KR102046435B1 - 항-gcc 항체 분자 및 gcc-표적화 치료법에 대한 감수성을 평가하기 위한 그 용도 - Google Patents

항-gcc 항체 분자 및 gcc-표적화 치료법에 대한 감수성을 평가하기 위한 그 용도 Download PDF

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KR102046435B1
KR102046435B1 KR1020147032890A KR20147032890A KR102046435B1 KR 102046435 B1 KR102046435 B1 KR 102046435B1 KR 1020147032890 A KR1020147032890 A KR 1020147032890A KR 20147032890 A KR20147032890 A KR 20147032890A KR 102046435 B1 KR102046435 B1 KR 102046435B1
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gcc
delete delete
antibody molecule
cancer
antibody
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KR20150004882A (ko
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헬렌 알리슨 프랭크
앨리스 에이. 맥도날드
테레사 엘. 오'케페
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밀레니엄 파머슈티컬스 인코퍼레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase

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  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020147032890A 2012-04-27 2013-04-27 항-gcc 항체 분자 및 gcc-표적화 치료법에 대한 감수성을 평가하기 위한 그 용도 Expired - Fee Related KR102046435B1 (ko)

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US201261639376P 2012-04-27 2012-04-27
US61/639,376 2012-04-27
PCT/US2013/038542 WO2013163633A1 (en) 2012-04-27 2013-04-27 Anti-gcc antibody molecules and use of same to test for susceptibility to gcc-targeted therapy

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KR20150004882A KR20150004882A (ko) 2015-01-13
KR102046435B1 true KR102046435B1 (ko) 2019-11-19

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JP6472746B2 (ja) 2019-02-20
US20160130344A1 (en) 2016-05-12
BR112014026742A2 (pt) 2017-07-11
SG11201406855TA (en) 2014-11-27
CN104395470A (zh) 2015-03-04
HRP20191690T1 (hr) 2019-12-27
CO7280144A2 (es) 2015-05-29
PH12014502399A1 (en) 2014-12-22
AU2013251312B2 (en) 2018-03-22
US9273146B1 (en) 2016-03-01
ES2749181T3 (es) 2020-03-19
US9000129B2 (en) 2015-04-07
ECSP14028523A (es) 2015-09-30
AU2013251312A1 (en) 2014-10-30
KR20150004882A (ko) 2015-01-13
ME03560B (me) 2020-07-20
EA201491977A1 (ru) 2015-04-30
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