ES2745704T3 - Células madre y células pancreáticas útiles para el tratamiento de diabetes mellitus insulinodependiente - Google Patents

Células madre y células pancreáticas útiles para el tratamiento de diabetes mellitus insulinodependiente Download PDF

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ES2745704T3
ES2745704T3 ES13733516T ES13733516T ES2745704T3 ES 2745704 T3 ES2745704 T3 ES 2745704T3 ES 13733516 T ES13733516 T ES 13733516T ES 13733516 T ES13733516 T ES 13733516T ES 2745704 T3 ES2745704 T3 ES 2745704T3
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cells
pancreatic
cell
lineage
reprogrammed
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William Rust
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SERAXIS Inc
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • C12N5/0678Stem cells; Progenitor cells; Precursor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K35/39Pancreas; Islets of Langerhans
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • C12N2500/20Transition metals
    • C12N2500/24Iron; Fe chelators; Transferrin
    • C12N2500/25Insulin-transferrin; Insulin-transferrin-selenium
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    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/385Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1329Cardiomyocytes
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/22Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Immunology (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Emergency Medicine (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
ES13733516T 2012-06-26 2013-06-24 Células madre y células pancreáticas útiles para el tratamiento de diabetes mellitus insulinodependiente Active ES2745704T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261664259P 2012-06-26 2012-06-26
PCT/US2013/047243 WO2014004341A1 (en) 2012-06-26 2013-06-24 Stem cells and pancreatic cells useful for the treatment of insulin-dependent diabetes mellitus

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ES2745704T3 true ES2745704T3 (es) 2020-03-03

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US (2) US9968639B2 (enExample)
EP (2) EP3611255A1 (enExample)
JP (2) JP6386453B2 (enExample)
KR (2) KR102058259B1 (enExample)
CN (2) CN104640979B (enExample)
AU (2) AU2013280698B2 (enExample)
BR (1) BR112014031676A2 (enExample)
CA (1) CA2876677C (enExample)
DK (1) DK2864473T3 (enExample)
EA (2) EA033954B1 (enExample)
ES (1) ES2745704T3 (enExample)
IL (2) IL236346B (enExample)
IN (1) IN2015DN00281A (enExample)
PT (1) PT2864473T (enExample)
SG (1) SG11201408717XA (enExample)
WO (1) WO2014004341A1 (enExample)

Families Citing this family (9)

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CN106467918B (zh) * 2015-08-18 2020-07-31 中国科学技术大学先进技术研究院 一种基于人皮肤细胞的胰岛素分泌细胞的诱导方法及应用
CN105434471A (zh) * 2015-11-26 2016-03-30 深圳爱生再生医学科技有限公司 治疗糖尿病的干细胞制剂及其制备方法
WO2019157329A1 (en) * 2018-02-09 2019-08-15 Seraxis, Inc. Pancreatic cells for treating diabetes and methods of generating the same
AU2019360857A1 (en) * 2018-10-15 2021-06-03 Evia Life Sciences Inc. Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ
CN114845727B (zh) * 2019-12-11 2025-08-26 国立大学法人东京大学 基于Mycl瞬时表达的可增殖性胰岛前体细胞样细胞的诱导和胰岛素阳性细胞的分化诱导
US20220409855A1 (en) 2021-06-29 2022-12-29 Staffan Holmin Methods of delivering cells and therapeutic agents to organs and extravascular sites
AU2023254488A1 (en) 2022-04-15 2024-12-05 Smartcella Solutions Ab COMPOSITIONS AND METHODS FOR EXOSOME-MEDIATED DELIVERY OF mRNA AGENTS
EP4658761A1 (en) 2023-02-03 2025-12-10 Seraxis, Inc. Therapeutic cells and methods relating to the same
WO2025029826A1 (en) 2023-07-31 2025-02-06 Seraxis, Inc. Modified therapeutics cells and methods relating to the same

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CA2876677C (en) 2021-09-07
EA201590088A1 (ru) 2015-04-30
EP2864473B1 (en) 2019-08-21
US9968639B2 (en) 2018-05-15
JP6856586B2 (ja) 2021-04-07
EA201992135A1 (ru) 2020-02-05
US20150231181A1 (en) 2015-08-20
IL236346B (en) 2019-06-30
AU2019202085A1 (en) 2019-04-18
US20130344594A1 (en) 2013-12-26
JP2015522281A (ja) 2015-08-06
IL236346A0 (en) 2015-02-26
SG11201408717XA (en) 2015-02-27
DK2864473T3 (da) 2019-09-23
CN113265370A (zh) 2021-08-17
EA033954B1 (ru) 2019-12-13
EP3611255A1 (en) 2020-02-19
KR102058259B1 (ko) 2019-12-23
AU2013280698A1 (en) 2015-01-22
WO2014004341A1 (en) 2014-01-03
KR20190141263A (ko) 2019-12-23
IN2015DN00281A (enExample) 2015-06-12
PT2864473T (pt) 2019-09-27
IL266965A (en) 2019-07-31
AU2013280698B2 (en) 2019-01-17
JP2018193394A (ja) 2018-12-06
KR102174581B1 (ko) 2020-11-06
CN104640979B (zh) 2021-05-04
CA2876677A1 (en) 2014-01-03
US9474772B2 (en) 2016-10-25
KR20150036059A (ko) 2015-04-07
IL266965B (en) 2021-08-31
JP6386453B2 (ja) 2018-09-05
CN104640979A (zh) 2015-05-20
EP2864473A1 (en) 2015-04-29
BR112014031676A2 (pt) 2017-10-31

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