KR102129150B1 - 이사부코나졸 또는 라부코나졸의 제조 방법 - Google Patents

이사부코나졸 또는 라부코나졸의 제조 방법 Download PDF

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KR102129150B1
KR102129150B1 KR1020157001779A KR20157001779A KR102129150B1 KR 102129150 B1 KR102129150 B1 KR 102129150B1 KR 1020157001779 A KR1020157001779 A KR 1020157001779A KR 20157001779 A KR20157001779 A KR 20157001779A KR 102129150 B1 KR102129150 B1 KR 102129150B1
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KR20150037875A (ko
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숨메렌 뤼벤 판
하리 페쎈
다닐 민크
마리오 바저
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바실리어 파마슈티카 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020157001779A 2012-08-07 2013-07-31 이사부코나졸 또는 라부코나졸의 제조 방법 Active KR102129150B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12179540 2012-08-07
EP12179540.5 2012-08-07
PCT/EP2013/066071 WO2014023623A1 (en) 2012-08-07 2013-07-31 Process for the manufacture of isavuconazole or ravuconazole

Publications (2)

Publication Number Publication Date
KR20150037875A KR20150037875A (ko) 2015-04-08
KR102129150B1 true KR102129150B1 (ko) 2020-07-02

Family

ID=48979725

Family Applications (1)

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KR1020157001779A Active KR102129150B1 (ko) 2012-08-07 2013-07-31 이사부코나졸 또는 라부코나졸의 제조 방법

Country Status (15)

Country Link
US (2) US9783508B2 (https=)
EP (1) EP2882723B1 (https=)
JP (1) JP6334529B2 (https=)
KR (1) KR102129150B1 (https=)
CN (1) CN104507917B (https=)
BR (1) BR112015002526B1 (https=)
CA (1) CA2878361C (https=)
ES (1) ES2616412T3 (https=)
HR (1) HRP20170171T1 (https=)
HU (1) HUE031679T2 (https=)
MX (1) MX360783B (https=)
PL (1) PL2882723T3 (https=)
PT (1) PT2882723T (https=)
SI (1) SI2882723T1 (https=)
WO (1) WO2014023623A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105801500B (zh) * 2014-12-31 2018-08-24 四川科伦药物研究院有限公司 拆分艾沙康唑中间化合物消旋体的方法
CN106317044A (zh) * 2015-06-30 2017-01-11 刘玫君 一种制造艾沙康唑或雷夫康唑的方法
CN104961695A (zh) * 2015-07-27 2015-10-07 成都塞恩斯医药科技有限公司 一种艾沙康唑和雷夫康唑中间体的制备方法
CN106467534B (zh) * 2015-08-17 2019-10-11 江苏奥赛康药业有限公司 一种硫酸艾沙康唑鎓化合物及其药物组合物
CN105907832B (zh) * 2015-12-02 2019-07-12 成都师范学院 一种酶法拆分艾沙康唑中间体的方法
CN108452848B (zh) * 2016-02-24 2020-12-11 上海兰立生物科技有限公司 一种催化剂
CA3061133A1 (en) 2017-04-27 2018-11-01 Codexis, Inc. Ketoreductase polypeptides and polynucleotides
WO2021245590A1 (en) * 2020-06-04 2021-12-09 Metrochem Api Private Limited An improved process for the preparation of triazole derivatives
CN111574444A (zh) * 2020-07-07 2020-08-25 安徽贝克生物制药有限公司 一种贝达喹啉的制备方法
CN116478103B (zh) * 2023-03-24 2025-07-25 四川澄华生物科技有限公司 一种拆分艾沙康唑中间体4的方法
CN119661453B (zh) * 2025-02-17 2025-04-22 四川澄华生物科技有限公司 一种制备艾沙康唑的主链中间体的方法

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
GB8510195D0 (en) * 1985-04-22 1985-05-30 Ici Plc Heterocyclic compounds
US5134152A (en) 1989-12-07 1992-07-28 Sankyo Company, Limited Oxetane derivatives and their use as anti-fungal or fungicidal agents
JP2887523B2 (ja) * 1990-11-30 1999-04-26 富山化学工業株式会社 新規なトリアゾール誘導体およびその塩
GB9107055D0 (en) 1991-04-04 1991-05-22 Pfizer Ltd Triazole antifungal agents
JP4208269B2 (ja) * 1996-10-01 2009-01-14 東芝ソリューション株式会社 異種物混入検査方法及びそのシステム
AU7937998A (en) 1997-07-08 1999-02-08 Sankyo Company Limited Antifungal triazole compounds
AU2931399A (en) 1998-03-06 1999-09-20 F. Hoffmann-La Roche Ag 3-(4-(4-cyanophenyl)thiazol-2-y))-1-(1h-1,2,4-triazol-1-yl) -butan-2-ol derivatives having antifungal activity
PT1399402E (pt) * 2001-06-26 2010-11-30 Basilea Pharmaceutica Ag Derivados intermédios do grupo halofenilo e sua utilização em um processo para a preparação de derivados de azole
EP1954264B1 (en) 2005-12-01 2009-10-07 Basilea Pharmaceutica AG Process for the manufacture of epoxybutanol intermediates
GB0712972D0 (en) 2007-07-04 2007-08-15 Glaxosmithkline Consumer Healt Formulation
ES2652559T3 (es) 2007-07-04 2018-02-05 Dpx Holdings B.V. Preparación de una esterasa
CN102344457B (zh) 2007-09-12 2015-07-22 杏林制药株式会社 作为 gsk-3 抑制剂的螺环状氨基喹诺酮
NZ588983A (en) * 2008-06-25 2011-11-25 Daiichi Sankyo Co Ltd Carboxylic acid compound
WO2010001946A1 (ja) * 2008-07-03 2010-01-07 アステラス製薬株式会社 トリアゾール誘導体またはその塩
ES2689941T3 (es) 2009-04-24 2018-11-16 Patheon Austria Gmbh & Co Kg Esterasas de hígado de cerdo mejoradas
US8207352B2 (en) * 2009-10-08 2012-06-26 Drug Process Licensing Associates LLC Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole
WO2011145669A1 (ja) * 2010-05-19 2011-11-24 大日本住友製薬株式会社 アミド誘導体

Also Published As

Publication number Publication date
BR112015002526A2 (pt) 2018-06-12
JP2015527345A (ja) 2015-09-17
CA2878361C (en) 2020-09-22
CN104507917A (zh) 2015-04-08
ES2616412T3 (es) 2017-06-13
HUE031679T2 (en) 2017-07-28
PL2882723T3 (pl) 2017-05-31
US20190077771A1 (en) 2019-03-14
KR20150037875A (ko) 2015-04-08
MX360783B (es) 2018-11-16
US9783508B2 (en) 2017-10-10
US20150239852A1 (en) 2015-08-27
EP2882723A1 (en) 2015-06-17
CN104507917B (zh) 2017-10-17
BR112015002526B1 (pt) 2022-09-06
WO2014023623A1 (en) 2014-02-13
EP2882723B1 (en) 2016-11-16
JP6334529B2 (ja) 2018-05-30
CA2878361A1 (en) 2014-02-13
MX2015000744A (es) 2015-04-14
PT2882723T (pt) 2017-02-23
SI2882723T1 (sl) 2017-04-26
HRP20170171T1 (hr) 2017-04-07
US10590092B2 (en) 2020-03-17

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