BR112015002526B1 - Derivado do (2r,3r)-éster do ácido 3-hidróxi-2-metil-4 [1,2,4]triazol-1-il-3-fenil-butírico, mistura de diastereoisômeros do referido éster e seu processo de fabricação - Google Patents
Derivado do (2r,3r)-éster do ácido 3-hidróxi-2-metil-4 [1,2,4]triazol-1-il-3-fenil-butírico, mistura de diastereoisômeros do referido éster e seu processo de fabricação Download PDFInfo
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- BR112015002526B1 BR112015002526B1 BR112015002526-9A BR112015002526A BR112015002526B1 BR 112015002526 B1 BR112015002526 B1 BR 112015002526B1 BR 112015002526 A BR112015002526 A BR 112015002526A BR 112015002526 B1 BR112015002526 B1 BR 112015002526B1
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- 230000002068 genetic effect Effects 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 238000009815 homocoupling reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 description 1
- DLEDOFVPSDKWEF-UHFFFAOYSA-N lithium butane Chemical compound [Li+].CCC[CH2-] DLEDOFVPSDKWEF-UHFFFAOYSA-N 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- MZRVEZGGRBJDDB-UHFFFAOYSA-N n-Butyllithium Substances [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 125000001979 organolithium group Chemical group 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000011867 re-evaluation Methods 0.000 description 1
- QEVHRUUCFGRFIF-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-MDEJGZGSSA-N 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 150000004763 sulfides Chemical class 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12179540 | 2012-08-07 | ||
| EP12179540.5 | 2012-08-07 | ||
| PCT/EP2013/066071 WO2014023623A1 (en) | 2012-08-07 | 2013-07-31 | Process for the manufacture of isavuconazole or ravuconazole |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015002526A2 BR112015002526A2 (pt) | 2018-06-12 |
| BR112015002526B1 true BR112015002526B1 (pt) | 2022-09-06 |
Family
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| BR112015002526-9A BR112015002526B1 (pt) | 2012-08-07 | 2013-07-31 | Derivado do (2r,3r)-éster do ácido 3-hidróxi-2-metil-4 [1,2,4]triazol-1-il-3-fenil-butírico, mistura de diastereoisômeros do referido éster e seu processo de fabricação |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9783508B2 (https=) |
| EP (1) | EP2882723B1 (https=) |
| JP (1) | JP6334529B2 (https=) |
| KR (1) | KR102129150B1 (https=) |
| CN (1) | CN104507917B (https=) |
| BR (1) | BR112015002526B1 (https=) |
| CA (1) | CA2878361C (https=) |
| ES (1) | ES2616412T3 (https=) |
| HR (1) | HRP20170171T1 (https=) |
| HU (1) | HUE031679T2 (https=) |
| MX (1) | MX360783B (https=) |
| PL (1) | PL2882723T3 (https=) |
| PT (1) | PT2882723T (https=) |
| SI (1) | SI2882723T1 (https=) |
| WO (1) | WO2014023623A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105801500B (zh) * | 2014-12-31 | 2018-08-24 | 四川科伦药物研究院有限公司 | 拆分艾沙康唑中间化合物消旋体的方法 |
| CN106317044A (zh) * | 2015-06-30 | 2017-01-11 | 刘玫君 | 一种制造艾沙康唑或雷夫康唑的方法 |
| CN104961695A (zh) * | 2015-07-27 | 2015-10-07 | 成都塞恩斯医药科技有限公司 | 一种艾沙康唑和雷夫康唑中间体的制备方法 |
| CN106467534B (zh) * | 2015-08-17 | 2019-10-11 | 江苏奥赛康药业有限公司 | 一种硫酸艾沙康唑鎓化合物及其药物组合物 |
| CN105907832B (zh) * | 2015-12-02 | 2019-07-12 | 成都师范学院 | 一种酶法拆分艾沙康唑中间体的方法 |
| CN108452848B (zh) * | 2016-02-24 | 2020-12-11 | 上海兰立生物科技有限公司 | 一种催化剂 |
| CA3061133A1 (en) | 2017-04-27 | 2018-11-01 | Codexis, Inc. | Ketoreductase polypeptides and polynucleotides |
| WO2021245590A1 (en) * | 2020-06-04 | 2021-12-09 | Metrochem Api Private Limited | An improved process for the preparation of triazole derivatives |
| CN111574444A (zh) * | 2020-07-07 | 2020-08-25 | 安徽贝克生物制药有限公司 | 一种贝达喹啉的制备方法 |
| CN116478103B (zh) * | 2023-03-24 | 2025-07-25 | 四川澄华生物科技有限公司 | 一种拆分艾沙康唑中间体4的方法 |
| CN119661453B (zh) * | 2025-02-17 | 2025-04-22 | 四川澄华生物科技有限公司 | 一种制备艾沙康唑的主链中间体的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8510195D0 (en) * | 1985-04-22 | 1985-05-30 | Ici Plc | Heterocyclic compounds |
| US5134152A (en) | 1989-12-07 | 1992-07-28 | Sankyo Company, Limited | Oxetane derivatives and their use as anti-fungal or fungicidal agents |
| JP2887523B2 (ja) * | 1990-11-30 | 1999-04-26 | 富山化学工業株式会社 | 新規なトリアゾール誘導体およびその塩 |
| GB9107055D0 (en) | 1991-04-04 | 1991-05-22 | Pfizer Ltd | Triazole antifungal agents |
| JP4208269B2 (ja) * | 1996-10-01 | 2009-01-14 | 東芝ソリューション株式会社 | 異種物混入検査方法及びそのシステム |
| AU7937998A (en) | 1997-07-08 | 1999-02-08 | Sankyo Company Limited | Antifungal triazole compounds |
| AU2931399A (en) | 1998-03-06 | 1999-09-20 | F. Hoffmann-La Roche Ag | 3-(4-(4-cyanophenyl)thiazol-2-y))-1-(1h-1,2,4-triazol-1-yl) -butan-2-ol derivatives having antifungal activity |
| PT1399402E (pt) * | 2001-06-26 | 2010-11-30 | Basilea Pharmaceutica Ag | Derivados intermédios do grupo halofenilo e sua utilização em um processo para a preparação de derivados de azole |
| EP1954264B1 (en) | 2005-12-01 | 2009-10-07 | Basilea Pharmaceutica AG | Process for the manufacture of epoxybutanol intermediates |
| GB0712972D0 (en) | 2007-07-04 | 2007-08-15 | Glaxosmithkline Consumer Healt | Formulation |
| ES2652559T3 (es) | 2007-07-04 | 2018-02-05 | Dpx Holdings B.V. | Preparación de una esterasa |
| CN102344457B (zh) | 2007-09-12 | 2015-07-22 | 杏林制药株式会社 | 作为 gsk-3 抑制剂的螺环状氨基喹诺酮 |
| NZ588983A (en) * | 2008-06-25 | 2011-11-25 | Daiichi Sankyo Co Ltd | Carboxylic acid compound |
| WO2010001946A1 (ja) * | 2008-07-03 | 2010-01-07 | アステラス製薬株式会社 | トリアゾール誘導体またはその塩 |
| ES2689941T3 (es) | 2009-04-24 | 2018-11-16 | Patheon Austria Gmbh & Co Kg | Esterasas de hígado de cerdo mejoradas |
| US8207352B2 (en) * | 2009-10-08 | 2012-06-26 | Drug Process Licensing Associates LLC | Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole |
| WO2011145669A1 (ja) * | 2010-05-19 | 2011-11-24 | 大日本住友製薬株式会社 | アミド誘導体 |
-
2013
- 2013-07-31 HU HUE13747999A patent/HUE031679T2/en unknown
- 2013-07-31 EP EP13747999.4A patent/EP2882723B1/en active Active
- 2013-07-31 KR KR1020157001779A patent/KR102129150B1/ko active Active
- 2013-07-31 CA CA2878361A patent/CA2878361C/en active Active
- 2013-07-31 MX MX2015000744A patent/MX360783B/es active IP Right Grant
- 2013-07-31 JP JP2015525826A patent/JP6334529B2/ja active Active
- 2013-07-31 HR HRP20170171TT patent/HRP20170171T1/hr unknown
- 2013-07-31 WO PCT/EP2013/066071 patent/WO2014023623A1/en not_active Ceased
- 2013-07-31 US US14/419,153 patent/US9783508B2/en active Active
- 2013-07-31 ES ES13747999.4T patent/ES2616412T3/es active Active
- 2013-07-31 SI SI201330513A patent/SI2882723T1/sl unknown
- 2013-07-31 PT PT137479994T patent/PT2882723T/pt unknown
- 2013-07-31 CN CN201380038886.2A patent/CN104507917B/zh active Active
- 2013-07-31 PL PL13747999T patent/PL2882723T3/pl unknown
- 2013-07-31 BR BR112015002526-9A patent/BR112015002526B1/pt active IP Right Grant
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2017
- 2017-09-11 US US15/700,647 patent/US10590092B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015002526A2 (pt) | 2018-06-12 |
| JP2015527345A (ja) | 2015-09-17 |
| CA2878361C (en) | 2020-09-22 |
| CN104507917A (zh) | 2015-04-08 |
| ES2616412T3 (es) | 2017-06-13 |
| HUE031679T2 (en) | 2017-07-28 |
| PL2882723T3 (pl) | 2017-05-31 |
| US20190077771A1 (en) | 2019-03-14 |
| KR20150037875A (ko) | 2015-04-08 |
| KR102129150B1 (ko) | 2020-07-02 |
| MX360783B (es) | 2018-11-16 |
| US9783508B2 (en) | 2017-10-10 |
| US20150239852A1 (en) | 2015-08-27 |
| EP2882723A1 (en) | 2015-06-17 |
| CN104507917B (zh) | 2017-10-17 |
| WO2014023623A1 (en) | 2014-02-13 |
| EP2882723B1 (en) | 2016-11-16 |
| JP6334529B2 (ja) | 2018-05-30 |
| CA2878361A1 (en) | 2014-02-13 |
| MX2015000744A (es) | 2015-04-14 |
| PT2882723T (pt) | 2017-02-23 |
| SI2882723T1 (sl) | 2017-04-26 |
| HRP20170171T1 (hr) | 2017-04-07 |
| US10590092B2 (en) | 2020-03-17 |
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