KR102184970B1 - 뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법 - Google Patents

뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법 Download PDF

Info

Publication number
KR102184970B1
KR102184970B1 KR1020207000973A KR20207000973A KR102184970B1 KR 102184970 B1 KR102184970 B1 KR 102184970B1 KR 1020207000973 A KR1020207000973 A KR 1020207000973A KR 20207000973 A KR20207000973 A KR 20207000973A KR 102184970 B1 KR102184970 B1 KR 102184970B1
Authority
KR
South Korea
Prior art keywords
composition
weight
present
biocompatible
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020207000973A
Other languages
English (en)
Korean (ko)
Other versions
KR20200010567A (ko
Inventor
카타르지나 아이 고르나
안드레아스 게슬
하인츠 굴레
Original Assignee
백스터 인터내셔널 인코포레이티드
박스터 헬쓰케어 에스에이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 백스터 인터내셔널 인코포레이티드, 박스터 헬쓰케어 에스에이 filed Critical 백스터 인터내셔널 인코포레이티드
Publication of KR20200010567A publication Critical patent/KR20200010567A/ko
Application granted granted Critical
Publication of KR102184970B1 publication Critical patent/KR102184970B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L73/00—Compositions of macromolecular compounds obtained by reactions forming a linkage containing oxygen or oxygen and carbon in the main chain, not provided for in groups C08L59/00 - C08L71/00; Compositions of derivatives of such polymers
    • C08L73/02—Polyanhydrides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00831—Material properties
    • A61B2017/00933—Material properties bone or bone-like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/58—Ethylene oxide or propylene oxide copolymers, e.g. pluronics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020207000973A 2011-10-28 2012-10-29 뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법 Expired - Fee Related KR102184970B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161553032P 2011-10-28 2011-10-28
US61/553,032 2011-10-28
PCT/US2012/062437 WO2013063580A1 (en) 2011-10-28 2012-10-29 Nonaqueous compositions for bone hemostasis, and methods for their use and manufacture

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020147013908A Division KR102068118B1 (ko) 2011-10-28 2012-10-29 뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법

Publications (2)

Publication Number Publication Date
KR20200010567A KR20200010567A (ko) 2020-01-30
KR102184970B1 true KR102184970B1 (ko) 2020-12-03

Family

ID=48168649

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020207000973A Expired - Fee Related KR102184970B1 (ko) 2011-10-28 2012-10-29 뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법
KR1020147013908A Expired - Fee Related KR102068118B1 (ko) 2011-10-28 2012-10-29 뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020147013908A Expired - Fee Related KR102068118B1 (ko) 2011-10-28 2012-10-29 뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법

Country Status (12)

Country Link
US (2) US20130287818A1 (https=)
EP (2) EP3878483B1 (https=)
JP (1) JP6095675B2 (https=)
KR (2) KR102184970B1 (https=)
CN (1) CN104010669A (https=)
AU (1) AU2012328415B2 (https=)
BR (1) BR112014010192B1 (https=)
CA (2) CA2853732C (https=)
ES (2) ES2961982T3 (https=)
HK (1) HK1201213A1 (https=)
MX (1) MX359402B (https=)
WO (2) WO2013063580A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101712809B1 (ko) * 2015-03-19 2017-03-08 주식회사 엠아이텍 뼈 지혈용 생체 흡수성 조성물 및 이의 제조 방법
CN105816905B (zh) * 2016-04-15 2020-12-18 广州贝奥吉因生物科技有限公司 一种具有促愈合功能的可吸收骨蜡及其制备方法
CN106039390A (zh) * 2016-05-27 2016-10-26 中国人民解放军第七五医院 一种骨蜡组合物及其制备方法
KR101990069B1 (ko) * 2017-11-28 2019-06-18 ㈜솔시온바이오메디칼 뼈 지혈용품 조성물
CN109125791B (zh) * 2018-09-29 2019-08-30 广州贝奥吉因生物科技有限公司 一种具有促进骨修复功能的可吸收骨蜡及制备方法
KR102220832B1 (ko) 2018-12-13 2021-02-25 건양대학교 산학협력단 세포 독성이 감소된 생체흡수성 뼈 지혈제의 제조방법
KR102211765B1 (ko) * 2019-01-15 2021-02-03 주식회사 테라시온바이오메디칼 흡수성 골 지혈재 조성물 및 이를 이용한 골 지혈재 제조방법
CN111714684A (zh) * 2019-03-19 2020-09-29 广东博与再生医学有限公司 一种骨止血材料及其制备方法
KR102133503B1 (ko) * 2019-08-19 2020-07-13 한스바이오메드 주식회사 골지혈제용 생체 적합성 조성물, 이를 사용하는 치료 방법, 및 이의 제조 방법
CN114286694B (zh) * 2019-08-27 2023-06-20 株式会社多富 动物脂肪源性细胞外基质及动物脂肪源性细胞外基质保存液
CN114404642A (zh) * 2022-04-01 2022-04-29 天新福（北京）医疗器材股份有限公司 一种可吸收止血骨泥及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030095945A1 (en) * 1999-10-29 2003-05-22 Children's Hospital Los Angeles Bone hemostasis method and materials
JP2005531341A (ja) 2002-06-07 2005-10-20 カイフォン インコーポレイテッド ストロンチウム−アパタイト−セメント調合物、およびその利用
US20060280801A1 (en) * 2004-09-16 2006-12-14 Kronenthal Richard L Compositions and method for the reduction of post-operative pain
JP2007517543A (ja) * 2003-11-20 2007-07-05 アンジオテック インターナショナル アーゲー ポリマー化合物とその使用法
US20090149954A1 (en) 2007-12-07 2009-06-11 Xianbo Hu Bone substitute

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3175003D1 (en) * 1981-06-25 1986-08-28 Serapharm Gmbh & Co Kg Enriched plasma derivative for promoting wound sealing and wound healing
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
USRE38558E1 (en) 1991-03-19 2004-07-20 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
AU6898996A (en) * 1995-08-21 1997-03-12 Cytrx Corporation Compositions and methods for growth promotion
US6194515B1 (en) * 1997-10-10 2001-02-27 E. I. Du Pont De Nemours And Company Polyacetal composition with improved toughness
US8067032B2 (en) * 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
JP4489437B2 (ja) * 2002-02-21 2010-06-23 エンセル，インコーポレイテッド 表面コーティングとしての固定化生物活性ヒドロゲルマトリックス
WO2004028404A2 (en) * 2002-09-30 2004-04-08 Fibrogen, Inc. Dry tissue sealant compositions
EP1596767B1 (en) * 2003-02-12 2018-10-03 Syncera, Inc. Random and non-random alkylene oxide polymer alloy compositions
EP1773417A1 (en) 2004-06-23 2007-04-18 Angiotech Pharmaceuticals (US), Inc. Methods and crosslinked polymer compositions for cartilage repair
CA2616384A1 (en) * 2005-07-25 2007-02-01 Orthocon, Inc. Compositions and methods for the reduction of post-operative pain
CA2646486A1 (en) * 2006-03-23 2007-09-27 Citagenix Inc. Reverse phase osteoconductive composition
WO2007139760A2 (en) 2006-05-22 2007-12-06 Ceremed Inc. Resorbable polymer compositions for use in medicine, dentistry, and surgery
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
EP2192886B1 (en) * 2007-08-28 2017-12-20 Pioneer Surgical Technology, Inc. Cement products and methods of making and using the same
GB0801935D0 (en) 2008-02-01 2008-03-12 Apatech Ltd Porous biomaterial
CA2716872C (en) 2008-02-29 2015-02-10 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US20100233269A1 (en) * 2009-03-13 2010-09-16 Baxter International, Inc. Mineralized polymer particles and the method for their production
US8642080B2 (en) * 2009-06-29 2014-02-04 Bender Analytical Holdong B.V. Drug delivery system comprising polyoxazoline and a bioactive agent
EP2558135A1 (en) * 2010-04-16 2013-02-20 Apatech Limited Biomaterial
CA2893064C (en) * 2012-12-07 2021-05-04 Baxter International Inc. Hemostatic foam

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030095945A1 (en) * 1999-10-29 2003-05-22 Children's Hospital Los Angeles Bone hemostasis method and materials
JP2005531341A (ja) 2002-06-07 2005-10-20 カイフォン インコーポレイテッド ストロンチウム−アパタイト−セメント調合物、およびその利用
JP2007517543A (ja) * 2003-11-20 2007-07-05 アンジオテック インターナショナル アーゲー ポリマー化合物とその使用法
US20060280801A1 (en) * 2004-09-16 2006-12-14 Kronenthal Richard L Compositions and method for the reduction of post-operative pain
US20090149954A1 (en) 2007-12-07 2009-06-11 Xianbo Hu Bone substitute

Also Published As

Publication number Publication date
JP2014532481A (ja) 2014-12-08
KR20140084265A (ko) 2014-07-04
US20130287818A1 (en) 2013-10-31
AU2012328415B2 (en) 2016-03-17
MX359402B (es) 2018-09-26
EP2771040B1 (en) 2021-05-26
ES2961982T3 (es) 2024-03-14
BR112014010192A2 (pt) 2017-04-18
HK1201213A1 (en) 2015-08-28
EP3878483B1 (en) 2023-08-09
EP3878483A1 (en) 2021-09-15
US20130177601A1 (en) 2013-07-11
US9512277B2 (en) 2016-12-06
AU2012328415A1 (en) 2014-05-15
CA2853732A1 (en) 2013-05-02
BR112014010192B1 (pt) 2019-05-14
CA2853732C (en) 2021-06-08
EP2771040A4 (en) 2015-05-27
WO2013063580A1 (en) 2013-05-02
CN104010669A (zh) 2014-08-27
KR102068118B1 (ko) 2020-01-20
MX2014005135A (es) 2014-10-06
WO2013063585A1 (en) 2013-05-02
ES2877715T3 (es) 2021-11-17
JP6095675B2 (ja) 2017-03-15
EP2771040A1 (en) 2014-09-03
CA3107935A1 (en) 2013-05-02
KR20200010567A (ko) 2020-01-30

Similar Documents

Publication Publication Date Title
KR102184970B1 (ko) 뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법
EP1596767B1 (en) Random and non-random alkylene oxide polymer alloy compositions
AU2011239742B2 (en) Biomaterial
KR101712809B1 (ko) 뼈 지혈용 생체 흡수성 조성물 및 이의 제조 방법
US20030095945A1 (en) Bone hemostasis method and materials
EP1231869B1 (en) Bone hemostasis method and materials

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A16-div-PA0104

St.27 status event code: A-0-1-A10-A18-div-PA0104

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

Fee payment year number: 1

St.27 status event code: A-2-2-U10-U12-oth-PR1002

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PC1903 Unpaid annual fee

Not in force date: 20231126

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

St.27 status event code: A-4-4-U10-U13-oth-PC1903

PC1903 Unpaid annual fee

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20231126

St.27 status event code: N-4-6-H10-H13-oth-PC1903