KR102058259B1 - 인슐린 의존성 당뇨병의 치료에 유용한 줄기 세포 및 췌장 세포 - Google Patents
인슐린 의존성 당뇨병의 치료에 유용한 줄기 세포 및 췌장 세포 Download PDFInfo
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- KR102058259B1 KR102058259B1 KR1020157000845A KR20157000845A KR102058259B1 KR 102058259 B1 KR102058259 B1 KR 102058259B1 KR 1020157000845 A KR1020157000845 A KR 1020157000845A KR 20157000845 A KR20157000845 A KR 20157000845A KR 102058259 B1 KR102058259 B1 KR 102058259B1
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
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- C12N2500/38—Vitamins
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/42—Organic phosphate, e.g. beta glycerophosphate
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1329—Cardiomyocytes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Virology (AREA)
- Physiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261664259P | 2012-06-26 | 2012-06-26 | |
| US61/664,259 | 2012-06-26 | ||
| PCT/US2013/047243 WO2014004341A1 (en) | 2012-06-26 | 2013-06-24 | Stem cells and pancreatic cells useful for the treatment of insulin-dependent diabetes mellitus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197036838A Division KR102174581B1 (ko) | 2012-06-26 | 2013-06-24 | 인슐린 의존성 당뇨병의 치료에 유용한 줄기세포 및 췌장 세포 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150036059A KR20150036059A (ko) | 2015-04-07 |
| KR102058259B1 true KR102058259B1 (ko) | 2019-12-23 |
Family
ID=48746139
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157000845A Active KR102058259B1 (ko) | 2012-06-26 | 2013-06-24 | 인슐린 의존성 당뇨병의 치료에 유용한 줄기 세포 및 췌장 세포 |
| KR1020197036838A Active KR102174581B1 (ko) | 2012-06-26 | 2013-06-24 | 인슐린 의존성 당뇨병의 치료에 유용한 줄기세포 및 췌장 세포 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197036838A Active KR102174581B1 (ko) | 2012-06-26 | 2013-06-24 | 인슐린 의존성 당뇨병의 치료에 유용한 줄기세포 및 췌장 세포 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9968639B2 (enExample) |
| EP (2) | EP2864473B1 (enExample) |
| JP (2) | JP6386453B2 (enExample) |
| KR (2) | KR102058259B1 (enExample) |
| CN (2) | CN113265370A (enExample) |
| AU (2) | AU2013280698B2 (enExample) |
| BR (1) | BR112014031676A2 (enExample) |
| CA (1) | CA2876677C (enExample) |
| DK (1) | DK2864473T3 (enExample) |
| EA (2) | EA201992135A1 (enExample) |
| ES (1) | ES2745704T3 (enExample) |
| IL (2) | IL236346B (enExample) |
| IN (1) | IN2015DN00281A (enExample) |
| PT (1) | PT2864473T (enExample) |
| SG (1) | SG11201408717XA (enExample) |
| WO (1) | WO2014004341A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106467918B (zh) * | 2015-08-18 | 2020-07-31 | 中国科学技术大学先进技术研究院 | 一种基于人皮肤细胞的胰岛素分泌细胞的诱导方法及应用 |
| CN105434471A (zh) * | 2015-11-26 | 2016-03-30 | 深圳爱生再生医学科技有限公司 | 治疗糖尿病的干细胞制剂及其制备方法 |
| KR20250048481A (ko) * | 2018-02-09 | 2025-04-08 | 세라시스, 인코포레이티드 | 당뇨병을 치료하기 위한 췌장 세포 및 이를 생성하는 방법 |
| AU2019360857A1 (en) * | 2018-10-15 | 2021-06-03 | Evia Life Sciences Inc. | Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ |
| KR20220113389A (ko) * | 2019-12-11 | 2022-08-12 | 고쿠리츠다이가쿠호우진 도쿄다이가쿠 | Mycl 의 일과성 발현에 의한 증식 가능한 췌도 전구 세포형 세포의 유도와 인슐린 양성 세포로의 분화 유도 |
| US20220409855A1 (en) | 2021-06-29 | 2022-12-29 | Staffan Holmin | Methods of delivering cells and therapeutic agents to organs and extravascular sites |
| WO2023199113A1 (en) | 2022-04-15 | 2023-10-19 | Smartcella Solutions Ab | COMPOSITIONS AND METHODS FOR EXOSOME-MEDIATED DELIVERY OF mRNA AGENTS |
| WO2024163938A1 (en) | 2023-02-03 | 2024-08-08 | Seraxis, Inc. | Therapeutic cells and methods relating to the same |
| WO2025029826A1 (en) | 2023-07-31 | 2025-02-06 | Seraxis, Inc. | Modified therapeutics cells and methods relating to the same |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861313A (en) * | 1995-06-07 | 1999-01-19 | Ontogeny, Inc. | Method of isolating bile duct progenitor cells |
| AU2376200A (en) | 1999-01-07 | 2000-07-24 | Incyte Pharmaceuticals, Inc. | Insulin-synthesis genes |
| US6815203B1 (en) * | 1999-06-23 | 2004-11-09 | Joslin Diabetes Center, Inc. | Methods of making pancreatic islet cells |
| US20030082155A1 (en) | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| CA2392615A1 (en) | 1999-12-06 | 2001-06-07 | The General Hospital Corporation | Pancreatic stem cells and their use in transplantation |
| US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| JP2005537803A (ja) | 2002-09-06 | 2005-12-15 | アムサイト インコーポレーティッド | Cd56陽性ヒト成体膵臓内分泌前駆細胞 |
| WO2004113512A2 (en) | 2003-06-20 | 2004-12-29 | Vrije Universiteit Brussel | Method of generating islet beta-cells from exocrine pancreatic cells |
| JP2008500809A (ja) * | 2004-03-09 | 2008-01-17 | ライフスキャン・インコーポレイテッド | インスリン産生細胞を発生させるための方法 |
| US20060029987A1 (en) | 2004-08-06 | 2006-02-09 | Applera Corporation | Diagnosis of pancreatic cancer by using pancreatic targets |
| US7807459B2 (en) | 2005-09-27 | 2010-10-05 | Reneuron, Inc. | EphA4-positive human adult pancreatic endocrine progenitor cells |
| CN101553245A (zh) * | 2006-07-19 | 2009-10-07 | 佛罗里达大学研究基金会有限公司 | 用于细胞重编程的组合物及其用途 |
| WO2008112278A2 (en) | 2007-03-12 | 2008-09-18 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for modulating insulin secretion and glucose metabolism |
| EP2205724B1 (en) * | 2007-11-09 | 2016-04-27 | RNL Bio Co., Ltd. | Method for isolating and culturing adult stem cells derived from human amniotic epithelium |
| WO2009128533A1 (ja) | 2008-04-18 | 2009-10-22 | 国立大学法人名古屋大学 | 間葉系幹細胞およびその生産方法 |
| US20110158961A1 (en) * | 2008-05-09 | 2011-06-30 | The University Court Of The University Of Glasgow | Materials and methods relating to cell based therapies |
| US9683215B2 (en) * | 2008-08-22 | 2017-06-20 | President And Fellows Of Harvard College | Methods of reprogramming cells |
| EP2641911A3 (en) * | 2008-12-23 | 2014-01-01 | Vivoscript, Inc. | Compositions and methods for re-programming cells without genetic modification |
| US20120263689A1 (en) * | 2009-09-10 | 2012-10-18 | The Salk Institute For Biological Studies | Adipose-derived induced pluripotent stem cells |
| EP3498825A1 (en) * | 2010-05-12 | 2019-06-19 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| SG187830A1 (en) * | 2010-08-22 | 2013-03-28 | Univ Ramot | Induced pluripotent stem cells derived from human pancreatic beta cells |
| RU2673946C1 (ru) * | 2010-08-31 | 2018-12-03 | Янссен Байотек, Инк. | Дифференцирование плюрипотентных стволовых клеток |
| EP2616539A1 (en) * | 2010-09-15 | 2013-07-24 | Ramot at Tel-Aviv University Ltd. | Methods of expanding and redifferentiating islet beta cells |
| US20120135015A1 (en) * | 2010-09-28 | 2012-05-31 | Baylor Research Institute | Induction of Pancreatic Stem Cells by Transient Overexpression of Reprogramming Factors and PDX1 Selection |
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2013
- 2013-06-24 EA EA201992135A patent/EA201992135A1/ru unknown
- 2013-06-24 PT PT13733516T patent/PT2864473T/pt unknown
- 2013-06-24 US US13/925,248 patent/US9968639B2/en active Active
- 2013-06-24 EP EP13733516.2A patent/EP2864473B1/en active Active
- 2013-06-24 JP JP2015520349A patent/JP6386453B2/ja active Active
- 2013-06-24 DK DK13733516.2T patent/DK2864473T3/da active
- 2013-06-24 AU AU2013280698A patent/AU2013280698B2/en active Active
- 2013-06-24 EP EP19185702.8A patent/EP3611255A1/en active Pending
- 2013-06-24 SG SG11201408717XA patent/SG11201408717XA/en unknown
- 2013-06-24 CN CN202110419726.9A patent/CN113265370A/zh active Pending
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Non-Patent Citations (2)
| Title |
|---|
| CELL RESEARCH, vol.19(4), pp.429~438(2009) |
| PNASl, vol.108, no.51, pp.20713~20718(2011)* |
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