KR102132538B1 - Manufactureing method for cosmetic booster and cosmetic booster by the same and cosmetic composition having the same using rice bran extract - Google Patents

Abstract

The present invention relates to a cosmetic booster and a cosmetic composition using rice bran extract, a cosmetic booster that improves skin softening and penetration of active ingredients by inducing small changes in the lipid layer between cells by properly utilizing glycolipids and phospholipids contained in the rice bran extract. And it provides a composition comprising the same.

Description

Manufacturing method of rice bran extract cosmetic booster, cosmetic booster and cosmetic composition using same{MANUFACTUREING METHOD FOR COSMETIC BOOSTER AND COSMETIC BOOSTER BY THE SAME AND COSMETIC COMPOSITION HAVING THE SAME USING RICE BRAN EXTRACT}

The present invention relates to cosmetics using rice bran extract, and more particularly, to a cosmetic booster and a cosmetic composition comprising the same to increase the effectiveness of the cosmetic active ingredient.

Human skin is a primary barrier that protects the human body from various stimuli originating from the external environment. In addition, it is also a protective film that prevents moisture from the body, which is absolutely necessary to maintain bioactivity, from escaping to the outside. The human body is inevitably exposed to a relatively dry environment compared to the skin most of the time, which is why the skin, especially the stratum corneum, has various substances that store water and prevent evaporation, which plays a very important role in maintaining moisture in the body.

The two most important factors for the moisturizing function of the stratum corneum are the intercellular lamellar lipids, which act as a film to prevent evaporation of moisture, and the other are mainly the decomposition products of filaggrin in the keratinocytes. The composed natural moisturizing factor functions to hold moisture within the stratum corneum.

The skin barrier, which is well developed in the stratum corneum, has an excellent barrier function, and thus is well protected from the external environment, while blocking the active ingredients of cosmetics applied to enhance the function of the skin.

A wide variety of cosmetics are used in everyday life, and cosmetics with specific functions are classified as functional cosmetics. For example, whitening cosmetics that reduce melanin pigment in the skin, wrinkle cosmetics that improve wrinkles, and sunscreens that block the sun's UV rays are typical.

Almost all functional cosmetics, except sunscreens, have an effective ingredient to pass through the epidermal layer to melanocytes in the base layer or fibroblasts in the dermal layer to achieve their effects as a ratio.

However, as described above, due to the presence of the stratum corneum, the active ingredients of functional cosmetics do not penetrate well into the skin and often do not exhibit the desired function. Water-soluble components as well as fat-soluble components are very difficult to pass through the lipid layer of the skin barrier, and the transmittance of the active ingredient in the skin epidermis is known to be about 0.1 to 0.01%.

That is, less than 1/1,000 of the applied cosmetics reach the target cells, which can be understood to mean that an ideal effect can be expected only when 1,000 times or more of the effective concentration on the cells is applied to the skin. However, since most of the active ingredients used in cosmetics are added in the form of a mixture, there is a limit to use in high concentration.

Therefore, rather than increasing the purity of the active ingredient as a method for obtaining the expected effect in cosmetics, it is being developed toward developing a formulation capable of increasing the skin permeability.

Korean Patent Publication No. 10-2017-0003400 discloses a cosmetic composition for achieving the purpose of such absorbency, and FIG. 1 shows the encapsulation structure of the active material accordingly.

Looking specifically, it is composed of nanoparticles including a wrinkle-improving active substance, glycol dissolving agent, polyethylene oxide (PEO)-polypropylene oxide (PPO)-polyethylene oxide (PEO)] type triblock copolymers, and skin penetration promoting agents. , As shown, has a structure of nanoparticles encapsulated with wrinkle-improving active material.

However, in order to extract such an effective substance, a solvent that is toxic to the human body is often used, and methanol or butanol is also used in the encapsulation structure.

In addition, there is also a problem that the manufacturing method is complicated and the cost is excessive to form the structure.

Accordingly, there is a demand for the development of a cosmetic product by a manufacturing method that is economical while allowing water-soluble substances and fat-soluble substances to be effectively delivered to target cells among the active ingredients of cosmetics.

The present invention has been made to solve the above problems, and has an object to provide a cosmetic composition using a rice bran extract capable of protecting a skin barrier while increasing the penetration performance of an active ingredient of cosmetics.

The present invention is a method for producing a rice bran extract cosmetic booster,

a) preparing an organic solvent solution by mixing glycerin, 1,3-butylene glycol, ethanol and distilled water in a weight ratio of 30:30:30:30.

b) mixing the organic solvent solution and rice bran at a ratio of 80: 20 and immersing at a temperature of 50° C.,

c) centrifuging the mixture of immersed organic solvent solution and rice bran to extract rice bran extract containing glycolipid and phospholipid from the upper layer.

In the present invention, by the above-mentioned manufacturing method, a cosmetic booster comprising steryl glucoside, digalactosyldiacylglycerol, glucoceramide and phospholipid is provided.

In addition, the cosmetic booster 5% by weight, glycerin 10% by weight, panthenol 2% by weight, urea 1% by weight, carbomer 0.1% by weight, 1,3 butylene glycol 5% by weight, cetearyl glucoside 1% by weight, beads 1.8% by weight of wax, 2% by weight of cyclopentasiloxane, 2% by weight of cetearyl alcohol, 1% by weight of Changija extract, 1% by weight of Machi Prefecture extract, 1% by weight of Noni extract, 1% by weight of ginkgo biloba extract, 1% by weight of oil extract, Provided is a cosmetic composition comprising 1% by weight of a low-line extract, 1% by weight of an oat extract, and 63.1% by weight of purified water.

According to the present invention, the glycolipid components and phospholipid components contained in the rice bran extract increase the penetration of the active ingredient of cosmetics through the softening action of the skin, simultaneously protect the skin barrier and maximize the effect of the active ingredient as a cosmetic There is.

1 is a view showing an active ingredient encapsulation structure in a prior art cosmetic composition.
2 is a graph showing the results of satisfaction surveys before and after the use of the cosmetic composition using the rice bran extract according to the present invention.
3 is a graph showing skin permeability when using rice bran extract as a booster according to an embodiment of the present invention.

Hereinafter, preferred examples and experimental examples will be described in order to help understanding of the present invention. The following examples or experimental examples may be modified in various other forms, and the content of the present invention is not limited to the following examples.

Rice bran is a form of rind that occurs when rice is polished to make pure white rice. It is equivalent to 6 to 7% of brown rice, and a relatively large amount of rice is produced in Korea. Currently, these by-products are used to produce oils such as rice bran oil or are sold as supplements, and some are used as feed additives.

In the case of rice bran, the lipid component is composed of around 20% and can be seen as 80% neutral lipid, 6-7% glycolipid, and 4-5% phospholipid.

In the present invention, rice bran, in particular, steryl glucoside, digalactosyldiacylglycerol, and glucoceramide, which are glycolipids extracted from rice bran, have affinity for ceramide and cholesterol, which are the main components of the intercellular lipid layer, thereby causing a change in lipid layer structure and temporarily It is based on the discovery that at the same time as it weakens the function of the skin barrier, the phospholipid component contained within about 5% of the extract from rice bran can create a hydrophilic environment along with glycolipids to more easily pass water-soluble substances.

In addition, rice bran is a relatively inexpensive raw material because a large amount is produced and discarded domestically in the form of by-products, and rice bran oil contains a functional oil such as gamma oryzanol, contains a large amount of antioxidants, as well as some glycerides. Cosping ring feed has an antibacterial function and has a universal recognition that it has good ingredients for the skin, so it can be considered that the marketability is excellent as an alternative ingredient for cosmetics.

Accordingly, the present invention provides a method for manufacturing a cosmetic booster using rice bran extract, a cosmetic booster thereby and a functional cosmetic composition comprising the same.

<Rice bran extraction examples 1 to 14>

After washing and drying 20 g of rice bran purchased on the market, glycerin, 1,3-butylene glycol, ethanol, and distilled water were added to 80 g of a solvent mixed for each concentration, immersed for 72 hours at each temperature, and centrifuged to recover the supernatant. .

For reference, as a method for obtaining rice bran extract, an organic solvent extraction method such as nucleic acid, ethyl acetate, acetone, or methanol can be commonly applied, but in the present invention, considering the fact that it is used as a cosmetic composition, the human body for extracting the lipid component of rice bran Environmentally friendly solvents such as glycerin, 1,3-butylene glycol, and ethanol were selected. Conventionally, wax components and phospholipids were first removed by using hot water to extract glycolips derived from rice bran for various purposes, but in the present invention, the phospholipids as well as the wax components in the composition of cosmetics need to be used in the formulation, thereby removing the hot water. Note that is omitted.

Therefore, the rice bran extract of the present invention can be used as a cosmetic booster, which will be described later. The manufacturing method,

a) preparing an organic solvent solution by mixing glycerin, 1,3-butylene glycol, ethanol and distilled water in a weight ratio of 30:30:30:30;

b) mixing the organic solvent solution and rice bran at a ratio of 80:20 and immersing at a temperature of 50°C;

c) extracting a rice bran extract containing glycolipids and phospholipids from the upper layer by centrifuging the mixture of immersed organic solvent solution and rice bran;

It consists of.

In the following examples, glycolipids were extracted according to the ratio and temperature of the three solvents.

The concentration of glycolipid contained in the extract was qualitatively analyzed using a micro-TLC method using alpha-naphthol.

Extraction Example glycerin 1,3-butylene glycol ethanol Distilled water Temperature
℃ Glycolipids obtained One 10 30 10 50 50 - 2 10 30 30 30 50 + 3 10 30 30 30 25 - 4 10 30 50 10 50 ++ 5 10 30 50 10 25 + 6 20 30 10 40 50 - 7 20 30 30 20 25 - 8 20 30 30 20 50 + 9 20 30 50 - 50 +++ 10 20 30 50 - 25 + 11 30 30 10 30 50 + 12 30 30 30 10 50 ++ 13 30 30 30 10 25 ++ 14 30 30 20 - 50 +

In the case of 1,3-butylene glycol, the ratio was fixed, and as a result of experiments, the yield of glycolipids tended to increase as the concentration of ethanol increased. Here, the more glycols are obtained, the higher the yield is.

As a result of experiment, it was the same as in Example 9 that the glycolipid yield was the highest. In Example 9, glycerin, 1,3-butylene glycol, ethanol and distilled water were mixed at a ratio of 20:30:50:0 and extracted at 50°C. However, in this case, there was a problem that sediment was generated in the cosmetic manufacturing process due to the high concentration of neutral lipids in the extract. Then, the glycolipid yield was high and no sediment was found.

Therefore, the condition of Example 12 of rice bran extraction was adopted as the organic solvent composition for the extraction of glycolipids of rice bran as a cosmetic composition.

<Cosmetic Examples and Comparative Examples>

After applying the above method of extracting rice bran, the extracted rice bran extract was mixed with an active ingredient to prepare a cosmetic, and the results are summarized in Table 2 below.

Raw material name Example Comparative example glycerin 10 10 Panthenol 2 2 Urea One One Carbomer 0.1 0.1 1,3 butylene glycol 5 5 Cetearyl glucoside One One Beads wax 1.8 1.8 Cyclopentasiloxane 2 2 Cetearyl alcohol 2 2 Changi extract One One March extract One One Noni Extract One One Ginkgo Leaf Extract One One Oil extract One One Low-line extract One One Oat extract One One Rice bran extract 5 - Purified water 63.1 68.1 system 100 100

<Experimental Example 1: Change in skin moisture content and angular mass>

Rice bran extract Example 12 was applied to examine the changes in moisture content and angular mass of the skin as indicators of skin softening in contrast to the examples of the rice bran extract and cosmetic composition extracted and the comparative examples.

In order to measure changes in skin moisture and keratin, an experiment was conducted on 10 healthy adult women in their late 20s and early 30s, and before the start of the experiment, the subjects were first measured for moisture and angular mass on both cheeks of the face. Then, each of them was applied to the right and left parts of the face twice a day for 2 weeks, respectively, using the cosmetics of the example containing the rice bran extract and the cosmetics of the comparative example not included, and then visiting the hospital. For skin moisture measurement, Corneometer (CM825, Courage+Khazaka Germany) was used, and skin keratin was used for Robo skin analizer (CS-50, Inforward com. Japan).

The results are shown in Table 3 below.

Before the experiment after 2 weeks Moisture Angular mass Moisture Angular mass Example 45.2±8.6 2.3±1.3 49.5±4.9 1.9±1.6 Comparative example 48.9±6.8 2.2±1.3 50.2±5.7 2.2±1.1

As a result of application for 2 weeks, the skin moisture tended to increase in both the Examples and Comparative Examples, but it was confirmed that the angular mass was significantly decreased in the Examples. On the other hand, there was no significant change for each mass in the comparative example.

<Experimental Example 2: Subjective Satisfaction>

Subjective satisfaction was investigated with respect to the subjects of Experimental Example 1, and the results are as shown in FIG. 2.

The softness and smoothness of the skin are related to the reduction of angular mass, which is a factor related to Experimental Example 1, and it can be confirmed that the evaluation of subjective satisfaction is accurate.

In the case of Examples, subjective satisfaction mostly showed high results.

<Experimental Example 3: Skin transmittance>

The extracted rice bran extract was applied to the skin by applying Example 14 to the extract of the rice bran, which can be understood as a booster for a kind of cosmetic.

Accordingly, the effect on the penetration of active ingredients in cosmetics was investigated. For the skin penetration experiment, a Franz cell equipped with skin (2.4 cm ² ) of hairless mice was used. As an active ingredient in cosmetics, Genistein (GST) was selected and a 0.01% GST cream was prepared. Genistein is a kind of phytoestrogen, which is known to show skin-improving effects by acting on skin cells similar to female hormones, but is a substance that is difficult to penetrate the skin barrier.

First, 10 μl of rice bran extract was applied to the skin surface of the hairless rats, spread evenly, and left for 20 minutes. Then, 100 μg of 0.01% GST cream was applied again to the skin surface, and after 6 hours, 12 hours, and 24 hours, 100 μl in the lower layer, respectively. Each sample was sampled and stored frozen. The GST concentration in solution was determined using HPLC.

Skin permeability was calculated as follows.

3 is a result of skin permeability according to the experimental example.

As a result of conducting an in vitro skin permeation experiment in this way, the genistein transfer rate increased by about 1.6 times from 0.11% to 0.176% compared to the case where the rice bran extract was not used as a booster.

Claims (3)

Preparing an organic solvent solution by mixing glycerin, 1,3-butylene glycol, ethanol, and distilled water in a weight ratio of 30:30:30:30;
Mixing the organic solvent solution and rice bran at a ratio of 80: 20 to extract glycolipids, but immersing at a temperature of 50° C. without applying a hot water removal process to obtain phospholipids and wax components;
A method of manufacturing a rice bran extract cosmetic booster comprising; extracting a rice bran extract containing glycolipids and phospholipids from the upper layer by centrifuging the mixture of immersed organic solvent solution and rice bran.
A cosmetic booster produced by the method of claim 1,
A cosmetic booster containing steryl glucoside, digalactosyldiacylglycerol, gluceramide and phospholipids.
The cosmetic booster of claim 2, 5% by weight, 10% by weight of glycerin, 2% by weight of panthenol, 1% by weight of urea, 0.1% by weight of carbomer, 5% by weight of 1,3 butylene glycol, 1% by weight of cetearyl glucoside, beads 1.8% by weight of wax, 2% by weight of cyclopentasiloxane, 2% by weight of cetearyl alcohol, 1% by weight of Changija extract, 1% by weight of Machi Prefecture extract, 1% by weight of Noni extract, 1% by weight of ginkgo biloba extract, 1% by weight of oil extract, Cosmetic composition comprising 1% by weight of low-line extract, 1% by weight of oat extract, and 63.1% by weight of purified water.

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