KR102151288B1 - [오르토 바이 (헤테로 )아릴]-[2-(메타 바이 (헤테로 )아릴)-피롤리딘-1-일]-메타논 유도체인 오렉신 수용체 안타고니스트 - Google Patents
[오르토 바이 (헤테로 )아릴]-[2-(메타 바이 (헤테로 )아릴)-피롤리딘-1-일]-메타논 유도체인 오렉신 수용체 안타고니스트 Download PDFInfo
- Publication number
- KR102151288B1 KR102151288B1 KR1020157012089A KR20157012089A KR102151288B1 KR 102151288 B1 KR102151288 B1 KR 102151288B1 KR 1020157012089 A KR1020157012089 A KR 1020157012089A KR 20157012089 A KR20157012089 A KR 20157012089A KR 102151288 B1 KR102151288 B1 KR 102151288B1
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- triazol
- methanone
- pyrrolidin
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C*(C)C(c1c(C)cc(C)cc1)=CC=* Chemical compound C*(C)C(c1c(C)cc(C)cc1)=CC=* 0.000 description 7
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- NGQHIVVEGDOSKS-UHFFFAOYSA-N CCCOc(cccc1)c1-c1nnc(C)[nH]1 Chemical compound CCCOc(cccc1)c1-c1nnc(C)[nH]1 NGQHIVVEGDOSKS-UHFFFAOYSA-N 0.000 description 1
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- VJJYNIXLNXEIPL-UHFFFAOYSA-N CCOc(cccc1)c1-c1nnc(C)[nH]1 Chemical compound CCOc(cccc1)c1-c1nnc(C)[nH]1 VJJYNIXLNXEIPL-UHFFFAOYSA-N 0.000 description 1
- MXYFUEAKDVAGJD-UHFFFAOYSA-N CCOc(nccc1)c1/C(/N)=N/N Chemical compound CCOc(nccc1)c1/C(/N)=N/N MXYFUEAKDVAGJD-UHFFFAOYSA-N 0.000 description 1
- XQJSAQUPRQUJJG-UHFFFAOYSA-N CCc(cccc1)c1-c1nnc(C)[nH]1 Chemical compound CCc(cccc1)c1-c1nnc(C)[nH]1 XQJSAQUPRQUJJG-UHFFFAOYSA-N 0.000 description 1
- YTPLSJNNNAKWQJ-UHFFFAOYSA-N C[O](C)c(cc1)cc2c1[nH]cc2/C(/N)=N/O Chemical compound C[O](C)c(cc1)cc2c1[nH]cc2/C(/N)=N/O YTPLSJNNNAKWQJ-UHFFFAOYSA-N 0.000 description 1
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- BCJXDZGIFOIGOL-UHFFFAOYSA-N C[n]1c2cccc(/C(/N)=N/O)c2cc1 Chemical compound C[n]1c2cccc(/C(/N)=N/O)c2cc1 BCJXDZGIFOIGOL-UHFFFAOYSA-N 0.000 description 1
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- LKBDKLMNHFBFHT-UHFFFAOYSA-N Cc1nc(-c2c3OCCOc3cc(Cc3nc(-c4c5OCOc5ccc4)n[o]3)c2)n[o]1 Chemical compound Cc1nc(-c2c3OCCOc3cc(Cc3nc(-c4c5OCOc5ccc4)n[o]3)c2)n[o]1 LKBDKLMNHFBFHT-UHFFFAOYSA-N 0.000 description 1
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- LILJKQDJWHLMFP-UHFFFAOYSA-N Cc1nc(-c2c[n](C)c3c2cccc3)n[o]1 Chemical compound Cc1nc(-c2c[n](C)c3c2cccc3)n[o]1 LILJKQDJWHLMFP-UHFFFAOYSA-N 0.000 description 1
- FGTSBVMVXJRFBS-UHFFFAOYSA-N Cc1nc(-c2ccccc2)c[o]1 Chemical compound Cc1nc(-c2ccccc2)c[o]1 FGTSBVMVXJRFBS-UHFFFAOYSA-N 0.000 description 1
- WFOKVAOPGBIBLP-UHFFFAOYSA-N Cc1nc(-c2nccnc2Cl)n[o]1 Chemical compound Cc1nc(-c2nccnc2Cl)n[o]1 WFOKVAOPGBIBLP-UHFFFAOYSA-N 0.000 description 1
- MEPBOCYRWAQUAL-UHFFFAOYSA-N Cc1nnc(-c(cc2)ccc2OC)[nH]1 Chemical compound Cc1nnc(-c(cc2)ccc2OC)[nH]1 MEPBOCYRWAQUAL-UHFFFAOYSA-N 0.000 description 1
- DGYSTEOEOHNCTJ-UHFFFAOYSA-N Cc1nnc(-c(cccc2)c2OC(F)(F)F)[nH]1 Chemical compound Cc1nnc(-c(cccc2)c2OC(F)(F)F)[nH]1 DGYSTEOEOHNCTJ-UHFFFAOYSA-N 0.000 description 1
- CMCYXJKCYPQDMB-UHFFFAOYSA-N Cc1nnc(-c(cccc2)c2OC)[nH]1 Chemical compound Cc1nnc(-c(cccc2)c2OC)[nH]1 CMCYXJKCYPQDMB-UHFFFAOYSA-N 0.000 description 1
- KADVECDNZJFSJK-UHFFFAOYSA-N Cc1nnc(-c2cc(C)cc(C)c2)[nH]1 Chemical compound Cc1nnc(-c2cc(C)cc(C)c2)[nH]1 KADVECDNZJFSJK-UHFFFAOYSA-N 0.000 description 1
- QLKMRQIXXGJQGM-UHFFFAOYSA-N Cc1nnc(-c2cccc(Cl)c2C)[nH]1 Chemical compound Cc1nnc(-c2cccc(Cl)c2C)[nH]1 QLKMRQIXXGJQGM-UHFFFAOYSA-N 0.000 description 1
- QQOVIEPBWOTNQS-UHFFFAOYSA-N Cc1nnc(-c2cccc(Cl)c2OC)[nH]1 Chemical compound Cc1nnc(-c2cccc(Cl)c2OC)[nH]1 QQOVIEPBWOTNQS-UHFFFAOYSA-N 0.000 description 1
- YQFSAWBDRLCUHD-UHFFFAOYSA-N Cc1nnc(-c2cccc(F)c2C)[nH]1 Chemical compound Cc1nnc(-c2cccc(F)c2C)[nH]1 YQFSAWBDRLCUHD-UHFFFAOYSA-N 0.000 description 1
- FHOOTWCMVZWRDA-UHFFFAOYSA-N Cc1nnc(-c2cccc(F)c2OC)[nH]1 Chemical compound Cc1nnc(-c2cccc(F)c2OC)[nH]1 FHOOTWCMVZWRDA-UHFFFAOYSA-N 0.000 description 1
- FYZLKPKLEOIPQW-UHFFFAOYSA-N Cc1nnc(-c2cccc(OC)c2)[nH]1 Chemical compound Cc1nnc(-c2cccc(OC)c2)[nH]1 FYZLKPKLEOIPQW-UHFFFAOYSA-N 0.000 description 1
- UJCLXNPHJKRLPX-UHFFFAOYSA-N Cc1nnc(-c2ccccc2)[nH]1 Chemical compound Cc1nnc(-c2ccccc2)[nH]1 UJCLXNPHJKRLPX-UHFFFAOYSA-N 0.000 description 1
- YVDWFZIVIIKYBQ-UHFFFAOYSA-N Cc1nnc(C)[o]1 Chemical compound Cc1nnc(C)[o]1 YVDWFZIVIIKYBQ-UHFFFAOYSA-N 0.000 description 1
- SJTWCLYUHZCGQE-UHFFFAOYSA-N N/C(/c1ccnc2c1cc[nH]2)=N\O Chemical compound N/C(/c1ccnc2c1cc[nH]2)=N\O SJTWCLYUHZCGQE-UHFFFAOYSA-N 0.000 description 1
- RNNNZNACQXRGNS-UHFFFAOYSA-N c([nH]c1c2cccn1)c2-c1n[o]cn1 Chemical compound c([nH]c1c2cccn1)c2-c1n[o]cn1 RNNNZNACQXRGNS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Epidemiology (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12188019 | 2012-10-10 | ||
| EP12188019.9 | 2012-10-10 | ||
| EP13157809 | 2013-03-05 | ||
| EP13157809.8 | 2013-03-05 | ||
| PCT/IB2013/059233 WO2014057435A1 (en) | 2012-10-10 | 2013-10-09 | Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150064753A KR20150064753A (ko) | 2015-06-11 |
| KR102151288B1 true KR102151288B1 (ko) | 2020-09-03 |
Family
ID=49765598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157012089A Expired - Fee Related KR102151288B1 (ko) | 2012-10-10 | 2013-10-09 | [오르토 바이 (헤테로 )아릴]-[2-(메타 바이 (헤테로 )아릴)-피롤리딘-1-일]-메타논 유도체인 오렉신 수용체 안타고니스트 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9493446B2 (https=) |
| EP (1) | EP2906553B1 (https=) |
| JP (1) | JP6244365B2 (https=) |
| KR (1) | KR102151288B1 (https=) |
| CN (1) | CN104703980B (https=) |
| AR (1) | AR092955A1 (https=) |
| AU (1) | AU2013328301A1 (https=) |
| BR (1) | BR112015007516A2 (https=) |
| CA (1) | CA2885180C (https=) |
| EA (1) | EA201500399A1 (https=) |
| IL (1) | IL238052A0 (https=) |
| MX (1) | MX2015004638A (https=) |
| PH (1) | PH12015500627A1 (https=) |
| SG (1) | SG11201502493XA (https=) |
| TW (1) | TW201414727A (https=) |
| WO (1) | WO2014057435A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101689093B1 (ko) | 2012-06-04 | 2016-12-22 | 액테리온 파마슈티칼 리미티드 | 벤즈이미다졸-프롤린 유도체 |
| CA2902135A1 (en) | 2013-03-12 | 2014-09-18 | Actelion Pharmaceuticals Ltd | Azetidine amide derivatives as orexin receptor antagonists |
| HK1225731B (en) | 2013-12-03 | 2017-09-15 | Idorsia Pharmaceuticals Ltd | Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists |
| UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
| HRP20181710T1 (hr) | 2013-12-04 | 2018-12-28 | Idorsia Pharmaceuticals Ltd | Uporaba derivata benzimidazol-prolina |
| JP2017024990A (ja) * | 2013-12-13 | 2017-02-02 | 大正製薬株式会社 | オキサゾリジン及びオキサジナン誘導体 |
| US9938276B2 (en) | 2014-12-19 | 2018-04-10 | Merck Sharp & Dohme Corp. | 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists |
| WO2017012502A1 (en) | 2015-07-17 | 2017-01-26 | Sunshine Lake Pharma Co., Ltd. | Substituted quinazoline compounds and preparation and uses thereof |
| WO2017088759A1 (en) | 2015-11-23 | 2017-06-01 | Sunshine Lake Pharma Co., Ltd. | OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF |
| CN106986859B (zh) * | 2016-01-20 | 2020-02-11 | 广东东阳光药业有限公司 | 吲哚衍生物及其用途 |
| US11970486B2 (en) | 2016-10-24 | 2024-04-30 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
| EA201991650A1 (ru) | 2017-01-06 | 2020-01-20 | Юманити Терапьютикс, Инк. | Способы лечения неврологических расстройств |
| JP7012703B2 (ja) * | 2017-03-08 | 2022-02-14 | 武田薬品工業株式会社 | 置換ピロリジン化合物およびその用途 |
| CN108794454B (zh) * | 2017-04-27 | 2023-08-15 | 广东东阳光药业股份有限公司 | 一种咪唑环化合物的制备方法 |
| HRP20211304T1 (hr) * | 2017-05-03 | 2021-11-12 | Idorsia Pharmaceuticals Ltd | Pripravljanje derivata 2-([1,2,3]triazol-2-il)-benzojeve kiseline |
| WO2019018795A1 (en) * | 2017-07-20 | 2019-01-24 | Yumanity Therapeutics | COMPOUNDS AND USES THEREOF |
| CA3083000A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| CN111655260A (zh) | 2017-10-26 | 2020-09-11 | 南方研究院 | 作为TGF-β抑制剂的噁二唑和噻二唑 |
| BR112020019191A2 (pt) | 2018-03-23 | 2021-01-05 | Yumanity Therapeutics, Inc. | Compostos e seus usos |
| WO2019209962A1 (en) | 2018-04-25 | 2019-10-31 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| MX2021008903A (es) | 2019-01-24 | 2021-11-04 | Yumanity Therapeutics Inc | Compuestos y usos de los mismos. |
| JP7253640B2 (ja) | 2019-01-31 | 2023-04-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
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| WO2004024725A1 (de) | 2002-08-30 | 2004-03-25 | Grünenthal GmbH | 2-pyrrolidin-2-yl-[1,3,4]-oxadiazol-derivate und ihre verwendung als antidepressiva |
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| JP2015533157A (ja) | 2015-11-19 |
| IL238052A0 (en) | 2015-05-31 |
| WO2014057435A1 (en) | 2014-04-17 |
| JP6244365B2 (ja) | 2017-12-06 |
| EP2906553B1 (en) | 2019-06-26 |
| US9493446B2 (en) | 2016-11-15 |
| AU2013328301A1 (en) | 2015-05-28 |
| SG11201502493XA (en) | 2015-04-29 |
| MX2015004638A (es) | 2015-07-14 |
| CN104703980A (zh) | 2015-06-10 |
| EA201500399A1 (ru) | 2015-09-30 |
| AR092955A1 (es) | 2015-05-06 |
| CA2885180A1 (en) | 2014-04-17 |
| AU2013328301A8 (en) | 2015-06-11 |
| CA2885180C (en) | 2021-03-02 |
| PH12015500627A1 (en) | 2015-05-11 |
| TW201414727A (zh) | 2014-04-16 |
| CN104703980B (zh) | 2017-09-22 |
| BR112015007516A2 (pt) | 2017-07-04 |
| KR20150064753A (ko) | 2015-06-11 |
| EP2906553A1 (en) | 2015-08-19 |
| US20150252032A1 (en) | 2015-09-10 |
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