KR102068118B1 - 뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법 - Google Patents

뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법 Download PDF

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KR102068118B1
KR102068118B1 KR1020147013908A KR20147013908A KR102068118B1 KR 102068118 B1 KR102068118 B1 KR 102068118B1 KR 1020147013908 A KR1020147013908 A KR 1020147013908A KR 20147013908 A KR20147013908 A KR 20147013908A KR 102068118 B1 KR102068118 B1 KR 102068118B1
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composition
polyoxyethylene
block copolymer
polyoxypropylene block
weight
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Korean (ko)
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KR20140084265A (ko
Inventor
카타르지나 아이 고르나
안드레아스 게슬
하인츠 굴레
Original Assignee
백스터 인터내셔널 인코포레이티드
박스터 헬쓰케어 에스에이
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L73/00—Compositions of macromolecular compounds obtained by reactions forming a linkage containing oxygen or oxygen and carbon in the main chain, not provided for in groups C08L59/00 - C08L71/00; Compositions of derivatives of such polymers
    • C08L73/02—Polyanhydrides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00831—Material properties
    • A61B2017/00933—Material properties bone or bone-like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/58—Ethylene oxide or propylene oxide copolymers, e.g. pluronics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020147013908A 2011-10-28 2012-10-29 뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법 Expired - Fee Related KR102068118B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161553032P 2011-10-28 2011-10-28
US61/553,032 2011-10-28
PCT/US2012/062437 WO2013063580A1 (en) 2011-10-28 2012-10-29 Nonaqueous compositions for bone hemostasis, and methods for their use and manufacture

Related Child Applications (1)

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KR1020207000973A Division KR102184970B1 (ko) 2011-10-28 2012-10-29 뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법

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Publication Number Publication Date
KR20140084265A KR20140084265A (ko) 2014-07-04
KR102068118B1 true KR102068118B1 (ko) 2020-01-20

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KR1020147013908A Expired - Fee Related KR102068118B1 (ko) 2011-10-28 2012-10-29 뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법
KR1020207000973A Expired - Fee Related KR102184970B1 (ko) 2011-10-28 2012-10-29 뼈 지혈용 비-수성 조성물, 그의 사용 방법 및 제조 방법

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Country Status (12)

Country Link
US (2) US9512277B2 (https=)
EP (2) EP2771040B1 (https=)
JP (1) JP6095675B2 (https=)
KR (2) KR102068118B1 (https=)
CN (1) CN104010669A (https=)
AU (1) AU2012328415B2 (https=)
BR (1) BR112014010192B1 (https=)
CA (2) CA2853732C (https=)
ES (2) ES2961982T3 (https=)
HK (1) HK1201213A1 (https=)
MX (1) MX359402B (https=)
WO (2) WO2013063580A1 (https=)

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KR101712809B1 (ko) * 2015-03-19 2017-03-08 주식회사 엠아이텍 뼈 지혈용 생체 흡수성 조성물 및 이의 제조 방법
CN105816905B (zh) * 2016-04-15 2020-12-18 广州贝奥吉因生物科技有限公司 一种具有促愈合功能的可吸收骨蜡及其制备方法
CN106039390A (zh) * 2016-05-27 2016-10-26 中国人民解放军第七五医院 一种骨蜡组合物及其制备方法
KR101990069B1 (ko) * 2017-11-28 2019-06-18 ㈜솔시온바이오메디칼 뼈 지혈용품 조성물
CN109125791B (zh) * 2018-09-29 2019-08-30 广州贝奥吉因生物科技有限公司 一种具有促进骨修复功能的可吸收骨蜡及制备方法
KR102220832B1 (ko) 2018-12-13 2021-02-25 건양대학교 산학협력단 세포 독성이 감소된 생체흡수성 뼈 지혈제의 제조방법
KR102211765B1 (ko) * 2019-01-15 2021-02-03 주식회사 테라시온바이오메디칼 흡수성 골 지혈재 조성물 및 이를 이용한 골 지혈재 제조방법
CN111714684A (zh) * 2019-03-19 2020-09-29 广东博与再生医学有限公司 一种骨止血材料及其制备方法
KR102133503B1 (ko) * 2019-08-19 2020-07-13 한스바이오메드 주식회사 골지혈제용 생체 적합성 조성물, 이를 사용하는 치료 방법, 및 이의 제조 방법
US12285546B2 (en) 2019-08-27 2025-04-29 Dof Inc. Animal fat-derived extracellular matrix, and preservation solution of animal fat-derived extracellular matrix
CN114404642A (zh) * 2022-04-01 2022-04-29 天新福（北京）医疗器材股份有限公司 一种可吸收止血骨泥及其制备方法

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US20060280801A1 (en) * 2004-09-16 2006-12-14 Kronenthal Richard L Compositions and method for the reduction of post-operative pain

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US20030095945A1 (en) * 1999-10-29 2003-05-22 Children's Hospital Los Angeles Bone hemostasis method and materials
US20060280801A1 (en) * 2004-09-16 2006-12-14 Kronenthal Richard L Compositions and method for the reduction of post-operative pain

Also Published As

Publication number Publication date
KR102184970B1 (ko) 2020-12-03
CN104010669A (zh) 2014-08-27
EP3878483B1 (en) 2023-08-09
EP3878483A1 (en) 2021-09-15
EP2771040A4 (en) 2015-05-27
WO2013063580A1 (en) 2013-05-02
US9512277B2 (en) 2016-12-06
ES2877715T3 (es) 2021-11-17
EP2771040A1 (en) 2014-09-03
EP2771040B1 (en) 2021-05-26
BR112014010192A2 (pt) 2017-04-18
US20130287818A1 (en) 2013-10-31
MX2014005135A (es) 2014-10-06
WO2013063585A1 (en) 2013-05-02
CA2853732C (en) 2021-06-08
HK1201213A1 (en) 2015-08-28
AU2012328415B2 (en) 2016-03-17
US20130177601A1 (en) 2013-07-11
MX359402B (es) 2018-09-26
CA2853732A1 (en) 2013-05-02
AU2012328415A1 (en) 2014-05-15
ES2961982T3 (es) 2024-03-14
KR20140084265A (ko) 2014-07-04
KR20200010567A (ko) 2020-01-30
CA3107935A1 (en) 2013-05-02
JP2014532481A (ja) 2014-12-08
BR112014010192B1 (pt) 2019-05-14
JP6095675B2 (ja) 2017-03-15

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