KR102086709B1 - 뇌신경의 이개 마취에 의한 질병의 치료 방법 - Google Patents

뇌신경의 이개 마취에 의한 질병의 치료 방법 Download PDF

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KR102086709B1
KR102086709B1 KR1020157033239A KR20157033239A KR102086709B1 KR 102086709 B1 KR102086709 B1 KR 102086709B1 KR 1020157033239 A KR1020157033239 A KR 1020157033239A KR 20157033239 A KR20157033239 A KR 20157033239A KR 102086709 B1 KR102086709 B1 KR 102086709B1
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pharmaceutical composition
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nerve
pain
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KR20160003012A (ko
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토마스 엠. 크루즈
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토마스 엠. 크루즈
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020157033239A 2013-05-03 2014-05-05 뇌신경의 이개 마취에 의한 질병의 치료 방법 Active KR102086709B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361819023P 2013-05-03 2013-05-03
US61/819,023 2013-05-03
PCT/US2014/036855 WO2014179814A1 (en) 2013-05-03 2014-05-05 Method of treating disease by auricular anesthesia of cranial nerves

Publications (2)

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KR20160003012A KR20160003012A (ko) 2016-01-08
KR102086709B1 true KR102086709B1 (ko) 2020-03-09

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KR1020157033239A Active KR102086709B1 (ko) 2013-05-03 2014-05-05 뇌신경의 이개 마취에 의한 질병의 치료 방법
KR1020187015606A Active KR102796310B1 (ko) 2013-05-03 2016-11-02 뇌신경의 귀 마취에 의해 질환을 치료하는 방법

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US (5) US20140357686A1 (https=)
EP (2) EP2991620B1 (https=)
JP (3) JP6433985B2 (https=)
KR (2) KR102086709B1 (https=)
CN (2) CN105163718B (https=)
AU (2) AU2014262148B2 (https=)
CA (2) CA2910422C (https=)
DK (1) DK2991620T3 (https=)
ES (1) ES2823624T3 (https=)
HK (1) HK1212230A1 (https=)
IL (2) IL242339B (https=)
MX (2) MX381106B (https=)
MY (2) MY180310A (https=)
RU (2) RU2687249C2 (https=)
SG (1) SG11201508509XA (https=)
WO (2) WO2014179814A1 (https=)
ZA (2) ZA201508782B (https=)

Cited By (1)

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KR20180088408A (ko) * 2013-05-03 2018-08-03 토마스 엠. 크루즈 뇌신경의 귀 마취에 의해 질환을 치료하는 방법

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CA2976756A1 (en) * 2015-02-26 2016-09-01 Limited Liability Company "Konsortsium-Pik" Pharmaceutical composition for treatment of inflammatory ear diseases, method for producing same and method for treatment using said composition
CN110072523A (zh) 2016-09-07 2019-07-30 格利亚有限责任公司 通过脑神经的药理皮肤激活来治疗与神经退行性病症相关的症状
US20220105052A1 (en) * 2016-12-26 2022-04-07 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain
CN107789621A (zh) * 2017-12-15 2018-03-13 阜阳市平衡医疗保健器械有限公司 一种治疗头痛的药物及其配制方法
US11607275B2 (en) * 2019-05-20 2023-03-21 Medtronic Ireland Manufacturing Unlimited Company Selection of hypertensive patients for treatment with renal denervation

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US20120252730A1 (en) * 2009-09-03 2012-10-04 University Of Chicago Platelet aggregation inhibitors
CN103796573A (zh) * 2011-09-15 2014-05-14 优瑟夫·雅阿科比 一种治疗耳病的系统和方法
US20140357686A1 (en) * 2013-05-03 2014-12-04 Thomas M. Crews Method of treating disease by auricular anesthesia of cranial nerves

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International Journal of Pediatric Otorhinolaryngology 76(9):1229-1235 (2012)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180088408A (ko) * 2013-05-03 2018-08-03 토마스 엠. 크루즈 뇌신경의 귀 마취에 의해 질환을 치료하는 방법
KR102796310B1 (ko) * 2013-05-03 2025-04-16 토마스 엠. 크루즈 뇌신경의 귀 마취에 의해 질환을 치료하는 방법

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KR20180088408A (ko) 2018-08-03
AU2016349784A1 (en) 2018-05-17
AU2014262148A1 (en) 2015-11-05
CA2910422C (en) 2022-09-27
CA2910422A1 (en) 2014-11-06
EP3370716A1 (en) 2018-09-12
BR112018008893A8 (pt) 2019-02-26
ES2823624T3 (es) 2021-05-07
JP7512317B2 (ja) 2024-07-08
SG11201508509XA (en) 2015-11-27
JP2018536709A (ja) 2018-12-13
BR112018008893A2 (pt) 2018-11-06
RU2015148757A (ru) 2017-06-08
IL259019A (en) 2018-06-28
NZ742076A (en) 2024-12-20
EP2991620B1 (en) 2020-07-08
MY196979A (en) 2023-05-16
IL242339B (en) 2020-05-31
US9968589B2 (en) 2018-05-15
WO2014179814A1 (en) 2014-11-06
MY180310A (en) 2020-11-28
CN105163718A (zh) 2015-12-16
MX2018005625A (es) 2018-12-06
MX381106B (es) 2025-03-04
JP6433985B2 (ja) 2018-12-05
ZA201803483B (en) 2019-08-28
NZ713746A (en) 2021-01-29
ZA201508782B (en) 2017-08-30
US20260083666A1 (en) 2026-03-26
WO2017079270A1 (en) 2017-05-11
CN105163718B (zh) 2020-03-17
CA3004160C (en) 2023-03-14
US11123284B2 (en) 2021-09-21
US20220387307A1 (en) 2022-12-08
US20140357686A1 (en) 2014-12-04
US20180360745A1 (en) 2018-12-20
EP3370716A4 (en) 2019-04-17
JP2022065015A (ja) 2022-04-26
AU2014262148B2 (en) 2018-11-22
EP2991620A4 (en) 2017-01-11
MX2015015194A (es) 2016-02-11
RU2701548C1 (ru) 2019-09-30
JP2016522819A (ja) 2016-08-04
HK1212230A1 (en) 2016-06-10
EP2991620A1 (en) 2016-03-09
AU2016349784B2 (en) 2019-06-06
IL259019B (en) 2021-06-30
CN108430470A (zh) 2018-08-21
MX390998B (es) 2025-03-21
DK2991620T3 (da) 2020-10-12
CA3004160A1 (en) 2017-05-11
KR20160003012A (ko) 2016-01-08
KR102796310B1 (ko) 2025-04-16
US20160051516A1 (en) 2016-02-25
RU2687249C2 (ru) 2019-05-08

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