KR102177437B1 - 리포좀 제제 - Google Patents

리포좀 제제 Download PDF

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KR102177437B1
KR102177437B1 KR1020207005268A KR20207005268A KR102177437B1 KR 102177437 B1 KR102177437 B1 KR 102177437B1 KR 1020207005268 A KR1020207005268 A KR 1020207005268A KR 20207005268 A KR20207005268 A KR 20207005268A KR 102177437 B1 KR102177437 B1 KR 102177437B1
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peg
formulation
antibody
vegf
glycerol
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Korean (ko)
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KR20200023507A (ko
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아르투로 산토스
필립 프로스트
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옵코 파마슈티칼스, 엘엘씨
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    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P5/16Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
KR1020207005268A 2012-08-21 2013-08-15 리포좀 제제 Active KR102177437B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261691455P 2012-08-21 2012-08-21
US61/691,455 2012-08-21
US201361791693P 2013-03-15 2013-03-15
US61/791,693 2013-03-15
US201361862300P 2013-08-05 2013-08-05
US61/862,300 2013-08-05
PCT/US2013/055084 WO2014031429A2 (en) 2012-08-21 2013-08-15 Liposome formulations

Related Parent Applications (1)

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KR1020157004549A Division KR102083700B1 (ko) 2012-08-21 2013-08-15 리포좀 제제

Publications (2)

Publication Number Publication Date
KR20200023507A KR20200023507A (ko) 2020-03-04
KR102177437B1 true KR102177437B1 (ko) 2020-11-12

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ID=50150466

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KR1020207005268A Active KR102177437B1 (ko) 2012-08-21 2013-08-15 리포좀 제제
KR1020157004549A Active KR102083700B1 (ko) 2012-08-21 2013-08-15 리포좀 제제

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US (2) US10548841B2 (enExample)
EP (1) EP2887958B1 (enExample)
JP (3) JP6336448B2 (enExample)
KR (2) KR102177437B1 (enExample)
CN (1) CN104582728A (enExample)
AR (1) AR092372A1 (enExample)
BR (1) BR112015003658B1 (enExample)
CA (2) CA2879597C (enExample)
CL (1) CL2015000418A1 (enExample)
ES (1) ES2881671T3 (enExample)
HU (1) HUE058912T2 (enExample)
MX (2) MX363822B (enExample)
PL (1) PL2887958T3 (enExample)
RU (1) RU2680096C2 (enExample)
TW (2) TWI683675B (enExample)
WO (1) WO2014031429A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2676303C2 (ru) * 2013-07-11 2018-12-27 Новартис Аг Использование антагониста vegf для лечения ретролентальной фиброплазии
EP3524238A1 (en) * 2013-12-19 2019-08-14 F. Hoffmann-La Roche AG Cetp modulator for use in the treatment of eye disease
US20170056469A1 (en) * 2014-05-02 2017-03-02 Mayo Foundation For Medical Education And Research Individualized treatment of eye disease
KR101778004B1 (ko) 2015-06-22 2017-09-15 (주) 에빅스젠 이마티닙을 유효성분으로 포함하는 안구 건조 질환 예방 및 치료용 약학 조성물
WO2017083800A1 (en) * 2015-11-13 2017-05-18 Ohr Pharmaceutical, Inc. Occult cnv size as a predictor for treatment with squalamine
CN119733046A (zh) * 2018-02-06 2025-04-01 豪夫迈·罗氏有限公司 眼科疾病的治疗
JP2021535206A (ja) * 2018-08-23 2021-12-16 バーンスタイン,エリック,エフ. 皮膚状態を治療するために抗vegf化合物を適用するためおよびこのような化合物を使用するためのシステム、デバイスおよび方法
CN109180798B (zh) * 2018-09-04 2020-10-27 武汉原生药谷生物医药科技有限公司 一种增强型治疗性抗体及其应用
US20200323882A1 (en) * 2019-03-15 2020-10-15 University Of Rhode Island Board Of Trustees Phlip®-mediated targeting of corticosteroids to diseased tissue
WO2020231670A1 (en) * 2019-05-16 2020-11-19 Opko Pharmaceuticals, Llc Triamcinolone acetonide-loaded liposomes topical ophthalmic formulations for prevention of macular thickening and its associated visual outcomes after lens surgery
CN113546172A (zh) * 2020-04-24 2021-10-26 山东大学齐鲁医院 Vegf抑制剂在制备治疗缺氧相关疾病药物中的应用
WO2021257193A1 (en) * 2020-06-15 2021-12-23 Opko Pharmaceuticals, Llc Triamcinolone acetonide-loaded liposomes topical ophthalmic formulations as primary therapy for macular edema secondary to branch retinal vein occlusion
CN116585304B (zh) * 2023-04-25 2024-04-05 四川大学华西医院 一种急性肝损伤保护药物及其制备方法
WO2025146683A1 (en) 2024-01-03 2025-07-10 Lyotropic Delivery Systems Ltd. Topical formulations for delivery of an active compound to the back of the eye
CN119701010B (zh) * 2024-12-25 2025-10-28 山东第一医科大学附属眼科医院(山东省眼科医院) 一种基于中性粒细胞纳米囊泡的抗炎和抗血管双向诱捕联合自发光动力的复合物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120009185A1 (en) * 2006-11-10 2012-01-12 Genentech, Inc. Method for treating age-related macular degeneration

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6565861B1 (en) * 2000-02-11 2003-05-20 Isis Innovation Limited Artificial tear formulation
US6610322B1 (en) * 2000-12-20 2003-08-26 Brian Charles Keller Self forming, thermodynamically stable liposomes and their applications
US7785578B2 (en) 2002-10-11 2010-08-31 Aciont, Inc. Non-invasive ocular drug delivery
EP1643971A2 (en) * 2003-05-22 2006-04-12 Neopharm, Inc. Liposomal formulations comprising a combination of two or more active agents
WO2007076274A2 (en) * 2005-12-22 2007-07-05 Bausch & Lomb Incorporated Artificial tear solution containing poly (ethylene glycol) peg lipids
US20070148225A1 (en) * 2005-12-23 2007-06-28 Alcon, Inc. PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
EP2114949A1 (en) 2006-12-07 2009-11-11 F.Hoffmann-La Roche Ag Phosphoinositide 3-kinase inhibitor compounds and methods of use
MX2010004327A (es) * 2007-10-22 2010-05-13 Schering Corp Anticuerpos anti-vegf completamente humanos y metodos de uso.
US8887944B2 (en) * 2007-12-11 2014-11-18 Tokitae Llc Temperature-stabilized storage systems configured for storage and stabilization of modular units
JP5832293B2 (ja) * 2008-12-04 2015-12-16 オプコ ファーマシューティカルズ、エルエルシー 血管新生促進vegfイソ型を選択的に抑制する組成物および方法
US20110033527A1 (en) * 2009-06-02 2011-02-10 Nian Wu Opthalmic compositions of cyclosporin
AU2010257181A1 (en) 2009-06-02 2012-01-12 Brian Charles Keller Pure PEG-lipid conjugates
US8956600B2 (en) * 2009-08-10 2015-02-17 Taiwan Liposome Co. Ltd. Ophthalmic drug delivery system containing phospholipid and cholesterol
CN102625708A (zh) * 2009-09-09 2012-08-01 阿维拉制药公司 Pi3激酶抑制剂及其用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120009185A1 (en) * 2006-11-10 2012-01-12 Genentech, Inc. Method for treating age-related macular degeneration

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