KR102200906B1 - Composition for preventing hair loss or promoting hair growth comprising a plant extract from which chlorophyll or pigment is removed and the manufacturing methods - Google Patents
Composition for preventing hair loss or promoting hair growth comprising a plant extract from which chlorophyll or pigment is removed and the manufacturing methods Download PDFInfo
- Publication number
- KR102200906B1 KR102200906B1 KR1020190047113A KR20190047113A KR102200906B1 KR 102200906 B1 KR102200906 B1 KR 102200906B1 KR 1020190047113 A KR1020190047113 A KR 1020190047113A KR 20190047113 A KR20190047113 A KR 20190047113A KR 102200906 B1 KR102200906 B1 KR 102200906B1
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- KR
- South Korea
- Prior art keywords
- extract
- floral water
- chlorophyll
- leaves
- water extracted
- Prior art date
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Abstract
본 발명에 따른 본 발명은 호장근(Polygonum cuspidatum) 추출물, 동백나무(Camellia japonica) 잎 추출물, 및 개똥쑥(Artemisia annua) 추출물을 유효성분으로 포함하고, 녹차(Camellia sinensis) 잎 추출물, 편백나무(Chamaecyparis obtusa) 잎 추출물 및 어성초(Houttuynia cordata) 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 추가로 함유하는 탈모 억제 또는 발모 촉진용 조성물은 탈모 억제 또는 발모 촉진 효과가 우수함과 동시에 안전성이 높고 부작용이 없으므로, 상기 추출물을 탈모 억제 또는 발모 촉진용 조성물로 유용하게 이용할 수 있다.The present invention No. muscle (Polygonum cuspidatum) extract, camellia (Camellia japonica) leaf extract, and firefly wormwood (Artemisia annua) containing the extract as an active ingredient, and green tea (Camellia sinensis) leaves extract, cypress in accordance with the present invention ( Chamaecyparis obtusa ) leaf extract and Houttuynia cordata ( Houttuynia cordata ) The composition for inhibiting hair loss or promoting hair growth further containing one or more extracts selected from the group consisting of leaf extract is excellent in inhibiting hair loss or promoting hair growth, and at the same time has high safety and side effects Therefore, the extract can be usefully used as a composition for inhibiting hair loss or promoting hair growth.
Description
본 발명은 엽록소 또는 색소가 제거된 호장근(Polygonum cuspidatum) 추출물, 동백나무(Camellia japonica) 잎 추출물, 및 개똥쑥(Artemisia annua) 추출물을 유효성분으로 포함하고, 녹차(Camellia sinensis) 잎 추출물, 편백나무(Chamaecyparis obtusa) 잎 추출물 및 어성초(Houttuynia cordata) 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 추가로 함유하는 탈모 억제 또는 발모 촉진용 조성물 및 이의 제조방법에 관한 것이다.The present invention contains chlorophyll or pigment-removed polygonum cuspidatum extract, Camellia japonica leaf extract, and Artemisia annua extract as active ingredients, and green tea ( Camellia sinensis ) leaf extract, cypress Tree (Chamaecyparis obtusa) leaf extract and Eoseongcho ( Houttuynia cordata ) It relates to a composition for inhibiting hair loss or promoting hair growth further containing one or more extracts selected from the group consisting of leaf extract, and a method for preparing the same.
두피는 표피(Epidermis), 진피(Dermis) 및 피하조직(Subcutaneous tissue)으로 구성되어 있으며, 가장 바깥조직인 표피는 신체의 민감한 조직이 손상 받지 않도록 보호해주는 기능을 한다. 그러나 두피에 영향을 미치는 환경적인 요소, 예컨대, 온도 변화, 습도 변화, 공해물질 노출 등의 외부 자극으로 인한 스트레스 및 영향 결핍 등으로 인해 두피 기능이 상실될 수 있으며, 탈모 현상에도 영향을 미칠 수 있다.The scalp is composed of epidermis, dermis, and subcutaneous tissue, and the outermost tissue, the epidermis, functions to protect sensitive tissues of the body from damage. However, the scalp function may be lost due to environmental factors affecting the scalp, such as stress and lack of influence due to external stimuli such as temperature change, humidity change, exposure to pollutants, etc., and may affect hair loss. .
탈모와 연관되는 조직으로는 피지선(Sebaceous gland), 표피 및 모낭의 각화세포(Keratinocytes), 모유두 세포(Dermal papilla cell), 한선(Sweat gland), 모근초(Root sheath of the scalp hair follicle) 등이 있다.Tissues associated with hair loss include sebaceous gland, epidermis and hair follicle keratinocytes, dermal papilla cells, sweat gland, root sheath of the scalp hair follicle, etc. have.
남성의 형질발현에 있어서, 골격근 증가, 정자 형성 등은 테스토스테론(Testosterone)이 관여하고 여드름, 피지 증가, 탈모 및 전립선비대증 등은 다이하이드로테스토스테론(Dihydrotestosterone, DHT)이 해당 조직에서 관여하는 것으로 알려져 있다(Thiboutot et al., J. Invest. Dermatol., 105(2):2019-14, 1995).In the expression of men, it is known that testosterone is involved in skeletal muscle growth and sperm formation, and dihydrotestosterone (DHT) is involved in acne, sebum increase, hair loss, and prostatic hypertrophy in the tissues ( Thiboutot et al., J. Invest.Dermatol ., 105(2):2019-14, 1995).
남성형 탈모증은 테스토스테론이라는 남성호르몬에 의해 나타나는 현상으로 이 테스토스테론이 5-알파-리덕타아제(5α-reductase)라는 효소에 의해 더 강력한 호르몬인 다이하이드로테스토스테론으로 바뀌게 되면, 이 호르몬이 모낭에 작용하여 모낭을 성장기 단계에서 퇴화기 단계로 유도하여 탈모가 일어나게 한다. 따라서, 남성형 탈모증을 치료하기 위하여 5-알파-리덕타아제에 의한 DHT의 생성을 억제하는 방법이 주로 사용된다.Androgenetic alopecia is a phenomenon caused by a male hormone called testosterone. When this testosterone is converted into dihydrotestosterone, a more powerful hormone by an enzyme called 5α-reductase, this hormone acts on the hair follicles and It induces hair loss from the growth stage to the degenerative stage. Therefore, a method of inhibiting the production of DHT by 5-alpha-reductase is mainly used to treat androgenetic alopecia.
한편, 5-알파-리덕타아제 억제제인 피나스테라이드(Finasteride)는 탈모환자의 탈모 호르몬 DHT를 감소시켜 탈모를 개선시킨다는 것이 밝혀진 바 있는데(Van Neste et al., 2000), 이를 통해 5-알파-리덕타아제가 탈모 치료를 위한 중요한 타겟으로 탈모 치료제 개발에 이용되고 있으며, 테스토스테론에서 다이하이드로테스토스테론의 반응에 관여하는 생체 효소인 5-알파-리덕타아제의 활성을 저해함으로서 탈모증을 치료하는 약리활성 물질을 찾는 연구가 많이 이루어지고 있다.Meanwhile, finasteride, a 5-alpha-reductase inhibitor, has been found to improve hair loss by reducing the hair loss hormone DHT in hair loss patients (Van Neste et al., 2000), through which 5-alpha-reductase has been found. Tase is an important target for the treatment of hair loss and is used in the development of a hair loss treatment, and it is a pharmacologically active substance that treats alopecia by inhibiting the activity of 5-alpha-reductase, a biological enzyme involved in the reaction of dihydrotestosterone from testosterone. There is a lot of research to find.
여성형 탈모증은 주로 폐경기 이후 에스트로겐 양의 감소 때문에 발생한다. 여성형 탈모증을 위한 치료제로는 주로 미녹시딜(Minoxidil)이나 에스트로겐이 사용되고 있다. 원형 탈모증은 자가면역질환이나 정신적 스트레스, 유전적 소인에 의해 발생한다. 이러한 원형 탈모증은 안드로겐성 탈모증과는 근본적으로 원인이 다르며, 치료법 또한 달라서 부신피질 호르몬제를 처리하는 방법을 사용하거나, 미녹시딜을 환부에 바르거나 인위적으로 환부에 자극을 유발하는 방법을 사용한다.Gynecomastia occurs primarily due to a decrease in the amount of estrogen after menopause. Minoxidil or estrogen is mainly used as a treatment for gynecomastia. Alopecia areata is caused by autoimmune diseases, mental stress, or genetic predisposition. Such alopecia areata has a fundamentally different cause from androgenetic alopecia, and treatment is also different, so a method of treating adrenocorticosteroids, applying minoxidil to the affected area, or artificially inducing irritation to the affected area is used.
이와 같이 복합적인 탈모 원인에 대하여, 혈액 순환 촉진, 남성 호르몬 작용 억제, 모근 기능 강화 등을 목적으로 하는 성분 등이 시중에 제품으로 판매되고 있으나, 뚜렷한 효과를 지닌 것은 아직까지 없는 상태이고 부작용의 문제가 제기되기도 한다. 예를 들어, 미녹시딜의 경우 끈적이는 사용감과 피부에 자극을 유발하는 부작용이 보고된 바 있으며, 피나스테라이드의 경우 현재 경구투여용 제제로 사용되고 있으나, 이의 섭취에 따라 성기능 장애 등의 부작용이 보고되었을 뿐 아니라, 경구복용에 의해서만 효과를 기대할 수 있어 사용상에 많은 불편함이 있었다.For such complex causes of hair loss, components aimed at promoting blood circulation, inhibiting male hormone action, and strengthening hair root function are sold as products on the market, but there is no clear effect yet, and there is a problem of side effects. May be raised. For example, in the case of minoxidil, side effects that cause sticky feeling and skin irritation have been reported, and finasteride is currently used as a formulation for oral administration, but side effects such as sexual dysfunction have been reported according to its intake. Since the effect can be expected only by oral administration, there were many inconveniences in use.
이러한 탈모의 예방 및 치료를 위하여, 호르몬 대체요법이 가장 효과적인 방법으로 사용되고 있다. 그러나 에스트로겐과 같은 호르몬을 장기 투여하는 경우에는 유방암, 자궁암 등의 발암 위험성이 있고, 두통, 체중 증가와 같은 부작용 등이 발생하는 문제점이 있다.For the prevention and treatment of such hair loss, hormone replacement therapy has been used as the most effective method. However, when a hormone such as estrogen is administered for a long time, there is a risk of cancer such as breast cancer and uterine cancer, and side effects such as headache and weight gain occur.
이에, 본 발명자들은 탈모 억제 또는 발모 촉진 효과가 우수함과 동시에 안전성이 높고 부작용이 없는 식물 추출물을 연구하던 중, 호장근, 동백나무 잎, 개똥쑥, 녹차 잎, 편백나무 잎 및 어성초 잎의 추출물이 탈모 억제 또는 발모 촉진 효과가 있음을 확인하고, 이에 본 발명을 완성하였다.Accordingly, the present inventors were studying plant extracts having excellent safety and no side effects while inhibiting hair loss or promoting hair growth, and extracts of Hojanggeun, Camellia leaf, Mugwort, Green tea leaf, Cypress leaf and Eoseongcho leaf It was confirmed that there is an effect of inhibiting hair loss or promoting hair growth, and thus the present invention was completed.
본 발명은 탈모 억제 또는 발모 촉진 효과가 우수함과 동시에 안전성이 높고 부작용이 없는 탈모 억제 또는 발모 촉진용 조성물 및 이의 제조방법을 제공하기 위한 것이다.An object of the present invention is to provide a composition for inhibiting hair loss or promoting hair growth, and a method for producing the same, which is excellent in inhibiting hair loss or promoting hair growth, and has high safety and no side effects.
상기 목적을 달성하기 위하여, 본 발명은 호장근(Polygonum cuspidatum) 추출물, 동백나무(Camellia japonica) 잎 추출물, 및 개똥쑥(Artemisia annua) 추출물을 유효성분으로 포함하고, 녹차(Camellia sinensis) 잎 추출물, 편백나무(Chamaecyparis obtusa) 잎 추출물 및 어성초(Houttuynia cordata) 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 추가로 함유하는 탈모 억제 또는 발모 촉진용 조성물 및 이의 제조방법을 제공한다.In order to achieve the above object, the present invention No. muscle (Polygonum cuspidatum) extract, camellia (Camellia japonica) leaf extract, and firefly wormwood (Artemisia annua) containing the extract as an active ingredient, and green tea (Camellia sinensis) leaf extract, Cypress tree (Chamaecyparis obtusa) leaf extract and Eoseongcho ( Houttuynia cordata ) provides a composition for inhibiting hair loss or promoting hair growth, and a method for preparing the same, further containing at least one extract selected from the group consisting of leaf extract.
본 발명에 따른 호장근(Polygonum cuspidatum) 추출물, 동백나무(Camellia japonica) 잎 추출물, 및 개똥쑥(Artemisia annua) 추출물을 유효성분으로 포함하고, 녹차(Camellia sinensis) 잎 추출물, 편백나무(Chamaecyparis obtusa) 잎 추출물 및 어성초(Houttuynia cordata) 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 추가로 함유하는 탈모 억제 또는 발모 촉진용 조성물은 탈모 억제 또는 발모 촉진 효과가 우수함과 동시에 안전성이 높고 부작용이 없으므로, 상기 추출물을 탈모 억제 또는 발모 촉진용 조성물로 유용하게 이용할 수 있다. Polygonum cuspidatum extract according to the present invention, Camellia japonica leaf extract, and artemisia annua extract as active ingredients, green tea ( Camellia sinensis ) leaf extract, cypress tree (Chamaecyparis obtusa) The composition for inhibiting hair loss or promoting hair growth further containing one or more extracts selected from the group consisting of leaf extract and Houttuynia cordata leaf extract is excellent in inhibiting hair loss or promoting hair growth, and at the same time has high safety and no side effects. The extract can be usefully used as a composition for inhibiting hair loss or promoting hair growth.
도 1은 식물 추출물에서 엽록소 및 색소를 제거하는 공정을 나타낸 도이다.
도 2는 실시예 <3-1>에 따라 제조한 색소를 제거한 호장근 추출물을 나타낸 도이다.
도 3은 실시예 <3-2>에 따라 제조한 엽록소를 제거한 동백나무 잎 추출물을 나타낸 도이다.
도 4는 실시예 <3-3>에 따라 제조한 엽록소를 제거한 개똥쑥 추출물을 나타낸 도이다.
도 5는 실시예 <3-4>에 따라 제조한 엽록소를 제거한 녹차 잎 추출물을 나타낸 도이다.
도 6은 실시예 <3-5>에 따라 제조한 엽록소를 제거한 편백나무 잎 추출물을 나타낸 도이다.
도 7은 실시예 <3-6>에 따라 제조한 엽록소를 제거한 어성초 잎 추출물을 나타낸 도이다.
도 8은 <제조예 1>에 따라 제조한 미스트 형태의 탈모 억제 또는 발모 촉진용 조성물을 나타낸 도이다.
도 9는 <제조예 2>에 따라 제조한 샴푸 형태의 탈모 억제 또는 발모 촉진용 조성물을 나타낸 도이다.
도 10은 <제조예 1> 및 <제조예 2>에 따라 제조한 미스트 및 샴푸를 2016년 3월부터 2019년 3월까지 총 3년에 걸쳐 사용한 사용자 1의 광범위한 원형 탈모 부위인 정수리에 새로운 모발이 생성된 상태를 나타낸 도이다.
도 11은 <제조예 1> 및 <제조예 2>에 따라 제조한 샴푸를 2017년 2월부터 2018년 6월까지 총 16개월에 걸쳐 사용한 사용자 2의 모발 상태를 나타낸 도이다.
도 12는 <제조예 1>에 따라 제조한 미스트를 14개월 동안 사용한 사용자 3의 우측 이마 부위에 생성되지 않았던 모발이 생성된 상태를 나타낸 도이다.
도 13은 <제조예 1>에 따라 제조한 미스트를 14개월 동안 사용한 사용자 3의 좌측 이마 부위에 생성되지 않았던 모발이 생성된 상태를 나타낸 도이다.
도 14는 <제조예 2>에 따라 제조한 샴푸를 약 40일 동안 사용한 사용자 4의 광범위한 탈모 부위에 새로운 모발이 생성된 상태를 나타낸 도이다.
도 15는 <제조예 2>에 따라 제조한 샴푸를 약 40일 동안 사용한 사용자 5의 광범위한 탈모 부위에 새로운 모발이 생성된 상태를 나타낸 도이다.
도 16은 <제조예 2>에 따라 제조한 샴푸를 사용한 사용자 6의 모공 상태를 나타낸 도이다.
도 17은 <제조예 2>에 따라 제조한 샴푸를 사용한 사용자 7의 모공 상태를 나타낸 도이다.1 is a diagram showing a process of removing chlorophyll and pigment from a plant extract.
Figure 2 is a diagram showing the extract prepared in Example <3-1> from which the pigment was removed.
3 is a view showing a camellia leaf extract from which chlorophyll has been removed prepared according to Example <3-2>.
Figure 4 is a diagram showing a wormwood extract prepared according to Example <3-3> from which chlorophyll was removed.
5 is a diagram showing a green tea leaf extract from which chlorophyll is removed prepared according to Example <3-4>.
6 is a view showing a cypress leaf extract from which chlorophyll was removed prepared according to Example <3-5>.
7 is a diagram showing a leaf extract of Eoseongcho from which chlorophyll was removed prepared according to Example <3-6>.
8 is a diagram showing a composition for inhibiting hair loss or promoting hair growth in the form of a mist prepared according to <Preparation Example 1>.
9 is a diagram showing a composition for inhibiting hair loss or promoting hair growth in the form of a shampoo prepared according to <Preparation Example 2>.
FIG. 10 shows new hair on the crown, which is a wide range of circular hair loss sites of User 1, who used the mist and shampoo prepared according to <Preparation Example 1> and <Preparation Example 2> for a total of 3 years from March 2016 to March 2019. Is a diagram showing the generated state.
11 is a diagram showing the hair condition of User 2, who used the shampoo prepared according to <Preparation Example 1> and <Preparation Example 2> for a total of 16 months from February 2017 to June 2018.
FIG. 12 is a diagram showing a state in which hair that was not generated on the right forehead of User 3, who used the mist prepared according to <Production Example 1> for 14 months, was generated.
FIG. 13 is a diagram showing a state in which hair that was not generated on the left forehead of User 3, who used the mist prepared according to <Production Example 1> for 14 months, was generated.
14 is a diagram showing a state in which new hair was generated in a wide range of hair loss sites of User 4, who used the shampoo prepared according to <Production Example 2> for about 40 days.
15 is a diagram showing a state in which new hair is generated in a wide range of hair loss sites of User 5, who has used the shampoo prepared according to <Production Example 2> for about 40 days.
FIG. 16 is a diagram showing the state of pores of User 6 using the shampoo prepared according to <Preparation Example 2>.
17 is a diagram showing the pores of User 7 who used the shampoo prepared according to <Production Example 2>.
이하, 본 발명을 상세히 설명한다.Hereinafter, the present invention will be described in detail.
본 발명은 호장근(Polygonum cuspidatum) 추출물, 동백나무(Camellia japonica) 잎 추출물, 및 개똥쑥(Artemisia annua) 추출물을 유효성분으로 포함하고, 녹차(Camellia sinensis) 잎 추출물, 편백나무(Chamaecyparis obtusa) 잎 추출물 및 어성초(Houttuynia cordata) 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 추가로 함유하는 탈모 억제 또는 발모 촉진용 조성물을 제공한다.The present invention comprises a polygonum cuspidatum extract, Camellia japonica leaf extract, and artemisia annua extract as active ingredients, green tea ( Camellia sinensis ) leaf extract, cypress tree ( Chamaecyparis obtusa ) leaf It provides a composition for inhibiting hair loss or promoting hair growth further containing one or more extracts selected from the group consisting of extracts and Eoseongcho ( Houttuynia cordata ) leaf extracts.
상기 추출물은 맹종죽 잎에서 추출한 후로랄 워터, 신의대 잎에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터로 구성된 군으로부터 선택되는 1종 이상의 후로랄 워터 및 발효주정으로 구성된 추출용매와 혼합하여 추출된, 엽록소 또는 색소가 제거된 추출물인 것을 특징으로 하는 탈모 억제 또는 발모 촉진종 조성물일 수 있으나, 이에 한정되지 않는다.The extract is chlorophyll extracted by mixing with an extraction solvent consisting of at least one floral water selected from the group consisting of floral water extracted from Maengjongjuk leaves, floral water extracted from Sinuidae leaves, and floral water extracted from cypress leaves, and fermented alcohol. Or it may be a hair loss inhibiting or hair growth promoting species composition, characterized in that the extract from which the pigment has been removed, but is not limited thereto.
상기 호장근 추출물은 색소가 제거된 것이며, 상기 동백나무 잎 추출물, 개똥쑥 추출물, 녹차 잎 추출물, 편백나무 잎 추출물 및 어성초 잎 추출물은 엽록소가 제거된 것이다.The chlorophyll extract has been removed from the pigment, and the camellia leaf extract, mugwort extract, green tea leaf extract, cypress leaf extract, and Eoseongcho leaf extract have chlorophyll removed.
상기 엽록소 또는 색소가 제거된 호장근 추출물, 동백나무 잎 추출물, 개똥쑥 추출물, 녹차 잎 추출물, 편백나무 잎 추출물 및 어성초 잎 추출물은 하기와 같은 단계로 제조되는 것이 바람직하나 이에 한정되지 않는다.The chlorophyll or pigment-removed hojanggeun extract, camellia leaf extract, wormwood extract, green tea leaf extract, cypress leaf extract and Eoseongcho leaf extract are preferably prepared by the following steps, but are not limited thereto.
1) 호장근, 동백나무 잎, 개똥쑥, 녹차 잎, 편백나무 잎 또는 어성초 잎에 추출용매를 가하여 각각 추출하는 단계;1) adding an extraction solvent to the leaves of Hojanggeun, Camellia leaves, Mugwort, green tea leaves, Cypress leaves or Eoseongcho leaves, respectively, and extracting them;
2) 단계 1)의 추출물을 식힌 후 여과하는 단계;2) cooling the extract of step 1) and filtering;
3) 단계 2)의 여과한 추출물을 감압농축하는 단계; 및3) concentrating the filtered extract of step 2) under reduced pressure; And
4) 개똥쑥에서 추출한 후로랄 워터, 녹차 잎에서 추출한 후로랄 워터, 동백나무 잎에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터로 구성된 군으로부터 선택되는 어느 하나 이상의 후로랄 워터를 주정과 혼합한 후, 상기 단계 3)의 감압농축된 추출물에 첨가하거나, 상기 후로랄 워터로 구성된 군으로부터 선택되는 어느 하나 이상의 후로랄 워터를 상기 단계 3)의 감압농축된 추출물에 첨가하여 엽록소 또는 색소를 제거하는 단계.4) It is selected from the group consisting of floral water extracted from wormwood, floral water extracted from green tea leaves, floral water extracted from camellia leaves, floral water extracted from Maengjongjuk, floral water extracted from Shin Medical University, and floral water extracted from cypress leaves. After any one or more of the floral water is mixed with the alcohol, it is added to the vacuum-concentrated extract in step 3), or any one or more floral water selected from the group consisting of the floral water is added to the vacuum-concentrated extract in step 3). Adding to remove chlorophyll or pigment.
상기 방법에 있어서, 단계 1)의 호장근, 동백나무 잎, 개똥쑥, 녹차 잎, 편백나무 잎 또는 어성초 잎은 재배한 것 또는 시판되는 것 등 제한 없이 사용할 수 있다.In the above method, the leaves of the hawthorn, camellia leaves, wormwood wormwood, green tea leaves, cypress leaves or Eoseongcho leaves of step 1) can be used without limitation, such as those grown or commercially available.
상기 단계 1)의 추출용매는 물, 알코올 또는 이들의 혼합물을 사용하는 것이 바람직하나, 이에 한정하지 않는다. 상기 알코올로는 C1 내지 C2의 저급 알코올을 이용하는 것이 바람직하며, 저급 알코올로는 에탄올 또는 메탄올을 이용하는 것이 바람직하나, 이에 한정하지 않는다. 추출방법으로는 진탕 추출 또는 환류 추출을 이용하는 것이 바람직하나 이에 한정하지 않는다. 상기 추출 용매를 녹차 잎, 동백나무 잎 또는 호장근 분량에 2 내지 10 배 첨가하여 추출하는 것이 바람직하나 이에 한정하지 않는다. 추출온도는 상온 내지 50℃인 것이 바람직하나 이에 한정하지 않는다. 또한, 추출시간은 2 내지 5 일인 것이 바람직하나 이에 한정하지 않는다. 아울러, 추출 횟수는 1 내지 3 회인 것이 바람직하나 이에 한정하지 않는다.The extraction solvent of step 1) is preferably water, alcohol, or a mixture thereof, but is not limited thereto. It is preferable to use a lower alcohol of C 1 to C 2 as the alcohol, and it is preferable to use ethanol or methanol as the lower alcohol, but is not limited thereto. The extraction method is preferably shaking extraction or reflux extraction, but is not limited thereto. It is preferable to extract by adding the extraction solvent 2 to 10 times to the amount of green tea leaves, camellia leaves, or gooseberries, but is not limited thereto. The extraction temperature is preferably from room temperature to 50°C, but is not limited thereto. In addition, the extraction time is preferably 2 to 5 days, but is not limited thereto. In addition, the number of extractions is preferably 1 to 3, but is not limited thereto.
상기 방법에 있어서, 단계 3)의 감압농축은 진공감압농축기 또는 진공회전증발기를 이용하는 것이 바람직하나 이에 한정하지 않는다.In the above method, the vacuum concentration in step 3) is preferably a vacuum vacuum concentrator or a vacuum rotary evaporator, but is not limited thereto.
상기 단계 4)의 개똥쑥에서 추출한 후로랄 워터, 녹차 잎에서 추출한 후로랄 워터, 동백나무 잎에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 또는 편백나무 잎에서 추출한 후로랄 워터는 개똥쑥, 녹차 잎, 동백나무 잎, 맹종죽, 신의대 또는 편백나무 잎을 에센셜오일추출기로 8 시간 이상 각각 추출하여, 엽록소 및 색소 제거용 식물 액상 추출물을 제조하는 것이 바람직하지만, 이에 한정되지 않는다.The floral water extracted from the wormwood in step 4), the floral water extracted from the green tea leaves, the floral water extracted from the camellia leaves, the floral water extracted from Maengjongjuk, the floral water extracted from Shin Medical University or the floral water extracted from cypress leaves , Green tea leaves, camellia leaves, Maengjongjuk, Sinuidae or cypress leaves are extracted for 8 hours or more with an essential oil extractor, respectively, to prepare a plant liquid extract for removing chlorophyll and pigment, but is not limited thereto.
상기 단계 4)의 개똥쑥에서 추출한 후로랄 워터, 녹차 잎에서 추출한 후로랄 워터, 동백나무 잎에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 또는 편백나무 잎에서 추출한 후로랄 워터를 에탄올과 9：1 내지 7：3 비율로 혼합한 후, 상기 단계 3)의 농축된 추출물에 20 내지 25 배 첨가하여 희석한 후, －40 내지－60℃의 동결 조건에서 10 내지 14시간 정치시켜 침전된 엽록소 또는 색소를 분리하는 것이 바람직하지만, 이에 한정되지는 않는다. 상기 방법은 엽록소 또는 색소가 제거된 수용성 및 지용성 식물 추출물을 추출하는 방법이다. The floral water extracted from the wormwood in step 4), the floral water extracted from the green tea leaves, the floral water extracted from the camellia leaves, the floral water extracted from Maengjongjuk, the floral water extracted from Shin Medical University, or the floral water extracted from cypress leaves were mixed with ethanol. After mixing in a ratio of 9:1 to 7:3, it was diluted by adding 20 to 25 times to the concentrated extract of step 3), and then allowed to stand for 10 to 14 hours in freezing conditions at -40 to -60°C to precipitate It is preferable to separate the chlorophyll or pigment, but is not limited thereto. The method is a method of extracting water-soluble and fat-soluble plant extracts from which chlorophyll or pigment has been removed.
또한, 개똥쑥에서 추출한 후로랄 워터, 녹차 잎에서 추출한 후로랄 워터, 동백나무 잎에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 또는 편백나무 잎에서 추출한 후로랄 워터만을 추출용매로 활용하여 상기 단계 3)의 농축된 추출물에 20 내지 25 배 첨가하여 희석한 후, －40 내지－60℃의 동결 조건에서 10 내지 14 시간 정치시켜 침전된 엽록소 또는 색소를 분리하는 것이 바람직하지만, 이에 한정되지 않는다. 상기 방법은 엽록소 또는 색소가 제거된 수용성 식물 추출물을 추출하는 방법이다.In addition, only floral water extracted from wormwood, floral water extracted from green tea leaves, floral water extracted from camellia leaves, floral water extracted from Maengjongjuk, floral water extracted from Shin Medical University or floral water extracted from cypress leaves are used as extraction solvents. It is preferable to separate the precipitated chlorophyll or pigment by adding 20 to 25 times to the concentrated extract of step 3), diluting it, and then allowing it to stand for 10 to 14 hours in freezing conditions at -40 to -60°C, but not limited thereto. Does not. The method is a method of extracting a water-soluble plant extract from which chlorophyll or pigment has been removed.
상기 호장근 추출물은 개똥쑥에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터와 혼합하여 색소가 제거된 호장근 추출물을 제조하는 것이 바람직하지만, 이에 한정되는 것은 아니다.It is preferable to prepare a colorant-removed hojanggeun extract by mixing the extract with floral water extracted from wormwood, floral water extracted from Maengjongjuk, floral water extracted from Shin Medical University, and floral water extracted from cypress leaves. It is not limited.
상기 동백나무 잎 추출물은 개똥쑥에서 추출한 후로랄 워터, 동백나무 잎에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터와 혼합하여 엽록소가 제거된 동백나무 잎 추출물을 제조하는 것이 바람직하지만, 이에 한정되는 것은 아니다.It is preferable to prepare a camellia leaf extract from which chlorophyll has been removed by mixing the camellia leaf extract with floral water extracted from wormwood, floral water extracted from camellia leaves, floral water extracted from Maengjongjuk, and floral water extracted from cypress leaves. However, it is not limited thereto.
상기 개똥쑥 추출물은 개똥쑥에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터와 혼합하여 엽록소가 제거된 개똥쑥 추출물을 제조하는 것이 바람직하지만, 이에 한정되는 것은 아니다.The wormwood extract is preferably mixed with floral water extracted from wormwood, floral water extracted from Maengjongjuk, floral water extracted from Shin Medical University, and floral water extracted from cypress leaves to prepare a wormwood extract from which chlorophyll is removed. It is not limited.
상기 녹차 잎 추출물은 개똥쑥에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터와 혼합하여 엽록소가 제거된 녹차 잎 추출물을 제조하는 것이 바람직하지만, 이에 한정되는 것은 아니다.The green tea leaf extract is preferably mixed with floral water extracted from wormwood, floral water extracted from Maengjongjuk, floral water extracted from Shin Medical University, and floral water extracted from cypress leaves to prepare a green tea leaf extract from which chlorophyll has been removed. It is not limited.
상기 편백나무 잎 추출물은 개똥쑥에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터와 혼합하여 엽록소가 제거된 편백나무 잎 추출물을 제조하는 것이 바람직하지만, 이에 한정되는 것은 아니다.It is preferable to prepare a cypress leaf extract from which chlorophyll is removed by mixing the cypress tree leaf extract with floral water extracted from wormwood, floral water extracted from Maengjongjuk, floral water extracted from Shin Medical University, and floral water extracted from cypress leaves. , But is not limited thereto.
상기 어성초 잎 추출물은 개똥쑥에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터와 혼합하여 엽록소가 제거된 어성초 잎 추출물을 제조하는 것이 바람직하지만, 이에 한정되는 것은 아니다.The Eoseongcho leaf extract is preferably mixed with floral water extracted from wormwood wormwood, floral water extracted from Maengjongjuk, floral water extracted from Sinuidae, and floral water extracted from cypress leaves to prepare Eoseongcho leaf extract from which chlorophyll has been removed. It is not limited.
상기 추출물을 유효성분으로 함유하는 탈모 억제 또는 발모 촉진용 기능성 화장료 조성물을 이용한 화장품 제조 시, 본 발명의 엽록소 또는 색소가 제거된 식물 추출물의 함유 농도는 0.01 내지 5 mg/㎖이다. When manufacturing cosmetics using a functional cosmetic composition for inhibiting hair loss or promoting hair growth containing the extract as an active ingredient, the concentration of the plant extract from which the chlorophyll or pigment of the present invention is removed is 0.01 to 5 mg/ml.
상기 화장료 조성물은, 예를 들면 용액, 겔, 고체 또는 반죽 무수 생성물, 수상에 유상을 분산시켜 얻은 에멀젼, 현탁액, 마이크로에멀젼, 마이크로캡슐, 미세과립구 또는 이온형(리포좀), 비이온형의 소낭 분산제의 형태, 크림, 스킨, 로션, 파우더, 연고, 스프레이 또는 콘실 스틱의 형태로 제공될 수 있다. 또한, 포말(foam)의 형태 또는 압축된 추진제를 더 함유한 에어로졸 조성물의 형태로도 제조될 수 있다.The cosmetic composition may be, for example, a solution, a gel, an anhydrous product of a solid or dough, an emulsion obtained by dispersing an oil phase in an aqueous phase, a suspension, a microemulsion, a microcapsule, a microgranular sphere or an ionic (liposome), a nonionic vesicle dispersant It may be provided in the form of a cream, skin, lotion, powder, ointment, spray or conceal stick. In addition, it may be prepared in the form of a foam or an aerosol composition further containing a compressed propellant.
또한, 상기 화장료 조성물은 본 발명의 엽록소 또는 색소가 제거된 식물 추출물에 추가로 지방 물질, 유기 용매, 용해제, 농축제 및 겔화제, 연화제, 항산화제, 현탁화제, 안정화제, 발포제(foaming agent), 방향제, 계면활성제, 물, 이온형 또는 비이온형 유화제, 충전제, 금속이온봉쇄제, 킬레이트화제, 보존제, 비타민, 차단제, 습윤화제, 필수 오일, 염료, 안료, 친수성 또는 친유성 활성제, 지질 소낭 또는 화장품에 통상적으로 사용되는 임의의 다른 성분과 같은 화장품 분야에서 통상적으로 사용되는 보조제를 함유할 수 있다.In addition, the cosmetic composition is a fatty substance, an organic solvent, a solubilizer, a thickening agent and a gelling agent, an emollient, an antioxidant, a suspending agent, a stabilizer, a foaming agent in addition to the plant extract from which the chlorophyll or pigment of the present invention is removed. , Fragrances, surfactants, water, ionic or nonionic emulsifiers, fillers, sequestering agents, chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles Or it may contain adjuvants commonly used in the field of cosmetics, such as any other ingredients commonly used in cosmetics.
상기 추출물을 유효성분으로 함유하는 탈모 억제 또는 발모 촉진용 의약부외품 조성물일 수 있으나, 이에 한정되지 않는다.It may be a quasi-drug composition for inhibiting hair loss or promoting hair growth containing the extract as an active ingredient, but is not limited thereto.
본 발명에서 사용되는 용어 “의약부외품”은 사람이나 동물의 질병을 진단, 치료, 개선, 경감, 처치 또는 예방할 목적으로 사용하는 물품 중 기구, 기계 또는 장치가 아닌 것 및 사람이나 동물의 구조와 기능에 약리학적 영향을 줄 목적으로 사용하는 물품 중 기구, 기계 또는 장치가 아닌 것을 제외한 물품을 의미하며, 피부 외용제 및 개인위생용품도 포함한다.The term "quasi-drug" used in the present invention refers to items that are not instruments, machines, or devices among items used for the purpose of diagnosing, treating, improving, reducing, treating or preventing diseases of humans or animals, and structures and functions of humans or animals. It refers to items other than instruments, machines, or devices used for the purpose of having a pharmacological effect on the skin, and includes skin preparations and personal hygiene products.
상기 의약부외품 조성물을 탈모의 예방 또는 개선, 발모 또는 육모 촉진을 목적으로 의약외품에 포함시킬 경우, 상기 조성물을 그대로 포함하여 사용하거나 다른 의약외품 성분과 함께 사용할 수 있고, 통상적인 방법에 따라 적절하게 사용할 수 있다. 유효성분의 혼합량은 사용 목적에 따라 적합하게 경정할 수 있다.When the quasi-drug composition is included in a quasi-drug for the purpose of preventing or improving hair loss, promoting hair growth or hair growth, the composition may be used as it is or may be used together with other quasi-drug ingredients, and may be appropriately used according to conventional methods. have. The mixing amount of the active ingredient can be appropriately adjusted according to the purpose of use.
또한, 본 발명의 의약부외품은 특별히 이에 제한되지 않으나, 예를 들어 크림제, 로션제, 에어로졸제, 샴푸제, 젤제 또는 팩제의 형태로 제조되어 사용될 수 있다. 또한, 필요에 따라 안정제, 보존제, 흡수 촉진제, pH 조정제, 그 밖의 적당한 첨가제를 배합할 수 있다.In addition, the quasi-drug product of the present invention is not particularly limited thereto, but may be prepared and used in the form of, for example, a cream, lotion, aerosol, shampoo, gel or pack. Further, if necessary, a stabilizer, a preservative, an absorption accelerator, a pH adjuster, and other suitable additives may be blended.
상기 추출물을 유효성분으로 함유하는 탈모 억제 또는 발모 촉진용 약제학적 조성물일 수 있으나, 이에 한정되지 않는다.It may be a pharmaceutical composition for inhibiting hair loss or promoting hair growth containing the extract as an active ingredient, but is not limited thereto.
상기 약제학적 조성물은 약학적으로 허용 가능한 담체를 포함할 수 있다. 약제학적으로 허용 가능한 담체를 포함하는 상기 조성물은 경구 또는 비경구의 여러 가지 제형일 수 있다. 제제화할 경우에는 보통 사용하는 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제된다. 경구투여를 위한 고형제제에는 정제, 환제, 산제, 과립제, 캡슐제 등이 포함되며, 이러한 고형제제는 하나 이상의 화합물에 적어도 하나 이상의 부형제 예를 들면, 전분, 탄산칼슘, 수크로오스 또는 락토오스, 젤라틴 등을 섞어 조제된다. 또한, 단순한 부형제 이외에 스테아린산 마그네슘, 탈크 등과 같은 윤활제들도 사용될 수 있다. 경구투여를 위한 액상제제로는 현탁제, 내용액제, 유제, 시럽제 등이 해당되는데 흔히 사용되는 단순 희석제인 물, 리퀴드 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제, 보존제 등이 포함될 수 있다. 비경구투여를 위한 제제에는 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결건조제제, 좌제가 포함된다. 비수성용제, 현탁용제로는 프로필렌글리콜(Propylene glycol), 폴리에틸렌 글리콜, 올리브 오일과 같은 식물성 기름, 에틸올레이트와 같은 주사 가능한 에스테르 등이 사용될 수 있다. 좌제의 기제로는 위텝솔(witepsol), 마크로골, 트윈(tween) 61, 카카오지, 라우린지, 글리세로젤라틴 등이 사용될 수 있다.The pharmaceutical composition may contain a pharmaceutically acceptable carrier. The composition comprising a pharmaceutically acceptable carrier may be in various oral or parenteral formulations. In the case of formulation, it is prepared using diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrants, and surfactants that are usually used. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and these solid preparations contain at least one excipient, such as starch, calcium carbonate, sucrose or lactose, gelatin, etc. in one or more compounds. It is prepared by mixing. Further, in addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Liquid preparations for oral administration include suspensions, liquid solutions, emulsions, and syrups.In addition to water and liquid paraffin, which are commonly used simple diluents, various excipients such as humectants, sweeteners, fragrances, and preservatives may be included. have. Preparations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, lyophilized preparations, and suppositories. As the non-aqueous solvent and the suspension solvent, propylene glycol, polyethylene glycol, vegetable oil such as olive oil, and injectable ester such as ethyl oleate may be used. As a base for suppositories, witepsol, macrogol, tween 61, cacao butter, laurin paper, glycerogelatin, and the like may be used.
상기 약제학적 조성물은 정제, 환제, 산제, 과립제, 캡슐제, 현탁제, 내용액제, 유제, 시럽제, 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결건조제제 및 좌제로 이루어진 군으로부터 선택되는 어느 하나의 제형을 가질 수 있다.The pharmaceutical composition is any selected from the group consisting of tablets, pills, powders, granules, capsules, suspensions, solutions, emulsions, syrups, sterilized aqueous solutions, non-aqueous solvents, suspensions, emulsions, freeze-dried preparations, and suppositories. It can have one formulation.
또한, 상기 약제학적 조성물은 약학적으로 유효한 양으로 투여한다. “약학적으로 유효한 양”은 의학적 치료에 적용 가능한 합리적인 수혜/위험 비율로 질환을 치료하기에 충분한 양을 의미하며, 유효 용량 수준은 개체 종류 및 중증도, 연령, 성별, 약물의 활성, 약물에 대한 민감도, 투여 시간, 투여 경로 및 배출 비율, 치료 기간, 동시 사용되는 약물을 포함한 요소 및 기타 의학 분야에 잘 알려진 요소에 따라 결정될 수 있다.In addition, the pharmaceutical composition is administered in a pharmaceutically effective amount. “Pharmaceutically effective amount” means an amount sufficient to treat a disease with a reasonable benefit/risk ratio applicable to medical treatment, and the effective dose level is the type and severity of the subject, age, sex, activity of the drug, and Sensitivity, time of administration, route of administration and rate of excretion, duration of treatment, factors including co-used drugs and other factors well known in the medical field.
아울러, 상기 약제학적 조성물은 개별 치료제로 투여하거나 다른 치료제와 병용하여 투여될 수 있고, 종래의 치료제와 순차적으로 또는 동시에 투여될 수 있다. 그리고 단일 또는 다중 투여될 수 있다. 상기 요소를 모두 고려하여 부작용 없이 최소한의 양으로 최대 효과를 얻을 수 있는 양을 투여하는 것이 중요하며, 당업자에 의해 용이하게 결정될 수 있다.In addition, the pharmaceutical composition may be administered as an individual therapeutic agent or administered in combination with another therapeutic agent, and may be administered sequentially or simultaneously with a conventional therapeutic agent. And can be administered single or multiple. It is important to administer an amount capable of obtaining the maximum effect in a minimum amount without side effects in consideration of all the above factors, and can be easily determined by a person skilled in the art.
또한, 상기 약제학적 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 어떠한 일반적인 경로를 통하여 투여될 수 있다. 목적하는 바에 따라 복강내 투여, 정맥내 투여, 근육내 투여, 피하 투여, 피내 투여, 경구 투여, 비내 투여, 폐내 투여, 직장내 투여될 수 있으나, 이에 제한되지는 않는다.In addition, the route of administration of the pharmaceutical composition may be administered through any general route as long as it can reach the target tissue. As desired, intraperitoneal administration, intravenous administration, intramuscular administration, subcutaneous administration, intradermal administration, oral administration, intranasal administration, intrapulmonary administration, or rectal administration may be performed, but are not limited thereto.
상기 추출물을 유효성분으로 함유하는 탈모 억제 또는 발모 촉진용 건강식품일 수 있으나, 이에 한정되는 것은 아니다.It may be a health food for inhibiting hair loss or promoting hair growth containing the extract as an active ingredient, but is not limited thereto.
본 발명의 엽록소 또는 색소가 제거된 식물 추출물이 첨가되는 식품의 종류에는 특별한 제한은 없다. 상기 물질을 첨가할 수 있는 식품의 예로는 드링크제, 육류, 소시지, 빵, 비스킷, 떡, 초콜릿, 캔디류, 스낵류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 알코올 음료 및 비타민 복합제, 유제품 및 유가공 제품 등이 있으며, 통상적인 의미에서의 건강기능식품을 모두 포함한다.There is no particular limitation on the type of food to which the chlorophyll or pigment-removed plant extract of the present invention is added. Examples of foods to which the above substances can be added include drinks, meat, sausages, bread, biscuits, rice cakes, chocolates, candies, snacks, confectionery, pizza, ramen, other noodles, gum, dairy products including ice cream, various soups, There are beverages, alcoholic beverages and vitamin complexes, dairy products and dairy products, and all health functional foods in the usual sense are included.
본 발명의 엽록소 또는 색소가 제거된 식물 추출물은 식품에 그대로 첨가하거나 다른 식품 또는 식품 성분과 함께 사용될 수 있고, 통상적인 방법에 따라 적절하게 사용될 수 있다. 유효 성분의 혼합량은 그의 사용 목적(예방 또는 개선용)에 따라 적합하게 결정될 수 있다. 일반적으로, 건강기능식품 중의 상기 발효홍삼 농축액의 양은 전체 식품 중량의 0.1 중량부 내지 90 중량부로 가할 수 있다. 그러나 건강 및 위생을 목적으로 하거나 또는 건강 조절을 목적으로 하는 장기간의 섭취의 경우에는 상기 양은 상기 범위 이하일 수 있으며, 안전성 면에서 아무런 문제가 없기 때문에 유효성분은 상기 범위 이상의 양으로도 사용될 수 있다.The plant extract from which the chlorophyll or pigment of the present invention has been removed may be added to food as it is or may be used with other foods or food ingredients, and may be appropriately used according to a conventional method. The mixing amount of the active ingredient may be appropriately determined depending on the purpose of use (for prevention or improvement). In general, the amount of the fermented red ginseng concentrate in the health functional food may be added in an amount of 0.1 to 90 parts by weight of the total food weight. However, in the case of long-term intake for the purpose of health and hygiene or for the purpose of health control, the amount may be less than the above range, and since there is no problem in terms of safety, the active ingredient may be used in an amount above the above range.
본 발명에 따른 건강식품 조성물이 음료 조성물인 경우, 지시된 비율로 필수 성분으로써 상기 추출물을 함유하는 것 이외에는 다른 성분에는 특별한 제한이 없으며 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로써 함유할 수 있다. 상술한 천연 탄수화물의 예는 모노사카라이드, 예를 들어, 포도당, 과당 등; 디사카라이드, 예를 들어 말토스, 슈크로스 등; 및 폴리사카라이드, 예를 들어 덱스트린, 시클로덱스트린 등과 같은 통상적인 당, 및 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 상술한 것 이외의 향미제로서 천연 향미제(타우마틴, 스테비아 추출물(예를 들어 레바우디오시드 A, 글리시르히진 등) 및 합성 향미제(사카린, 아스파르탐 등)를 유리하게 사용할 수 있다. 상기 천연 탄수화물의 비율은 본 발명의 조성물 100 g 당 일반적으로 약 1 내지 20 g, 바람직하게는 약 5 내지 10 g이다.When the health food composition according to the present invention is a beverage composition, there are no special restrictions on other ingredients other than those containing the extract as an essential ingredient in the indicated ratio, and various flavoring agents or natural carbohydrates, etc., as in ordinary beverages, are added as additional ingredients. It can be contained as. Examples of the above-described natural carbohydrates include monosaccharides such as glucose, fructose, and the like; Disaccharides such as maltose, sucrose, and the like; And polysaccharides, for example, common sugars such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. As flavoring agents other than those described above, natural flavoring agents (taumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.)) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The proportion of the natural carbohydrate is generally about 1 to 20 g, preferably about 5 to 10 g per 100 g of the composition of the present invention.
또한, 본 발명에 따른 건강식품 조성물은 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 중진제(치즈, 초콜릿 등), 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산음료에 사용되는 탄산화제 등을 함유할 수 있다. 그 밖에 천연 과일 쥬스 및 과일 쥬스 음료, 및 야채 음료의 제조를 위한 과육을 함유할 수 있다. In addition, the health food composition according to the present invention includes various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic flavoring agents and natural flavoring agents, coloring agents and heavy weight agents (cheese, chocolate, etc.), pectic acid and salts thereof, Alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonates used in carbonated beverages, and the like may be contained. In addition, natural fruit juice and fruit juice beverages, and may contain flesh for the production of vegetable beverages.
본 발명의 구체적인 실시예에서, 본 발명자들은 식물 추출물인 호장근 추출물, 동백나무 잎 추출물, 개똥쑥 추출물, 녹차 잎 추출물, 편백나무 잎 추출물 및 어성초 잎 추출물을 제조하였다.In a specific embodiment of the present invention, the present inventors prepared plant extracts such as Hojanggeun extract, camellia leaf extract, wormwood extract, green tea leaf extract, cypress leaf extract and Eoseongcho leaf extract.
또한, 본 발명자들은 다양한 엽록소 및 색소 제거용 식물 후로랄 워터를 제조하고, 각각의 추출물의 엽록소 및 색소를 유의적으로 분리시키는 최적의 엽록소 및 색소 제거용 식물 후로랄 워터를 확인하여, 호장근 추출물의 색소를 제거하고, 동백나무 잎 추출물, 개똥쑥 추출물, 녹차 잎 추출물, 편백나무 잎 추출물 및 어성초 잎 추출물의 엽록소를 제거하였다.In addition, the present inventors prepared various chlorophyll and pigment removal plant floral water, and identified the optimal chlorophyll and pigment removal plant floral water that significantly separates the chlorophyll and pigment of each extract, Was removed, and the chlorophyll of the Camellia leaf extract, Mugwort extract, green tea leaf extract, cypress leaf extract and Eoseongcho leaf extract were removed.
아울러, 상기 방법으로 제조된 색소가 제거된 호장근 추출물, 엽록소가 제거된 동백나무 잎 및 개똥쑥 추출물을 유효성분으로 포함하고, 엽록소가 제거된 녹차 잎, 편백나무 잎 및 어성초 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 추가로 함유하는 조성물로 미스트, 샴푸 및 건강식품을 제조하였다.In addition, the group consisting of a pigment-removed Hojanggeun extract prepared by the above method, a camellia leaf from which chlorophyll has been removed, and a wormwood extract as active ingredients, and a green tea leaf from which chlorophyll has been removed, a cypress leaf and Eoseongcho leaf extract Mist, shampoo and health food were prepared with a composition further containing one or more extracts selected from.
이하, 본 발명을 실시예, 실험예 및 제조예 의해 상세히 설명한다.Hereinafter, the present invention will be described in detail by Examples, Experimental Examples and Preparation Examples.
단, 하기 실시예, 실험예 및 제조예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 하기 실시예, 실험예 및 제조예에 한정되는 것은 아니다.However, the following Examples, Experimental Examples, and Preparation Examples are merely illustrative of the present invention, and the contents of the present invention are not limited to the following Examples, Experimental Examples, and Preparation Examples.
<실시예 1> 식물 추출물의 제조<Example 1> Preparation of plant extract
<1-1> 호장근 추출물의 제조<1-1> Preparation of Hojanggeun extract
식물에서 주정[발효주정, 대한주정라이프㈜]을 용매로 추출하는 일반적 절차로 녹차 잎 추출물을 제조하였다.Green tea leaf extract was prepared by a general procedure of extracting alcohol [fermented alcohol, Daehan Alcohol Life Co., Ltd.] from plants with a solvent.
구체적으로, 천일약업사로부터 공급받은 세척 건조된 호장근(500 g)에 10 배 주정을 함유시킨 후 침지시키고, 상온에서 72 시간 정치시킨후 국물 팩[중 팩, 25 ㎝ × 35 ㎝, 8P, 티앤씨일레트로닉스㈜]으로 100 ㎛이하 입자들이 통과되게 여과시켰다. 주정을 휘발시키기 위해 일정시간 동안 50℃ 조건에서 감압농축기(CCA-1111, EYELA4)를 이용하여 증류시킨 후 농축시켜, 호장근 추출물을 제조하였다.Specifically, after containing 10 times alcohol in the washed and dried hojanggeun (500 g) supplied from Cheonil Pharmaceutical Co., Ltd., and immersed in it, and allowed to stand at room temperature for 72 hours, the broth pack [medium pack, 25 cm × 35 cm, 8P, TNC It was filtered so that particles less than 100 μm were passed through with [Eletronics Co., Ltd.]. In order to volatilize the alcohol, it was distilled using a vacuum concentrator (CCA-1111, EYELA4) at 50° C. for a certain period of time, and then concentrated to prepare an extract of Hojanggeun.
<1-2> 동백나무 잎 추출물의 제조<1-2> Preparation of Camellia Leaf Extract
㈜웰파이토로부터 구입한 동백나무 잎을 실시예 <1-1>의 호장근 추출물의 제조방법과 동일한 방법으로 추출 및 농축하여 동백나무 잎 추출물을 제조하였다.Camellia leaf extract was prepared by extracting and concentrating the camellia leaf purchased from WelPito Co., Ltd. in the same manner as in the method for preparing the Hojanggeun extract of Example <1-1>.
<1-3> 개똥쑥 추출물의 제조<1-3> Preparation of wormwood extract
곡성 농가(전남 곡성군 고달면 고달리)로부터 공급받은 개똥쑥을 실시예 <1-1>의 호장근 추출물의 제조방법과 동일한 방법으로 추출 및 농축하여 개똥쑥 추출물을 제조하였다.The wormwood wormwood supplied from the Gokseong farmhouse (Godal-myeon, Godal-myeon, Gokseong-gun, Jeollanam-do) was extracted and concentrated in the same manner as in Example <1-1> to prepare a wormwood extract.
<1-4> 녹차 잎 추출물의 제조<1-4> Preparation of green tea leaf extract
(재)하동녹차연구소로부터 공급받은 녹차 잎을 실시예 <1-1>의 호장근 추출물의 제조방법과 동일한 방법으로 추출 및 농축하여 녹차 잎 추출물을 제조하였다.Green tea leaves supplied from Hadong Green Tea Research Institute were extracted and concentrated in the same manner as in Example <1-1>, to prepare a green tea leaf extract.
<1-5> 편백나무 잎 추출물의 제조<1-5> Preparation of cypress leaf extract
장흥 편백나무 단지에서 공급받은 편백나무 잎을 실시예 <1-1>의 호장근 추출물의 제조방법과 동일한 방법으로 추출 및 농축하여 편백나무 잎 추출물을 제조하였다.Cypress tree leaves supplied from the Jangheung Cypress Tree Complex were extracted and concentrated in the same manner as in the preparation method of the Hojanggeun extract of Example <1-1> to prepare cypress leaves extract.
<1-6> 어성초 잎 추출물의 제조<1-6> Preparation of Eoseongcho leaf extract
곡성 농가(전남 곡성군 고달면 고달리)로부터 공급받은 어성초 잎을 실시예 <1-1>의 호장근 추출물의 제조방법과 동일한 방법으로 추출 및 농축하여 어성초 잎 추출물을 제조하였다.Eoseongcho leaves obtained from Gokseong farmhouse (Godal-myeon, Godal-myeon, Gokseong-gun, Jeollanam-do) were extracted and concentrated in the same manner as in Example <1-1>, to prepare Eoseongcho leaf extract.
<실시예 2> 엽록소 및 색소 제거용 식물 액상 추출물의 제조<Example 2> Preparation of liquid plant extract for removing chlorophyll and pigment
엽록소 및 색소 제거용 식물 액상 추출물을 제조하기 위해, 개똥쑥(7 ㎏), 녹차 잎(7 ㎏), 동백나무 잎(7 ㎏), 맹종죽 잎(6.5 ㎏), 신의대 잎(6.5 ㎏) 및 편백나무 잎(7 ㎏)을 현지에서 바로 구입한 후, (재)전남생물산업진흥원에서 에센셜오일추출기로 8 시간 이상 각각 추출하여, 엽록소 및 색소 제거용 식물 액상 추출물(후로랄 워터)을 제조하였다.To prepare a plant liquid extract for removing chlorophyll and pigment, mugwort (7 kg), green tea leaves (7 kg), camellia leaves (7 kg), maengjongjuk leaves (6.5 kg), Sinuidae leaves (6.5 kg) and After purchasing cypress leaves (7 kg) on the spot, they were extracted for more than 8 hours with an essential oil extractor at Jeonnam Biological Industry Promotion Agency (Re) to prepare a liquid plant extract (Floral Water) for removing chlorophyll and pigment.
<실시예 3> 엽록소 및 색소가 제거된 식물 추출물의 제조<Example 3> Preparation of plant extract from which chlorophyll and pigment were removed
<3-1> 색소가 제거된 호장근 추출물의 제조<3-1> Preparation of the extract from which the pigment has been removed
상기 <실시예 2>에서 제조한 엽록소 및 색소 제거용 식물 액상 추출물을 이용하여 호장근 추출물의 색소를 제거하였다.The pigments in the extract of chlorophyll roots were removed using the liquid plant extract for removing chlorophyll and pigments prepared in <Example 2>.
구체적으로, 도 1에 나타낸 바와 같이, 상기 <실시예 2>에서 제조한 엽록소 및 색소 제거용 식물 액상 추출물(편백나무 잎에서 추출한 후로랄 워터)을 에탄올과 9：1 비율로 혼합한 후, 상기 <실시예 1>에서 제조한 호장근 추출물에 20배로 첨가하여 희석한 후 －50℃의 동결 조건에서 12 시간 정도 충분히 정치시켰다.Specifically, as shown in Fig. 1, after mixing the chlorophyll and the pigment-removing plant liquid extract (furoral water extracted from cypress leaves) prepared in Example 2 with ethanol in a ratio of 9:1, the < After diluting by adding 20 times to the extract prepared in Example 1>, it was allowed to stand sufficiently for about 12 hours in a freezing condition at -50°C.
그 결과, 색소 층은 침전되고 유효성분은 상층부위로 분리되므로, 상층부위만 수확하여, 색소가 제거된 호장근 추출물을 제조하였다. 한편, 색소가 제거된 호장근 추출물은 냉동고에서 완전히 동결한 후, 동결건조기(FDU-1200, EYELA)로 동결 건조하였다(도 2).As a result, since the pigment layer was precipitated and the active ingredient was separated into the upper layer, only the upper layer was harvested, thereby preparing the extract from which the pigment was removed. On the other hand, the extract from which the pigment was removed was completely frozen in a freezer and then freeze-dried with a freeze dryer (FDU-1200, EYELA) (FIG. 2).
<3-2> 엽록소가 제거된 동백나무 잎 추출물의 제조<3-2> Preparation of camellia leaf extract from which chlorophyll was removed
상기 실시예 <3-1>과 동일한 방법으로 엽록소가 제거된 동백나무 잎 추출물을 제조하였다(도 3).A camellia leaf extract from which chlorophyll was removed was prepared in the same manner as in Example <3-1> (FIG. 3).
<3-3> 엽록소가 제거된 개똥쑥 추출물의 제조<3-3> Preparation of chlorophyll-removed mugwort extract
상기 실시예 <3-1>과 동일한 방법으로 엽록소가 제거된 개똥쑥 추출물을 제조하였다(도 4).A wormwood extract from which chlorophyll was removed was prepared in the same manner as in Example <3-1> (FIG. 4).
<3-4> 엽록소가 제거된 녹차 잎 추출물의 제조<3-4> Preparation of green tea leaf extract from which chlorophyll has been removed
상기 실시예 <3-1>과 동일한 방법으로 엽록소가 제거된 녹차 잎 추출물을 제조하였다(도 5).A green tea leaf extract from which chlorophyll was removed was prepared in the same manner as in Example <3-1> (FIG. 5).
<3-5> 엽록소가 제거된 편백나무 잎 추출물의 제조<3-5> Preparation of cypress leaf extract from which chlorophyll was removed
상기 실시예 <3-1>과 동일한 방법으로 엽록소가 제거된 편백나무 잎 추출물을 제조하였다(도 6).Cypress tree leaf extract from which chlorophyll was removed was prepared in the same manner as in Example <3-1> (FIG. 6).
<3-6> 엽록소가 제거된 어성초 잎 추출물의 제조<3-6> Preparation of Eoseongcho leaf extract from which chlorophyll was removed
상기 실시에 <3-1>과 동일한 방법으로 엽록소가 제거된 어성초 잎 추출물을 제조하였다(도 7).Eoseongcho leaf extract from which chlorophyll was removed was prepared in the same manner as in <3-1> in the above embodiment (FIG. 7).
<실험예 1> 식물 추출물의 최적 엽록소 또는 색소 제거용 식물 후로랄 워터 확인<Experimental Example 1> Identification of plant floral water for removing optimal chlorophyll or pigment from plant extracts
<1-1> 호장근 추출물의 최적 색소 제거용 식물 후로랄 워터 확인<1-1> Confirmation of plant floral water for optimal pigment removal of Hojanggeun extract
상기 <실시예 2>에서 제조한 다양한 엽록소 및 색소 제거용 식물 후로랄 워터 중 최적 엽록소 및 색소 제거용 식물 후로랄 워터를 확인하였다.Among the various chlorophyll and pigment-removing plant floral waters prepared in <Example 2>, the optimum chlorophyll- and pigment-removing plant floral water was identified.
구체적으로, 엽록소 및 색소 제거는 상기 실시예 <3-1>과 동일한 방법을 이용하여 수행하였다.Specifically, chlorophyll and pigment removal were performed using the same method as in Example <3-1>.
그 결과, 하기 표 1에 나타낸 바와 같이, 개똥쑥에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터는 호장근 추출물의 색소를 유의적으로 분리시키나, 녹차 잎에서 추출한 후로랄 워터, 동백나무 잎에서 추출한 후로랄 워터 및 정제수는 색소를 분리하지 못하는 것을 확인하였다(표 1).As a result, as shown in Table 1 below, floral water extracted from wormwood, floral water extracted from Maengjongjuk, floral water extracted from Sinuidae, and floral water extracted from cypress leaves significantly separate the pigments of Hojanggeun extract. , It was confirmed that floral water extracted from green tea leaves, floral water and purified water extracted from camellia leaves could not separate the pigment (Table 1).
<1-2> 동백나무 잎 추출물의 최적 엽록소 제거용 식물 후로랄 워터 확인<1-2> Confirmation of plant floral water for optimal chlorophyll removal of camellia leaf extract
상기 실험예 <1-1>과 동일한 방법으로 동백나무 잎 추출물의 최적 엽록소 제거용 식물 후로랄 워터를 확인하였다.Plant floral water for optimal chlorophyll removal of the camellia leaf extract was confirmed in the same manner as in Experimental Example <1-1>.
그 결과, 하기 표 2에 나타낸 바와 같이, 개똥쑥에서 추출한 후로랄 워터, 동백나무 잎에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터는 동백나무 잎 추출물의 엽록소를 유의적으로 분리시키나, 녹차 잎에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 및 정제수는 엽록소를 분리하지 못하는 것을 확인하였다(표 2).As a result, as shown in Table 2 below, floral water extracted from wormwood, floral water extracted from camellia leaves, floral water extracted from Maengjongjuk, and floral water extracted from cypress leaves significantly reduce chlorophyll from camellia leaf extract. However, it was confirmed that floral water extracted from green tea leaves, floral water and purified water extracted from Shin Medical University could not separate chlorophyll (Table 2).
<1-3> 개똥쑥 추출물의 최적 엽록소 제거용 식물 후로랄 워터 확인<1-3> Confirmation of plant floral water for optimal chlorophyll removal of wormwood extract
상기 실험예 <1-1>과 동일한 방법으로 개똥쑥 추출물의 최적 엽록소 제거용 식물 후로랄 워터를 확인하였다.In the same manner as in Experimental Example <1-1>, plant floral water for optimal chlorophyll removal of wormwood extract was confirmed.
그 결과, 하기 표 3에 나타낸 바와 같이, 개똥쑥에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터는 개똥쑥 추출물의 엽록소를 유의적으로 분리시키나, 녹차 잎에서 추출한 후로랄 워터, 동백나무 잎에서 추출한 후로랄 워터 및 정제수는 엽록소를 분리하지 못하는 것을 확인하였다(표 3).As a result, as shown in Table 3 below, floral water extracted from wormwood, floral water extracted from Maengjongjuk, floral water extracted from Sinuidae, and floral water extracted from cypress leaves significantly separate the chlorophyll of wormwood extract. , It was confirmed that floral water extracted from green tea leaves, floral water extracted from camellia leaves, and purified water did not separate chlorophyll (Table 3).
<1-4> 녹차 잎 추출물의 최적 엽록소 제거용 식물 후로랄 워터 확인<1-4> Confirmation of plant floral water for optimal chlorophyll removal of green tea leaf extract
상기 실험예 <1-1>과 동일한 방법으로 녹차 잎 추출물의 최적 엽록소 제거용 식물 후로랄 워터를 확인하였다.Plant floral water for optimal chlorophyll removal of green tea leaf extract was confirmed in the same manner as in Experimental Example <1-1>.
그 결과, 하기 표 4에 나타낸 바와 같이, 개똥쑥에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터는 녹차 잎 추출물의 엽록소를 유의적으로 분리시키나, 녹차 잎에서 추출한 후로랄 워터, 동백나무 잎에서 추출한 후로랄 워터 및 정제수는 엽록소를 분리하지 못하는 것을 확인하였다(표 4).As a result, as shown in Table 4 below, floral water extracted from wormwood, floral water extracted from Maengjongjuk, floral water extracted from Sinuidae, and floral water extracted from cypress leaves significantly separate chlorophyll from green tea leaf extract. , It was confirmed that floral water extracted from green tea leaves, floral water extracted from camellia leaves, and purified water could not separate chlorophyll (Table 4).
<1-5> 편백나무 잎 추출물의 최적 엽록소 제거용 식물 후로랄 워터 확인<1-5> Identification of plant floral water for optimal chlorophyll removal from cypress leaf extract
상기 실험예 <1-1>과 동일한 방법으로 편백나무 잎 추출물의 최적 엽록소 제거용 식물 후로랄 워터를 확인하였다.In the same manner as in Experimental Example <1-1>, plant floral water for optimal chlorophyll removal of cypress leaf extract was confirmed.
그 결과, 하기 표 5에 나타낸 바와 같이, 개똥쑥에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터는 편백나무 잎 추출물의 엽록소를 유의적으로 분리시키나, 녹차 잎에서 추출한 후로랄 워터, 동백나무 잎에서 추출한 후로랄 워터 및 정제수는 엽록소를 분리하지 못하는 것을 확인하였다(표 5).As a result, as shown in Table 5 below, floral water extracted from wormwood, floral water extracted from Maengjongjuk, floral water extracted from Sinuidae, and floral water extracted from cypress leaves significantly separate chlorophyll from cypress leaf extract. Shikina, floral water extracted from green tea leaves, floral water extracted from camellia leaves, and purified water were found to be unable to separate chlorophyll (Table 5).
<1-6> 어성초 잎 추출물의 최적 엽록소 제거용 식물 후로랄 워터 확인<1-6> Confirmation of plant floral water for optimal chlorophyll removal from Eoseongcho leaf extract
상기 실험예 <1-6>과 동일한 방법으로 어성초 추출물의 최적 엽록소 제거용 식물 후로랄 워터를 확인하였다.In the same manner as in Experimental Example <1-6>, plant floral water for optimal chlorophyll removal of Eoseongcho extract was confirmed.
그 결과, 하기 표 6에 나타낸 바와 같이, 개똥쑥에서 추출한 후로랄 워터, 맹종죽에서 추출한 후로랄 워터, 신의대에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터는 어성초 잎 추출물의 엽록소를 유의적으로 분리시키나, 녹차 잎에서 추출한 후로랄 워터, 동백나무 잎에서 추출한 후로랄 워터 및 정제수는 엽록소를 분리하지 못하는 것을 확인하였다(표 6).As a result, as shown in Table 6 below, floral water extracted from wormwood, floral water extracted from Maengjongjuk, floral water extracted from Sinuidae, and floral water extracted from cypress leaves significantly separate chlorophyll from Eoseongcho leaf extract. , It was confirmed that floral water extracted from green tea leaves, floral water extracted from camellia leaves, and purified water could not separate chlorophyll (Table 6).
<제조예 1> 미스트 형태의 탈모 억제 또는 발모 촉진용 조성물 제조<Production Example 1> Preparation of a composition for inhibiting hair loss or promoting hair growth in a mist form
<실시예 1> 내지 <실시예 3>의 과정을 거쳐 제조된 색소가 제거된 호장근 추출물, 엽록소가 제거된 동백나무 잎 및 개똥쑥 추출물을 유효성분으로 포함하고, 추가로 엽록소가 제거된 녹차 잎, 편백나무 잎 및 어성초 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 함유하는 탈모 억제 또는 발모 촉진용 조성물을 함유하여, 화학 성분의 함유가 전혀 없는 탈모 억제 또는 발모 촉진용 미스트를 제조하고, 보존성을 높이기 위해 정제수와 편백나무 잎에서 추출된 후로럴 워터의 비율은 1：1 내지 19로 유지하였다(도 8).Green tea containing as an active ingredient, a pigment-removed Hojanggeun extract, a camellia leaf from which chlorophyll was removed, and a wormwood extract prepared through the process of <Example 1> to <Example 3>, and additionally removed chlorophyll Contains a composition for inhibiting hair loss or promoting hair growth containing at least one extract selected from the group consisting of leaves, cypress leaves and Eoseongcho leaf extracts, to prepare a mist for inhibiting hair loss or promoting hair growth without any chemical components, In order to increase preservation, the ratio of purified water and floral water extracted from cypress leaves was maintained at 1:1 to 19 (FIG. 8).
각 추출물의 함유 농도는 0.01 내지 5 mg/㎖이다.The concentration of each extract is 0.01 to 5 mg/ml.
<제조예 2> 샴푸 형태의 탈모 억제 또는 발모 촉진용 조성물 제조<Production Example 2> Preparation of a shampoo-type composition for inhibiting hair loss or promoting hair growth
<실시예 1> 내지 <실시예 3>의 과정을 거쳐 제조된 색소가 제거된 호장근 추출물, 엽록소가 제거된 동백나무 잎 및 개똥쑥 추출물을 유효성분으로 포함하고, 추가로 엽록소가 제거된 녹차 잎, 편백나무 잎 및 어성초 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출을 함유하는 탈모 억제 또는 발모 촉진용 조성물물에 공지된 샴푸 원료를 혼합하여 탈모 억제 또는 발모 촉진용 샴푸를 제조하였다(도 9).Green tea containing as an active ingredient, a pigment-removed Hojanggeun extract, a camellia leaf from which chlorophyll was removed, and a wormwood extract prepared through the process of <Example 1> to <Example 3>, and additionally removed chlorophyll A shampoo for inhibiting hair loss or promoting hair growth was prepared by mixing known shampoo ingredients in a composition for inhibiting hair loss or promoting hair growth containing one or more extracts selected from the group consisting of leaves, cypress leaves, and Eoseongcho leaf extracts (FIG. 9 ).
각 추출물의 함유 농도는 0.01 내지 5 mg/㎖이다.The concentration of each extract is 0.01 to 5 mg/ml.
<제조예 3> 건강식품 형태의 탈모 억제 또는 발모 촉진용 조성물 제조<Production Example 3> Preparation of a composition for inhibiting hair loss or promoting hair growth in the form of health food
<3-1> 밀가루 식품의 제조<3-1> Preparation of flour food
<실시예 1> 내지 <실시예 3>의 과정을 거쳐 제조된 색소가 제거된 호장근 추출물, 엽록소가 제거된 동백나무 잎 및 개똥쑥 추출물을 유효성분으로 포함하고, 추가로 엽록소가 제거된 녹차 잎, 편백나무 잎 및 어성초 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 함유하는 탈모 억제 또는 발모 촉진용 조성물을 0.5 내지 5.0 중량부 밀가루에 첨가하고, 이 혼합물을 이용하여 빵, 케이크, 쿠키, 크래커 및 면류를 제조하였다.Green tea containing as an active ingredient, a pigment-removed Hojanggeun extract, a camellia leaf from which chlorophyll was removed, and a wormwood extract prepared through the process of <Example 1> to <Example 3>, and additionally removed chlorophyll A composition for inhibiting hair loss or promoting hair growth containing one or more extracts selected from the group consisting of leaves, cypress leaves and Eoseongcho leaf extracts is added to 0.5 to 5.0 parts by weight of wheat flour, and bread, cakes, cookies, Crackers and noodles were prepared.
<3-2> 스프 및 육즙(Gravies)의 제조<3-2> Preparation of soups and gravy
<실시예 1> 내지 <실시예 3>의 과정을 거쳐 제조된 색소가 제거된 호장근 추출물, 엽록소가 제거된 동백나무 잎 및 개똥쑥 추출물을 유효성분으로 포함하고, 추가로 엽록소가 제거된 녹차 잎, 편백나무 잎 및 어성초 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 함유하는 탈모 억제 또는 발모 촉진용 조성물을 0.1 내지 5.0 중량부 스프 및 육즙에 첨가하여 건강 증진용 육가공 제품, 면류의 수프 및 육즙을 제조하였다.Green tea containing as an active ingredient, a pigment-removed Hojanggeun extract, a camellia leaf from which chlorophyll was removed, and a wormwood extract prepared through the process of <Example 1> to <Example 3>, and additionally removed chlorophyll 0.1 to 5.0 parts by weight of a composition for inhibiting hair loss or promoting hair growth containing one or more extracts selected from the group consisting of leaves, cypress leaves and Eoseongcho leaf extracts are added to soups and broth to promote health products, soup of noodles, and The juice was prepared.
<3-3> 그라운드 비프(Ground beef)의 제조<3-3> Preparation of ground beef
<실시예 1> 내지 <실시예 3>의 과정을 거쳐 제조된 색소가 제거된 호장근 추출물, 엽록소가 제거된 동백나무 잎 및 개똥쑥 추출물을 유효성분으로 포함하고, 추가로 엽록소가 제거된 녹차 잎, 편백나무 잎 및 어성초 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 함유하는 탈모 억제 또는 발모 촉진용 조성물을 10 중량부 그라운드 비프에 첨가하여 건강 증진용 그라운드 비프를 제조하였다.Green tea containing as an active ingredient, a pigment-removed Hojanggeun extract, a camellia leaf from which chlorophyll was removed, and a wormwood extract prepared through the process of <Example 1> to <Example 3>, and additionally removed chlorophyll A composition for inhibiting hair loss or promoting hair growth containing at least one extract selected from the group consisting of leaves, cypress leaves and Eoseongcho leaf extracts was added to 10 parts by weight of ground beef to prepare ground beef for health promotion.
<3-4> 유제품(Dairy products)의 제조<3-4> Manufacture of Dairy products
<실시예 1> 내지 <실시예 3>의 과정을 거쳐 제조된 색소가 제거된 호장근 추출물, 엽록소가 제거된 동백나무 잎 및 개똥쑥 추출물을 유효성분으로 포함하고, 추가로 엽록소가 제거된 녹차 잎, 편백나무 잎 및 어성초 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 함유하는 탈모 억제 또는 발모 촉진용 조성물을 5 내지 10 중량부 우유에 첨가하고, 상기 우유를 이용하여 버터 및 아이스크림과 같은 다양한 유제품을 제조하였다.Green tea containing as an active ingredient, a pigment-removed Hojanggeun extract, a camellia leaf from which chlorophyll was removed, and a wormwood extract prepared through the process of <Example 1> to <Example 3>, and additionally removed chlorophyll A composition for inhibiting hair loss or promoting hair growth containing at least one extract selected from the group consisting of leaves, cypress leaves and Eoseongcho leaf extracts is added to 5 to 10 parts by weight of milk, and various such as butter and ice cream using the milk Dairy products were prepared.
<3-5> 선식의 제조<3-5> Manufacturing of Seonsik
현미, 보리, 찹쌀, 율무를 공지의 방법으로 알파화시켜 건조시킨 것을 배전한 후 분쇄기로 입도 60 메쉬의 분말로 제조하였다.Brown rice, barley, glutinous rice, and adlay were gelatinized by a known method, dried, and then roasted, and then prepared into a powder having a particle size of 60 mesh with a grinder.
검정콩, 검정깨, 들깨도 공지의 방법으로 쪄서 건조시킨 것을 배전한 후 분쇄기로 입도 60 메쉬의 분말로 제조하였다.Black soybeans, black sesame seeds, and perilla seeds were also steamed and dried by a known method, and then roasted, and then prepared into powder having a particle size of 60 mesh by a grinder.
<실시예 1> 내지 <실시예 3>의 과정을 거쳐 제조된 색소가 제거된 호장근 추출물, 엽록소가 제거된 동백나무 잎 및 개똥쑥 추출물을 유효성분으로 포함하고, 추가로 엽록소가 제거된 녹차 잎, 편백나무 잎 및 어성초 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 함유하는 탈모 억제 또는 발모 촉진용 조성물을 진공 농축기에서 감압농축하고, 분무, 열풍 건조기로 건조하여 얻은 건조물을 분쇄기로 입도 60 메쉬로 분쇄하여 건조분말을 얻었다.Green tea containing as an active ingredient, a pigment-removed Hojanggeun extract, a camellia leaf from which chlorophyll was removed, and a wormwood extract prepared through the process of <Example 1> to <Example 3>, and additionally removed chlorophyll A composition for inhibiting hair loss or promoting hair growth containing at least one extract selected from the group consisting of leaves, cypress leaves and Eoseongcho leaf extracts is concentrated under reduced pressure in a vacuum concentrator, and the dried product obtained by drying with spraying and hot air dryer is subjected to particle size 60 It was pulverized with a mesh to obtain dry powder.
상기에서 제조한 곡물류, 종실류 및 추출물류를 다음의 비율로 배합하여 제조하였다.It was prepared by mixing the grains, seeds and extracts prepared above in the following ratio.
곡물류(현미 30 중량부, 율무 15 중량부, 보리 20 중량부),Grains (30 parts by weight of brown rice, 15 parts by weight of barley, 20 parts by weight of barley)
종실류(들깨 7 중량부, 검정콩 8 중량부, 검정깨 7 중량부).Seeds (perilla 7 parts by weight, black soybean 8 parts by weight, black sesame 7 parts by weight).
본 발명의 추출물류(3 중량부),Extracts of the present invention (3 parts by weight),
영지(0.5 중량부),Ganoderma lucidum (0.5 parts by weight),
지황(0.5 중량부)Rehmannia (0.5 parts by weight)
<3-6> 건강음료의 제조<3-6> Manufacture of health drinks
액상과당 0.5 ％, 올리고당 2 ％, 설탕 2 ％, 식염 0.5 ％, 물 75 ％와 같은 부재료 및 본 발명의 색소가 제거된 호장근 추출물, 엽록소가 제거된 동백나무 잎 및 개똥쑥 추출물을 유효성분으로 포함하고, 추가로 엽록소가 제거된 녹차 잎, 편백나무 잎 및 어성초 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 함유하는 탈모 억제 또는 발모 촉진용 조성물 0.5 g을 균질하게 배합하여 순간 살균을 한 후 이를 유리병, 페트병 등 소포장 용기에 포장하여 제조하였다.Subsidiary materials such as liquid fructose 0.5%, oligosaccharide 2%, sugar 2%, salt 0.5%, water 75%, and the pigment of the present invention are removed, Camellia leaves and Mugwort extracts from which chlorophyll is removed as active ingredients Including, in addition, 0.5 g of a composition for inhibiting hair loss or promoting hair growth containing at least one extract selected from the group consisting of green tea leaves, cypress leaves, and Eoseongcho leaf extracts from which chlorophyll has been removed is homogeneously blended, It was prepared by packaging it in a small container such as a glass bottle or a PET bottle.
<3-7> 야채 주스의 제조<3-7> Preparation of vegetable juice
본 발명의 색소가 제거된 호장근 추출물, 엽록소가 제거된 동백나무 잎 및 개똥쑥 추출물을 유효성분으로 포함하고, 추가로 엽록소가 제거된 녹차 잎, 편백나무 잎 및 어성초 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 함유하는 탈모 억제 또는 발모 촉진용 조성물 0.5 g을 토마토 또는 당근 주스 1,000 ㎖에 가하여 야채 주스를 제조하였다.Selected from the group consisting of the extract of the present invention from which the pigments have been removed, the Camellia leaves from which chlorophyll has been removed, and the Mugwort extract as active ingredients, and additionally from the group consisting of green tea leaves from which chlorophyll has been removed, cypress leaves and Eoseongcho leaves extract Vegetable juice was prepared by adding 0.5 g of a composition for inhibiting hair loss or promoting hair growth containing at least one extract to be added to 1,000 ml of tomato or carrot juice.
<3-8> 과일 주스의 제조<3-8> Preparation of fruit juice
본 발명의 색소가 제거된 호장근 추출물, 엽록소가 제거된 동백나무 잎 및 개똥쑥 추출물을 유효성분으로 포함하고, 추가로 엽록소가 제거된 녹차 잎, 편백나무 잎 및 어성초 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 함유하는 탈모 억제 또는 발모 촉진용 조성물 0.1 g을 사과 또는 포도 주스 1,000 ㎖에 가하여 과일 주스를 제조하였다.Selected from the group consisting of the extract of the present invention from which the pigments have been removed, the Camellia leaves from which chlorophyll has been removed, and the Mugwort extract as active ingredients, and additionally from the group consisting of green tea leaves from which chlorophyll has been removed, cypress leaves and Eoseongcho leaves extract A fruit juice was prepared by adding 0.1 g of a composition for inhibiting hair loss or promoting hair growth containing one or more extracts to be added to 1,000 ml of apple or grape juice.
Claims (6)
녹차(Camellia sinensis) 잎 추출물, 편백나무(Chamaecyparis obtusa) 잎 추출물 및 어성초(Houttuynia cordata) 잎 추출물로 구성된 군으로부터 선택되는 하나 이상의 추출물을 추가로 함유하는 탈모 억제 또는 발모 촉진용 조성물로서,
상기 추출물은 맹종죽 잎에서 추출한 후로랄 워터, 신의대 잎에서 추출한 후로랄 워터 및 편백나무 잎에서 추출한 후로랄 워터로 구성된 군으로부터 선택되는 1종 이상의 후로랄 워터 및 발효주정으로 구성된 추출용매와 혼합하여 추출된 엽록소 또는 색소가 제거된 추출물인 것을 특징으로 하는 조성물.
Including polygonum cuspidatum extract, Camellia japonica leaf extract, and Artemisia annua extract as active ingredients,
As a composition for inhibiting hair loss or promoting hair growth further containing one or more extracts selected from the group consisting of green tea ( Camellia sinensis ) leaf extract, Cypress tree ( Chamaecyparis obtusa ) leaf extract and Houttuynia cordata leaf extract,
The extract is chlorophyll extracted by mixing with an extraction solvent consisting of at least one type of floral water selected from the group consisting of floral water extracted from Maengjongjuk leaves, floral water extracted from Sinuidae leaves, and floral water extracted from cypress leaves, or A composition, characterized in that the extract from which the pigment has been removed.
A functional cosmetic composition for inhibiting hair loss or promoting hair growth, comprising the composition according to claim 1 as an active ingredient.
A quasi-drug composition for inhibiting hair loss or promoting hair growth, comprising the composition according to claim 1 as an active ingredient.
A pharmaceutical composition for inhibiting hair loss or promoting hair growth, comprising the composition according to claim 1 as an active ingredient.
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| PCT/KR2020/005359 WO2020218840A1 (en) | 2019-04-23 | 2020-04-23 | Composition for inhibiting hair loss or promoting hair growth containing plant extract removed of chlorophyll or pigment as active ingredient, and method for producing same |
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| KR101802961B1 (en) * | 2016-02-26 | 2017-11-29 | 농업회사법인 우리엘바이오 주식회사 | Composition for preventing hair loss method for manufacturing the same |
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| KR101687447B1 (en) * | 2014-03-05 | 2016-12-16 | 배용태 | Method for isolating and removing chlorophyll from natural material |
| KR20160008055A (en) * | 2014-07-11 | 2016-01-21 | 주식회사 엘지생활건강 | Composition for improving hair or skin conditions comprising Camellia japonica leaf extract |
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| KR101762796B1 (en) * | 2015-12-02 | 2017-07-31 | 한국 한의학 연구원 | Composition comprising a fermentative product of an herbal extracts complex for hair loss prevention |
| KR101802961B1 (en) * | 2016-02-26 | 2017-11-29 | 농업회사법인 우리엘바이오 주식회사 | Composition for preventing hair loss method for manufacturing the same |
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