KR102086788B1 - 간암의 비-침습성 진단을 위한 특이적 바이오마커 세트 - Google Patents

간암의 비-침습성 진단을 위한 특이적 바이오마커 세트 Download PDF

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KR102086788B1
KR102086788B1 KR1020167032783A KR20167032783A KR102086788B1 KR 102086788 B1 KR102086788 B1 KR 102086788B1 KR 1020167032783 A KR1020167032783 A KR 1020167032783A KR 20167032783 A KR20167032783 A KR 20167032783A KR 102086788 B1 KR102086788 B1 KR 102086788B1
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KR20170021234A (ko
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코넬리아 윙 인 만
노만 펑 맨 와이
벤자민 치 인 와이
빙 로우 웡
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드래곤 빅토리 디벨롭먼트 리미티드
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • G—PHYSICS
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Immunology (AREA)
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  • Urology & Nephrology (AREA)
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  • Hematology (AREA)
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  • Food Science & Technology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
KR1020167032783A 2014-07-02 2014-07-31 간암의 비-침습성 진단을 위한 특이적 바이오마커 세트 KR102086788B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14/321,867 2014-07-02
US14/321,870 US9885718B2 (en) 2014-07-02 2014-07-02 Specific biomarker set for non-invasive diagnosis of liver cancer
US14/321,867 US9506925B2 (en) 2014-07-02 2014-07-02 Specific biomarker set for non-invasive diagnosis of liver cancer
US14/321,870 2014-07-02
PCT/US2014/049038 WO2016003479A1 (en) 2014-07-02 2014-07-31 Specific biomarker set for non-invasive diagnosis of liver cancer

Publications (2)

Publication Number Publication Date
KR20170021234A KR20170021234A (ko) 2017-02-27
KR102086788B1 true KR102086788B1 (ko) 2020-03-09

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EP (1) EP3164711A4 (es)
JP (2) JP2017520763A (es)
KR (1) KR102086788B1 (es)
CN (2) CN105319362B (es)
AU (2) AU2014399919B2 (es)
CA (1) CA2939912C (es)
HK (2) HK1224370A1 (es)
MY (2) MY179845A (es)
NZ (1) NZ722492A (es)
SG (1) SG11201606106SA (es)
TW (1) TWI700493B (es)
UY (1) UY36200A (es)
WO (1) WO2016003479A1 (es)

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CN106383231B (zh) * 2016-09-02 2020-03-17 四川大学 一种诊断肝癌的标记物组合及其应用
KR102175265B1 (ko) 2019-03-13 2020-11-06 충남대학교산학협력단 Txndc7을 포함하는 간세포암종 진단 또는 예후 예측용 바이오마커 조성물
CN110646615B (zh) * 2019-08-27 2021-07-13 南方医科大学 肝纤维化的生物学标志物、治疗靶点及其用途
WO2023282916A1 (en) 2021-07-09 2023-01-12 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
CN113502328A (zh) * 2021-05-27 2021-10-15 深圳市人民医院 检测样本中标志物表达水平的试剂在制备用于检测或诊断乳腺癌的试剂盒中的应用
CN113777295B (zh) * 2021-09-15 2024-03-19 江南大学 用于检测肿瘤标志物pd-l1的高灵敏度量子点探针、制备方法及应用
CN113956344A (zh) * 2021-10-14 2022-01-21 江南大学 一种新型治疗肝癌的fgf类似物及其应用
CN114113611B (zh) * 2021-12-13 2023-07-14 郑州大学 一种用于肝癌诊断的生物标志物及检测试剂盒

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US20040059519A1 (en) 1998-08-18 2004-03-25 Chandler Van S. Multiplexed analysis of clinical specimens apparatus and methods
WO2004052392A2 (en) 2002-12-11 2004-06-24 The University Of Birmingham Cancer immunotherapy using polycomb proteins
JP2005099001A (ja) * 2003-08-31 2005-04-14 Kyogo Ito 抗ペプチド抗体測定法とペプチドワクチンのワクチン候補選択方法
JP2008026290A (ja) 2006-07-25 2008-02-07 Ehime Univ 腫瘍マーカ、腫瘍診断キットおよび腫瘍マーカの測定方法
JP2012047543A (ja) 2010-08-25 2012-03-08 Yamaguchi Univ 自己抗体の検出方法
WO2013049704A3 (en) 2011-09-28 2013-05-23 Armune Biosciences, Inc. Method and system of particle-phage epitope complex

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US7387881B2 (en) * 2001-09-19 2008-06-17 The Regents Of The University Of Michigan Detection and treatment of cancers of the liver
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Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
US20040059519A1 (en) 1998-08-18 2004-03-25 Chandler Van S. Multiplexed analysis of clinical specimens apparatus and methods
WO2004052392A2 (en) 2002-12-11 2004-06-24 The University Of Birmingham Cancer immunotherapy using polycomb proteins
JP2005099001A (ja) * 2003-08-31 2005-04-14 Kyogo Ito 抗ペプチド抗体測定法とペプチドワクチンのワクチン候補選択方法
JP2008026290A (ja) 2006-07-25 2008-02-07 Ehime Univ 腫瘍マーカ、腫瘍診断キットおよび腫瘍マーカの測定方法
JP2012047543A (ja) 2010-08-25 2012-03-08 Yamaguchi Univ 自己抗体の検出方法
WO2013049704A3 (en) 2011-09-28 2013-05-23 Armune Biosciences, Inc. Method and system of particle-phage epitope complex

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Dai Liping et al, Clinical Immunology (2014.03.22.), vol 152, no 1, pp 127-139.
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HK1224370A1 (zh) 2017-08-18
CN107478842B (zh) 2020-10-16
SG11201606106SA (en) 2016-08-30
JP2017520763A (ja) 2017-07-27
TW201602579A (zh) 2016-01-16
CN105319362B (zh) 2018-07-13
JP2020160082A (ja) 2020-10-01
CN105319362A (zh) 2016-02-10
AU2014399919B2 (en) 2019-10-24
CN107478842A (zh) 2017-12-15
NZ722492A (en) 2019-09-27
UY36200A (es) 2016-01-29
AU2017232129A1 (en) 2017-10-12
AU2014399919A1 (en) 2016-08-11
HK1248803A1 (zh) 2018-10-19
KR20170021234A (ko) 2017-02-27
CA2939912C (en) 2019-04-16
WO2016003479A1 (en) 2016-01-07
MY179845A (en) 2020-11-18
EP3164711A4 (en) 2018-05-23
AU2017232129B2 (en) 2018-10-25
EP3164711A1 (en) 2017-05-10
TWI700493B (zh) 2020-08-01
CA2939912A1 (en) 2016-01-07
MY195045A (en) 2023-01-04

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