KR102074528B1 - 뉴클레오티드를 함유하는 뉴클레오솜의 검출 방법 - Google Patents

뉴클레오티드를 함유하는 뉴클레오솜의 검출 방법 Download PDF

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KR102074528B1
KR102074528B1 KR1020147008108A KR20147008108A KR102074528B1 KR 102074528 B1 KR102074528 B1 KR 102074528B1 KR 1020147008108 A KR1020147008108 A KR 1020147008108A KR 20147008108 A KR20147008108 A KR 20147008108A KR 102074528 B1 KR102074528 B1 KR 102074528B1
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nucleosomes
nucleosome
dna
cancer
cell free
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KR20140078637A (ko
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자콥 빈센트 미칼레프
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벨지언 볼리션 에스피알엘
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    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
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    • G01N33/57545—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the ovaries
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
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KR1020147008108A 2011-09-01 2012-08-31 뉴클레오티드를 함유하는 뉴클레오솜의 검출 방법 Expired - Fee Related KR102074528B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161530295P 2011-09-01 2011-09-01
GBGB1115095.0A GB201115095D0 (en) 2011-09-01 2011-09-01 Method for detecting nucleosomes containing nucleotides
US61/530,295 2011-09-01
GB1115095.0 2011-09-01
PCT/GB2012/052128 WO2013030577A1 (en) 2011-09-01 2012-08-31 Method for detecting nucleosomes containing nucleotides

Publications (2)

Publication Number Publication Date
KR20140078637A KR20140078637A (ko) 2014-06-25
KR102074528B1 true KR102074528B1 (ko) 2020-02-06

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US (2) US10900064B2 (enExample)
EP (2) EP2751568B1 (enExample)
JP (1) JP6322845B2 (enExample)
KR (1) KR102074528B1 (enExample)
CN (1) CN104067124B (enExample)
AU (1) AU2012300641B2 (enExample)
BR (1) BR112014005087B1 (enExample)
CA (1) CA2845993C (enExample)
DK (1) DK2751568T3 (enExample)
ES (1) ES2717659T3 (enExample)
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HU (1) HUE043386T2 (enExample)
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RU (2) RU2687483C2 (enExample)
SG (2) SG11201400270PA (enExample)
TR (1) TR201904386T4 (enExample)
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Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
CN104732118B (zh) 2008-08-04 2017-08-22 纳特拉公司 等位基因调用和倍性调用的方法
ES2640776T3 (es) 2009-09-30 2017-11-06 Natera, Inc. Métodos para denominar de forma no invasiva ploidía prenatal
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
EP2854058A3 (en) 2010-05-18 2015-10-28 Natera, Inc. Methods for non-invasive pre-natal ploidy calling
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
AU2011348100B2 (en) 2010-12-22 2016-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
GB201115095D0 (en) 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
EP2775304A1 (en) * 2013-03-07 2014-09-10 Universitätsspital Basel Methods for detecting inflammatory disorder
WO2015048535A1 (en) * 2013-09-27 2015-04-02 Natera, Inc. Prenatal diagnostic resting standards
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
RU2717641C2 (ru) 2014-04-21 2020-03-24 Натера, Инк. Обнаружение мутаций и плоидности в хромосомных сегментах
US20180173845A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
CN107002021B (zh) * 2014-09-30 2021-12-03 深圳华大基因科技有限公司 类风湿性关节炎的生物标记物及其用途
SG11201702978VA (en) 2014-10-29 2017-05-30 Belgian Volition Sprl Method for the enrichment of circulating tumor dna
EP3256858B1 (en) * 2015-02-10 2020-03-25 B.R.A.H.M.S GmbH Histone h4 peptide as a biomarker
EP4428863A3 (en) 2015-05-11 2024-12-11 Natera, Inc. Methods and compositions for determining ploidy
EP3298169B1 (en) 2015-05-18 2024-10-02 Karius, Inc. Compositions and methods for enriching populations of nucleic acids
GB201511512D0 (en) * 2015-07-01 2015-08-12 Singapore Volition Pte Ltd Use of cell-free nucleosomes as biomarkers
GB201511542D0 (en) * 2015-07-01 2015-08-12 Singapore Volition Pte Ltd Use of cell free nucleosomes as biomarkers
GB201518665D0 (en) 2015-10-21 2015-12-02 Singapore Volition Pte Ltd Method for enrichment of cell free nucleosomes
GB201518674D0 (en) * 2015-10-21 2015-12-02 Singapore Volition Pte Ltd Method for detecting nuleosomes containing histone modifications and variants
GB201604806D0 (en) * 2016-03-22 2016-05-04 Singapore Volition Pte Ltd Method of identifying a cancer of unknown origin
JP7280044B2 (ja) 2016-04-15 2023-05-23 ナテラ， インコーポレイテッド 肺癌の検出方法
CN107858416B (zh) * 2016-09-19 2021-05-28 深圳华大生命科学研究院 用于子宫内膜异位症检测的生物标志物组合及其应用
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CA3049139A1 (en) 2017-02-21 2018-08-30 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
CN107164508A (zh) * 2017-06-16 2017-09-15 上海易毕恩基因科技有限公司 用于检测肝癌的基因标志物及其用途
CN107385051A (zh) * 2017-08-04 2017-11-24 上海易毕恩生物技术有限公司 用于检测肝肿瘤良恶性的基因标志物、试剂盒及检测方法
WO2019118926A1 (en) 2017-12-14 2019-06-20 Tai Diagnostics, Inc. Assessing graft suitability for transplantation
EP3737773B1 (en) 2018-01-12 2023-04-12 Natera, Inc. Novel primers and uses thereof
WO2019161244A1 (en) 2018-02-15 2019-08-22 Natera, Inc. Methods for isolating nucleic acids with size selection
CN111918971B (zh) 2018-03-01 2024-09-03 埃皮塞弗公司 利用化学确定的重组核小体定量核小体修饰
DK3781714T3 (da) 2018-04-14 2026-03-30 Natera Inc Fremgangsmåder til cancerpåvisning og -overvågning ved personlig påvisning af cirkulerende tumor-dna
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
GB201818965D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Method for the detection of colorectal cancer
GB201818963D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Methof for the detection of prostate cancer
GB201906199D0 (en) 2019-05-02 2019-06-19 Belgian Volition Sprl Method for the detection of cancer
GB201906201D0 (en) 2019-05-02 2019-06-19 Belgian Voltion Sprl Method for the detection of protate cancer
US12305235B2 (en) 2019-06-06 2025-05-20 Natera, Inc. Methods for detecting immune cell DNA and monitoring immune system
GB201912251D0 (en) 2019-08-27 2019-10-09 Belgian Volition Sprl Method of isolating circulating nucleosomes
JP2022545821A (ja) 2019-08-27 2022-10-31 ベルジアン ボリション エスアールエル 循環ヌクレオソームを単離する方法
US20230003735A1 (en) 2019-12-02 2023-01-05 Belgian Volition Srl Use of cell free nucleosomes as biomarkers
BR112022018792A2 (pt) 2020-03-20 2022-11-01 Belgian Volition Srl Método de triagem usando níveis de nucleossomos livres de células
TW202238131A (zh) 2020-11-25 2022-10-01 比利時商比利時意志有限公司 測量無細胞核蛋白染色質片段之方法
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EP4781203A1 (en) 2023-09-19 2026-07-29 Belgian Volition SRL Lateral flow test device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002507722A (ja) * 1998-03-18 2002-03-12 ロシュ ダイアグノスティックス ゲーエムベーハー アポトーシス産物の検出

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2652901A1 (fr) 1989-10-11 1991-04-12 Pasteur Institut Complexes biologiques a base de nucleosomes, et leurs applications, notamment dans le domaine du diagnostic in vitro du lupus erythemateux dissemine (led).
US6630301B1 (en) * 1997-03-14 2003-10-07 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum
CA2250118C (en) * 1996-03-26 2009-09-29 Michael S. Kopreski Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer
NL1014106C2 (nl) 2000-01-18 2001-07-20 Univ Amsterdam Werkwijze voor het detecteren van een pathologische afwijking bij een cel, een antistof en een assay kit.
CA2530506A1 (en) 2003-07-04 2005-01-13 Johnson & Johnson Research Pty. Limited Method for detection of alkylated cytosine in dna
GB0319376D0 (en) 2003-08-18 2003-09-17 Chroma Therapeutics Ltd Histone modification detection
WO2005040814A1 (en) 2003-10-14 2005-05-06 Cancer Research Technology Limited Methods and means of cancer detection by histone modification
US7741086B2 (en) * 2004-12-16 2010-06-22 President And Fellows Of Harvard College Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
DE102005034628B4 (de) 2005-07-19 2007-08-23 Epigenomics Ag Verfahren zur Untersuchung von Cytosin-Methylierungen in DNA
WO2007049286A1 (en) * 2005-10-27 2007-05-03 Tata Memorial Centre A system for ex-vivo separation of apoptotic chromatin particles from blood or plasma
WO2007050706A2 (en) 2005-10-27 2007-05-03 University Of Missouri-Columbia Dna methylation biomarkers in lymphoid and hematopoietic malignancies
US20080311122A1 (en) 2005-11-28 2008-12-18 Medimmune, Llc Antagonists of Hmgb1 and/or Rage and Methods of Use Thereof
DE102006035600B3 (de) 2006-07-27 2007-11-08 Epigenomics Ag Verfahren zum Nachweis eines Methylierungsmusters
US20080131954A1 (en) * 2006-11-30 2008-06-05 Canon U.S. Life Sciences, Inc. Method of Separating Target DNA from Mixed DNA
CA2683854A1 (en) * 2007-04-11 2008-10-30 Manel Esteller Epigenetic biomarkers for early detection, therapeutic effectiveness, and relapse monitoring of cancer
US7608402B2 (en) * 2008-01-10 2009-10-27 Weiwei Li DNA methylation specific signal amplification
WO2009115313A1 (en) 2008-03-19 2009-09-24 Oryzon Genomics, S.A. Method and composition for methylation analysis
SI2865387T1 (sl) 2008-11-21 2019-10-30 Kobenhavns Univ University Of Copenhagen Primiranje imunskega odziva
AU2010236415A1 (en) 2009-04-14 2011-12-01 The Regents Of The University Of California Histone modification patterns for clinical diagnosis and prognosis of cancer
WO2011017677A2 (en) 2009-08-06 2011-02-10 Cornell University Device and methods for epigenetic analysis
EP2561367A1 (en) 2010-04-22 2013-02-27 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Means and methods for identifying an increased risk of systemic lupus erythematosus (sle) patients for developing renal manifestations
EP2577313A1 (en) 2010-06-03 2013-04-10 Porto Conte Ricerche S.r.l. Biomarkers for lung neuroendocrine tumors
FI20105715A0 (fi) 2010-06-18 2010-06-18 Helsingin Yliopisto Asetyloituun HMGB1:een sitoutuva polyklonaalinen vasta-aine
CN101955998A (zh) * 2010-07-20 2011-01-26 赵英仁 一种血浆游离dna水平检测肝细胞坏死程度的方法
GB201115098D0 (en) 2011-09-01 2011-10-19 Belgian Volition Sa Method for detecting nucleosomes containing histone variants
GB201115095D0 (en) 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
JP6263474B2 (ja) * 2011-12-07 2018-01-17 シンガポール ボリション ピーティーイー リミテッド ヌクレオソームアダクト検出法
EP4155401A1 (en) 2012-03-02 2023-03-29 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
GB201303575D0 (en) 2013-02-28 2013-04-10 Singapore Volition Pte Ltd Method for detecting histone modifications in nucleosomes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002507722A (ja) * 1998-03-18 2002-03-12 ロシュ ダイアグノスティックス ゲーエムベーハー アポトーシス産物の検出

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DOROTHY J. BALL et al., ‘5-Methylcytosine is localized in nucleosomes that contain histone H1’, Proc. Natl. Acad. Sci., 1983, Vol. 80, pp. 5490-5494. 1부.*
SYLVIE HUCK et al., ‘Abnormal DNA methylation and deoxycytosine-deoxyguanine content in nucleosomes from lymphocytes undergoing apoptosis’, FASEB j., 1999, Vol. 13, pp 1415-1422. 1부.*

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