) * 2003-09-10 2003-10-08 Central Research Lab Ltd Apparatus and method for handling cells,embryos or oocytes
CN1942590B (zh) 2004-02-18 2012-09-05 周小川 多元化学和生化反应的流体装置和方法
US7414118B1 (en) 2004-04-14 2008-08-19 Applied Biosystems Inc. Modified oligonucleotides and applications thereof
MXPA06014185A (es) 2004-06-07 2007-04-16 Strides Arcolab Ltd Composicion farmaceutica que contiene una solucion estable y clara de medicamento anti-inflmatorio en capsulas de gelatina blanda, y proceso para producirlo.
US7473533B2 (en) 2004-12-30 2009-01-06 Corning Incorporated Membrane arrays and methods of manufacture
GB2423710A (en) 2005-03-01 2006-09-06 Boots Healthcare Int Ltd Lozenge production process
WO2007002588A2 (en) * 2005-06-23 2007-01-04 Applera Corporation Thermal-cycling pipette tip
JP4878601B2 (ja) * 2005-10-13 2012-02-15 日水製薬株式会社 試験デバイス
CN103622926A (zh) 2005-11-02 2014-03-12 帝国制药美国公司 感官上可接受的布洛芬口服给药制剂、制备和使用它的方法
US8900828B2 (en) 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
US8119352B2 (en) 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
US8187557B2 (en) 2006-07-13 2012-05-29 Cepheid Reagent reservoir system for analytical instruments
JP3126208U (ja) * 2006-08-04 2006-10-19 株式会社島津製作所 示差屈折率検出器及び液体クロマトグラフ。
US20080108122A1 (en) 2006-09-01 2008-05-08 State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon Microchemical nanofactories
US20090093374A1 (en) * 2007-01-25 2009-04-09 Kahp-Yang Suh Method of arraying cells at single-cell level inside microfluidic channel and method of analysing cells using the same, and cell analysis chip used for carrying out the same
EP2152893B1 (en) 2007-06-11 2014-02-26 Wako Pure Chemical Industries, Ltd. Method for nucleic acid amplification using a microchip PCR with integrated real-time CE detection
NL1036865C2 (en) 2009-04-16 2010-10-19 Maxi Miliaan Bv Child vehicle seat.
JP5881936B2 (ja) * 2009-04-20 2016-03-09 ソニー株式会社 試料溶液導入キット及び試料溶液注入器
US20130004967A1 (en) * 2009-11-23 2013-01-03 Halverson Kurt J Microwell array articles and methods of use
DE102010041478A1 (de) 2010-09-27 2012-03-29 Zumtobel Lighting Gmbh Anordnung zur gerichteten Lichtabgabe
EP2441520A1 (en) 2010-10-12 2012-04-18 Eppendorf AG Real-time amplification and micro-array based detection of nucleic acid targets in a flow chip assay
US8968684B2 (en) * 2011-04-28 2015-03-03 Bin Lian Microplates, reaction modules and detection systems
US9095852B2 (en) * 2011-08-22 2015-08-04 The Regents Of The University Of California Multilayer high density microwells
GB201118774D0 (en) * 2011-10-31 2011-12-14 British American Tobacco Co Fluid distribution in an exposure device
US9808798B2 (en) * 2012-04-20 2017-11-07 California Institute Of Technology Fluidic devices for biospecimen preservation
US9914968B2 (en) 2012-09-26 2018-03-13 Cepheid Honeycomb tube
WO2015116627A1 (en) * 2014-01-29 2015-08-06 Arizona Board Of Regents On Behalf Of Arizona State University Microreactor array platform
WO2015143442A2 (en) * 2014-03-21 2015-09-24 The Trustees Of Columbia University In The City Of New York Methods and devices for selection and isolation of aptamers
CA3029276C (en) * 2016-10-05 2023-03-07 Abbott Laboratories Devices and methods for sample analysis
JP7575189B2 (ja) * 2017-11-17 2024-10-29 Toppanホールディングス株式会社 標的分子の検出方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060263242A1 (en) 2005-04-28 2006-11-23 Fuji Photo Film Co., Ltd. Microchip and analysis method using the same
JP2011506998A (ja) 2007-12-17 2011-03-03 ハイ−チング ゴング マイクロ流体デバイス

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