NZ701601A - Anti-gcc antibody molecules and use of same to test for susceptibility to gcc-targeted therapy - Google Patents

Anti-gcc antibody molecules and use of same to test for susceptibility to gcc-targeted therapy

Info

Publication number
NZ701601A
NZ701601A NZ701601A NZ70160113A NZ701601A NZ 701601 A NZ701601 A NZ 701601A NZ 701601 A NZ701601 A NZ 701601A NZ 70160113 A NZ70160113 A NZ 70160113A NZ 701601 A NZ701601 A NZ 701601A
Authority
NZ
New Zealand
Prior art keywords
gcc
antibody molecules
targeted therapy
methods
antibodies
Prior art date
Application number
NZ701601A
Other languages
English (en)
Inventor
Helen Alison Frank
Alice A Mcdonald
Theresa L O’Keefe
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49477498&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ701601(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of NZ701601A publication Critical patent/NZ701601A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/988Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NZ701601A 2012-04-27 2013-04-27 Anti-gcc antibody molecules and use of same to test for susceptibility to gcc-targeted therapy NZ701601A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261639376P 2012-04-27 2012-04-27
PCT/US2013/038542 WO2013163633A1 (en) 2012-04-27 2013-04-27 Anti-gcc antibody molecules and use of same to test for susceptibility to gcc-targeted therapy

Publications (1)

Publication Number Publication Date
NZ701601A true NZ701601A (en) 2016-09-30

Family

ID=49477498

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ701601A NZ701601A (en) 2012-04-27 2013-04-27 Anti-gcc antibody molecules and use of same to test for susceptibility to gcc-targeted therapy

Country Status (41)

Country Link
US (3) US9000129B2 (https=)
EP (1) EP2841575B1 (https=)
JP (2) JP6472746B2 (https=)
KR (1) KR102046435B1 (https=)
CN (1) CN104395470B (https=)
AR (1) AR090884A1 (https=)
AU (1) AU2013251312B2 (https=)
CA (1) CA2871614C (https=)
CL (1) CL2014002911A1 (https=)
CO (1) CO7280144A2 (https=)
CR (1) CR20140497A (https=)
CY (1) CY1122557T1 (https=)
DK (1) DK2841575T3 (https=)
DO (1) DOP2014000242A (https=)
EA (1) EA034689B1 (https=)
EC (1) ECSP14028523A (https=)
ES (1) ES2749181T3 (https=)
GE (1) GEP201706737B (https=)
HR (1) HRP20191690T1 (https=)
HU (1) HUE046404T2 (https=)
IL (1) IL235307B (https=)
LT (1) LT2841575T (https=)
MA (1) MA37569B1 (https=)
ME (1) ME03560B (https=)
MX (1) MX362020B (https=)
MY (1) MY188442A (https=)
NZ (1) NZ701601A (https=)
PE (1) PE20142322A1 (https=)
PH (1) PH12014502399B1 (https=)
PL (1) PL2841575T3 (https=)
PT (1) PT2841575T (https=)
RS (1) RS59370B1 (https=)
SA (1) SA113340502B1 (https=)
SG (1) SG11201406855TA (https=)
SI (1) SI2841575T1 (https=)
SM (1) SMT201900536T1 (https=)
TN (1) TN2014000454A1 (https=)
TW (1) TWI631137B (https=)
UA (1) UA117910C2 (https=)
WO (1) WO2013163633A1 (https=)
ZA (1) ZA201407723B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201407757XA (en) 2009-10-23 2015-01-29 Millennium Pharm Inc Anti-gcc antibody molecules and related compositions and methods
US20160264663A1 (en) * 2013-10-21 2016-09-15 The Centre For Drug Research And Development Anti-podocalyxin antibodies and methods of using the same
AU2015218355B2 (en) 2014-02-14 2019-09-12 Arkansas Children's Hospital Research Institute, Inc. Acetaminophen protein adducts and methods of use thereof
EP3227681B1 (en) 2014-12-03 2020-10-21 Bioventures, LLC Anti-acetaminophen antibodies and acetaminophen protein adducts
US11090383B2 (en) 2015-10-01 2021-08-17 Centre For Drug Research And Development Anti-podocalyxin antibodies and methods of using the same
US11473081B2 (en) * 2016-12-12 2022-10-18 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
KR102080887B1 (ko) * 2017-11-07 2020-02-24 고려대학교 산학협력단 Gcc2 유전자 또는 단백질을 과발현하는 엑소좀 기반 폐암 진단 또는 예후 예측용 마커 조성물
JP7197584B2 (ja) * 2017-12-06 2022-12-27 ベンタナ メディカル システムズ, インコーポレイテッド デジタル病理学分析結果の格納および読み出し方法
US11568657B2 (en) 2017-12-06 2023-01-31 Ventana Medical Systems, Inc. Method of storing and retrieving digital pathology analysis results
FI3846788T3 (fi) * 2018-09-05 2025-12-17 Univ Amsterdam Pde11-estäjiä parkinsonin taudin hoitoon
WO2021205325A1 (en) * 2020-04-08 2021-10-14 Pfizer Inc. Anti-gucy2c antibodies and uses thereof
CN115605594A (zh) * 2020-06-02 2023-01-13 帝人制药株式会社(Jp) 抗igf-1受体人源化抗体
WO2022127871A1 (en) * 2020-12-17 2022-06-23 Parasol Biotech Ltd. Gucy2c binding molecules and uses thereof
CN116964100A (zh) * 2021-04-07 2023-10-27 株式会社Lg化学 Gucy2c结合多肽及其用途
EP4594364A1 (en) * 2022-09-28 2025-08-06 Legend Biotech Ireland Limited Antibody and chimeric antigen receptors targeting gcc and methods of use thereof
KR20250099224A (ko) 2022-11-01 2025-07-01 하이델베르크 파마 리서치 게엠베하 항-gucy2c 항체 및 이의 용도
CN116535514B (zh) * 2023-06-15 2024-02-02 上海斯丹赛生物技术有限公司 抗鸟苷酸环化酶c抗体及其在癌症治疗中的应用
CN117069848B (zh) * 2023-08-02 2025-02-28 武汉爱博泰克生物科技有限公司 抗人cd146兔单克隆抗体及其应用
CN121866270A (zh) * 2023-09-21 2026-04-14 南京传奇生物科技有限公司 抗gcc抗体、嵌合抗原受体及其用途
EP4566631A1 (en) 2023-12-06 2025-06-11 Heidelberg Pharma Research GmbH New antibody drug conjugate as well as methods of production and uses thereof
CN120965861B (zh) * 2025-10-22 2026-02-13 杭州博茵生物技术有限公司 一种Fc效应消除的新型骨架流式抗体及其制备方法与应用

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5237051A (en) 1990-12-06 1993-08-17 Vanderbilt University Purified enterotoxin receptor protein
US7097839B1 (en) 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
US5518888A (en) 1993-10-26 1996-05-21 Thomas Jefferson University ST receptor binding compounds and methods of using the same
US5879656A (en) 1993-10-26 1999-03-09 Thomas Jefferson University Methods of treating metastatic colorectal cancer with ST receptor binding compounds
EP0734264B1 (en) 1993-10-26 2004-02-18 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
US5601990A (en) 1994-09-13 1997-02-11 Thomas Jefferson University Methods of diagnosing colorectal tumors and metastasis thereof
US6455251B1 (en) 1994-09-13 2002-09-24 Thomas Jefferson University Methods of and kits and compositions for diagnosing colorectal tumors and metastasis thereof
DE69723580T2 (de) 1996-05-03 2004-06-03 Thomas Jefferson University Impfstoff gegen metastasierenden kolorektalkrebs.
US6602659B1 (en) 1996-05-03 2003-08-05 Thomas Jefferson University Methods of and kits and compositions for diagnosing colorectal tumors and metastasis thereof
US6120995A (en) 1997-08-07 2000-09-19 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
US6696550B2 (en) 1998-07-23 2004-02-24 Millennium Pharmaceuticals, Inc. Humanized anti-CCR2 antibodies and methods of use therefor
US8092514B1 (en) 1998-11-16 2012-01-10 Boston Scientific Scimed, Inc. Stretchable anti-buckling coiled-sheet stent
US20040031072A1 (en) 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
CA2404431C (en) 2000-03-27 2011-06-07 Thomas Jefferson University Guanylyl cyclase c in the detection of stomach and esophageal cancers
PE20020574A1 (es) 2000-12-06 2002-07-02 Wyeth Corp Anticuerpos humanizados que reconocen el peptido amiloideo beta
PT1377314E (pt) 2001-01-26 2012-01-02 Inhibitex Inc Anticorpos monoclonais para a proteína clfa e método de utilização no tratamento ou prevenção de infecções
CA2905585C (en) 2001-03-29 2020-02-18 Bausch Health Ireland Limited Guanylate cyclase receptor agonists for the treatment and/or prevention of cancer or polyps
DE60236735D1 (de) 2001-04-13 2010-07-29 Biogen Idec Inc Antikörper gegen vla-1
EP1470146B8 (en) 2001-12-28 2007-09-12 Amgen Fremont Inc. Antibodies against the muc18 antigen
US20040110933A1 (en) 2002-09-13 2004-06-10 Dyax Corporation CD44-binding ligands
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
US7371727B2 (en) 2003-01-28 2008-05-13 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7304036B2 (en) 2003-01-28 2007-12-04 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US8206704B2 (en) 2003-02-10 2012-06-26 Thomas Jefferson University Use of GCC ligands
US20090005257A1 (en) 2003-05-14 2009-01-01 Jespers Laurent S Process for Recovering Polypeptides that Unfold Reversibly from a Polypeptide Repertoire
US7871610B2 (en) 2003-08-12 2011-01-18 Dyax Corp. Antibodies to Tie1 ectodomain
EP1781339B1 (en) 2004-06-25 2013-12-25 Thomas Jefferson University Guanylyl cyclase C ligands
ZA200705695B (en) 2004-12-21 2009-02-25 Astrazeneca Ab Antibodies directed to angiopoietin-2 and uses thereof
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
AU2008287128B2 (en) * 2007-08-10 2013-07-18 Janssen Biotech, Inc. Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such
MX2010001395A (es) 2007-08-10 2010-03-10 Regeneron Pharma Anticuerpos humanos de alta afinidad de factor de crecimiento de nervio humano.
CA2705792A1 (en) * 2007-11-30 2009-06-11 Milan Radovich Vegf polymorphisms and anti-angiogenesis therapy
US20110195415A1 (en) 2008-05-13 2011-08-11 Thomas Jefferson University Guanylyl cyclase c qrt-pcr
WO2009149278A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010065293A1 (en) 2008-12-03 2010-06-10 Boehringer Ingelheim Pharmaceuticals Inc. Antibodies for guanylyl cyclase receptors
EP3266795A1 (en) * 2009-02-12 2018-01-10 Cell Signaling Technology, Inc. Method for detecting a fig-ros fusion polynucleotide
JP2012518389A (ja) 2009-02-25 2012-08-16 ダイアグノキュア インコーポレイテッド Gi癌の転移を検出するための方法
US8598188B2 (en) * 2009-03-12 2013-12-03 Kinki University Method for predicting therapeutic efficacy of chemotherapy on non-small-cell lung cancer
CA2801729A1 (en) 2009-06-15 2010-12-23 Thomas Jefferson University Compositions for and methods of activating guanylyl cyclase c
WO2011066048A1 (en) 2009-10-22 2011-06-03 Thomas Jefferson University Cell-based anti-cancer compositions and methods of making and using the same
SG10201407757XA (en) * 2009-10-23 2015-01-29 Millennium Pharm Inc Anti-gcc antibody molecules and related compositions and methods
EP2576622A4 (en) * 2010-06-01 2013-11-27 Univ Monash ON THE UNPROCESSED RECEPTOR TYROSINE KINASE C-MET TARGETED ANTIBODIES
BR112013001879A2 (pt) * 2010-08-13 2019-09-03 F. Hoffmann-La Roche Ag "método para aprefeiçoar o efeito de tratamento em um paciente que sofre de câncer gástrico, método in vitro, kit, uso de um olignucleotídeo ou polipetídio e uso de bevacizumabe"
US20150086481A1 (en) 2011-07-28 2015-03-26 Memorial Sloan-Kettering Cancer Center Diagnosis and treatment of parkinson's disease
US9156915B2 (en) 2012-04-26 2015-10-13 Thomas Jefferson University Anti-GCC antibody molecules
EP2961424A4 (en) * 2013-02-28 2016-10-19 Millennium Pharm Inc ADMINISTRATION OF AN ANTI-GCC-ANTIBODY-ACTIVE CONJUGATE AND A DNA DAMAGING ACTIVE IN THE TREATMENT OF CANCER

Also Published As

Publication number Publication date
JP6472746B2 (ja) 2019-02-20
US20160130344A1 (en) 2016-05-12
BR112014026742A2 (pt) 2017-07-11
SG11201406855TA (en) 2014-11-27
CN104395470A (zh) 2015-03-04
HRP20191690T1 (hr) 2019-12-27
CO7280144A2 (es) 2015-05-29
PH12014502399A1 (en) 2014-12-22
AU2013251312B2 (en) 2018-03-22
US9273146B1 (en) 2016-03-01
ES2749181T3 (es) 2020-03-19
US9000129B2 (en) 2015-04-07
ECSP14028523A (es) 2015-09-30
AU2013251312A1 (en) 2014-10-30
KR20150004882A (ko) 2015-01-13
ME03560B (me) 2020-07-20
EA201491977A1 (ru) 2015-04-30
CN104395470B (zh) 2018-02-06
DOP2014000242A (es) 2014-11-30
CR20140497A (es) 2015-02-10
EP2841575A1 (en) 2015-03-04
JP6517267B2 (ja) 2019-05-22
GEP201706737B (en) 2017-09-25
JP2015516985A (ja) 2015-06-18
KR102046435B1 (ko) 2019-11-19
JP2017131245A (ja) 2017-08-03
DK2841575T3 (da) 2019-09-23
EP2841575A4 (en) 2016-06-15
EA034689B1 (ru) 2020-03-06
IL235307B (en) 2019-07-31
TWI631137B (zh) 2018-08-01
US20130287783A1 (en) 2013-10-31
PH12014502399B1 (en) 2022-04-22
PL2841575T3 (pl) 2020-01-31
WO2013163633A1 (en) 2013-10-31
PE20142322A1 (es) 2015-01-25
SMT201900536T1 (it) 2019-11-13
HK1208049A1 (en) 2016-02-19
MX362020B (es) 2019-01-04
MX2014013081A (es) 2015-01-12
SA113340502B1 (ar) 2015-09-17
TN2014000454A1 (en) 2016-03-30
CA2871614A1 (en) 2013-10-31
CY1122557T1 (el) 2021-01-27
UA117910C2 (uk) 2018-10-25
IL235307A0 (en) 2014-12-31
PT2841575T (pt) 2019-10-11
ZA201407723B (en) 2019-01-30
EP2841575B1 (en) 2019-06-26
HUE046404T2 (hu) 2020-02-28
MA37569B1 (fr) 2020-08-31
TW201348258A (zh) 2013-12-01
CL2014002911A1 (es) 2015-01-30
MY188442A (en) 2021-12-09
LT2841575T (lt) 2019-10-10
RS59370B1 (sr) 2019-11-29
SI2841575T1 (sl) 2019-11-29
AR090884A1 (es) 2014-12-10
CA2871614C (en) 2021-08-31

Similar Documents

Publication Publication Date Title
PH12014502399A1 (en) Anti-gcc antibody molecules and use of same to test for susceptibility to gcc-targeted therapy
BR112012020101A2 (pt) método diagnósticos e terapêuticos usando anticorpos anti-cd200.
WO2009085216A3 (en) Compositions and methods for detecting or elimninating senescent cells to diagnose or treat disease
BR112018005322A2 (pt) anticorpo monoclonal ou seu fragmento de ligação a antígenos, composição farmacêutica, anticorpo monoclonal ou seu fragmento de ligação a antígenos para uso, método de tratamento de lesão de isquemia-reperfusão, método de tratamento de câncer em um paciente humano, método de avaliação da expressão de cd47 em células tumorais e/ou imunes usando um anticorpo monoclonal ou seu fragmento de ligação a antígenos
CY1121392T1 (el) Μορια δεσμευσης εναντι-αλφα συνουκλεϊνης
MX383886B (es) Anticuerpo anti-trop-2 humano que tiene una actividad antitumoral in vivo.
IL214255B (en) Use of antibodies for preparation of medicaments for treatment of cancer associated with a tumor antigen and methods for diagnosis of cancer associated with a tumor antigen
EA201291260A1 (ru) Антитело против trop-2 человека, обладающее противоопухолевой активностью in vivo
MX362514B (es) Kits y ensayos de diagnostico para la deteccion del receptor 1 de folato.
BR112016002000A2 (pt) Diagnóstico e terapia de câncer envolvendo células-tronco tumorais
EP3236262A3 (en) Surrogate functional diagnostics test for cancer
WO2008103645A8 (en) Prostate cancer and melanoma antigens
EA201100923A1 (ru) Антитела человека против тканевого фактора
CO6351751A2 (es) Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
UA106771C2 (uk) Моноклональні антитіла до прогастрину та їх використання
WO2011015333A3 (en) Targeting of bone marrow neovasculature
CY1120063T1 (el) Αντισωματα κατα του ανθρωπινου dlk-1 που εχει δραση κατα των ογκων in vivo
MX2010005057A (es) Metodos y composiciones para uso de diagnostico en pacientes de cancer.
EP2614375A4 (en) COMBINATION METHOD FOR CANCER DIAGNOSIS
BR112013016107A2 (pt) molécula dimérica, método de tratamento de câncer, composição farmacêutica e kit para o diagnóstico de uma patologia ou tumor mediado(a) por upar
FR2979346B1 (fr) Nanocorps anti-vcam-1
BRPI0923652A2 (pt) diagnóstico e tratamento de câncer usando anticorpo anti-lgr7
EP2844776A4 (en) CANCER BLOOD TEST USING INSULATED BC200 RNA FROM PERIPHERAL BLOOD FOR THE DIAGNOSIS AND TREATMENT OF INVASIVE BREAST CANCER
WO2012119989A3 (en) Antibodies against cadmi for the diagnosis and treatment of cancer
TH1401006471A (th) โมเลกุลแอนติบอดีต้าน gcc และการใช้โมเลกุลดังกล่าวเพื่อทดสอบภูมิไวรับต่อการรักษาที่มุ่งเป้าไปที่ gcc

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 APR 2018 BY COMPUTER PACKAGES INC

Effective date: 20170331

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 APR 2019 BY COMPUTER PACKAGES INC

Effective date: 20180331

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 APR 2020 BY COMPUTER PACKAGES INC

Effective date: 20190402

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 APR 2021 BY COMPUTER PACKAGES INC

Effective date: 20200331

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 APR 2022 BY COMPUTER PACKAGES INC

Effective date: 20210330

ASS Change of ownership

Owner name: TAKEDA PHARMACEUTICAL COMPANY, JP

Effective date: 20211022

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 APR 2023 BY ANAQUA SERVICES

Effective date: 20220322

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 APR 2024 BY ANAQUA SERVICES

Effective date: 20230322

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 APR 2025 BY ANAQUA SERVICES

Effective date: 20240320

LAPS Patent lapsed