KR102086788B1 - 간암의 비-침습성 진단을 위한 특이적 바이오마커 세트 - Google Patents
간암의 비-침습성 진단을 위한 특이적 바이오마커 세트 Download PDFInfo
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- KR102086788B1 KR102086788B1 KR1020167032783A KR20167032783A KR102086788B1 KR 102086788 B1 KR102086788 B1 KR 102086788B1 KR 1020167032783 A KR1020167032783 A KR 1020167032783A KR 20167032783 A KR20167032783 A KR 20167032783A KR 102086788 B1 KR102086788 B1 KR 102086788B1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/321,867 US9506925B2 (en) | 2014-07-02 | 2014-07-02 | Specific biomarker set for non-invasive diagnosis of liver cancer |
| US14/321,870 US9885718B2 (en) | 2014-07-02 | 2014-07-02 | Specific biomarker set for non-invasive diagnosis of liver cancer |
| US14/321,867 | 2014-07-02 | ||
| US14/321,870 | 2014-07-02 | ||
| PCT/US2014/049038 WO2016003479A1 (en) | 2014-07-02 | 2014-07-31 | Specific biomarker set for non-invasive diagnosis of liver cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20170021234A KR20170021234A (ko) | 2017-02-27 |
| KR102086788B1 true KR102086788B1 (ko) | 2020-03-09 |
Family
ID=55019816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167032783A Expired - Fee Related KR102086788B1 (ko) | 2014-07-02 | 2014-07-31 | 간암의 비-침습성 진단을 위한 특이적 바이오마커 세트 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP3164711A4 (enExample) |
| JP (2) | JP2017520763A (enExample) |
| KR (1) | KR102086788B1 (enExample) |
| CN (2) | CN105319362B (enExample) |
| AU (2) | AU2014399919B2 (enExample) |
| CA (1) | CA2939912C (enExample) |
| MY (2) | MY179845A (enExample) |
| NZ (1) | NZ722492A (enExample) |
| SG (1) | SG11201606106SA (enExample) |
| TW (1) | TWI700493B (enExample) |
| UY (1) | UY36200A (enExample) |
| WO (1) | WO2016003479A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106383231B (zh) * | 2016-09-02 | 2020-03-17 | 四川大学 | 一种诊断肝癌的标记物组合及其应用 |
| GB201619954D0 (en) * | 2016-11-25 | 2017-01-11 | Oncimmune Ltd | Antibody assay |
| KR102175265B1 (ko) | 2019-03-13 | 2020-11-06 | 충남대학교산학협력단 | Txndc7을 포함하는 간세포암종 진단 또는 예후 예측용 바이오마커 조성물 |
| CN110646615B (zh) * | 2019-08-27 | 2021-07-13 | 南方医科大学 | 肝纤维化的生物学标志物、治疗靶点及其用途 |
| WO2023282916A1 (en) | 2021-07-09 | 2023-01-12 | Guardant Health, Inc. | Methods of detecting genomic rearrangements using cell free nucleic acids |
| ES2987661T3 (es) | 2020-07-10 | 2024-11-15 | Guardant Health Inc | Métodos de detección de reordenamientos genómicos utilizando ácidos nucleicos libres de células |
| CN113502328A (zh) * | 2021-05-27 | 2021-10-15 | 深圳市人民医院 | 检测样本中标志物表达水平的试剂在制备用于检测或诊断乳腺癌的试剂盒中的应用 |
| CN113777295B (zh) * | 2021-09-15 | 2024-03-19 | 江南大学 | 用于检测肿瘤标志物pd-l1的高灵敏度量子点探针、制备方法及应用 |
| CN113956344A (zh) * | 2021-10-14 | 2022-01-21 | 江南大学 | 一种新型治疗肝癌的fgf类似物及其应用 |
| CN114113611B (zh) * | 2021-12-13 | 2023-07-14 | 郑州大学 | 一种用于肝癌诊断的生物标志物及检测试剂盒 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040059519A1 (en) | 1998-08-18 | 2004-03-25 | Chandler Van S. | Multiplexed analysis of clinical specimens apparatus and methods |
| WO2004052392A2 (en) | 2002-12-11 | 2004-06-24 | The University Of Birmingham | Cancer immunotherapy using polycomb proteins |
| JP2005099001A (ja) * | 2003-08-31 | 2005-04-14 | Kyogo Ito | 抗ペプチド抗体測定法とペプチドワクチンのワクチン候補選択方法 |
| JP2008026290A (ja) | 2006-07-25 | 2008-02-07 | Ehime Univ | 腫瘍マーカ、腫瘍診断キットおよび腫瘍マーカの測定方法 |
| JP2012047543A (ja) | 2010-08-25 | 2012-03-08 | Yamaguchi Univ | 自己抗体の検出方法 |
| WO2013049704A3 (en) | 2011-09-28 | 2013-05-23 | Armune Biosciences, Inc. | Method and system of particle-phage epitope complex |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6893844B1 (en) * | 1998-09-22 | 2005-05-17 | Long Yu | DNA encoding a new human hepatoma derived growth factor and producing method thereof |
| US7387881B2 (en) * | 2001-09-19 | 2008-06-17 | The Regents Of The University Of Michigan | Detection and treatment of cancers of the liver |
| US20040241653A1 (en) * | 2001-12-31 | 2004-12-02 | Elena Feinstein | Methods for identifying marker genes for cancer |
| GB0406215D0 (en) * | 2004-03-19 | 2004-04-21 | Procure Therapeutics Ltd | Prostate stem cell |
| WO2005123944A1 (en) * | 2004-06-18 | 2005-12-29 | Roche Diagnostics Gmbh | Use of protein pdx1 as a marker for breast cancer |
| US20110281284A1 (en) * | 2007-08-10 | 2011-11-17 | Otsuka Pharmaceutical Co., Ltd | Novel liver cancer marker |
| US8512963B2 (en) * | 2009-11-25 | 2013-08-20 | The Johns Hopkins University | Detection and quantitation of full-length thioredoxin (TRX) and truncated thioredoxin (TRX 80) in complex samples |
| US9523680B2 (en) * | 2010-06-30 | 2016-12-20 | Ambergen, Inc. | Global Proteomic screening of random bead arrays using mass spectrometry imaging |
| EP2678448A4 (en) * | 2011-02-22 | 2014-10-01 | Caris Life Sciences Luxembourg Holdings S A R L | CIRCULATING BIOMARKERS |
-
2014
- 2014-07-31 TW TW103126171A patent/TWI700493B/zh not_active IP Right Cessation
- 2014-07-31 NZ NZ72249214A patent/NZ722492A/en not_active IP Right Cessation
- 2014-07-31 WO PCT/US2014/049038 patent/WO2016003479A1/en not_active Ceased
- 2014-07-31 CA CA2939912A patent/CA2939912C/en active Active
- 2014-07-31 KR KR1020167032783A patent/KR102086788B1/ko not_active Expired - Fee Related
- 2014-07-31 MY MYPI2017001446A patent/MY179845A/en unknown
- 2014-07-31 AU AU2014399919A patent/AU2014399919B2/en not_active Ceased
- 2014-07-31 MY MYPI2016002278A patent/MY195045A/en unknown
- 2014-07-31 JP JP2016571689A patent/JP2017520763A/ja active Pending
- 2014-07-31 SG SG11201606106SA patent/SG11201606106SA/en unknown
- 2014-07-31 EP EP14896556.9A patent/EP3164711A4/en not_active Withdrawn
-
2015
- 2015-07-01 CN CN201510379493.9A patent/CN105319362B/zh not_active Expired - Fee Related
- 2015-07-01 CN CN201710545890.8A patent/CN107478842B/zh not_active Expired - Fee Related
- 2015-07-01 UY UY0001036200A patent/UY36200A/es unknown
-
2017
- 2017-09-21 AU AU2017232129A patent/AU2017232129B2/en not_active Ceased
-
2020
- 2020-06-22 JP JP2020106731A patent/JP2020160082A/ja not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040059519A1 (en) | 1998-08-18 | 2004-03-25 | Chandler Van S. | Multiplexed analysis of clinical specimens apparatus and methods |
| WO2004052392A2 (en) | 2002-12-11 | 2004-06-24 | The University Of Birmingham | Cancer immunotherapy using polycomb proteins |
| JP2005099001A (ja) * | 2003-08-31 | 2005-04-14 | Kyogo Ito | 抗ペプチド抗体測定法とペプチドワクチンのワクチン候補選択方法 |
| JP2008026290A (ja) | 2006-07-25 | 2008-02-07 | Ehime Univ | 腫瘍マーカ、腫瘍診断キットおよび腫瘍マーカの測定方法 |
| JP2012047543A (ja) | 2010-08-25 | 2012-03-08 | Yamaguchi Univ | 自己抗体の検出方法 |
| WO2013049704A3 (en) | 2011-09-28 | 2013-05-23 | Armune Biosciences, Inc. | Method and system of particle-phage epitope complex |
Non-Patent Citations (5)
| Title |
|---|
| Chang Kyu Heo et al, BMB Reports (2012), vol 45, no 12 pp 677-685. |
| Dai Liping et al, Clinical Immunology (2014.03.22.), vol 152, no 1, pp 127-139. |
| Junko Akada et al, Proteome Science (2013), 11:33, pp 1-10. |
| Kalpa Patel et al, International Journal of Cancer (2010), vol 129, no 1, pp 133-142. |
| Salama O et al, Biosensors and Bioelectronice (2006), vol 22, pp 1508-1516. |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014399919B2 (en) | 2019-10-24 |
| JP2020160082A (ja) | 2020-10-01 |
| SG11201606106SA (en) | 2016-08-30 |
| CA2939912A1 (en) | 2016-01-07 |
| CN107478842B (zh) | 2020-10-16 |
| AU2014399919A1 (en) | 2016-08-11 |
| JP2017520763A (ja) | 2017-07-27 |
| WO2016003479A1 (en) | 2016-01-07 |
| HK1224370A1 (zh) | 2017-08-18 |
| CN105319362B (zh) | 2018-07-13 |
| EP3164711A1 (en) | 2017-05-10 |
| NZ722492A (en) | 2019-09-27 |
| UY36200A (es) | 2016-01-29 |
| MY195045A (en) | 2023-01-04 |
| TWI700493B (zh) | 2020-08-01 |
| CN107478842A (zh) | 2017-12-15 |
| AU2017232129A1 (en) | 2017-10-12 |
| CN105319362A (zh) | 2016-02-10 |
| TW201602579A (zh) | 2016-01-16 |
| MY179845A (en) | 2020-11-18 |
| CA2939912C (en) | 2019-04-16 |
| HK1248803A1 (zh) | 2018-10-19 |
| KR20170021234A (ko) | 2017-02-27 |
| AU2017232129B2 (en) | 2018-10-25 |
| EP3164711A4 (en) | 2018-05-23 |
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